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The map label for this gene is galE2 [H]

Identifier: 225861627

GI number: 225861627

Start: 1662665

End: 1663675

Strand: Reverse

Name: galE2 [H]

Synonym: SPT_1748

Alternate gene names: 225861627

Gene position: 1663675-1662665 (Counterclockwise)

Preceding gene: 225861628

Following gene: 225861626

Centisome position: 78.77

GC content: 36.8

Gene sequence:

>1011_bases
ATGGCAATATTGGTAACAGGCGGTGCTGGTTATATTGGTAGCCATACCGTAGTAGAATTACTAAATTTAGGAAAGGAAGT
CGTCATTGTTGACAACCTTTCTAACTCTAGCATCTTGGTGTTAGACCGTATTGAAGCAATTACAGGAATACGTCCCGTGT
TTTACGAATTAGATGTTTGTGATAAACAAGCATTGAGAAAGGTATTTGAACAAGAATCGATTGATGCTGCAATTCATTTT
GCAGGTTATAAAGCTGTCGGAGAATCCGTGCAAAAGCCTGTGATGTACTACAAAAATAATATTATGAGTACATTGGCACT
TGTTGAAGTGATGTCAGAATTTAATGTTAAAAAGATTGTCTTTTCTTCAAGTGCGACTGTATATGGAATTAACAATCAGT
CACCTCTAATTGAGACGATGCAAACAAGTGCGACAAATCCTTATGGGTATACGAAAGTGATGCTTGAGCAAATTTTAAAA
GATGTTCATGTGGCAGATTCAGAATGGAGTATTGCGTTGCTTCGTTATTTCAATCCAATTGGTGCTCATGAGTCTGGTTT
GATTGGGGAAGATCCCTCAGGAATTCCTAACAACTTGATGCCCTATATTGCGCAAGTAGCGGTAGGTAAGCTGTCAGAGC
TAAGTGTGTTCGGAAATGATTATGATACGCTTGATGGTACTGGTGTGCGTGATTATATCCATGTAGTAGATTTAGCAATA
GGACATATAAAAGCTTTAGAAAAAGTATCTGAAAAAACAGATGTTTATATCTATAACCTAGGCTCGGGAGAAGGCACTAG
TGTATTACAACTTGTAAATACATTTGAAAGTGTTAATAAGATCCCTATTCCTTATAAAATAGTTCCAAGACGTTCAGGAG
ACGTTGCAACTTGTTATGCAAATGCAGACAAAGCATATAAGGAATTAAATTGGAGGACAACAAAATCGATTGAAGACATG
TGTAGAGATACATGGAATTGGCAATCAAAAAATCCCAATGGCTATAATTGA

Upstream 100 bases:

>100_bases
AGTTCTTGAAGATGCAGGTGTTTATAAGAATACTCCGTCTGGACATGAAGCGTTTATGAGATTTGTTAAATCAGTTGGAA
TTAATTAGGAGGAAACCCAA

Downstream 100 bases:

>100_bases
TGATACTGTCTATATGAGTGTTGTATTTTGGGAAAATTACTTAACCTTTTAATGAAAGATAATTTTTTAAAAAAATGTTT
GAAAGCGCTTGACAAAGTAA

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAILVTGGAGYIGSHTVVELLNLGKEVVIVDNLSNSSILVLDRIEAITGIRPVFYELDVCDKQALRKVFEQESIDAAIHF
AGYKAVGESVQKPVMYYKNNIMSTLALVEVMSEFNVKKIVFSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILK
DVHVADSEWSIALLRYFNPIGAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFGNDYDTLDGTGVRDYIHVVDLAI
GHIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFESVNKIPIPYKIVPRRSGDVATCYANADKAYKELNWRTTKSIEDM
CRDTWNWQSKNPNGYN

Sequences:

>Translated_336_residues
MAILVTGGAGYIGSHTVVELLNLGKEVVIVDNLSNSSILVLDRIEAITGIRPVFYELDVCDKQALRKVFEQESIDAAIHF
AGYKAVGESVQKPVMYYKNNIMSTLALVEVMSEFNVKKIVFSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILK
DVHVADSEWSIALLRYFNPIGAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFGNDYDTLDGTGVRDYIHVVDLAI
GHIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFESVNKIPIPYKIVPRRSGDVATCYANADKAYKELNWRTTKSIEDM
CRDTWNWQSKNPNGYN
>Mature_335_residues
AILVTGGAGYIGSHTVVELLNLGKEVVIVDNLSNSSILVLDRIEAITGIRPVFYELDVCDKQALRKVFEQESIDAAIHFA
GYKAVGESVQKPVMYYKNNIMSTLALVEVMSEFNVKKIVFSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILKD
VHVADSEWSIALLRYFNPIGAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFGNDYDTLDGTGVRDYIHVVDLAIG
HIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFESVNKIPIPYKIVPRRSGDVATCYANADKAYKELNWRTTKSIEDMC
RDTWNWQSKNPNGYN

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=341, Percent_Identity=54.8387096774194, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI56118217, Length=341, Percent_Identity=54.8387096774194, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI189083684, Length=341, Percent_Identity=54.8387096774194, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI7657641, Length=280, Percent_Identity=25, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1786974, Length=336, Percent_Identity=55.952380952381, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI48994969, Length=354, Percent_Identity=26.271186440678, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788353, Length=367, Percent_Identity=25.8855585831063, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71982035, Length=346, Percent_Identity=52.8901734104046, Blast_Score=378, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71982038, Length=348, Percent_Identity=52.5862068965517, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17568069, Length=335, Percent_Identity=25.6716417910448, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI115532424, Length=348, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=342, Percent_Identity=53.2163742690059, Blast_Score=376, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19923002, Length=342, Percent_Identity=54.3859649122807, Blast_Score=377, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37139; Mature: 37008

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVTGGAGYIGSHTVVELLNLGKEVVIVDNLSNSSILVLDRIEAITGIRPVFYELDVC
CEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHHHCCCHHEEEECHH
DKQALRKVFEQESIDAAIHFAGYKAVGESVQKPVMYYKNNIMSTLALVEVMSEFNVKKIV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
FSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILKDVHVADSEWSIALLRYFNPI
EECCCEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
GAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFGNDYDTLDGTGVRDYIHVVDLAI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHEEEECCCCCCCCCCCHHHHHHHHHHHH
GHIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFESVNKIPIPYKIVPRRSGDVATCYA
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEE
NADKAYKELNWRTTKSIEDMCRDTWNWQSKNPNGYN
CHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AILVTGGAGYIGSHTVVELLNLGKEVVIVDNLSNSSILVLDRIEAITGIRPVFYELDVC
EEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHHHCCCHHEEEECHH
DKQALRKVFEQESIDAAIHFAGYKAVGESVQKPVMYYKNNIMSTLALVEVMSEFNVKKIV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
FSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILKDVHVADSEWSIALLRYFNPI
EECCCEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
GAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFGNDYDTLDGTGVRDYIHVVDLAI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHEEEECCCCCCCCCCCHHHHHHHHHHHH
GHIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFESVNKIPIPYKIVPRRSGDVATCYA
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEE
NADKAYKELNWRTTKSIEDMCRDTWNWQSKNPNGYN
CHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]