Click here to switch to the map view.

The map label for this gene is aqpZ [H]

Identifier: 225859533

GI number: 225859533

Start: 1697659

End: 1698327

Strand: Reverse

Name: aqpZ [H]

Synonym: SP70585_1823

Alternate gene names: 225859533

Gene position: 1698327-1697659 (Counterclockwise)

Preceding gene: 225859534

Following gene: 225859528

Centisome position: 77.74

GC content: 44.54

Gene sequence:

>669_bases
ATGAAAAAATTTGTTGCTGAGTTAATCGGTACGTTCATGCTTGTGTTCGTTGGGACAGGAGCTGTTGTTTTTGGAAATGG
TCTTGATGGCCTTGGTCACCTTGGAATCGCCTTTGCCTTTGGTTTGGCAATCGTGGTGGCAGCCTACTCAATCGGAACTG
TTTCAGGTGCTCACTTGAACCCGGCTGTTTCGATTGCTATGTTTGTAAACAAACGTTTGTCATCTTCAGAACTTGTAAAC
TACATCCTTGGTCAGGTTGTTGGAGCTTTCATCGCTTCTGGCGCAGTCTTCTTCCTCTTGGGTAATTCAGGTATGTCAAC
TGCTAGTCTTGGTGAAAATGCCTTGGCAAACGGTGTCACTGTCTTTGGTGGTTTCTTGTTTGAAGTCATTGCAACTTTCT
TGTTTGTCTTAGTTATTATGACTGTGACTTCAGAAAGTAAGGGCAATGGCGCGATTGCTGGTTTGGTAATCGGTTTGTCA
TTGATGGCGATGATTCTTGTCGGATTGAAGATTACTGGACTTTCAGTAAACCCAGCTCGTAGCTTGGCACCAGCTGTCTT
GGTAGGCGGCGCAGCCCTTCAACAAGTTTGGATTTTCATCCTTGCACCAATCGCTGGTGGAGTTCTTGCAGCCCTTGTTG
CAAAAAATTTCCTTGGAACAGAAAAATAA

Upstream 100 bases:

>100_bases
ATAGTTCTATGATTTTCAAAAAATTTCCAATCAATTTTCTTGAAACCCTTTCCTACTTTTGATAGACTAGTATCTAGTTT
TTGAAAAAAGGAGAAAGAAA

Downstream 100 bases:

>100_bases
TTGAAACTCAAAAAGCCTTGCTCCTCATCTTGAGGAACAGGGCTTTTTCGTATGATACTCTTCGAAAATCTCTTCAAACC
ACGTCAGCTTTACCTTGCCG

Product: aquaporin Z - water channel protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGHLGIAFAFGLAIVVAAYSIGTVSGAHLNPAVSIAMFVNKRLSSSELVN
YILGQVVGAFIASGAVFFLLGNSGMSTASLGENALANGVTVFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLS
LMAMILVGLKITGLSVNPARSLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFLGTEK

Sequences:

>Translated_222_residues
MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGHLGIAFAFGLAIVVAAYSIGTVSGAHLNPAVSIAMFVNKRLSSSELVN
YILGQVVGAFIASGAVFFLLGNSGMSTASLGENALANGVTVFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLS
LMAMILVGLKITGLSVNPARSLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFLGTEK
>Mature_222_residues
MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGHLGIAFAFGLAIVVAAYSIGTVSGAHLNPAVSIAMFVNKRLSSSELVN
YILGQVVGAFIASGAVFFLLGNSGMSTASLGENALANGVTVFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLS
LMAMILVGLKITGLSVNPARSLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFLGTEK

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=223, Percent_Identity=35.8744394618834, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4502179, Length=210, Percent_Identity=36.1904761904762, Blast_Score=103, Evalue=9e-23,
Organism=Homo sapiens, GI4502181, Length=214, Percent_Identity=32.7102803738318, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4755125, Length=214, Percent_Identity=32.7102803738318, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI6912506, Length=216, Percent_Identity=34.7222222222222, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI4502183, Length=216, Percent_Identity=35.6481481481481, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI86792455, Length=218, Percent_Identity=32.1100917431193, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI4502187, Length=247, Percent_Identity=29.1497975708502, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI157266307, Length=241, Percent_Identity=30.7053941908714, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI22538420, Length=232, Percent_Identity=30.6034482758621, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4826645, Length=251, Percent_Identity=28.2868525896414, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI45446752, Length=215, Percent_Identity=28.8372093023256, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI310133356, Length=173, Percent_Identity=29.4797687861272, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI310114181, Length=173, Percent_Identity=29.4797687861272, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787101, Length=208, Percent_Identity=37.9807692307692, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1790362, Length=253, Percent_Identity=28.4584980237154, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71993722, Length=233, Percent_Identity=30.9012875536481, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17558372, Length=234, Percent_Identity=31.6239316239316, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71992966, Length=241, Percent_Identity=26.1410788381743, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71994009, Length=246, Percent_Identity=28.8617886178862, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71992961, Length=240, Percent_Identity=25.4166666666667, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=203, Percent_Identity=30.0492610837438, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24652747, Length=222, Percent_Identity=32.4324324324324, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45551084, Length=222, Percent_Identity=32.4324324324324, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24762344, Length=215, Percent_Identity=33.4883720930233, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24762346, Length=215, Percent_Identity=33.4883720930233, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24762348, Length=215, Percent_Identity=33.4883720930233, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI20130305, Length=215, Percent_Identity=33.4883720930233, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI45550503, Length=229, Percent_Identity=30.1310043668122, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24762342, Length=235, Percent_Identity=32.7659574468085, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24652751, Length=218, Percent_Identity=32.1100917431193, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922038, Length=219, Percent_Identity=31.9634703196347, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136672, Length=220, Percent_Identity=30.4545454545455, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 22438; Mature: 22438

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGHLGIAFAFGLAIVVAAYSIGTVSGAHLN
CHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PAVSIAMFVNKRLSSSELVNYILGQVVGAFIASGAVFFLLGNSGMSTASLGENALANGVT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHCCCHHHHCCHH
VFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLSLMAMILVGLKITGLSVNPAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
SLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFLGTEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGHLGIAFAFGLAIVVAAYSIGTVSGAHLN
CHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PAVSIAMFVNKRLSSSELVNYILGQVVGAFIASGAVFFLLGNSGMSTASLGENALANGVT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHCCCHHHHCCHH
VFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLSLMAMILVGLKITGLSVNPAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
SLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFLGTEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]