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The map label for this gene is bdhA [H]

Identifier: 225860458

GI number: 225860458

Start: 433034

End: 434077

Strand: Reverse

Name: bdhA [H]

Synonym: SPT_0472

Alternate gene names: 225860458

Gene position: 434077-433034 (Counterclockwise)

Preceding gene: 225860459

Following gene: 225860456

Centisome position: 20.55

GC content: 40.23

Gene sequence:

>1044_bases
ATGGCTACAATGAAGGCAGCTCGCTGGCATGCAGCGAAAGATGTTCGTATTCAAGAAATAGAAGTTCCTGAAGTACTTCC
GCACCAAGTAAAAGTTGCAGTTAAGTTCACAGGAATTTGTGGTACTGACCTCCATGAATTTTTAGATGGACCTATCTTTA
TCCCAACAGATGAGCACGTCTATTCTGGTCAAAAAGCACCGGTAACACTGGGACATGAATTTTCTGGTGAAATCATAGAA
GTCGGAAGCGATGTTACCCGTGTTAAAGTTGGTGATCGTGTTGCTGTGGAACCAATTCTAGCTAAAAATAACTTAGTTGG
TGATTATAATTTGGATCCAAACCTTAATTTTGTCGGTTTGGCTGCAGACGGTGGATTTGCCAAATATTGTGTTTTAGACG
GTGACTTAGTACATGTCATTCCAGATAGTTTGAGCTATGAGCAAGCTGCTCTTACTGAACCCGCTGCTGTTGCAGTCTAT
GCTGTTCGTCAATCTTCTTTGAAGGCTGGCGATACAGCTGTTGTCTTTGGTTTAGGCCCGATTGGTCTATTAATTGTAGA
AGCTCTTCGTGCAGCTGGTGCTTCTAAGATTTATGCTGTTGAACTATCACCTGAACGTCAAGCAAAAGCTGAAGAGTTAG
GAGCTATCGTTGTCCGTCCGGAAGAAGGTGAAACAGCTGTTGAAGCTATTCATCGTTTAACAAACGGTGGTGTAGATGTT
TCTTATGAAGTAACGGGTGTGCCAGTAGTTTTAGGACAAGCCTTAGCTGCCGTACATAAAGCAGGTGAGTGCATGGTGGT
CTCTATCTGGGAACGAGAAGCAAATATTAATCCGAATGAATTTGCAATCCAAGAAAAGACACTAAAAGGAATCATTGCTT
ATCGTCATATCTTCCCTAAAGTATTAGAATTGATGGAACAAGGCTACTTCTCTGCTGAAAAATTAGTTACTAAGAAAATT
AAATTGGAAAATATCGTCGAAGAAGACTTTATCGAATTAACTCAAGATAAGTCACAAATTAAAATTTTGGTAGAACCAGA
ATAA

Upstream 100 bases:

>100_bases
TTGGTTTTTTCTTGACAAATAGAAAGAAAACGTTTGCAATATTGCGTGTAAAGTTTCCAAACAAGAAAACTAAAAATCGC
AACAATAAGGAGTTATTTAT

Downstream 100 bases:

>100_bases
AAAATCAATCTTTTTAAGACAATACTAACAGGTCGGAGTAAACTTACTTCGGCCTTTTGAAATATAATACTCTTCGAAAA
TCTCTTCAGACCACGTCAGC

Product: L-iditol 2-dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MATMKAARWHAAKDVRIQEIEVPEVLPHQVKVAVKFTGICGTDLHEFLDGPIFIPTDEHVYSGQKAPVTLGHEFSGEIIE
VGSDVTRVKVGDRVAVEPILAKNNLVGDYNLDPNLNFVGLAADGGFAKYCVLDGDLVHVIPDSLSYEQAALTEPAAVAVY
AVRQSSLKAGDTAVVFGLGPIGLLIVEALRAAGASKIYAVELSPERQAKAEELGAIVVRPEEGETAVEAIHRLTNGGVDV
SYEVTGVPVVLGQALAAVHKAGECMVVSIWEREANINPNEFAIQEKTLKGIIAYRHIFPKVLELMEQGYFSAEKLVTKKI
KLENIVEEDFIELTQDKSQIKILVEPE

Sequences:

>Translated_347_residues
MATMKAARWHAAKDVRIQEIEVPEVLPHQVKVAVKFTGICGTDLHEFLDGPIFIPTDEHVYSGQKAPVTLGHEFSGEIIE
VGSDVTRVKVGDRVAVEPILAKNNLVGDYNLDPNLNFVGLAADGGFAKYCVLDGDLVHVIPDSLSYEQAALTEPAAVAVY
AVRQSSLKAGDTAVVFGLGPIGLLIVEALRAAGASKIYAVELSPERQAKAEELGAIVVRPEEGETAVEAIHRLTNGGVDV
SYEVTGVPVVLGQALAAVHKAGECMVVSIWEREANINPNEFAIQEKTLKGIIAYRHIFPKVLELMEQGYFSAEKLVTKKI
KLENIVEEDFIELTQDKSQIKILVEPE
>Mature_346_residues
ATMKAARWHAAKDVRIQEIEVPEVLPHQVKVAVKFTGICGTDLHEFLDGPIFIPTDEHVYSGQKAPVTLGHEFSGEIIEV
GSDVTRVKVGDRVAVEPILAKNNLVGDYNLDPNLNFVGLAADGGFAKYCVLDGDLVHVIPDSLSYEQAALTEPAAVAVYA
VRQSSLKAGDTAVVFGLGPIGLLIVEALRAAGASKIYAVELSPERQAKAEELGAIVVRPEEGETAVEAIHRLTNGGVDVS
YEVTGVPVVLGQALAAVHKAGECMVVSIWEREANINPNEFAIQEKTLKGIIAYRHIFPKVLELMEQGYFSAEKLVTKKIK
LENIVEEDFIELTQDKSQIKILVEPE

