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The map label for this gene is rnr [H]

Identifier: 225861138

GI number: 225861138

Start: 1171113

End: 1173467

Strand: Reverse

Name: rnr [H]

Synonym: SPT_1228

Alternate gene names: 225861138

Gene position: 1173467-1171113 (Counterclockwise)

Preceding gene: 225861139

Following gene: 225861137

Centisome position: 55.56

GC content: 42.72

Gene sequence:

>2355_bases
ATGAAAGATAGAATAAAAGAATATTTACAAGACAAGGGAAAGGTGACTGTTAATGATTTGGCTCAGGCTTTGGGAAAAGA
CAGTTCCAAGGATTTTCGTGAGTTGATTAAAACCTTGTCCTTAATGGAAAGAAAGCACCAAATTCGTTTTGAAGAAGATG
GCAGTCTGACCTTGGAAGCCAAGAAAAAACATGAGATTACCCTCAAGGGGATTTTTCATGCCCATAAAAATGGTTTTGGT
TTTGTCAGCCTAGAAGGGGAAGAGGACGACCTTTTTGTAGGGAAAAATGATGTCAACTATGCTATTGATGGTGATACCGT
CGAGGTAGTGATTAAGAAAGTCGCTGACCGCAATAAGGGAACAGCAGCAGAAGCCAAAATTATTGATATCCTAGAACACA
GTTTGACAACAGTTGTCGGGCAAATCGTTCTGGATCAGGAAAAGCCTAAGTATGCTGGCTATATTCGTTCAAAAAATCAG
AAAATCAGTCAACCGATTTATGTTAAGAAACCAGCCCTAAAGTTAGAAGGAACAGAAGTTCTCAAGGTCTTTATCGATAA
ATACCCAAGCAAGAAACATGATTTCTTTGTCGCGAGTGTTCTCGATGTGGTGGGACACTCAACGGATGTCGGAATTGATG
TTCTTGAGGTCTTGGAATCAATGGACATTGTATCCGAGTTTCCAGAAGCTGTTGTCAAGGAAGCAGAAAGTGTGCCTGAT
GCTCCGTCTCAAAAGGATATGGAAGGTCGTCTGGATCTAAGAGATGAAATTACCTTTACCATTGACGGTGCGGATGCCAA
GGACTTGGACGATGCAGTGCATATCAAGGCTCTGAAAAATGGCAATCTGGAGCTTGGGGTTCACATCGCAGATGTTTCCT
ATTATGTGACCGAGGGTTCTGCCCTTGACAAGGAAGCCCTTAACCGTGCGACTTCTGTTTACGTGACAGACCGAGTGGTG
CCAATGCTTCCAGAACGACTATCAAATGGCATCTGCTCTCTCAATCCCCAAGTTGACCGCCTGACCCAGTCTGCTATTAT
GGAGATTGATAAACATGGTCGTGTGGTCAACTATACCATTACACAAACAGTTATCAAGACCAGTTTTCGTATGACCTATA
GCGATGTCAATGATATCCTAGCTGGCGATGAAGAAAAGAGAAAAGAATACCATAAAATTGTACCAAGTATCGAACTCATG
GCCAAGCTTCATGAAACTTTAGAAAACATGCGTGTGAAACGTGGAGCTCTCAATTTTGATACCAATGAAGCGAAGATTTT
AGTGGATAAACAAGGTAAGCCTGTTGATATCGTTCTTCGGCAGCGTGGCATTGCCGAGCGGATGATTGAGTCTTTTATGT
TGATGGCTAATGAAACAGTTGCCGAACATTTCAGCAAGTTGGATTTGCCTTTTATCTACCGAATTCACGAGGAGCCTAAG
GCTGAAAAGGTTCAGAAGTTTATTGATTATGCTTCGAGTTTTGGCTTGCGCATTTATGGGACTGCCAGTGAGATTAGCCA
GGAGGCACTTCAAGACATCATGCGTGCTGTTGAGGGAGAACCTTATGCAGATGTATTGTCCATGATGCTTCTTCGCTCTA
TGCAGCAGGCTCGTTATTCGGAGCACAATCACGGCCACTATGGACTAGCTGCTGACTATTATACTCACTTTACCAGTCCA
ATTCGTCGTTATCCAGACCTTCTTGTTCACCGTATGATTCGGGATTACGGCCGTTCTAAGGAAATAGCAGAGCATTTTGA
ACAAGTGATTCCAGAGATTGCGACCCAGTCTTCCAACCGTGAACGTCGTGCCATAGAAGCTGAGCGTGAAGTCGAAGCCA
TGAAAAAGGCTGAGTATATGGAAGAATACGTGGGTGAAGAGTATGATGCAGTTGTATCAAGTATTGTCAAATTCGGTCTC
TTTGTCGAATTGCCAAACACAGTTGAAGGCTTGATTCACATCACTAATCTACCTGAATTTTATCATTTCAATGAGCGTGA
TTTGACTCTTCGTGGAGAAAAATCAGGTATCACTTTCCGAGTGGGTCAGCAGATCCGTATCCGTGTTGAAAGAGCGGATA
AAATGACTGGAGAGATTGATTTTTCATTCGTACCTAGTGAGTTTGATGTGATTGAAAAAGGCTTGAAACAGTCTAGTCGT
AGTGGCAGAGGGCGTGGTTCAAATCGTCGTTCGGATAAGAAGGAAGACAAGAGAAAATCAGGACGCTCAAATGATAAGCG
TAAACATTCACAAAAAGACAAGAAGAAAAAAGGAAAGAAACCTTTTTACAAGGAAGTAGCTAAGAAAGGAGCCAAGCATG
GCAAAGGGCGAGGGAAAGGTCGTCGCACAAAATAA

