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The map label for this gene is polC [H]

Identifier: 225861122

GI number: 225861122

Start: 1156812

End: 1157402

Strand: Reverse

Name: polC [H]

Synonym: SPT_1211

Alternate gene names: 225861122

Gene position: 1157402-1156812 (Counterclockwise)

Preceding gene: 225861123

Following gene: 225861121

Centisome position: 54.8

GC content: 39.76

Gene sequence:

>591_bases
ATGGAACGATTAGAAGATTACATTGCTTTTGACTTAGAATTTAATCAGCACGAAGGACAAAAACACTTGATTCAAGTATC
GGCAGTGCGTTTTAGAGATGGTCGGGAAATCGATGCCTATGATTCCTATGTTCATACCAGCGTCCCTCTAAAAAGCTTTA
TCAATGGTTTGACCGGGATTACAGCTGAGACCTTAAAAGATGCTCCTCCAGTTGAGAAAGTCTTAGAAGAATTCCAAGAG
TTTGTGGGTTCTTTGCTGATGATAGGCTACAATGCTGCTAAAAGTGATTTACCTATTTTAGCAGAGTATGGTTTAGACTA
TAGCCAACAGTACAAGGTGGATTTGTATGATGAAGCTTTTGAACGTCGGAGTTCAGATTTACATGGTATTGCCAATCTCA
AATTGCAAACTGTTGCCTCATTTCTTGGATTTCAAGGTCAGTCTCATAATAGTTTAGAGGATGCTCGGATGACGGCGCGT
GTTTACGAATCCTTCTTAGAGTCGGATCAAGCTAGGGAATTGTTAGAGACAGAAAGTAGCTTATCAAACAATCCTTTTGG
TGGCTTGGACTTGTCTCAATTATTTGACTAG

Upstream 100 bases:

>100_bases
TAATCAAGGAGCTGTTTAGGTTAAATGCTAACCTGATGGCTTCTTTTGTTTGTGAATAGTATAGTTGATTAGAACAGAGA
CAGTAGAGGAGAGGTACAGA

Downstream 100 bases:

>100_bases
GAGTGCCTATGAAACCTGAAAAACCTAAAAAATTGGGTCTTAAACAGATTTACCTCAATCTTGATAAAATCCTCTTTCTA
TTTTTCTTGATTTTTATGAT

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MERLEDYIAFDLEFNQHEGQKHLIQVSAVRFRDGREIDAYDSYVHTSVPLKSFINGLTGITAETLKDAPPVEKVLEEFQE
FVGSLLMIGYNAAKSDLPILAEYGLDYSQQYKVDLYDEAFERRSSDLHGIANLKLQTVASFLGFQGQSHNSLEDARMTAR
VYESFLESDQARELLETESSLSNNPFGGLDLSQLFD

Sequences:

>Translated_196_residues
MERLEDYIAFDLEFNQHEGQKHLIQVSAVRFRDGREIDAYDSYVHTSVPLKSFINGLTGITAETLKDAPPVEKVLEEFQE
FVGSLLMIGYNAAKSDLPILAEYGLDYSQQYKVDLYDEAFERRSSDLHGIANLKLQTVASFLGFQGQSHNSLEDARMTAR
VYESFLESDQARELLETESSLSNNPFGGLDLSQLFD
>Mature_196_residues
MERLEDYIAFDLEFNQHEGQKHLIQVSAVRFRDGREIDAYDSYVHTSVPLKSFINGLTGITAETLKDAPPVEKVLEEFQE
FVGSLLMIGYNAAKSDLPILAEYGLDYSQQYKVDLYDEAFERRSSDLHGIANLKLQTVASFLGFQGQSHNSLEDARMTAR
VYESFLESDQARELLETESSLSNNPFGGLDLSQLFD

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR016027
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 22189; Mature: 22189

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLEDYIAFDLEFNQHEGQKHLIQVSAVRFRDGREIDAYDSYVHTSVPLKSFINGLTGI
CCHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHCC
TAETLKDAPPVEKVLEEFQEFVGSLLMIGYNAAKSDLPILAEYGLDYSQQYKVDLYDEAF
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCHHCCEEHHHHHH
ERRSSDLHGIANLKLQTVASFLGFQGQSHNSLEDARMTARVYESFLESDQARELLETESS
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LSNNPFGGLDLSQLFD
CCCCCCCCCCHHHHCC
>Mature Secondary Structure
MERLEDYIAFDLEFNQHEGQKHLIQVSAVRFRDGREIDAYDSYVHTSVPLKSFINGLTGI
CCHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHCC
TAETLKDAPPVEKVLEEFQEFVGSLLMIGYNAAKSDLPILAEYGLDYSQQYKVDLYDEAF
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCHHCCEEHHHHHH
ERRSSDLHGIANLKLQTVASFLGFQGQSHNSLEDARMTARVYESFLESDQARELLETESS
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LSNNPFGGLDLSQLFD
CCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]