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The map label for this gene is pncB

Identifier: 225859185

GI number: 225859185

Start: 1352726

End: 1354186

Strand: Reverse

Name: pncB

Synonym: SP70585_1459

Alternate gene names: 225859185

Gene position: 1354186-1352726 (Counterclockwise)

Preceding gene: 225859186

Following gene: 225859184

Centisome position: 61.99

GC content: 45.65

Gene sequence:

>1461_bases
ATGTATCCAGATGATAGTTTGACATTGCACACGGACTTGTACCAGATCAACATGATGCAGGTTTACTTTGACCAAGGGAT
TCACAATAAGAAGGCGGTCTTTGAGGTGTATTTCCGCCAACAGCCTTTTAAGAACGGCTATGCGGTTTTTGCAGGTTTGG
AAAGAATTGTGAACTATCTTGAAGACTTGCGTTTTTCAGATAGTGATATAGCCTATTTGGAGTCGCTTGGTTATCATGGG
GCGTTCTTGGATTACCTTCGCAATTTCAAGTTGGAGTTGACCGTTCGTTCTGCCCAAGAAGGGGATTTGGTTTTTGCTAA
TGAACCGATTGTGCAGGTGGAAGGACCTCTAGCCCAATGTCAGTTGGTCGAAACGGCTCTTTTGAACATCGTCAACTACC
AGACCTTGGTGGCGACGAAGGCAGCTCGTATTCGTTCGGTTATCGAAGATGAACCCTTGATGGAGTTTGGGACACGTCGG
GCTCAAGAAATGGATGCGGCCATCTGGGGAACACGCGCAGCGGTGATTGGTGGGGCCAATGGAACCAGCAACGTGCGTGC
GGGTAAGCTCTTTGACATTCCTGTTTTGGGAACCCATGCCCATGCCTTGGTACAGGTTTATGGCAATGACTATGAAGCTT
TCAAGGCTTACGCTGAGACCCACAAAAATTGTGTCTTTCTTGTGGATACCTATGACACCCTTCGCATCGGTGTACCAGCT
GCCATTCAGGTGGCGTGTGAGCTGGGTGATCAGATTAACTTTATGGGTGTGCGGATTGACTCTGGGGATATTGCCTACAT
TTCTAAGAAAGTCCGTCAGCAACTGGACGAGGCTGGATTTACAGAGGCTAAGATTTATGCTTCTAATGATTTGGACGAAA
ATACTATCCTCAATCTCAAGATGCAAAAGGCCAAGATTGATGTCTGGGGCGTGGGTACCAAGCTGATTACAGCTTATGAC
CAGCCAGCTCTTGGTGCAGTTTACAAGATTGTTGCAATCGAAGATGAAACTGGTCAGATGCGCAATACGATTAAGCTGTC
TAATAATGCTGAAAAAGTTTCTACGCCAGGTAAGAAGCAGGTGTGGCGCATTACCAGTCGTGAAAAAGGCAAGTCAGAAG
GCGACTATATCACTTATGATGGTGTGGATATTAGCGACATGACAGAAATCAAGATGTTCCATCCGACCTATACATACATC
AAGAAGACGGTTCGTAATTTTGATGCCGTTCCTCTCTTGGTGGATATCTTCAAAGAAGGAATATTAGTTTACAACTTGCC
TAGTTTGACTGACATTCAGGATTATGCCCGTAAGGAATTTGACAAGTTGTGGGATGAGTATAAGCGTGTGCTCAATCCGC
AGCACTATCCAGTGGATTTGGCGCGTGATGTATGGCAAGATAAGATGGACTTGATTGATAAGATGCGCAAGGAAGCCCTT
GGTGAAGGAGAAGAAGAATGA

Upstream 100 bases:

>100_bases
TCAATCCAGCTAAAATGTGATATAATAGTACTAATTTATTGGAATACATGAAAGTTCTTGAAAATTTTCATGGGTTTCTA
GCTAAGGAAGTAGGAAAAGT

Downstream 100 bases:

>100_bases
GTTTGCAAGAAACGATTATCCAAGAGCTGGGTGTCAAACCAGTGATTGATGCCCAGGAAGAAATCCGTCGTTCTATTGAT
TTCTTAAAAAGATATCTGAA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MYPDDSLTLHTDLYQINMMQVYFDQGIHNKKAVFEVYFRQQPFKNGYAVFAGLERIVNYLEDLRFSDSDIAYLESLGYHG
AFLDYLRNFKLELTVRSAQEGDLVFANEPIVQVEGPLAQCQLVETALLNIVNYQTLVATKAARIRSVIEDEPLMEFGTRR
AQEMDAAIWGTRAAVIGGANGTSNVRAGKLFDIPVLGTHAHALVQVYGNDYEAFKAYAETHKNCVFLVDTYDTLRIGVPA
AIQVACELGDQINFMGVRIDSGDIAYISKKVRQQLDEAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYD
QPALGAVYKIVAIEDETGQMRNTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITYDGVDISDMTEIKMFHPTYTYI
KKTVRNFDAVPLLVDIFKEGILVYNLPSLTDIQDYARKEFDKLWDEYKRVLNPQHYPVDLARDVWQDKMDLIDKMRKEAL
GEGEEE

Sequences:

>Translated_486_residues
MYPDDSLTLHTDLYQINMMQVYFDQGIHNKKAVFEVYFRQQPFKNGYAVFAGLERIVNYLEDLRFSDSDIAYLESLGYHG
AFLDYLRNFKLELTVRSAQEGDLVFANEPIVQVEGPLAQCQLVETALLNIVNYQTLVATKAARIRSVIEDEPLMEFGTRR
AQEMDAAIWGTRAAVIGGANGTSNVRAGKLFDIPVLGTHAHALVQVYGNDYEAFKAYAETHKNCVFLVDTYDTLRIGVPA
AIQVACELGDQINFMGVRIDSGDIAYISKKVRQQLDEAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYD
QPALGAVYKIVAIEDETGQMRNTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITYDGVDISDMTEIKMFHPTYTYI
KKTVRNFDAVPLLVDIFKEGILVYNLPSLTDIQDYARKEFDKLWDEYKRVLNPQHYPVDLARDVWQDKMDLIDKMRKEAL
GEGEEE
>Mature_486_residues
MYPDDSLTLHTDLYQINMMQVYFDQGIHNKKAVFEVYFRQQPFKNGYAVFAGLERIVNYLEDLRFSDSDIAYLESLGYHG
AFLDYLRNFKLELTVRSAQEGDLVFANEPIVQVEGPLAQCQLVETALLNIVNYQTLVATKAARIRSVIEDEPLMEFGTRR
AQEMDAAIWGTRAAVIGGANGTSNVRAGKLFDIPVLGTHAHALVQVYGNDYEAFKAYAETHKNCVFLVDTYDTLRIGVPA
AIQVACELGDQINFMGVRIDSGDIAYISKKVRQQLDEAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYD
QPALGAVYKIVAIEDETGQMRNTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITYDGVDISDMTEIKMFHPTYTYI
KKTVRNFDAVPLLVDIFKEGILVYNLPSLTDIQDYARKEFDKLWDEYKRVLNPQHYPVDLARDVWQDKMDLIDKMRKEAL
GEGEEE

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=513, Percent_Identity=31.9688109161793, Blast_Score=238, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI71997947, Length=532, Percent_Identity=35.1503759398496, Blast_Score=291, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI71997952, Length=532, Percent_Identity=35.1503759398496, Blast_Score=291, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI71997955, Length=219, Percent_Identity=43.8356164383562, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24581587, Length=523, Percent_Identity=34.6080305927342, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI161076680, Length=226, Percent_Identity=42.4778761061947, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24581595, Length=226, Percent_Identity=42.4778761061947, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI28574709, Length=226, Percent_Identity=42.4778761061947, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24581593, Length=226, Percent_Identity=42.4778761061947, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24581591, Length=226, Percent_Identity=42.4778761061947, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 55133; Mature: 55133

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPDDSLTLHTDLYQINMMQVYFDQGIHNKKAVFEVYFRQQPFKNGYAVFAGLERIVNYL
CCCCCCEEEEEEEEEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
EDLRFSDSDIAYLESLGYHGAFLDYLRNFKLELTVRSAQEGDLVFANEPIVQVEGPLAQC
HHCCCCCCCHHHHHHCCCCHHHHHHHHCCEEEEEEECCCCCCEEEECCCEEEECCCHHHH
QLVETALLNIVNYQTLVATKAARIRSVIEDEPLMEFGTRRAQEMDAAIWGTRAAVIGGAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GTSNVRAGKLFDIPVLGTHAHALVQVYGNDYEAFKAYAETHKNCVFLVDTYDTLRIGVPA
CCCCCCCCEEEECCEECCCCEEEEEEECCCHHHHHHHHHHCCCEEEEEECCCEEEECCCH
AIQVACELGDQINFMGVRIDSGDIAYISKKVRQQLDEAGFTEAKIYASNDLDENTILNLK
HHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEE
MQKAKIDVWGVGTKLITAYDQPALGAVYKIVAIEDETGQMRNTIKLSNNAEKVSTPGKKQ
EEEEEEEEEECCCEEEEECCCCCCCEEEEEEEEECCCCCCCCEEEECCCCHHCCCCCHHH
VWRITSREKGKSEGDYITYDGVDISDMTEIKMFHPTYTYIKKTVRNFDAVPLLVDIFKEG
EEEECCCCCCCCCCCEEEECCCCCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHCC
ILVYNLPSLTDIQDYARKEFDKLWDEYKRVLNPQHYPVDLARDVWQDKMDLIDKMRKEAL
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GEGEEE
CCCCCC
>Mature Secondary Structure
MYPDDSLTLHTDLYQINMMQVYFDQGIHNKKAVFEVYFRQQPFKNGYAVFAGLERIVNYL
CCCCCCEEEEEEEEEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
EDLRFSDSDIAYLESLGYHGAFLDYLRNFKLELTVRSAQEGDLVFANEPIVQVEGPLAQC
HHCCCCCCCHHHHHHCCCCHHHHHHHHCCEEEEEEECCCCCCEEEECCCEEEECCCHHHH
QLVETALLNIVNYQTLVATKAARIRSVIEDEPLMEFGTRRAQEMDAAIWGTRAAVIGGAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GTSNVRAGKLFDIPVLGTHAHALVQVYGNDYEAFKAYAETHKNCVFLVDTYDTLRIGVPA
CCCCCCCCEEEECCEECCCCEEEEEEECCCHHHHHHHHHHCCCEEEEEECCCEEEECCCH
AIQVACELGDQINFMGVRIDSGDIAYISKKVRQQLDEAGFTEAKIYASNDLDENTILNLK
HHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEE
MQKAKIDVWGVGTKLITAYDQPALGAVYKIVAIEDETGQMRNTIKLSNNAEKVSTPGKKQ
EEEEEEEEEECCCEEEEECCCCCCCEEEEEEEEECCCCCCCCEEEECCCCHHCCCCCHHH
VWRITSREKGKSEGDYITYDGVDISDMTEIKMFHPTYTYIKKTVRNFDAVPLLVDIFKEG
EEEECCCCCCCCCCCEEEECCCCCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHCC
ILVYNLPSLTDIQDYARKEFDKLWDEYKRVLNPQHYPVDLARDVWQDKMDLIDKMRKEAL
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GEGEEE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]