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The map label for this gene is csd [H]

Identifier: 225861238

GI number: 225861238

Start: 1273859

End: 1275085

Strand: Reverse

Name: csd [H]

Synonym: SPT_1332

Alternate gene names: 225861238

Gene position: 1275085-1273859 (Counterclockwise)

Preceding gene: 225861239

Following gene: 225861237

Centisome position: 60.37

GC content: 44.66

Gene sequence:

>1227_bases
ATGTTAGATGTAGAAGCGATTCGCAAGGATTTTCCAATTTTAGATCAGATTGTCAATGATGAACCTCTGGTCTATCTGGA
CAATGCTGCGACGACACAAAAACCACTAGTAGTTCTGAAAGCTATTAACAGCTACTATGAGCAGGACAATGCCAATGTTC
ACCGTGGTGTCCATACCTTAGCGGAACGAGCGACAGCTTCTTATGAAGCTGCTCGTGAAACCATTCGTAAGTTTATTAAT
GCAGGCTCTACAAAGGAAGTTCTCTTTACCAGAGGAACGACAACCAGCCTTAACTGGGTGGCACGCTTTGCTGAGGAAAT
TCTCGCTGAGGGAGACCAGGTCTTGATTTCAGTAATGGAACACCATTCTAATATCATTCCATGGCAGGAAGCTTGTCGAA
AGACTGGAGCAGAGCTTGTCTATGTCTATCTTAAAGACGGTGCCTTGGATATGGAGGATTTGCGAGCTAAATTGACTGAT
AAGGTTAAATTTGTTTCCCTAGCTCATGCCTCCAATGTTCTTGGTGTGGTCAATCCGATCAAGGAAATCACTCAATTAGC
CCACCAAGTTGGGGCAATTATGGTAGTGGATGGTGCTCAATCTACACCTCATATGAAGATTGATGTCCAGGACTTGGATC
TGGACTTTTTCGCCTTTTCGGGTCACAAGATGGCTGGTCCGACTGGTATCGGTGTCCTTTACGGCAAAGAAAAGTATCTT
GAGCAAATGTCTCCAGTAGAATTTGGCGGCGAGATGATTGATTTTGTCTACGAGCAATTTGCTAGTTGGAAGGAATTGCC
TTGGAAATTTGAGGCTGGAACGCCAAATATGGCAGGAGCTATTGGACTTGCGACTGCAGTTGATTATCTGGAAAAGATTG
GTATGGATGCCGTTGAAGCTCATGAACAGGAATTGATTGCGTACGTCTATCCAAAACTGCAGGCAATTGAGGGATTGACC
ATTTACGGTTCTCAGGATTTGGCTCAACGTTCGGGTGTTATTGCCTTTAACCTAGGTGATCTCCATCCTCACGATCTTGC
GACGGCTCTGGATTATGAAGGAGTGGCTGTTCGTGCTGGTCACCATTGTGCGCAACCCTTGCTTCAGTATTTGGAAGTCC
CAGCAACAGCTCGTGCAAGTTTTTATATCTACAATACCAAGGCAGATTGCGACAAACTAGTCGATGCCCTACAAAAGACA
AAGGAGTTTTTCAATGGCACTTTCTAA

Upstream 100 bases:

>100_bases
TTCCTTGGATCTGTTATCGTGGAGATTCCAGTCAAGGAAGTTCGTGATGAAATGATTGCAACTATCGAAGAGAAATTGTC
AAAACGCTAAGGGGAAGCCT

Downstream 100 bases:

>100_bases
ACTAGATAGCCTTTATATGGCAGTGGTAGCAGACCATTCGAAAAATCCACATCACCAAGGGAAGTTAGAAGATGCTGAGC
AAATCAGTCTCAACAATCCG

Product: cysteine desulfurase (Selenocysteine lyase) (Selenocysteine reductase) (Selenocysteine beta-lyase) (SCL)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINSYYEQDNANVHRGVHTLAERATASYEAARETIRKFIN
AGSTKEVLFTRGTTTSLNWVARFAEEILAEGDQVLISVMEHHSNIIPWQEACRKTGAELVYVYLKDGALDMEDLRAKLTD
KVKFVSLAHASNVLGVVNPIKEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFAFSGHKMAGPTGIGVLYGKEKYL
EQMSPVEFGGEMIDFVYEQFASWKELPWKFEAGTPNMAGAIGLATAVDYLEKIGMDAVEAHEQELIAYVYPKLQAIEGLT
IYGSQDLAQRSGVIAFNLGDLHPHDLATALDYEGVAVRAGHHCAQPLLQYLEVPATARASFYIYNTKADCDKLVDALQKT
KEFFNGTF

Sequences:

