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The map label for this gene is dltA

Identifier: 225859948

GI number: 225859948

Start: 2118842

End: 2120392

Strand: Reverse

Name: dltA

Synonym: SP70585_2304

Alternate gene names: 225859948

Gene position: 2120392-2118842 (Counterclockwise)

Preceding gene: 225859949

Following gene: 225859947

Centisome position: 97.06

GC content: 44.17

Gene sequence:

>1551_bases
GTGTCAAATAAACCAATAGCAGATATGATTGAAACCATTGAGCATTTTGCTCAGACACAGCCTAGCTATCCTGTCTATAA
TGTTTTGGGGCAGGAACACACTTATGGCGATTTAAAGTCTGATTCGGATAGTTTGGCTGCAGTCATTGACCAACTAGGCT
TGCCTGAGAAGTCTCCTGTGGTTGTTTTTGGTGGCCAAGAATATGAAATGTTGGCAACCTTTGTAGCGCTGACTAAGTCA
GGTCATGCCTACATTCCAATTGATAGCCATTCGGCCTTGGAGCGAGTTTCAGCTATTTTAGAAGTAGCAGAGCCAAGCTT
GATTATTGCCATTTCAGCCTTTCCCTTGGAGCAGGTTTCTACACCAATGATAAATCTAGCTCAGGTTCAAGAAGCCTTTG
CCCAAGGGAACAACTATGAAATCACGCATCCAGTCAAGGGAGATGATAATTACTACATTATCTTTACTTCTGGTACGACT
GGTCAGCCTAAGGGAGTGCAGATTTCACATGATAATCTCCTCAGCTTTACAAACTGGATGATTACGGATAAGGAATTTGC
GACACCGAGTCGTCCGCAAATGCTGGCACAGCCACCTTATTCTTTTGACTTGTCTGTCATGTATTGGGCACCGACCTTGG
CACTTGGTGGTACGCTTTTCACTCTTCCTTCAGTCATCACTCAGGACTTTAAGCAACTCTTTGCGGCTATCTTTTCATTG
CCAATCGCTATCTGGACATCAACACCATCCTTTGCAGATATGGCCATGTTGTCTGAATACTTCAACAGTGAGAAAATGCC
TGGAATCACGCATTTCTACTTTGATGGTGAAGAATTGACGGTCAAAACAGCTCAAAAACTGCGCGAGCGTTTCCCAAATG
CCCGTATCATCAATGCTTACGGCCCAACAGAAGCGACAGTAGCTCTGTCAGCAGTTGCCGTGACAGACGAGATGTTAGCG
ACTCTCAAACGCCTACCAATCGGCTATACCAAGGCTGATTCTCCAACCTTTATCATTGACGAGGAAGGAAATAAACTGCC
AAATGGTGAGCAGGGAGAAATCATTGTTTCTGGGCCAGCTGTTTCAAAAGGTTATATGAACAATCCTGAAAAAACAGCAG
AAGCCTTCTTTGAGTTTGAAGATCTGCCAGCCTATCACACAGGCGATGTGGGAACCATGACAGATGAGGGCTTGCTTCTC
TACGGCGGACGCATGGACTTCCAGATTAAGTTTAACGGTTACCGCATTGAGTTAGAAGATGTCTCTCAAAACCTCAACAA
GTCTCGCTTTATCGAATCTGCTGTCGCAGTACCGCGCTATAACAAGGACCACAAGGTACAAAATCTATTGGCTTATGTCA
TCTTAAAAGACAGTGTTCGTGAGCAGTTTGAGCGAGATATCGATATTACCAAGGCCATCAAGGAAGACCTGACAGACATC
ATGATGTCCTACATGATACCATCTAAATTCCTTTACCGAGACAGTTTGCCACTGACTCCAAATGGAAAGATTGACATCAA
AGGATTGATTAACGAGGTGAATAAGAGATGA

Upstream 100 bases:

>100_bases
TTCTTATCTTTCTAGGGCTGCTTTACTTCTTTAGCTATCTTGGTCAGGGTCAAGGAAGCTTTATCTATAATGAATTTTAA
CTTGAAGGAGAATCCCTATT

Downstream 100 bases:

>100_bases
TGGAGTTTTTTCAACAGCTTCCTCATTTAGAGCCATATGGCAATCCTCAGTATTTTGTTTATGTGATTGCTGCAACCTTG
CCCATCTTTATAGGTCTCTT

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKSDSDSLAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKS
GHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTT
GQPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSL
PIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLA
TLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGTMTDEGLLL
YGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDSVREQFERDIDITKAIKEDLTDI
MMSYMIPSKFLYRDSLPLTPNGKIDIKGLINEVNKR

Sequences:

>Translated_516_residues
MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKSDSDSLAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKS
GHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTT
GQPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSL
PIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLA
TLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGTMTDEGLLL
YGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDSVREQFERDIDITKAIKEDLTDI
MMSYMIPSKFLYRDSLPLTPNGKIDIKGLINEVNKR
>Mature_515_residues
SNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKSDSDSLAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKSG
HAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTTG
QPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSLP
IAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLAT
LKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGTMTDEGLLLY
GGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDSVREQFERDIDITKAIKEDLTDIM
MSYMIPSKFLYRDSLPLTPNGKIDIKGLINEVNKR

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI115511026, Length=385, Percent_Identity=28.3116883116883, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI45580730, Length=376, Percent_Identity=25.531914893617, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI42544132, Length=540, Percent_Identity=24.2592592592593, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI38505220, Length=389, Percent_Identity=26.7352185089974, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI156151445, Length=554, Percent_Identity=22.9241877256318, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI157311624, Length=380, Percent_Identity=26.0526315789474, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI157311622, Length=380, Percent_Identity=26.0526315789474, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1786801, Length=496, Percent_Identity=26.2096774193548, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1786810, Length=512, Percent_Identity=21.875, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI145693145, Length=408, Percent_Identity=23.7745098039216, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788107, Length=557, Percent_Identity=22.4416517055655, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789201, Length=284, Percent_Identity=25.3521126760563, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32563687, Length=488, Percent_Identity=24.1803278688525, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=488, Percent_Identity=23.155737704918, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994703, Length=544, Percent_Identity=23.3455882352941, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=544, Percent_Identity=23.3455882352941, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=544, Percent_Identity=23.3455882352941, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17550940, Length=360, Percent_Identity=26.3888888888889, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17556356, Length=464, Percent_Identity=27.5862068965517, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538037, Length=424, Percent_Identity=26.4150943396226, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17557194, Length=433, Percent_Identity=24.9422632794457, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17531443, Length=329, Percent_Identity=25.2279635258359, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319591, Length=560, Percent_Identity=24.8214285714286, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319699, Length=376, Percent_Identity=29.2553191489362, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648676, Length=462, Percent_Identity=26.6233766233766, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI18859661, Length=372, Percent_Identity=24.7311827956989, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21355181, Length=375, Percent_Identity=23.4666666666667, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356441, Length=412, Percent_Identity=20.1456310679612, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 57456; Mature: 57325

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKSDSDSLAAVIDQLGLPEKSPV
CCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCE
VVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVS
EEECCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHC
TPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWM
CCCHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHEE
ITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSL
EECHHCCCCCCCCEECCCCCCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
PIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAY
CEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCCEEEHHHHHHHHHHCCCCEEEECC
GPTEATVALSAVAVTDEMLATLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCC
VSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGTMTDEGLLLYGGRMDFQIKFNGYRIELED
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEEEEEEEECCEEEEHHH
VSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDSVREQFERDIDITKAIKEDLTDI
HHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
MMSYMIPSKFLYRDSLPLTPNGKIDIKGLINEVNKR
HHHHHCCHHHHCCCCCCCCCCCCEEHHHHHHHHCCC
>Mature Secondary Structure 
SNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKSDSDSLAAVIDQLGLPEKSPV
CCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCE
VVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVS
EEECCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHC
TPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWM
CCCHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHEE
ITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSL
EECHHCCCCCCCCEECCCCCCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
PIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAY
CEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCCEEEHHHHHHHHHHCCCCEEEECC
GPTEATVALSAVAVTDEMLATLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCC
VSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGTMTDEGLLLYGGRMDFQIKFNGYRIELED
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEEEEEEEECCEEEEHHH
VSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDSVREQFERDIDITKAIKEDLTDI
HHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
MMSYMIPSKFLYRDSLPLTPNGKIDIKGLINEVNKR
HHHHHCCHHHHCCCCCCCCCCCCEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA