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The map label for this gene is ndk

Identifier: 225859715

GI number: 225859715

Start: 1866875

End: 1867288

Strand: Reverse

Name: ndk

Synonym: SP70585_2030

Alternate gene names: 225859715

Gene position: 1867288-1866875 (Counterclockwise)

Preceding gene: 225859716

Following gene: 225859710

Centisome position: 85.47

GC content: 42.03

Gene sequence:

>414_bases
ATGGAACAAACATTCTTTATCATCAAACCAGATGGTGTAAAAAGAGGGCTAGTGGGTGAAGTGTTAAAGCGCATCGAACA
ACGTGGATTTACAATCGAAAAATTGGAGTTTCGTTCACAGGTTTCAGAAGAGTTGATTGACCAGCACTATCAGGACTTGG
TTGGTCAGAGTTTTTACCTACCGATTCGTGAATTCATGACTTCAGGTCCAGTTCTTGTGGGTGTCATTTCTGGTCCCAAA
GTAATCGAAACTTGGCGGACCATGATGGGTGCAACTCGTCCAGAAGAAGCTTTACCAGGCACTATTCGAGGTGACTTTGC
AAAAGCTGCTGGAGAAAATGAGATTATCCAAAATGTTGTACATGGTTCAGATTCAGAAGAGTCAGCTAAGCGAGAAATTG
CTCTTTGGTTTTAA

Upstream 100 bases:

>100_bases
GAGAACCTGAGGGTTCTCTCATTCTCTCTTCTGAAAACTTTCTCCATTTTTCCACGAAATGTGGTAAAATAAAAGAAAGA
AGCTGACAAAGGAGACGGGT

Downstream 100 bases:

>100_bases
GAGTGGATTGGCTCAATCAATTGGTTAAAAGCTCATTTGAATAGAAAGTATAGTCAATTAGTTTAAGACATGACGCATGA
TATCAAACTTTTTAGTTTTT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEELIDQHYQDLVGQSFYLPIREFMTSGPVLVGVISGPK
VIETWRTMMGATRPEEALPGTIRGDFAKAAGENEIIQNVVHGSDSEESAKREIALWF

Sequences:

>Translated_137_residues
MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEELIDQHYQDLVGQSFYLPIREFMTSGPVLVGVISGPK
VIETWRTMMGATRPEEALPGTIRGDFAKAAGENEIIQNVVHGSDSEESAKREIALWF
>Mature_137_residues
MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEELIDQHYQDLVGQSFYLPIREFMTSGPVLVGVISGPK
VIETWRTMMGATRPEEALPGTIRGDFAKAAGENEIIQNVVHGSDSEESAKREIALWF

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=50.3649635036496, Blast_Score=138, Evalue=1e-33,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=50.3649635036496, Blast_Score=138, Evalue=1e-33,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=48.9051094890511, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=48.9051094890511, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=48.9051094890511, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=48.9051094890511, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=48.9051094890511, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=50, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=47.0588235294118, Blast_Score=122, Evalue=8e-29,
Organism=Homo sapiens, GI5031951, Length=141, Percent_Identity=34.7517730496454, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI30023828, Length=141, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=32.3741007194245, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=32.3741007194245, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=39.4160583941606, Blast_Score=103, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=46.3235294117647, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=45.5882352941176, Blast_Score=125, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=49.2647058823529, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI18860097, Length=140, Percent_Identity=30, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15456; Mature: 15456

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEELIDQHYQDLVGQSFYL
CCCCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
PIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTIRGDFAKAAGENEIIQNVV
HHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHCCCHHHHHHHH
HGSDSEESAKREIALWF
CCCCCCHHHHHCEECCC
>Mature Secondary Structure
MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEELIDQHYQDLVGQSFYL
CCCCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
PIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTIRGDFAKAAGENEIIQNVV
HHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHCCCHHHHHHHH
HGSDSEESAKREIALWF
CCCCCCHHHHHCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA