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The map label for this gene is pkn1 [H]

Identifier: 225859569

GI number: 225859569

Start: 1726813

End: 1727661

Strand: Reverse

Name: pkn1 [H]

Synonym: SP70585_1860

Alternate gene names: 225859569

Gene position: 1727661-1726813 (Counterclockwise)

Preceding gene: 225859570

Following gene: 225859568

Centisome position: 79.08

GC content: 39.46

Gene sequence:

>849_bases
ATGAAAATGAAAAAAATCAAGGGTGGGACATTTATGATGGGAACAAATTCTGAAGAGGGCTTTTTAGATGATTTTGAAGG
TCCTCAAGTCGCTGTTAGTGTAAAGGATTTTTCCATTGCGGATACTCCAGTTACGAATCAAGAATTTGCTCAATTTGTGA
AAGAAACAGGCTATAAAACACTAGCTGAGCGACAAGAGTGGTCTTTTGTTTTTATATTGTTCGTTCCAGAGGCAGAAAGG
GAGGGATATCCTCATCCTGCTGGGGCTCCGTGGTGGTTACAAGTTCCGAACGCTTGCTGGAAACATCCCTACGGTGAGAA
CAGTAATCTAGTGGGTTTAGAAGACCATCCAGTAGTTCATGTTGCTTTAGAAGATGCATTGGCTTTCTGTAATTGGAGCG
GAATGTCTTTACCGACTGAAGCACAGTGGGAATATGCTGCTAGAGGAGGAAGACAATCTGAATATCCTTGGGGAGATACT
CTTTTAGAAGGTGGATATTATCATGCCAATACTTGGCAAGGAAGATTTCCTTATGAAAATACTGCCTTAGATGGATTTAT
AGGAACGGCTCCTGTCTATGAATTTTTACCTAATGATTTTGGTCTATATCAAATGATTGGGAATGTTTGGGAATGGTGTC
GCAATCCGAGATATACCTTATTAGCTAGTTTTAATGAAGATGACTATGAGTTGCCAAAATATGGGATACAAGATGAGGAG
TATGCTATCAGAGGAGGTTCCTTTTTATGTCATTGTTCTTATTGTAATCGATACCGAGTAGCTGCTAGAAATGGATGTAT
TTCTACTTCCACTAGTAGCCATCTAGGTTTTAGATGTTTGAAAGAATAG

Upstream 100 bases:

>100_bases
TTAGATATAGAGAAGAAGGTTTTGTTGTGGATGAAGAGTTAGTTCCTGTTGAACTTTCTAAAATAACGCCAACTCTAACG
AAAACGAGGGATAGTCAATC

Downstream 100 bases:

>100_bases
GATGGACTTAAAAAGTGGTTGAGATTATTTATTTTCTAATCATTATAATAGCTAGTGGATTGGGTTCTATATCAGGCATG
GGTGGTGGAATTATAATTAA

Product: sulfatase-modifying factor 1 (C-alpha-formyglycine-generating enzyme 1)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MKMKKIKGGTFMMGTNSEEGFLDDFEGPQVAVSVKDFSIADTPVTNQEFAQFVKETGYKTLAERQEWSFVFILFVPEAER
EGYPHPAGAPWWLQVPNACWKHPYGENSNLVGLEDHPVVHVALEDALAFCNWSGMSLPTEAQWEYAARGGRQSEYPWGDT
LLEGGYYHANTWQGRFPYENTALDGFIGTAPVYEFLPNDFGLYQMIGNVWEWCRNPRYTLLASFNEDDYELPKYGIQDEE
YAIRGGSFLCHCSYCNRYRVAARNGCISTSTSSHLGFRCLKE

Sequences:

>Translated_282_residues
MKMKKIKGGTFMMGTNSEEGFLDDFEGPQVAVSVKDFSIADTPVTNQEFAQFVKETGYKTLAERQEWSFVFILFVPEAER
EGYPHPAGAPWWLQVPNACWKHPYGENSNLVGLEDHPVVHVALEDALAFCNWSGMSLPTEAQWEYAARGGRQSEYPWGDT
LLEGGYYHANTWQGRFPYENTALDGFIGTAPVYEFLPNDFGLYQMIGNVWEWCRNPRYTLLASFNEDDYELPKYGIQDEE
YAIRGGSFLCHCSYCNRYRVAARNGCISTSTSSHLGFRCLKE
>Mature_282_residues
MKMKKIKGGTFMMGTNSEEGFLDDFEGPQVAVSVKDFSIADTPVTNQEFAQFVKETGYKTLAERQEWSFVFILFVPEAER
EGYPHPAGAPWWLQVPNACWKHPYGENSNLVGLEDHPVVHVALEDALAFCNWSGMSLPTEAQWEYAARGGRQSEYPWGDT
LLEGGYYHANTWQGRFPYENTALDGFIGTAPVYEFLPNDFGLYQMIGNVWEWCRNPRYTLLASFNEDDYELPKYGIQDEE
YAIRGGSFLCHCSYCNRYRVAARNGCISTSTSSHLGFRCLKE

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI38202250, Length=283, Percent_Identity=44.1696113074205, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI257470975, Length=282, Percent_Identity=41.8439716312057, Blast_Score=214, Evalue=6e-56,
Organism=Homo sapiens, GI257470977, Length=283, Percent_Identity=41.696113074205, Blast_Score=207, Evalue=7e-54,
Organism=Homo sapiens, GI194248088, Length=285, Percent_Identity=40.3508771929825, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI194248087, Length=284, Percent_Identity=38.3802816901408, Blast_Score=174, Evalue=5e-44,
Organism=Homo sapiens, GI194248090, Length=202, Percent_Identity=44.0594059405941, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI226437577, Length=221, Percent_Identity=38.9140271493213, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI194248084, Length=84, Percent_Identity=45.2380952380952, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130397, Length=283, Percent_Identity=40.9893992932862, Blast_Score=203, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 32116; Mature: 32116

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKKIKGGTFMMGTNSEEGFLDDFEGPQVAVSVKDFSIADTPVTNQEFAQFVKETGYKT
CCCCEECCCEEEEECCCCCCCCCCCCCCEEEEEEECCEECCCCCCHHHHHHHHHHCCHHH
LAERQEWSFVFILFVPEAEREGYPHPAGAPWWLQVPNACWKHPYGENSNLVGLEDHPVVH
HHHCCCCCEEEEEEEECHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCEEECCCCCEEE
VALEDALAFCNWSGMSLPTEAQWEYAARGGRQSEYPWGDTLLEGGYYHANTWQGRFPYEN
EEEHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHCCCEEECCCCCCCCCCCC
TALDGFIGTAPVYEFLPNDFGLYQMIGNVWEWCRNPRYTLLASFNEDDYELPKYGIQDEE
CCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCC
YAIRGGSFLCHCSYCNRYRVAARNGCISTSTSSHLGFRCLKE
EEEECCCEEEEECCCCCEEEECCCCCEECCCCCCCCEEEECC
>Mature Secondary Structure
MKMKKIKGGTFMMGTNSEEGFLDDFEGPQVAVSVKDFSIADTPVTNQEFAQFVKETGYKT
CCCCEECCCEEEEECCCCCCCCCCCCCCEEEEEEECCEECCCCCCHHHHHHHHHHCCHHH
LAERQEWSFVFILFVPEAEREGYPHPAGAPWWLQVPNACWKHPYGENSNLVGLEDHPVVH
HHHCCCCCEEEEEEEECHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCEEECCCCCEEE
VALEDALAFCNWSGMSLPTEAQWEYAARGGRQSEYPWGDTLLEGGYYHANTWQGRFPYEN
EEEHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHCCCEEECCCCCCCCCCCC
TALDGFIGTAPVYEFLPNDFGLYQMIGNVWEWCRNPRYTLLASFNEDDYELPKYGIQDEE
CCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCC
YAIRGGSFLCHCSYCNRYRVAARNGCISTSTSSHLGFRCLKE
EEEECCCEEEEECCCCCEEEECCCCCEECCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]