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The map label for this gene is apt [H]

Identifier: 225861411

GI number: 225861411

Start: 1447247

End: 1447759

Strand: Reverse

Name: apt [H]

Synonym: SPT_1517

Alternate gene names: 225861411

Gene position: 1447759-1447247 (Counterclockwise)

Preceding gene: 225861412

Following gene: 225861409

Centisome position: 68.54

GC content: 41.33

Gene sequence:

>513_bases
ATGAATTTAAAAGATTATATTGCAACAATTGAAAATTATCCAAAGGAAGGAATTACCTTCCGTGATATCAGTCCTTTGAT
GGCTGATGGAAATGCTTATAGCTATGCTGTTCGTGAAATTGTTCAGTATGCTACTGACAAGAAAATAGACATGATTGTAG
GGCCTGAGGCTCGTGGATTTATCGTGGGCTGTCCAGTTGCCTTTGAGTTGGGAATTGGTTTTGCGCCTGTTCGTAAGCCA
GGTAAATTGCCACGCGAAGTCATTTTTGCTGACTATGAAAAAGAGTACGGTGTTGATACCTTGACTATGCATGCGGATGC
CATCAAGCCAGGTCAACGTGTTCTGATCGTAGATGACCTCTTGGCGACAGGTGGAACTGTTAAGGCAACTATCGAGATGA
TTGAAAAACTTGGTGGTGTTGTAGCAGGTTGTGCCTTCCTTGTTGAATTGGATGAATTGAACGGTCGTGAAAAAATCGGT
GACTACGATTACAAAGTTTTGATGCATTATTAA

Upstream 100 bases:

>100_bases
TCGTCAAAACGTTAGATAATTATTGAAGTTAACTTTTCCTTTTTTCTTTCTTAAAAAATATGCTATAATAGAGAGTAAAA
ACTTTGAAAGAAAGAAAAAG

Downstream 100 bases:

>100_bases
TGAAAAACAGTCCCTAGGGCTGTTTTCTCTACATTAGGATATAAAAATAGACTATAGCTAGTTAGAGAAAAACTATAATT
GAAAACTATATCTTCTTGCA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKIDMIVGPEARGFIVGCPVAFELGIGFAPVRKP
GKLPREVIFADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVVAGCAFLVELDELNGREKIG
DYDYKVLMHY

Sequences:

>Translated_170_residues
MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKIDMIVGPEARGFIVGCPVAFELGIGFAPVRKP
GKLPREVIFADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVVAGCAFLVELDELNGREKIG
DYDYKVLMHY
>Mature_170_residues
MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKIDMIVGPEARGFIVGCPVAFELGIGFAPVRKP
GKLPREVIFADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVVAGCAFLVELDELNGREKIG
DYDYKVLMHY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=41.5204678362573, Blast_Score=134, Evalue=3e-32,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=42.4, Blast_Score=101, Evalue=3e-22,
Organism=Escherichia coli, GI1786675, Length=157, Percent_Identity=52.8662420382166, Blast_Score=176, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=42.1052631578947, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=162, Percent_Identity=41.358024691358, Blast_Score=110, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=170, Percent_Identity=32.9411764705882, Blast_Score=85, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17136334, Length=159, Percent_Identity=44.6540880503145, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 18771; Mature: 18771

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKIDMIVGPEARGF
CCHHHHHHHHHCCCCCCCEEECCCHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCE
IVGCPVAFELGIGFAPVRKPGKLPREVIFADYEKEYGVDTLTMHADAIKPGQRVLIVDDL
EEECCEEEECCCCCCCCCCCCCCCHHHEEECCCHHCCCCEEEEECCCCCCCCEEEEEEHH
LATGGTVKATIEMIEKLGGVVAGCAFLVELDELNGREKIGDYDYKVLMHY
HHCCCCHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKIDMIVGPEARGF
CCHHHHHHHHHCCCCCCCEEECCCHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCE
IVGCPVAFELGIGFAPVRKPGKLPREVIFADYEKEYGVDTLTMHADAIKPGQRVLIVDDL
EEECCEEEECCCCCCCCCCCCCCCHHHEEECCCHHCCCCEEEEECCCCCCCCEEEEEEHH
LATGGTVKATIEMIEKLGGVVAGCAFLVELDELNGREKIGDYDYKVLMHY
HHCCCCHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA