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The map label for this gene is scrR [H]

Identifier: 225861602

GI number: 225861602

Start: 1638949

End: 1639950

Strand: Reverse

Name: scrR [H]

Synonym: SPT_1723

Alternate gene names: 225861602

Gene position: 1639950-1638949 (Counterclockwise)

Preceding gene: 225861603

Following gene: 225861601

Centisome position: 77.64

GC content: 33.33

Gene sequence:

>1002_bases
ATGGTAGAACAAAGAAAATCAATTACCATGAAAGATGTTGCTTTAGAAGCAGGAGTTAGTGTTGGAACTGTTTCACGTGT
AATTAATAAAGAAAAAGGCATTAAAGAAGTAACTTTGAAAAAAGTGGAACAAGCGATTAAAACTTTGAATTACATTCCAG
ATTACTACGCTAGAGGAATGAAAAAAAATCGAACAGAAACGATTGCAATCATTGTACCAAGTATCTGGCATCCCTTCTTT
TCAGAATTTGCTATGCATGTGGAAAATGAAGTCTATAAGAGAAATAACAAATTACTCTTATGTTCTATCAATGGTACAAA
TAGAGAGCAAGACTATCTGGAGATGTTGCGTCATAATAAAGTTGATGGAGTGGTTGCCATTACCTATAGTCCAATTGAAC
ATTACTTGACGTCAGGAATTCCCTTTGTTAGTATTGACCGCACATACTCAGATATTGCCATTCCTTGTGTTTCATCAGAT
AATGATGCAGGTGGAAGAGAAGCAGCTAAACAATTAATTAGTAAAGGATGTCAGCATTTAGCCTTTGTGGGCGGACATAA
TACAACCATTAATGAAACCAAACGTCGTAGAATTTCATTTGAAAAGTATGTCCAAGAGCATAAAATACCTCTTAGTATTT
TTGATTTGGATGAGACAGTTACTGACTATTATGGAAAGCTAGAGAGTTTCTTGGAAGAAAATTCTTCTATAGATGGAATT
TTTACAATCAACGATTTTACAGCTTTGGATGTGATTGAAATACTAAAAAAAAATGGCAAACGTATTCCTCATGATGTCCA
AATTATTGGATACGATGGAATTAAAATGGCTGGAGATAGAGATTATCTACTTTCAACTATTGAACAACCATTGGAAGAAA
TGGCAAAAGAAGCGGTTCGTATTTTGTTTGATATAATTGATGGAAAGACTGTTAATTTGCAGACAATCCTACCAGTAAAA
TTTGTTGAAGGAAAAACAACAAAAAATGAAAATAAGTCTTGA

Upstream 100 bases:

>100_bases
TTTTATTCATGATGGGATAAATGATCTGGCCAAAAATGATTGAGAAATAGTTGCTTAAAAAGCATTTGCATGATACTATA
TATTGAAAGGAGGTGATAAT

Downstream 100 bases:

>100_bases
CAGAAAGCGCTATCAATGATAGAATGAATTCAGATAAAAAGATTTATTTTTAAAACAAAAATGAAACGTTTCAAAAAAAG
AAATAAAGAGACAGCGCCAA

Product: sugar-binding transcriptional regulator, LacI family

Products: NA

Alternate protein names: Scr operon regulatory protein [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLKKVEQAIKTLNYIPDYYARGMKKNRTETIAIIVPSIWHPFF
SEFAMHVENEVYKRNNKLLLCSINGTNREQDYLEMLRHNKVDGVVAITYSPIEHYLTSGIPFVSIDRTYSDIAIPCVSSD
NDAGGREAAKQLISKGCQHLAFVGGHNTTINETKRRRISFEKYVQEHKIPLSIFDLDETVTDYYGKLESFLEENSSIDGI
FTINDFTALDVIEILKKNGKRIPHDVQIIGYDGIKMAGDRDYLLSTIEQPLEEMAKEAVRILFDIIDGKTVNLQTILPVK
FVEGKTTKNENKS

Sequences:

