| Definition | Streptococcus pneumoniae 70585, complete genome. |
|---|---|
| Accession | NC_012468 |
| Length | 2,184,682 |
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The map label for this gene is pbpA [H]
Identifier: 225859854
GI number: 225859854
Start: 2011966
End: 2014428
Strand: Reverse
Name: pbpA [H]
Synonym: SP70585_2205
Alternate gene names: 225859854
Gene position: 2014428-2011966 (Counterclockwise)
Preceding gene: 225859856
Following gene: 225859853
Centisome position: 92.21
GC content: 42.83
Gene sequence:
>2463_bases ATGCAAAATCAATTAAATGAATTAAAACGAAAAATGCTGGAATTTTTCCAGCAAAAACAAAAAAATAAAAAATCAGCTAG ACCTGGCAAGAAAGGTTCAAGTACCAAAAAATCTAAAACCTTAGATAAGTCAGCCATTTTCCCAGCTATTTTACTGAGTA TAAAAGCCTTATTTAACTTACTCTTTGTACTCTGTTTTCTAGGAGGAATGTTGGGAGCTGGGATTGCTTTGGGATACGGA GTGGCCTTATTTGACAAGGTTCGGGTGCCTCAGACAGAAGAATTGGTGAATCAGGTCAAGGACATCTCTTCTATTTCAGA GATTACCTATTTGGACGGGACGGTGATTGCTTCCATAGAGAGTGATTTGTTGCGCACTTCTATCTCATCTGAGCAAATTT CGGAAAATCTGAAGAAGGCTATCATTGCGACAGAAGATGAACACTTTAAAGAACATAAGGGTGTAGTACCCAAGGCGGTG ATTCGTGCGACCTTGGGGAAATTTGTAGGTTTGGGTTCCTCTAGTGGGGGTTCAACCTTGACCCAGCAACTAATTAAACA GCAGGTGGTTGGGGATGCGCCGACCTTGGCTCGTAAGGCGGCAGAGATTGTGGATGCTCTTGCCTTGGAACGCGCCATGA CTAAAGATGAGATTTTAACGACCTATCTCAATGTGGCTCCCTTTGGCCGAAATAATAAGGGACAGAATATTGCAGGGGCT CGGCAAGCAGCTGAGGGAATTTTCGGTGTAGATGCCAGTCAGTTGACTGTTCCTCAAGCAGCATTTTTAGCAGGACTTCC ACAGAGTCCCATTACTTACTCTCCTTATGAAAATACTGGGGAGTTGAAGAGTGATGAAGGCCTAGAAATTGGCTTAAGAC GGGCTAAGGCAGTTCTTTACAGTATGTATCGTACAGGTGCATTAAGCAAAGACGAGTATTCTCAGTACAAGGATTATGAC CTTAAACAGGACTTTTTACCATCGGGCACGGTTACAGGAATTTCACGAGACTATTTATACTTTACAACTTTGGCAGAAGC TCAAGAACGTATGTATGACTATCTAGCTCAGAGAGACAATGTCTCCGCTAAGGAGTTGAAAAATGAGGCAACTCAGAAGT TTTATCGAGATTTGGCAGCCAAGGAAATTGAAAATGGTGGTTATAAGATTACTACTACCATAGATCAGAAAATTCATTCT GCCATGCAAAGTGCGGTTGCTGATTATGGCTATCTTTTAGACGATGGAACAGGTCGTGTAGAAGTAGGGAATGTCTTGAT GGACAACCAAACAGGTGCTATTCTAGGCTTTGTAGGTGGTCGTAATTATCAAGAAAATCAAAATAATCATGCCTTTGATA CCAAACGTTCGCCAGCTTCTACTACCAAGCCCTTGCTGGCCTACGGTATTGCTATTGACCAGGGCTTGATGGGAAGTGAA ACGATTCTATCTAACTATCCAACAAACTTTGCTAATGGCAATCCGATTATGTATGCTAATAGCAAGGGAACAGGAATGAT GACCTTGGGAGAAGCTCTGAACTATTCATGGAATATCCCTGCTTACTGGACCTATCGTATGCTCCGTGAAAAGGGTGTTG ATGTCAAGGGTTATATGGAAAAGATGGGTTACGAGATTCCTGAGTACGGTATTGAGAGCTTGCCAATGGGTGGTGGTATT GAAGTCACAGTTGCCCAGCATACCAATGGCTATCAGACCTTAGCTAATAATGGAGTTTATCATCAGAAGCATGTGATTTC AAAGATTGAAGCAGCAGATGGTAGAGTGGTGTATGAGTATCAGGATAAACCGGTTCAAGTCTATTCAAAAGCTACTGCGA CGATTATGCAGGGATTGCTACGAGAAGTTCTATCCTCTCGTGTGACAACAACCTTCAAGTCTAACCTGACTTCTTTAAAT CCTACTCTGGCTAATGCAGATTGGATTGGGAAGACTGGTACAACCAACCAAGACGAAAATATGTGGCTCATGCTTTCGAC ACCTAGATTAACCCTAGGTGGCTGGATTGGGCATGATGATAATCATTCATTGTCACGTAGAGCAGGTTATTCTAATAACT CTAATTACATGGCTCATCTAGTAAATGCGATTCAGCAAGCTTCCCCAAGCATTTGGGGGAACGAGCGCTTTGCTTTAGAT CCTAGTGTAGTGAAATCGGAAGTCTTGAAATCAACAGGTCAAAAACCAGGGAAGGTTTCTGTTGAAGGAAAAGAGGTAGA GGTCACAGGTTCGACTGTTACCAGCTATTGGGCTAATAAGTCAGGAGCGCCAGCGACAAGTTATCGCTTTGCTATTGGCG GAAGTGATGCGGATTATCAGAATGCTTGGTCTAGTATTGTGGGGAGTCTACCAACTCCATCCAGCTCCAGCAGTTCAAGT AGTAGTTCTAGCGATAGCAGTAACTCAAGTACTACACGACCTTCTTCAAGGGCGAGACGATAA
Upstream 100 bases:
>100_bases TATCACAAACTTGGGCAATAGCCTAGCAGAATAGGGAAGAAAGTGGCTATTTTATTGAAAATTTCCCTTTTGTGGTATAA TAGATAGAGTGAGGAAATCC
Downstream 100 bases:
>100_bases TTCTCTAAATGAAGTGGCCAATCAATGGATTGCCACTTTTTTCCTTTCGTGTTACAATAAGGGTATGAATCAGTATCAGA AAAAGATTGTTAACGGAAAA
Product: penicillin-binding protein 1B
Products: NA
Alternate protein names: PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 820; Mature: 820
Protein sequence:
>820_residues MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKSAIFPAILLSIKALFNLLFVLCFLGGMLGAGIALGYG VALFDKVRVPQTEELVNQVKDISSISEITYLDGTVIASIESDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAV IRATLGKFVGLGSSSGGSTLTQQLIKQQVVGDAPTLARKAAEIVDALALERAMTKDEILTTYLNVAPFGRNNKGQNIAGA RQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPYENTGELKSDEGLEIGLRRAKAVLYSMYRTGALSKDEYSQYKDYD LKQDFLPSGTVTGISRDYLYFTTLAEAQERMYDYLAQRDNVSAKELKNEATQKFYRDLAAKEIENGGYKITTTIDQKIHS AMQSAVADYGYLLDDGTGRVEVGNVLMDNQTGAILGFVGGRNYQENQNNHAFDTKRSPASTTKPLLAYGIAIDQGLMGSE TILSNYPTNFANGNPIMYANSKGTGMMTLGEALNYSWNIPAYWTYRMLREKGVDVKGYMEKMGYEIPEYGIESLPMGGGI EVTVAQHTNGYQTLANNGVYHQKHVISKIEAADGRVVYEYQDKPVQVYSKATATIMQGLLREVLSSRVTTTFKSNLTSLN PTLANADWIGKTGTTNQDENMWLMLSTPRLTLGGWIGHDDNHSLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALD PSVVKSEVLKSTGQKPGKVSVEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQNAWSSIVGSLPTPSSSSSSS SSSSDSSNSSTTRPSSRARR
Sequences:
>Translated_820_residues MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKSAIFPAILLSIKALFNLLFVLCFLGGMLGAGIALGYG VALFDKVRVPQTEELVNQVKDISSISEITYLDGTVIASIESDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAV IRATLGKFVGLGSSSGGSTLTQQLIKQQVVGDAPTLARKAAEIVDALALERAMTKDEILTTYLNVAPFGRNNKGQNIAGA RQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPYENTGELKSDEGLEIGLRRAKAVLYSMYRTGALSKDEYSQYKDYD LKQDFLPSGTVTGISRDYLYFTTLAEAQERMYDYLAQRDNVSAKELKNEATQKFYRDLAAKEIENGGYKITTTIDQKIHS AMQSAVADYGYLLDDGTGRVEVGNVLMDNQTGAILGFVGGRNYQENQNNHAFDTKRSPASTTKPLLAYGIAIDQGLMGSE TILSNYPTNFANGNPIMYANSKGTGMMTLGEALNYSWNIPAYWTYRMLREKGVDVKGYMEKMGYEIPEYGIESLPMGGGI EVTVAQHTNGYQTLANNGVYHQKHVISKIEAADGRVVYEYQDKPVQVYSKATATIMQGLLREVLSSRVTTTFKSNLTSLN PTLANADWIGKTGTTNQDENMWLMLSTPRLTLGGWIGHDDNHSLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALD PSVVKSEVLKSTGQKPGKVSVEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQNAWSSIVGSLPTPSSSSSSS SSSSDSSNSSTTRPSSRARR >Mature_820_residues MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKSAIFPAILLSIKALFNLLFVLCFLGGMLGAGIALGYG