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The map label for this gene is tktA [C]

Identifier: 225859901

GI number: 225859901

Start: 2062319

End: 2063176

Strand: Reverse

Name: tktA [C]

Synonym: SP70585_2254

Alternate gene names: 225859901

Gene position: 2063176-2062319 (Counterclockwise)

Preceding gene: 225859902

Following gene: 225859900

Centisome position: 94.44

GC content: 34.62

Gene sequence:

>858_bases
ATGATTTTAAGTAAAAATAGAGAAGATGAGTTAAGAAAATTTGCGACTAACATCCGATTAAATACTCTTAGAACATTGAA
TCATCTTGGATTCGGACATTACGGAGGAAGTTTGTCTATCGTAGAAGTTTTAGCAGTGCTTTATGGTGAAATAATGCCAA
TGACTCCAGAAATATTTGCAGCACGAGATAGAGATTATTTCATATTATCAAAAGGTCATGGAGGACCAGCTCTATACAGT
ACACTCTATTTGAATGGTTTCTTTGACAAAGAATTCTTATATTCTTTAAATAAAAATGGAACCAAATTACCGTCTCATCC
TGATAGAAATCTAACGCCAGGCATAGATATGACAACGGGCTCTTTAGGACAAGGAATTAGTGTTGCAACTGGACTTGCAT
ATGGTCAGAGAATAAGAAAGAGTCCCTTTTATACTTATGCTATTGTTGGAGATGGTGAGTTAAATGAGGGACAATGTTGG
GAGGCTATACAGTTTGCTTCTCATCAACAGTTATCCAACTTAATTGTATTTGTTGATGATAACAAAAAACAATTAGATGG
TTTTACAAAGGATATTTGTAATCCAGGTGATTTCGTAGAAAAATTTTCAGCATTTGGATTTGAATCCATTAGGGTCAAGG
GTTCAGATATTAGAGAAATTTATGAAGGGATTGTCCAATTAAAACAGTCAAATAATTCATCACCTAAGTGCATTGTATTA
GATACTATTAAAGGTCAAGGGGTTCAAGAGCTGGAAGAAATGAAATCCAACCATCATCTTCGCCCTACTGTAGAGGAGAG
ACAAATGTTAACTTCAGTTGTAGAAAGATTAAGTCAGGAATTGGAGGAAACAGAATGA

Upstream 100 bases:

>100_bases
TGGCTCACAAGCAGGCATTGTGATTGGTCTTGTTCTTATTTTAGCAGTTATGTTTGGAGTATCCTTTATTAAAAAGCCAT
CTGCAAAGGAGGAATAAGGG

Downstream 100 bases:

>100_bases
TGAGAAGTACGAAAGAATTACGGCATGTATATAGAGACTTCCTTTTAGAGGCTAATCAAAGTGATTCTGATATAGTAGTC
TTAGAAGCCGATTTGTCAAG

Product: transketolase, thiamine disphosphate-binding subunit

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MILSKNREDELRKFATNIRLNTLRTLNHLGFGHYGGSLSIVEVLAVLYGEIMPMTPEIFAARDRDYFILSKGHGGPALYS
TLYLNGFFDKEFLYSLNKNGTKLPSHPDRNLTPGIDMTTGSLGQGISVATGLAYGQRIRKSPFYTYAIVGDGELNEGQCW
EAIQFASHQQLSNLIVFVDDNKKQLDGFTKDICNPGDFVEKFSAFGFESIRVKGSDIREIYEGIVQLKQSNNSSPKCIVL
DTIKGQGVQELEEMKSNHHLRPTVEERQMLTSVVERLSQELEETE

Sequences:

>Translated_285_residues
MILSKNREDELRKFATNIRLNTLRTLNHLGFGHYGGSLSIVEVLAVLYGEIMPMTPEIFAARDRDYFILSKGHGGPALYS
TLYLNGFFDKEFLYSLNKNGTKLPSHPDRNLTPGIDMTTGSLGQGISVATGLAYGQRIRKSPFYTYAIVGDGELNEGQCW
EAIQFASHQQLSNLIVFVDDNKKQLDGFTKDICNPGDFVEKFSAFGFESIRVKGSDIREIYEGIVQLKQSNNSSPKCIVL
DTIKGQGVQELEEMKSNHHLRPTVEERQMLTSVVERLSQELEETE
>Mature_285_residues
MILSKNREDELRKFATNIRLNTLRTLNHLGFGHYGGSLSIVEVLAVLYGEIMPMTPEIFAARDRDYFILSKGHGGPALYS
TLYLNGFFDKEFLYSLNKNGTKLPSHPDRNLTPGIDMTTGSLGQGISVATGLAYGQRIRKSPFYTYAIVGDGELNEGQCW
EAIQFASHQQLSNLIVFVDDNKKQLDGFTKDICNPGDFVEKFSAFGFESIRVKGSDIREIYEGIVQLKQSNNSSPKCIVL
DTIKGQGVQELEEMKSNHHLRPTVEERQMLTSVVERLSQELEETE

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=276, Percent_Identity=32.6086956521739, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI205277463, Length=261, Percent_Identity=32.5670498084291, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4507521, Length=261, Percent_Identity=32.5670498084291, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI225637459, Length=258, Percent_Identity=25.968992248062, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI225637463, Length=154, Percent_Identity=32.4675324675325, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI225637461, Length=154, Percent_Identity=32.4675324675325, Blast_Score=88, Evalue=8e-18,
Organism=Escherichia coli, GI48994911, Length=248, Percent_Identity=31.0483870967742, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788808, Length=272, Percent_Identity=31.6176470588235, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17539652, Length=269, Percent_Identity=33.0855018587361, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6325331, Length=245, Percent_Identity=35.9183673469388, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319593, Length=244, Percent_Identity=32.3770491803279, Blast_Score=109, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24666278, Length=251, Percent_Identity=35.4581673306773, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI45551847, Length=254, Percent_Identity=33.0708661417323, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45550715, Length=254, Percent_Identity=33.0708661417323, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24645119, Length=199, Percent_Identity=37.1859296482412, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 32011; Mature: 32011

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILSKNREDELRKFATNIRLNTLRTLNHLGFGHYGGSLSIVEVLAVLYGEIMPMTPEIFA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHE
ARDRDYFILSKGHGGPALYSTLYLNGFFDKEFLYSLNKNGTKLPSHPDRNLTPGIDMTTG
ECCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SLGQGISVATGLAYGQRIRKSPFYTYAIVGDGELNEGQCWEAIQFASHQQLSNLIVFVDD
CCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEEEC
NKKQLDGFTKDICNPGDFVEKFSAFGFESIRVKGSDIREIYEGIVQLKQSNNSSPKCIVL
CHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEE
DTIKGQGVQELEEMKSNHHLRPTVEERQMLTSVVERLSQELEETE
ECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MILSKNREDELRKFATNIRLNTLRTLNHLGFGHYGGSLSIVEVLAVLYGEIMPMTPEIFA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHE
ARDRDYFILSKGHGGPALYSTLYLNGFFDKEFLYSLNKNGTKLPSHPDRNLTPGIDMTTG
ECCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SLGQGISVATGLAYGQRIRKSPFYTYAIVGDGELNEGQCWEAIQFASHQQLSNLIVFVDD
CCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEEEC
NKKQLDGFTKDICNPGDFVEKFSAFGFESIRVKGSDIREIYEGIVQLKQSNNSSPKCIVL
CHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEE
DTIKGQGVQELEEMKSNHHLRPTVEERQMLTSVVERLSQELEETE
ECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]