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The map label for this gene is pfbA [H]

Identifier: 225859599

GI number: 225859599

Start: 1754064

End: 1756190

Strand: Reverse

Name: pfbA [H]

Synonym: SP70585_1890

Alternate gene names: 225859599

Gene position: 1756190-1754064 (Counterclockwise)

Preceding gene: 225859600

Following gene: 225859598

Centisome position: 80.39

GC content: 31.41

Gene sequence:

>2127_bases
ATGAAATATTTTGTTCCTAATGAGGTATTCAGTATTCGTAAATTAAAGGTGGGGACTTGCTCGGTACTATTGGCAATTTC
AATTTTGGGAAGCCAAGGTATTTTATCGGATGAAGTTGTTACTAGTTCTTCACCGATGGCTACAAAAGAGTCTTCTAATG
CAATTACTAATGATTTAGATAATTCACCAACTGTTAATCAAAATCGTTCTGCTGAAATGATTGCCTCTAATTCAACCACT
AATGGTTTAGATAATTCGTTAAGTGTTAATAGTATCAGCTCTAATGGTACTATTCGTTCCAATTCACAATTAGACAACAG
AACAGTTGAATCTACAGTAATATCTACTAATGAAAATAAGAGTTATAAGGAAGATGTTATAAGTGACAGAATTATCAAAA
AAGAATTTGAAGATACTGCTTTAAGTGTAAAAGATTATGGTGCGGTAGGTGATGGGATTCATGATGATCGACAAGCAATT
CAAGATGCAATAGATGCTGCAGCTCAAGGGCTAGGTGGAGGAAATGTATATTTTCCTGAAGGAACTTATTTAGTAAAAGA
AATTGTTTTTTTAAAAAGTCATACACACTTAGAATTGAATGAGAAAGCTACAATTCTAAATGGTATAAATATTAAGAATC
ACCCTTCCATTGTTTTTATGACAGGTTTATTTACGGATGATGGTGCGCAAGTAGAGTGGGGCCCAACAGAAGATATTAGT
TATTCTGGTGGTACGATTGATATGAACGGTGCTTTGAATGAAGAAGGAACTAAAGCAAAAAATCTACCACTTATAAATTC
TTCAGGTGCATTTGCTATTGGGAATTCAAATAACGTAACTATAAAAAATGTAACATTCAAGGATAGTTATCAAGGGCATG
CTATTCAAATTGCAGGTTCGAAAAATGTATTAGTTGATAATTCTCGTTTTCTTGGGCAAGCCTTACCCAAAACGATGAAG
GATGGGCAAATCATAAGTAAGGAGAGCATTCAGATTGAACCATTAACTAGAAAAGGTTTTCCTTATGCCTTGAATGATGA
TGGGAAAAAATCTGAAAATGTGACTATTCAAAATTCCTATTTTGGCAAAAGTGATAAATCTGGGGAATTAGTAACAGCAA
TTGGCACACACTATCAAACATTGTCGACACAGAACCCCTCTAATATTAAAATTTTAAATAATCATTTTGATAACATGATG
TATGCAGGTGTACGTTTTACAGGATTCACTGATGTATTAATCAAAGGAAATCGCTTTGATAAGAAAGTTAAAGGAGAGAG
TGTACATTATCGAGAAAGCGGAGCAGCTTTAGTAAATGCTTATAGCTATAAAAACACTAAAGACCTATTAGATTTAAATA
AACAGGTGGTTATCGCAGAAAATATATTTAATATTGCCGATCCTAAAACAAAAGCGATACGAGTTGCAAAAGATAGTGCA
GAATATTTAGGAAAAGTATCAGATATTACTGTAACAAAAAATGTAATTAATAATAATTCTAAGGAAACAGAACAACCAAA
TATTGAATTATTACGAGTTAGTGATAATTTAGTAGTCTCAGAGAATAGTATATTCGGGGGTAAAGAAGGAATTGTTATTG
AGGATTCAAAGGGTAAAATAACCGTTTTAAATAACCAATTTTATAATTTATCCGGTAAGTATATATCATTCATCAAATCT
AATGCAAATGGGAAAGAACCTGTTATACGTGATAGCGATGGTAATTTCAATATTGTAACGGAGAATGGGCTTTACAAAAT
TGTAACAAATAATTTAAGTGATAAAAACGAAAAAGAAAAAAACAAAGAGGAAAAACAATCTAATTCAAATAATGTAATTG
ATAGTAACCAGAAGAACAGAGAGTTTAACTCAAGTAAAGATAATAGACAAATGAATGACAAGATCGACAATAAACAAGAT
AATAAGACAGAAGAAGTAAACTATAAAATAGTTGGAGATGGCAGAGAAACTGAAAATCATATTAATAAATCTAAAGAAAT
AGTAGATGTAAAACAAAAATTACCAAAGACTGGTTCGAACAAGATTATGGAACTATTCTTAACAGTGACAGGAATTGGTT
TACTTTTGACACTAAAAGGGTTGAAGTATTATGGTAAAGATAAATAA

Upstream 100 bases:

>100_bases
GGAAAATATATGATAAAGATAATGACAGCGGTGTCATTCTATCTATTTTAAGAAAAGTAATAATCAATTGTTAAAAATAG
TAAAAAAATTGGAGGTTCTG

Downstream 100 bases:

>100_bases
AATTTGTTCGATACAAGGAAGTTCCGTAGAAAATGAGGATACTGTAGGTTCACAAAATCAGTATTTTTGGATTATTGATG
GAGCTACAGATTTATATAAT

Product: cell wall surface anchor family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 708; Mature: 708

Protein sequence:

>708_residues
MKYFVPNEVFSIRKLKVGTCSVLLAISILGSQGILSDEVVTSSSPMATKESSNAITNDLDNSPTVNQNRSAEMIASNSTT
NGLDNSLSVNSISSNGTIRSNSQLDNRTVESTVISTNENKSYKEDVISDRIIKKEFEDTALSVKDYGAVGDGIHDDRQAI
QDAIDAAAQGLGGGNVYFPEGTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDIS
YSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALPKTMK
DGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMM
YAGVRFTGFTDVLIKGNRFDKKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSA
EYLGKVSDITVTKNVINNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYISFIKS
NANGKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVIDSNQKNREFNSSKDNRQMNDKIDNKQD
NKTEEVNYKIVGDGRETENHINKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK

Sequences:

>Translated_708_residues
MKYFVPNEVFSIRKLKVGTCSVLLAISILGSQGILSDEVVTSSSPMATKESSNAITNDLDNSPTVNQNRSAEMIASNSTT
NGLDNSLSVNSISSNGTIRSNSQLDNRTVESTVISTNENKSYKEDVISDRIIKKEFEDTALSVKDYGAVGDGIHDDRQAI
QDAIDAAAQGLGGGNVYFPEGTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDIS
YSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALPKTMK
DGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMM
YAGVRFTGFTDVLIKGNRFDKKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSA
EYLGKVSDITVTKNVINNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYISFIKS
NANGKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVIDSNQKNREFNSSKDNRQMNDKIDNKQD
NKTEEVNYKIVGDGRETENHINKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK
>Mature_708_residues
MKYFVPNEVFSIRKLKVGTCSVLLAISILGSQGILSDEVVTSSSPMATKESSNAITNDLDNSPTVNQNRSAEMIASNSTT
NGLDNSLSVNSISSNGTIRSNSQLDNRTVESTVISTNENKSYKEDVISDRIIKKEFEDTALSVKDYGAVGDGIHDDRQAI
QDAIDAAAQGLGGGNVYFPEGTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDIS
YSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALPKTMK
DGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMM
YAGVRFTGFTDVLIKGNRFDKKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSA
EYLGKVSDITVTKNVINNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYISFIKS
NANGKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVIDSNQKNREFNSSKDNRQMNDKIDNKQD
NKTEEVNYKIVGDGRETENHINKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK

Specific function: Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover

COG id: COG5434

COG function: function code M; Endopolygalacturonase

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 5 PbH1 repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005877
- InterPro:   IPR006626
- InterPro:   IPR012334
- InterPro:   IPR011050 [H]

Pfam domain/function: PF04650 YSIRK_signal [H]

EC number: NA

Molecular weight: Translated: 77832; Mature: 77832

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYFVPNEVFSIRKLKVGTCSVLLAISILGSQGILSDEVVTSSSPMATKESSNAITNDLD
CCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCHHCCCC
NSPTVNQNRSAEMIASNSTTNGLDNSLSVNSISSNGTIRSNSQLDNRTVESTVISTNENK
CCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCEEECCCCCCCCEEEEEEEECCCCC
SYKEDVISDRIIKKEFEDTALSVKDYGAVGDGIHDDRQAIQDAIDAAAQGLGGGNVYFPE
CHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCC
GTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDIS
CHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCEEEEEEEECCCCCEEECCCCCCCC
YSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGS
CCCCEEEECCCCCCCCCCCCCCCEEECCCCEEECCCCCEEEEEEEECCCCCCCEEEEECC
KNVLVDNSRFLGQALPKTMKDGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSY
CCEEEECCHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCCEEECCCCCCCCCEEEEECC
FGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMMYAGVRFTGFTDVLIKGNRFD
CCCCCCCCCEEEEECCCEEEECCCCCCCEEEEECCCCCEEEECEEECCCEEEEEECCCCC
KKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSA
CCCCCCCEEEECCCCEEEEEECCCCCHHHHCCCCCEEEEECHHCCCCCCCEEEEEECCCH
EYLGKVSDITVTKNVINNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKI
HHCCCCCCEEEEHHHHCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCCEEEECCCCEE
TVLNNQFYNLSGKYISFIKSNANGKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEK
EEEECCEEECCCCEEEEEECCCCCCCCEEECCCCCEEEEECCCEEEEEECCCCCCCHHHH
NKEEKQSNSNNVIDSNQKNREFNSSKDNRQMNDKIDNKQDNKTEEVNYKIVGDGRETENH
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEEEECCCCHHHH
INKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEHHHHHHHCCCCC
>Mature Secondary Structure
MKYFVPNEVFSIRKLKVGTCSVLLAISILGSQGILSDEVVTSSSPMATKESSNAITNDLD
CCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCHHCCCC
NSPTVNQNRSAEMIASNSTTNGLDNSLSVNSISSNGTIRSNSQLDNRTVESTVISTNENK
CCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCEEECCCCCCCCEEEEEEEECCCCC
SYKEDVISDRIIKKEFEDTALSVKDYGAVGDGIHDDRQAIQDAIDAAAQGLGGGNVYFPE
CHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCC
GTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDIS
CHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCEEEEEEEECCCCCEEECCCCCCCC
YSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGS
CCCCEEEECCCCCCCCCCCCCCCEEECCCCEEECCCCCEEEEEEEECCCCCCCEEEEECC
KNVLVDNSRFLGQALPKTMKDGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSY
CCEEEECCHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCCEEECCCCCCCCCEEEEECC
FGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMMYAGVRFTGFTDVLIKGNRFD
CCCCCCCCCEEEEECCCEEEECCCCCCCEEEEECCCCCEEEECEEECCCEEEEEECCCCC
KKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSA
CCCCCCCEEEECCCCEEEEEECCCCCHHHHCCCCCEEEEECHHCCCCCCCEEEEEECCCH
EYLGKVSDITVTKNVINNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKI
HHCCCCCCEEEEHHHHCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCCEEEECCCCEE
TVLNNQFYNLSGKYISFIKSNANGKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEK
EEEECCEEECCCCEEEEEECCCCCCCCEEECCCCCEEEEECCCEEEEEECCCCCCCHHHH
NKEEKQSNSNNVIDSNQKNREFNSSKDNRQMNDKIDNKQDNKTEEVNYKIVGDGRETENH
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEEEECCCCHHHH
INKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11544234 [H]