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The map label for this gene is pfbA [H]

Identifier: 225861631

GI number: 225861631

Start: 1666605

End: 1668683

Strand: Reverse

Name: pfbA [H]

Synonym: SPT_1752

Alternate gene names: 225861631

Gene position: 1668683-1666605 (Counterclockwise)

Preceding gene: 225861632

Following gene: 225861630

Centisome position: 79.0

GC content: 31.75

Gene sequence:

>2079_bases
ATGAAATCTTTTCAACAAAATGAGGTTTTCTCTATTCGTAAGTCTAAGGTGGGAGTTTGCTCAGTTCTCTTAGCGGTTTT
ATTTATTGGAACACAAAGTGTTTTAGCTAATGAAGTAGTTGGTGAAACTTCTTCGTCTAAAGATAATATGCAAATGAACT
CTTTGTTGAGTAGCACATCTACATCATTATCTGCGGAACCCCATTCTGATACTCTCAGTCTTGATAACAATTCAAGTTTA
AGTACTGATAATAATGGAGGAGTGAGTATTAATCAAAATAAACCTGATATAACAAATGATACTATGATGGGTAACATCTC
TGGGATGGAAGTGAATACTATTTTAAGTACTAATCTGAACGAACACGTAGCTTTGAATGTTAAAGATTATGGAGCAATAG
GTGACGGGGTTAATGATGATCGACAAGCAATTCAAGATGCAATAGATGCTGCAGCTCAAGGGCTAGGTGGAGGAAATGTA
TATTTTCCGGAAGGAACTTATTTAGTAAAAGAAATTGTTTTTTTAAAAAGTCATACACACTTAGAATTGAATGAGAAAGC
TACCATTCTAAATGGTATAAATATTAAGAATCACCCTTCTATTGTTTTTATGACAGGTTTATTTACGGATGATGGTGCGC
AAGTAGAATGGGGCCCAACAGAAGATATTAGTTATTCTGGTGGTACTATTGATATGAACGGTGCTTTGAATGAAGAAGGA
ACTAAAGCAAAAAATCTACCACTTATAAATTCTTCAGGTGCATTTGCTATTGGGAATTCAAATAACGTAACTATAAAAAA
TGTAACATTCAAGGATAGTTATCAAGGGCATGCTATTCAAATTGCAGGTTCGAAAAATGTATTAGTTGATAATTCTCGTT
TTCTTGGGCAAGCCTTACCCAAAACGATGAAGGATGGGCAAATCATAAGTAAGGAGAGCATTCAGATTGAACCATTAACT
AGAAAAGGTTTTCCTTATGCCTTGAATGATGATGGGAAAAAATCTGAAAATGTGACTATTCAAAATTCCTATTTTGGCAA
AAGTGATAAATCTGGGGAATTAGTAACAGCAATTGGCACACACTATCAAACATTGTCGACACAGAACCCCTCTAATATTA
AAATTTTAAATAATCATTTTGATAACATGATGTATGCAGGTGTACGTTTTACAGGATTCACTGATGTATTAATCAAAGGA
AATCGCTTTGATAAGAAAGTTAAAGGAGAGAGTGTACATTATCGAGAAAGCGGAGCAGCTTTAGTAAATGCTTATAGCTA
TAAAAACACTAAAGACCTATTAGATTTAAATAAACAGGTGGTTATCGCCGAAAATATATTTAATATTGCCGATCCTAAAA
CAAAAGCGATACGAGTTGCAAAAGATAGTGCAGAATATTTAGGAAAAGTATCAGATATTACTGTAACAAAAAATGTAATT
AATAATAATTCTAAGGAAACAGAACAACCAAATATTGAATTATTACGAGTTAGTGATAATTTAGTAGTCTCAGAGAATAG
TATATTCGGTGGTAAAGAAGGAATTGTTATTGAGGATTCAAAGGGTAAAATAACCGTTTTAAATAACCAATTTTATAATT
TATCCGGTAAGTATATATCATTCATCAAATCTAATGCAAATGAGAAAGAGCCTGTTATACGTGATAGCGATGGTAATTTC
AATATTGTAACGGAGAATGGGCTTTACAAAATTGTAACAAATAACTTAAGTGATAAAAACGAAAAAGAAAAAAACAAAGA
GGAAAAACAATCTAATTCAAATAATGTAATTGATAGTAACCAGAAGAACGGAGAGTTTAACTCAAGTAAAGATAATAGAC
AAATGAATGACAAGATCGACAATAAACAAGATAATAAGACAGAAGAAGTAAACTATAAAATAGTTGGAGATGGCAGAGAA
ACTGAAAATCATATTAATAAATCTAAAGAAATAGTAGATGTAAAACAAAAATTACCAAAGACTGGTTCGAACAAGATTAT
GGAACTATTCTTAACAGTGACAGGAATTGGTTTACTTTTGACACTAAAAGGGTTGAAGTATTATGGTAAAGATAAATAA