Upstream 100 bases:

>100_bases
AAAATAATGGGCAGGACTAGGTCTTTGCCTCTTTTTATTTTTAAAGGATGTTTGAGAAGGTTTTACAGTAAAAGAAAATT
AAAAAATCTAGAAAGAAAAT

Downstream 100 bases:

>100_bases
AAAGGCACGCCACGACTATACAATCGTAGATACGCTAGAGGCAGGGATGGTCCTGACTGGAACTGAAATCAAGAGTGTAC
GAGCTGCTCGAATTAATCTC

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R 1; VacB protein homolog 1 [H]

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFG
FVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
KISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVV
PMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKEYHKIVPSIELM
AKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSP
IRRYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGL
FVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
SGRGRGSNRRSDKKEDKRKSGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK

Sequences:

>Translated_784_residues
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFG
FVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
KISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVV
PMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKEYHKIVPSIELM
AKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSP
IRRYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGL
FVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
SGRGRGSNRRSDKKEDKRKSGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK
>Mature_784_residues
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFG
FVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
KISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVV
PMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKEYHKIVPSIELM
AKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSP
IRRYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGL
FVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
SGRGRGSNRRSDKKEDKRKSGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=416, Percent_Identity=33.8942307692308, Blast_Score=214, Evalue=3e-55,
Organism=Homo sapiens, GI190014623, Length=416, Percent_Identity=33.8942307692308, Blast_Score=214, Evalue=3e-55,
Organism=Homo sapiens, GI134288890, Length=391, Percent_Identity=33.2480818414322, Blast_Score=202, Evalue=1e-51,
Organism=Homo sapiens, GI19115966, Length=500, Percent_Identity=28.2, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI219521928, Length=500, Percent_Identity=28.2, Blast_Score=166, Evalue=7e-41,
Organism=Homo sapiens, GI156105695, Length=133, Percent_Identity=32.3308270676692, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI156105693, Length=133, Percent_Identity=32.3308270676692, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI87082383, Length=720, Percent_Identity=33.8888888888889, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1787542, Length=677, Percent_Identity=24.8153618906942, Blast_Score=142, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17553506, Length=458, Percent_Identity=30.5676855895196, Blast_Score=200, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI212645896, Length=570, Percent_Identity=27.1929824561404, Blast_Score=174, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324552, Length=595, Percent_Identity=29.4117647058824, Blast_Score=193, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320499, Length=319, Percent_Identity=24.7648902821317, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323943, Length=468, Percent_Identity=23.2905982905983, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24649634, Length=571, Percent_Identity=29.9474605954466, Blast_Score=218, Evalue=2e-56,
Organism=Drosophila melanogaster, GI19922976, Length=517, Percent_Identity=28.4332688588008, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24654597, Length=517, Percent_Identity=28.4332688588008, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24654592, Length=517, Percent_Identity=28.4332688588008, Blast_Score=168, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 89159; Mature: 89159

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEA
CCHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
KKKHEITLKGIFHAHKNGFGFVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKG
CCCCEEEEEHHHHHCCCCEEEEEEECCCCCEEECCCCCCEEECCHHHHHHHHHHHCCCCC
TAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQKISQPIYVKKPALKLEGTEV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCCHHHH
LKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGS
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHEEEEECCCCEEEEEEEEEEEEEEECCC
ALDKEALNRATSVYVTDRVVPMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTI
CCCHHHHHHHHEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEH
TQTVIKTSFRMTYSDVNDILAGDEEKRKEYHKIVPSIELMAKLHETLENMRVKRGALNFD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
TNEAKILVDKQGKPVDIVLRQRGIAERMIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
CCCCEEEEECCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYS
HHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
EHNHGHYGLAADYYTHFTSPIRRYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
ERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGLFVELPNTVEGLIHITNLPEF
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCHHHHHEEECCCCHH
YHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
HCCCCCCEEEECCCCCCEEEECCEEEEEEEHHHCCCCCEEEEECCCHHHHHHHHHHHHCC
SGRGRGSNRRSDKKEDKRKSGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKG
CCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
RRTK
CCCC
>Mature Secondary Structure
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEA
CCHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
KKKHEITLKGIFHAHKNGFGFVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKG
CCCCEEEEEHHHHHCCCCEEEEEEECCCCCEEECCCCCCEEECCHHHHHHHHHHHCCCCC
TAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQKISQPIYVKKPALKLEGTEV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCCHHHH
LKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGS
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHEEEEECCCCEEEEEEEEEEEEEEECCC
ALDKEALNRATSVYVTDRVVPMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTI
CCCHHHHHHHHEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEH
TQTVIKTSFRMTYSDVNDILAGDEEKRKEYHKIVPSIELMAKLHETLENMRVKRGALNFD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
TNEAKILVDKQGKPVDIVLRQRGIAERMIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
CCCCEEEEECCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYS
HHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
EHNHGHYGLAADYYTHFTSPIRRYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
ERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGLFVELPNTVEGLIHITNLPEF
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCHHHHHEEECCCCHH
YHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
HCCCCCCEEEECCCCCCEEEECCEEEEEEEHHHCCCCCEEEEECCCHHHHHHHHHHHHCC
SGRGRGSNRRSDKKEDKRKSGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKG
CCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
RRTK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]