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=329, Percent_Identity=30.3951367781155, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI4501933, Length=379, Percent_Identity=29.8153034300792, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI4501929, Length=380, Percent_Identity=29.7368421052632, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI34577061, Length=376, Percent_Identity=30.0531914893617, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI71565152, Length=382, Percent_Identity=27.2251308900524, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI262073058, Length=359, Percent_Identity=27.0194986072423, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI71743840, Length=359, Percent_Identity=27.0194986072423, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI71565154, Length=288, Percent_Identity=28.4722222222222, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI156523966, Length=377, Percent_Identity=25.1989389920424, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4501939, Length=360, Percent_Identity=25.5555555555556, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1788073, Length=333, Percent_Identity=30.3303303303303, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1787863, Length=352, Percent_Identity=26.1363636363636, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788407, Length=208, Percent_Identity=35.0961538461538, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI226510992, Length=348, Percent_Identity=25.8620689655172, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788075, Length=353, Percent_Identity=27.7620396600567, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790718, Length=320, Percent_Identity=26.875, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790045, Length=334, Percent_Identity=26.0479041916168, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082125, Length=267, Percent_Identity=29.2134831460674, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1786552, Length=386, Percent_Identity=25.1295336787565, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081918, Length=320, Percent_Identity=25.625, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=351, Percent_Identity=32.1937321937322, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17562878, Length=350, Percent_Identity=31.4285714285714, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI25146526, Length=292, Percent_Identity=28.0821917808219, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=294, Percent_Identity=27.891156462585, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=188, Percent_Identity=29.2553191489362, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17565904, Length=271, Percent_Identity=28.7822878228782, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=377, Percent_Identity=33.9522546419098, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319257, Length=377, Percent_Identity=30.2387267904509, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319955, Length=325, Percent_Identity=32, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6322619, Length=325, Percent_Identity=32, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6323099, Length=361, Percent_Identity=29.6398891966759, Blast_Score=139, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6320033, Length=364, Percent_Identity=24.4505494505494, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=228, Percent_Identity=26.7543859649123, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=229, Percent_Identity=27.0742358078603, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=229, Percent_Identity=27.5109170305677, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=184, Percent_Identity=27.1739130434783, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=29.8192771084337, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI17137530, Length=322, Percent_Identity=29.8136645962733, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI221457811, Length=286, Percent_Identity=25.1748251748252, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45551930, Length=286, Percent_Identity=25.1748251748252, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45550770, Length=286, Percent_Identity=25.1748251748252, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 37598; Mature: 37466

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATMKAARWHAAKDVRIQEIEVPEVLPHQVKVAVKFTGICGTDLHEFLDGPIFIPTDEHV
CCCCCCHHHCCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCHHHHHCCCCEEECCCCHH
YSGQKAPVTLGHEFSGEIIEVGSDVTRVKVGDRVAVEPILAKNNLVGDYNLDPNLNFVGL
HCCCCCCEEECCCCCCCEEECCCCEEEEEECCEEEECEEEECCCEEECCCCCCCCCEEEE
AADGGFAKYCVLDGDLVHVIPDSLSYEQAALTEPAAVAVYAVRQSSLKAGDTAVVFGLGP
ECCCCEEEEEEECCCEEEECCCCCCCCHHHCCCCHHEEEEEEHHHCCCCCCEEEEEECCH
IGLLIVEALRAAGASKIYAVELSPERQAKAEELGAIVVRPEEGETAVEAIHRLTNGGVDV
HHHHHHHHHHHCCCCEEEEEEECCHHHCCHHHCCEEEEECCCCCHHHHHHHHHCCCCCEE
SYEVTGVPVVLGQALAAVHKAGECMVVSIWEREANINPNEFAIQEKTLKGIIAYRHIFPK
EEEECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHH
VLELMEQGYFSAEKLVTKKIKLENIVEEDFIELTQDKSQIKILVEPE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
>Mature Secondary Structure 
ATMKAARWHAAKDVRIQEIEVPEVLPHQVKVAVKFTGICGTDLHEFLDGPIFIPTDEHV
CCCCCHHHCCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCHHHHHCCCCEEECCCCHH
YSGQKAPVTLGHEFSGEIIEVGSDVTRVKVGDRVAVEPILAKNNLVGDYNLDPNLNFVGL
HCCCCCCEEECCCCCCCEEECCCCEEEEEECCEEEECEEEECCCEEECCCCCCCCCEEEE
AADGGFAKYCVLDGDLVHVIPDSLSYEQAALTEPAAVAVYAVRQSSLKAGDTAVVFGLGP
ECCCCEEEEEEECCCEEEECCCCCCCCHHHCCCCHHEEEEEEHHHCCCCCCEEEEEECCH
IGLLIVEALRAAGASKIYAVELSPERQAKAEELGAIVVRPEEGETAVEAIHRLTNGGVDV
HHHHHHHHHHHCCCCEEEEEEECCHHHCCHHHCCEEEEECCCCCHHHHHHHHHCCCCCEE
SYEVTGVPVVLGQALAAVHKAGECMVVSIWEREANINPNEFAIQEKTLKGIIAYRHIFPK
EEEECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHH
VLELMEQGYFSAEKLVTKKIKLENIVEEDFIELTQDKSQIKILVEPE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]