Upstream 100 bases:

>100_bases
TAAAAATATATTATAAAGAAAATGACAGCGGTGTCATTTTCTGGTATGGAATTTATATGAATATTAAATTAGGACATAAT
ATTTTTAATTGGAGGCTAAT

Downstream 100 bases:

>100_bases
AATTTGTTCGATACAAGGAAGTTCCGCAGAAAATGAGGATACTGTAGGTTCACAAAATCAGTATTTTTGGATTATTGATG
GAGCTACAGATTTATATAAT

Product: cell wall surface anchor family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 692; Mature: 692

Protein sequence:

>692_residues
MKSFQQNEVFSIRKSKVGVCSVLLAVLFIGTQSVLANEVVGETSSSKDNMQMNSLLSSTSTSLSAEPHSDTLSLDNNSSL
STDNNGGVSINQNKPDITNDTMMGNISGMEVNTILSTNLNEHVALNVKDYGAIGDGVNDDRQAIQDAIDAAAQGLGGGNV
YFPEGTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDISYSGGTIDMNGALNEEG
TKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALPKTMKDGQIISKESIQIEPLT
RKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMMYAGVRFTGFTDVLIKG
NRFDKKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSAEYLGKVSDITVTKNVI
NNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYISFIKSNANEKEPVIRDSDGNF
NIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVIDSNQKNGEFNSSKDNRQMNDKIDNKQDNKTEEVNYKIVGDGRE
TENHINKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK

Sequences:

>Translated_692_residues
MKSFQQNEVFSIRKSKVGVCSVLLAVLFIGTQSVLANEVVGETSSSKDNMQMNSLLSSTSTSLSAEPHSDTLSLDNNSSL
STDNNGGVSINQNKPDITNDTMMGNISGMEVNTILSTNLNEHVALNVKDYGAIGDGVNDDRQAIQDAIDAAAQGLGGGNV
YFPEGTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDISYSGGTIDMNGALNEEG
TKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALPKTMKDGQIISKESIQIEPLT
RKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMMYAGVRFTGFTDVLIKG
NRFDKKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSAEYLGKVSDITVTKNVI
NNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYISFIKSNANEKEPVIRDSDGNF
NIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVIDSNQKNGEFNSSKDNRQMNDKIDNKQDNKTEEVNYKIVGDGRE
TENHINKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK
>Mature_692_residues
MKSFQQNEVFSIRKSKVGVCSVLLAVLFIGTQSVLANEVVGETSSSKDNMQMNSLLSSTSTSLSAEPHSDTLSLDNNSSL
STDNNGGVSINQNKPDITNDTMMGNISGMEVNTILSTNLNEHVALNVKDYGAIGDGVNDDRQAIQDAIDAAAQGLGGGNV
YFPEGTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDISYSGGTIDMNGALNEEG
TKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALPKTMKDGQIISKESIQIEPLT
RKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMMYAGVRFTGFTDVLIKG
NRFDKKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSAEYLGKVSDITVTKNVI
NNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYISFIKSNANEKEPVIRDSDGNF
NIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVIDSNQKNGEFNSSKDNRQMNDKIDNKQDNKTEEVNYKIVGDGRE
TENHINKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK

Specific function: Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover

COG id: COG5434

COG function: function code M; Endopolygalacturonase

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 5 PbH1 repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005877
- InterPro:   IPR006626
- InterPro:   IPR012334
- InterPro:   IPR011050 [H]

Pfam domain/function: PF04650 YSIRK_signal [H]