VALFDKVRVPQTEELVNQVKDISSISEITYLDGTVIASIESDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAV IRATLGKFVGLGSSSGGSTLTQQLIKQQVVGDAPTLARKAAEIVDALALERAMTKDEILTTYLNVAPFGRNNKGQNIAGA RQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPYENTGELKSDEGLEIGLRRAKAVLYSMYRTGALSKDEYSQYKDYD LKQDFLPSGTVTGISRDYLYFTTLAEAQERMYDYLAQRDNVSAKELKNEATQKFYRDLAAKEIENGGYKITTTIDQKIHS AMQSAVADYGYLLDDGTGRVEVGNVLMDNQTGAILGFVGGRNYQENQNNHAFDTKRSPASTTKPLLAYGIAIDQGLMGSE TILSNYPTNFANGNPIMYANSKGTGMMTLGEALNYSWNIPAYWTYRMLREKGVDVKGYMEKMGYEIPEYGIESLPMGGGI EVTVAQHTNGYQTLANNGVYHQKHVISKIEAADGRVVYEYQDKPVQVYSKATATIMQGLLREVLSSRVTTTFKSNLTSLN PTLANADWIGKTGTTNQDENMWLMLSTPRLTLGGWIGHDDNHSLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALD PSVVKSEVLKSTGQKPGKVSVEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQNAWSSIVGSLPTPSSSSSSS SSSSDSSNSSTTRPSSRARR
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG0744
COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)
Gene ontology:
Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI87082258, Length=349, Percent_Identity=30.0859598853868, Blast_Score=119, Evalue=6e-28, Organism=Escherichia coli, GI1788867, Length=613, Percent_Identity=23.3278955954323, Blast_Score=106, Evalue=5e-24, Organism=Escherichia coli, GI1786343, Length=590, Percent_Identity=23.3898305084746, Blast_Score=102, Evalue=7e-23, Organism=Escherichia coli, GI1789601, Length=238, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=1e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-; 3.4.-.- [C]
Molecular weight: Translated: 89410; Mature: 89410
Theoretical pI: Translated: 8.99; Mature: 8.99
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.1 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.1 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKSAIFPAILLSIKALFNL CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH LFVLCFLGGMLGAGIALGYGVALFDKVRVPQTEELVNQVKDISSISEITYLDGTVIASIE HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHH SDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAVIRATLGKFVGLGSSSGGSTL HHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHH TQQLIKQQVVGDAPTLARKAAEIVDALALERAMTKDEILTTYLNVAPFGRNNKGQNIAGA HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH RQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPYENTGELKSDEGLEIGLRRAKAVLY HHHHCCCCCCCHHHHCCCHHHHHHCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHH SMYRTGALSKDEYSQYKDYDLKQDFLPSGTVTGISRDYLYFTTLAEAQERMYDYLAQRDN HHHHHCCCCHHHHHHHCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC VSAKELKNEATQKFYRDLAAKEIENGGYKITTTIDQKIHSAMQSAVADYGYLLDDGTGRV CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEECCCCCE EVGNVLMDNQTGAILGFVGGRNYQENQNNHAFDTKRSPASTTKPLLAYGIAIDQGLMGSE EECCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCH TILSNYPTNFANGNPIMYANSKGTGMMTLGEALNYSWNIPAYWTYRMLREKGVDVKGYME HHHHCCCCCCCCCCEEEEECCCCCCEEEEHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHH KMGYEIPEYGIESLPMGGGIEVTVAQHTNGYQTLANNGVYHQKHVISKIEAADGRVVYEY HCCCCCCCCCHHHCCCCCCEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHCCCCEEEEEE QDKPVQVYSKATATIMQGLLREVLSSRVTTTFKSNLTSLNPTLANADWIGKTGTTNQDEN CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC MWLMLSTPRLTLGGWIGHDDNHSLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALD EEEEEECCCEEECCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEC PSVVKSEVLKSTGQKPGKVSVEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQ HHHHHHHHHHHHCCCCCEEEECCCEEEEECCHHHHHHCCCCCCCCCCEEEEECCCCCHHH NAWSSIVGSLPTPSSSSSSSSSSSDSSNSSTTRPSSRARR HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCC >Mature Secondary Structure MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKSAIFPAILLSIKALFNL CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH LFVLCFLGGMLGAGIALGYGVALFDKVRVPQTEELVNQVKDISSISEITYLDGTVIASIE HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHH SDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAVIRATLGKFVGLGSSSGGSTL HHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHH TQQLIKQQVVGDAPTLARKAAEIVDALALERAMTKDEILTTYLNVAPFGRNNKGQNIAGA HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH RQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPYENTGELKSDEGLEIGLRRAKAVLY HHHHCCCCCCCHHHHCCCHHHHHHCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHH SMYRTGALSKDEYSQYKDYDLKQDFLPSGTVTGISRDYLYFTTLAEAQERMYDYLAQRDN HHHHHCCCCHHHHHHHCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC VSAKELKNEATQKFYRDLAAKEIENGGYKITTTIDQKIHSAMQSAVADYGYLLDDGTGRV CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEECCCCCE EVGNVLMDNQTGAILGFVGGRNYQENQNNHAFDTKRSPASTTKPLLAYGIAIDQGLMGSE EECCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCH TILSNYPTNFANGNPIMYANSKGTGMMTLGEALNYSWNIPAYWTYRMLREKGVDVKGYME HHHHCCCCCCCCCCEEEEECCCCCCEEEEHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHH KMGYEIPEYGIESLPMGGGIEVTVAQHTNGYQTLANNGVYHQKHVISKIEAADGRVVYEY HCCCCCCCCCHHHCCCCCCEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHCCCCEEEEEE QDKPVQVYSKATATIMQGLLREVLSSRVTTTFKSNLTSLNPTLANADWIGKTGTTNQDEN CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC MWLMLSTPRLTLGGWIGHDDNHSLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALD EEEEEECCCEEECCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEC PSVVKSEVLKSTGQKPGKVSVEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQ HHHHHHHHHHHHCCCCCEEEECCCEEEEECCHHHHHHCCCCCCCCCCEEEEECCCCCHHH NAWSSIVGSLPTPSSSSSSSSSSSDSSNSSTTRPSSRARR HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA