| Definition | Streptococcus pneumoniae 70585, complete genome. |
|---|---|
| Accession | NC_012468 |
| Length | 2,184,682 |
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The map label for this gene is yvgN [H]
Identifier: 225859239
GI number: 225859239
Start: 1400366
End: 1401208
Strand: Reverse
Name: yvgN [H]
Synonym: SP70585_1519
Alternate gene names: 225859239
Gene position: 1401208-1400366 (Counterclockwise)
Preceding gene: 225859240
Following gene: 225859238
Centisome position: 64.14
GC content: 42.94
Gene sequence:
>843_bases ATGAATACCTATCAATTAAATAATGGAGTAGAAATTCCAGTATTGGGATTTGGAACTTTTAAGGCTAAGGATGGAGAAGA AGCCTATCGTGCAGTGTTAGAAGCCTTGAAGGCTGGTTATCGTCATATTGATACGGCGGCGATTTATCAGAATGAAGAAA GTGTTGGTCAAGCAATCAAAGATAGCGGAGTTCCACGTGAAGAAATGTTCGTAACTACCAAGCTTTGGAATAGTCAGCAA ACCTATGAGCAAACTCGTCAAGCTTTGGAAAAATCTATAGAAAAACTGGGCTTGGATTATTTGGATTTGTATTTGATTCA TTGGCCGAACCCAAAACCGCTCAGAGAAAATGACGCATGGAAAACTCGCAATGCGGAAGTTTGGAGAGCGATGGAAGACC TCTATCAAGAAGGGAAAATCCGTGCTATCGGCGTTAGCAATTTTCTTCCCCATCATTTGGATGCCTTGCTTGAAACTGCA ACTATCGTTCCTGCGGTCAATCAAGTTCGCTTGGCGCCAGGTGTGTATCAAGAGGAAGTCGTAGCTTACTGTCGTGAAAA GGGAATTTTATTGGAAGCTTGGGGGCCTTTTGGACAAGGAGAACTGTTTGATAGCAAGCAAGTCCAAGAAATAGCAGCAA ATCACGGAAAATCGGTTGCTCAGATAGCCTTGGCCTGGAGCTTGGCAGAAGGATTTTTACCACTTCCAAAATCTGTCACA ACCTCTCGTATTCAAGCTAATCTTGATTGTTTTGGAATTGAACTGAGTCATGAGGAGAGAGAAACCTTAAAAACGACTGC TGTTCAGTCGGGGGCTCCACGAGTTGATGATGTGGATTTCTAG
Upstream 100 bases:
>100_bases GGTCTGTCAGATATGTGATAGACTTATTTTTTACAGAAGATAGTACTAATTAGCAAAAAAATTATGCTATAAATGATAAA GAAAATAGAAGGAGAAGCAT
Downstream 100 bases:
>100_bases AAAATCATAAAAAGAATTGTACATTATTCTAATTTTTGATATAATAGTCAGCAGGAAAGAAAGTCTTATGGCGTTCTTCA AGCGAGCTTGGGACAGTGGG
Product: 2,5-diketo-D-gluconic acid reductase A
Products: NA
Alternate protein names: GR; Methylglyoxal reductase [H]
Number of amino acids: Translated: 280; Mature: 280
Protein sequence:
>280_residues MNTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIKDSGVPREEMFVTTKLWNSQQ TYEQTRQALEKSIEKLGLDYLDLYLIHWPNPKPLRENDAWKTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLETA TIVPAVNQVRLAPGVYQEEVVAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKSVAQIALAWSLAEGFLPLPKSVT TSRIQANLDCFGIELSHEERETLKTTAVQSGAPRVDDVDF
Sequences:
>Translated_280_residues MNTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIKDSGVPREEMFVTTKLWNSQQ TYEQTRQALEKSIEKLGLDYLDLYLIHWPNPKPLRENDAWKTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLETA TIVPAVNQVRLAPGVYQEEVVAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKSVAQIALAWSLAEGFLPLPKSVT TSRIQANLDCFGIELSHEERETLKTTAVQSGAPRVDDVDF >Mature_280_residues MNTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIKDSGVPREEMFVTTKLWNSQQ TYEQTRQALEKSIEKLGLDYLDLYLIHWPNPKPLRENDAWKTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLETA TIVPAVNQVRLAPGVYQEEVVAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKSVAQIALAWSLAEGFLPLPKSVT TSRIQANLDCFGIELSHEERETLKTTAVQSGAPRVDDVDF
Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=283, Percent_Identity=38.5159010600707, Blast_Score=195, Evalue=3e-50, Organism=Homo sapiens, GI5174391, Length=283, Percent_Identity=38.5159010600707, Blast_Score=195, Evalue=3e-50, Organism=Homo sapiens, GI223468663, Length=290, Percent_Identity=36.8965517241379, Blast_Score=185, Evalue=4e-47, Organism=Homo sapiens, GI4502049, Length=284, Percent_Identity=38.3802816901408, Blast_Score=167, Evalue=1e-41, Organism=Homo sapiens, GI93277124, Length=292, Percent_Identity=33.2191780821918, Blast_Score=161, Evalue=8e-40, Organism=Homo sapiens, GI310109920, Length=288, Percent_Identity=35.0694444444444, Blast_Score=160, Evalue=1e-39, Organism=Homo sapiens, GI45446745, Length=288, Percent_Identity=35.0694444444444, Blast_Score=160, Evalue=1e-39, Organism=Homo sapiens, GI4503285, Length=288, Percent_Identity=35.0694444444444, Blast_Score=160, Evalue=1e-39, Organism=Homo sapiens, GI291291012, Length=259, Percent_Identity=35.5212355212355, Blast_Score=159, Evalue=3e-39, Organism=Homo sapiens, GI5453543, Length=288, Percent_Identity=34.7222222222222, Blast_Score=159, Evalue=3e-39, Organism=Homo sapiens, GI310109922, Length=278, Percent_Identity=34.8920863309352, Blast_Score=155, Evalue=3e-38, Organism=Homo sapiens, GI24497583, Length=288, Percent_Identity=34.0277777777778, Blast_Score=152, Evalue=3e-37, Organism=Homo sapiens, GI24497585, Length=288, Percent_Identity=34.0277777777778, Blast_Score=152, Evalue=3e-37, Organism=Homo sapiens, GI5174695, Length=289, Percent_Identity=31.4878892733564, Blast_Score=149, Evalue=4e-36, Organism=Homo sapiens, GI300116273, Length=273, Percent_Identity=32.2344322344322, Blast_Score=142, Evalue=4e-34, Organism=Homo sapiens, GI300116271, Length=284, Percent_Identity=27.4647887323944, Blast_Score=112, Evalue=3e-25, Organism=Homo sapiens, GI310109926, Length=111, Percent_Identity=48.6486486486487, Blast_Score=106, Evalue=3e-23, Organism=Homo sapiens, GI207028673, Length=111, Percent_Identity=48.6486486486487, Blast_Score=105, Evalue=3e-23, Organism=Escherichia coli, GI87082198, Length=257, Percent_Identity=42.4124513618677, Blast_Score=209, Evalue=2e-55, Organism=Escherichia coli, GI1786400, Length=253, Percent_Identity=36.3636363636364, Blast_Score=172, Evalue=2e-44, Organism=Escherichia coli, GI1788081, Length=279, Percent_Identity=29.7491039426523, Blast_Score=105, Evalue=4e-24, Organism=Escherichia coli, GI1788070, Length=296, Percent_Identity=26.0135135135135, Blast_Score=88, Evalue=6e-19, Organism=Escherichia coli, GI48994888, Length=270, Percent_Identity=28.5185185185185, Blast_Score=77, Evalue=2e-15, Organism=Escherichia coli, GI87081735, Length=308, Percent_Identity=25, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1787674, Length=264, Percent_Identity=23.8636363636364, Blast_Score=64, Evalue=1e-11, Organism=Caenorhabditis elegans, GI71998625, Length=269, Percent_Identity=40.5204460966543, Blast_Score=194, Evalue=4e-50, Organism=Caenorhabditis elegans, GI17538386, Length=286, Percent_Identity=38.8111888111888, Blast_Score=189, Evalue=2e-48, Organism=Caenorhabditis elegans, GI17564128, Length=299, Percent_Identity=34.7826086956522, Blast_Score=173, Evalue=8e-44, Organism=Caenorhabditis elegans, GI17537079, Length=297, Percent_Identity=35.016835016835, Blast_Score=172, Evalue=1e-43, Organism=Caenorhabditis elegans, GI17537077, Length=284, Percent_Identity=37.6760563380282, Blast_Score=172, Evalue=1e-43, Organism=Caenorhabditis elegans, GI17537075, Length=288, Percent_Identity=36.8055555555556, Blast_Score=170, Evalue=9e-43, Organism=Caenorhabditis elegans, GI17552492, Length=276, Percent_Identity=32.6086956521739, Blast_Score=165, Evalue=3e-41, Organism=Caenorhabditis elegans, GI17561298, Length=275, Percent_Identity=36, Blast_Score=164, Evalue=6e-41, Organism=Caenorhabditis elegans, GI17562292, Length=283, Percent_Identity=29.3286219081272, Blast_Score=148, Evalue=3e-36, Organism=Caenorhabditis elegans, GI17550248, Length=280, Percent_Identity=32.8571428571429, Blast_Score=143, Evalue=8e-35, Organism=Caenorhabditis elegans, GI17566692, Length=288, Percent_Identity=30.2083333333333, Blast_Score=138, Evalue=4e-33, Organism=Caenorhabditis elegans, GI17561300, Length=258, Percent_Identity=30.6201550387597, Blast_Score=135, Evalue=3e-32, Organism=Saccharomyces cerevisiae, GI6320576, Length=298, Percent_Identity=42.9530201342282, Blast_Score=237, Evalue=2e-63, Organism=Saccharomyces cerevisiae, GI6324694, Length=292, Percent_Identity=41.7808219178082, Blast_Score=223, Evalue=3e-59, Organism=Saccharomyces cerevisiae, GI6322556, Length=269, Percent_Identity=37.546468401487, Blast_Score=185, Evalue=9e-48, Organism=Saccharomyces cerevisiae, GI6319625, Length=275, Percent_Identity=34.1818181818182, Blast_Score=150, Evalue=2e-37, Organism=Saccharomyces cerevisiae, GI6321896, Length=283, Percent_Identity=32.5088339222615, Blast_Score=144, Evalue=2e-35, Organism=Saccharomyces cerevisiae, GI6320079, Length=281, Percent_Identity=32.0284697508897, Blast_Score=135, Evalue=9e-33, Organism=Drosophila melanogaster, GI24663317, Length=285, Percent_Identity=38.9473684210526, Blast_Score=197, Evalue=5e-51, Organism=Drosophila melanogaster, GI24657054, Length=286, Percent_Identity=37.4125874125874, Blast_Score=189, Evalue=1e-48, Organism=Drosophila melanogaster, GI24644950, Length=292, Percent_Identity=37.3287671232877, Blast_Score=189, Evalue=2e-48, Organism=Drosophila melanogaster, GI221378297, Length=312, Percent_Identity=34.9358974358974, Blast_Score=181, Evalue=4e-46, Organism=Drosophila melanogaster, GI21356425, Length=283, Percent_Identity=34.2756183745583, Blast_Score=173, Evalue=1e-43, Organism=Drosophila melanogaster, GI20129731, Length=274, Percent_Identity=37.5912408759124, Blast_Score=171, Evalue=7e-43, Organism=Drosophila melanogaster, GI45553081, Length=287, Percent_Identity=34.8432055749129, Blast_Score=167, Evalue=5e-42, Organism=Drosophila melanogaster, GI24662789, Length=271, Percent_Identity=33.5793357933579, Blast_Score=158, Evalue=4e-39, Organism=Drosophila melanogaster, GI24662781, Length=276, Percent_Identity=36.9565217391304, Blast_Score=153, Evalue=1e-37, Organism=Drosophila melanogaster, GI24662785, Length=273, Percent_Identity=37.7289377289377, Blast_Score=152, Evalue=2e-37, Organism=Drosophila melanogaster, GI281366140, Length=250, Percent_Identity=32.8, Blast_Score=140, Evalue=9e-34, Organism=Drosophila melanogaster, GI24646155, Length=279, Percent_Identity=27.9569892473118, Blast_Score=76, Evalue=2e-14,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.283 [H]
Molecular weight: Translated: 31406; Mature: 31406
Theoretical pI: Translated: 4.79; Mature: 4.79
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.8 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIK CCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHH DSGVPREEMFVTTKLWNSQQTYEQTRQALEKSIEKLGLDYLDLYLIHWPNPKPLRENDAW HCCCCHHHHEEEHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCC KTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLETATIVPAVNQVRLAPGVYQEEV CCCCHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHHHHHHHCHHHEECCCCCHHHHH VAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKSVAQIALAWSLAEGFLPLPKSVT HHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHH TSRIQANLDCFGIELSHEERETLKTTAVQSGAPRVDDVDF HHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCC >Mature Secondary Structure MNTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHIDTAAIYQNEESVGQAIK CCCEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHH DSGVPREEMFVTTKLWNSQQTYEQTRQALEKSIEKLGLDYLDLYLIHWPNPKPLRENDAW HCCCCHHHHEEEHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCC KTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLETATIVPAVNQVRLAPGVYQEEV CCCCHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHHHHHHHCHHHEECCCCCHHHHH VAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKSVAQIALAWSLAEGFLPLPKSVT HHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHH TSRIQANLDCFGIELSHEERETLKTTAVQSGAPRVDDVDF HHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9639930; 9384377 [H]