EC number: NA

Molecular weight: Translated: 75852; Mature: 75852

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSFQQNEVFSIRKSKVGVCSVLLAVLFIGTQSVLANEVVGETSSSKDNMQMNSLLSSTS
CCCCCCCCHHEEHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
TSLSAEPHSDTLSLDNNSSLSTDNNGGVSINQNKPDITNDTMMGNISGMEVNTILSTNLN
CCCCCCCCCCEEEECCCCCCCCCCCCCEEECCCCCCCCCCCEEECCCCEEEEEEEECCCC
EHVALNVKDYGAIGDGVNDDRQAIQDAIDAAAQGLGGGNVYFPEGTYLVKEIVFLKSHTH
CEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCE
LELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDISYSGGTIDMNGALNEEG
EEECCCEEEEECCCCCCCCCEEEEEEEECCCCCEEECCCCCCCCCCCCEEEECCCCCCCC
TKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALP
CCCCCCCEEECCCCEEECCCCCEEEEEEEECCCCCCCEEEEECCCCEEEECCHHHHHHHH
KTMKDGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGT
HHHCCCCEEECCCEEEEEECCCCCCEEECCCCCCCCCEEEEECCCCCCCCCCCEEEEECC
HYQTLSTQNPSNIKILNNHFDNMMYAGVRFTGFTDVLIKGNRFDKKVKGESVHYRESGAA
CEEEECCCCCCCEEEEECCCCCEEEECEEECCCEEEEEECCCCCCCCCCCCEEEECCCCE
LVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSAEYLGKVSDITVTKNVI
EEEEECCCCCHHHHCCCCCEEEEECHHCCCCCCCEEEEEECCCHHHCCCCCCEEEEHHHH
NNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYIS
CCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCCEEEECCCCEEEEEECCEEECCCCEEH
FIKSNANEKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVIDSN
EECCCCCCCCCEEECCCCCEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCC
QKNGEFNSSKDNRQMNDKIDNKQDNKTEEVNYKIVGDGRETENHINKSKEIVDVKQKLPK
CCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
TGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK
CCCHHHHHHHHHHHHHHHEEHHHCCCCCCCCC
>Mature Secondary Structure
MKSFQQNEVFSIRKSKVGVCSVLLAVLFIGTQSVLANEVVGETSSSKDNMQMNSLLSSTS
CCCCCCCCHHEEHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
TSLSAEPHSDTLSLDNNSSLSTDNNGGVSINQNKPDITNDTMMGNISGMEVNTILSTNLN
CCCCCCCCCCEEEECCCCCCCCCCCCCEEECCCCCCCCCCCEEECCCCEEEEEEEECCCC
EHVALNVKDYGAIGDGVNDDRQAIQDAIDAAAQGLGGGNVYFPEGTYLVKEIVFLKSHTH
CEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCE
LELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDISYSGGTIDMNGALNEEG
EEECCCEEEEECCCCCCCCCEEEEEEEECCCCCEEECCCCCCCCCCCCEEEECCCCCCCC
TKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALP
CCCCCCCEEECCCCEEECCCCCEEEEEEEECCCCCCCEEEEECCCCEEEECCHHHHHHHH
KTMKDGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGT
HHHCCCCEEECCCEEEEEECCCCCCEEECCCCCCCCCEEEEECCCCCCCCCCCEEEEECC
HYQTLSTQNPSNIKILNNHFDNMMYAGVRFTGFTDVLIKGNRFDKKVKGESVHYRESGAA
CEEEECCCCCCCEEEEECCCCCEEEECEEECCCEEEEEECCCCCCCCCCCCEEEECCCCE
LVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSAEYLGKVSDITVTKNVI
EEEEECCCCCHHHHCCCCCEEEEECHHCCCCCCCEEEEEECCCHHHCCCCCCEEEEHHHH
NNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYIS
CCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCCEEEECCCCEEEEEECCEEECCCCEEH
FIKSNANEKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVIDSN
EECCCCCCCCCEEECCCCCEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCC
QKNGEFNSSKDNRQMNDKIDNKQDNKTEEVNYKIVGDGRETENHINKSKEIVDVKQKLPK
CCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
TGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK
CCCHHHHHHHHHHHHHHHEEHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11544234 [H]