>Translated_408_residues
MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINSYYEQDNANVHRGVHTLAERATASYEAARETIRKFIN
AGSTKEVLFTRGTTTSLNWVARFAEEILAEGDQVLISVMEHHSNIIPWQEACRKTGAELVYVYLKDGALDMEDLRAKLTD
KVKFVSLAHASNVLGVVNPIKEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFAFSGHKMAGPTGIGVLYGKEKYL
EQMSPVEFGGEMIDFVYEQFASWKELPWKFEAGTPNMAGAIGLATAVDYLEKIGMDAVEAHEQELIAYVYPKLQAIEGLT
IYGSQDLAQRSGVIAFNLGDLHPHDLATALDYEGVAVRAGHHCAQPLLQYLEVPATARASFYIYNTKADCDKLVDALQKT
KEFFNGTF
>Mature_408_residues
MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINSYYEQDNANVHRGVHTLAERATASYEAARETIRKFIN
AGSTKEVLFTRGTTTSLNWVARFAEEILAEGDQVLISVMEHHSNIIPWQEACRKTGAELVYVYLKDGALDMEDLRAKLTD
KVKFVSLAHASNVLGVVNPIKEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFAFSGHKMAGPTGIGVLYGKEKYL
EQMSPVEFGGEMIDFVYEQFASWKELPWKFEAGTPNMAGAIGLATAVDYLEKIGMDAVEAHEQELIAYVYPKLQAIEGLT
IYGSQDLAQRSGVIAFNLGDLHPHDLATALDYEGVAVRAGHHCAQPLLQYLEVPATARASFYIYNTKADCDKLVDALQKT
KEFFNGTF

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=231, Percent_Identity=29.004329004329, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI156713448, Length=324, Percent_Identity=26.2345679012346, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787970, Length=407, Percent_Identity=46.6830466830467, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1789175, Length=400, Percent_Identity=42.25, Blast_Score=307, Evalue=8e-85,
Organism=Escherichia coli, GI48994898, Length=218, Percent_Identity=29.8165137614679, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI193211090, Length=384, Percent_Identity=28.125, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25143064, Length=223, Percent_Identity=31.390134529148, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319831, Length=347, Percent_Identity=26.2247838616715, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI20129463, Length=241, Percent_Identity=28.6307053941909, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45195; Mature: 45195

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINSYYEQDNANVHRGVHTL
CCCHHHHHHCCCHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
AERATASYEAARETIRKFINAGSTKEVLFTRGTTTSLNWVARFAEEILAEGDQVLISVME
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
HHSNIIPWQEACRKTGAELVYVYLKDGALDMEDLRAKLTDKVKFVSLAHASNVLGVVNPI
HCCCCCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
KEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFAFSGHKMAGPTGIGVLYGKEKYL
HHHHHHHHHHCEEEEEECCCCCCCEEEEEEECCEEEEEECCCCCCCCCCEEEEECCHHHH
EQMSPVEFGGEMIDFVYEQFASWKELPWKFEAGTPNMAGAIGLATAVDYLEKIGMDAVEA
HHCCCHHHCHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHH
HEQELIAYVYPKLQAIEGLTIYGSQDLAQRSGVIAFNLGDLHPHDLATALDYEGVAVRAG
HHHHHHHHHHHHHHHHCCEEEECCHHHHHHCCEEEEECCCCCHHHHHHHCCCCCEEEECC
HHCAQPLLQYLEVPATARASFYIYNTKADCDKLVDALQKTKEFFNGTF
HHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINSYYEQDNANVHRGVHTL
CCCHHHHHHCCCHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
AERATASYEAARETIRKFINAGSTKEVLFTRGTTTSLNWVARFAEEILAEGDQVLISVME
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
HHSNIIPWQEACRKTGAELVYVYLKDGALDMEDLRAKLTDKVKFVSLAHASNVLGVVNPI
HCCCCCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
KEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFAFSGHKMAGPTGIGVLYGKEKYL
HHHHHHHHHHCEEEEEECCCCCCCEEEEEEECCEEEEEECCCCCCCCCCEEEEECCHHHH
EQMSPVEFGGEMIDFVYEQFASWKELPWKFEAGTPNMAGAIGLATAVDYLEKIGMDAVEA
HHCCCHHHCHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHH
HEQELIAYVYPKLQAIEGLTIYGSQDLAQRSGVIAFNLGDLHPHDLATALDYEGVAVRAG
HHHHHHHHHHHHHHHHCCEEEECCHHHHHHCCEEEEECCCCCHHHHHHHCCCCCEEEECC
HHCAQPLLQYLEVPATARASFYIYNTKADCDKLVDALQKTKEFFNGTF
HHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]