>Translated_333_residues
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLKKVEQAIKTLNYIPDYYARGMKKNRTETIAIIVPSIWHPFF
SEFAMHVENEVYKRNNKLLLCSINGTNREQDYLEMLRHNKVDGVVAITYSPIEHYLTSGIPFVSIDRTYSDIAIPCVSSD
NDAGGREAAKQLISKGCQHLAFVGGHNTTINETKRRRISFEKYVQEHKIPLSIFDLDETVTDYYGKLESFLEENSSIDGI
FTINDFTALDVIEILKKNGKRIPHDVQIIGYDGIKMAGDRDYLLSTIEQPLEEMAKEAVRILFDIIDGKTVNLQTILPVK
FVEGKTTKNENKS
>Mature_333_residues
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLKKVEQAIKTLNYIPDYYARGMKKNRTETIAIIVPSIWHPFF
SEFAMHVENEVYKRNNKLLLCSINGTNREQDYLEMLRHNKVDGVVAITYSPIEHYLTSGIPFVSIDRTYSDIAIPCVSSD
NDAGGREAAKQLISKGCQHLAFVGGHNTTINETKRRRISFEKYVQEHKIPLSIFDLDETVTDYYGKLESFLEENSSIDGI
FTINDFTALDVIEILKKNGKRIPHDVQIIGYDGIKMAGDRDYLLSTIEQPLEEMAKEAVRILFDIIDGKTVNLQTILPVK
FVEGKTTKNENKS

Specific function: Negative regulator of scrB expression [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=322, Percent_Identity=33.2298136645963, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1790369, Length=321, Percent_Identity=27.1028037383178, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1787948, Length=318, Percent_Identity=30.188679245283, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788474, Length=305, Percent_Identity=26.8852459016393, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1789202, Length=301, Percent_Identity=27.2425249169435, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786540, Length=336, Percent_Identity=23.8095238095238, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789068, Length=334, Percent_Identity=24.5508982035928, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI48994940, Length=320, Percent_Identity=23.4375, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1790715, Length=330, Percent_Identity=21.8181818181818, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787906, Length=266, Percent_Identity=23.6842105263158, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786268, Length=289, Percent_Identity=22.4913494809689, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787580, Length=317, Percent_Identity=22.397476340694, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790689, Length=209, Percent_Identity=23.9234449760766, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37729; Mature: 37729

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLKKVEQAIKTLNYIPDYYARGM
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCC
KKNRTETIAIIVPSIWHPFFSEFAMHVENEVYKRNNKLLLCSINGTNREQDYLEMLRHNK
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCC
VDGVVAITYSPIEHYLTSGIPFVSIDRTYSDIAIPCVSSDNDAGGREAAKQLISKGCQHL
CCCEEEEEECHHHHHHHCCCCEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHE
AFVGGHNTTINETKRRRISFEKYVQEHKIPLSIFDLDETVTDYYGKLESFLEENSSIDGI
EEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCEE
FTINDFTALDVIEILKKNGKRIPHDVQIIGYDGIKMAGDRDYLLSTIEQPLEEMAKEAVR
EEECCCHHHHHHHHHHHCCCCCCCCEEEEEECCEEECCCHHHHHHHHHHHHHHHHHHHHH
ILFDIIDGKTVNLQTILPVKFVEGKTTKNENKS
HHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLKKVEQAIKTLNYIPDYYARGM
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCC
KKNRTETIAIIVPSIWHPFFSEFAMHVENEVYKRNNKLLLCSINGTNREQDYLEMLRHNK
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCC
VDGVVAITYSPIEHYLTSGIPFVSIDRTYSDIAIPCVSSDNDAGGREAAKQLISKGCQHL
CCCEEEEEECHHHHHHHCCCCEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHE
AFVGGHNTTINETKRRRISFEKYVQEHKIPLSIFDLDETVTDYYGKLESFLEENSSIDGI
EEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCEE
FTINDFTALDVIEILKKNGKRIPHDVQIIGYDGIKMAGDRDYLLSTIEQPLEEMAKEAVR
EEECCCHHHHHHHHHHHCCCCCCCCEEEEEECCEEECCCHHHHHHHHHHHHHHHHHHHHH
ILFDIIDGKTVNLQTILPVKFVEGKTTKNENKS
HHHHHHCCCEEEEEEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9673256; 12397186 [H]