| Definition | Streptococcus pneumoniae 70585, complete genome. |
|---|---|
| Accession | NC_012468 |
| Length | 2,184,682 |
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The map label for this gene is alaS
Identifier: 225859149
GI number: 225859149
Start: 1319094
End: 1321712
Strand: Reverse
Name: alaS
Synonym: SP70585_1421
Alternate gene names: 225859149
Gene position: 1321712-1319094 (Counterclockwise)
Preceding gene: 225859150
Following gene: 225859147
Centisome position: 60.5
GC content: 44.64
Gene sequence:
>2619_bases ATGAAACAACTATCTAGTGCACAAGTACGCCAAATGTGGCTTGATTTCTGGGCGACCAAAGCTCACTCAGTAGAACCATC AGTAAGTTTGGTTCCTGTAAATGACCCAACTCTTTTGTGGATCAACTCTGGGGTAGCAACCCTTAAGAAATACTTTGACG GGACCATTATCCCTGAAAATCCACGTATTACCAATGCCCAAAAGGCTATCCGTACCAACGACATCGAAAACGTAGGGAAG ACTGCGCGTCACCATACCATGTTTGAAATGCTGGGGAACTTCTCTATCGGGGATTACTTCCGTGACGAAGCTATCACTTG GGCTTATGAGCTTTTGACAAGCCCTGAATGGTTTGATTTCCCTGCTGAAAAACTTTACATGACCTACTATCCAGACGATA AAGATTCTTACAACCGCTGGATTGAAGTGGGAGTGGATCCAAGTCACTTGATTCCAATTGAGGACAACTTCTGGGAAATC GGTGCGGGACCTTCTGGACCAGATACAGAAATCTTCTTTGACCGTGGGGAAGCCTTTGACCCAGAAAATATCGGTCTTCG CCTGCTTGCAGAAGATATTGAAAACGACCGTTATATTGAAATCTGGAACATCGTTTTGTCACAATTTAACGCAGACCCTG CTGTTCCTCGTAGCGAATACAAGGAATTGCCACATAAGAACATTGATACGGGCGCTGGTTTGGAGCGTTTGGTGGCTGTT ATCCAAGGGGCTAAGACCAACTTTGAAACGGACCTCTTCATGCCGATTATCCGTGAAGTCGAGAAATTGTCTGGTAAGGT TTATGACCAAGATGGCGACAACATGAGCTTCAAGGTTATCGCAGACCACATTCGTTCTCTTTCATTTGCTATCGGTGATG GTGCCCTTCCAGGAAATGAAGGTCGTGGTTATGTTCTTCGTCGTCTTCTCCGTCGTGCTTCTATGCATGGTCAAAAATTG GGTATCAACGAGCCTTTCCTTTACAAACTTGTTCCAACTGTTGGAAAAATCATGGAAAGCTACTACCCAGAAGTGCTTGA GAAACGTGACTTTATTGAGAAAATCGTTAAGAGCGAAGAAGAATCATTTGCCCGTACCCTTCACTCAGGTCAACACTTTG CCCAAGGCATTGTGGCAGACTTGAAAGAAAAAGGTCAATCTGTCATTGCTGGTCAAGATGTCTTTAAACTCTATGATACA TACGGATTCCCAGTTGAATTGACTGAAGAAATTGCTGAAGAAGCTGGTATGACTGTAGACCGTGAAGGTTTTGAAGCAGC CATGAAAGAACAGCAAGAACGCGCGCGTGCGTCAGCTGTCAAGGGTGGCTCAATGGGTATGCAAAATGAAACTCTTCAAA ACATCACTGTAGAAAGTGTCTTCAACTACAATACTAGCCAATTGTCTTCTAAATTGGTAGCTATCGTTGCTGACAATGCA GAAGTAGGAGCTGTTTCAGAAGGAACTGCCTCTCTTATCTTTGCGGAAACGTCATTTTATGCTGAAATGGGTGGACAGGT AGCTGACTACGGACAAATCTTGGATGAGTCAGGTAAGATTGTGGCTACTGTGACCAATGTTCAGAAAGCCCCAAATGGTC AAGCCCTTCATACAGTTGAAGTCCTTGCACCGCTTGCCTTGAACCAAGAATATATCTTGGCAATTGATAGCAATCGCCGT CACCGTGTCATGAAAAACCACACTGCGACTCATTTGCTTCACGCTGCCCTTCACAATATCCTTGGAAACCACGCAACACA GGCAGGATCTCTTAACGAAGTTGAATTCCTTCGCTTTGACTTTACCCACTTCCAAGCAGTAACTGCTGAGGAACTTCGTG CGATTGAACAGCAAGTTAACGAGAAAATTTGGGAAGCACTTGAAGTGAAGACAGTTGAAACGGATATTGACACTGCTAAA GAAATGGGAGCTATGGCCCTCTTTGGTGAGAAATACGGCAAGGAAGTTCGTGTCGTGACTATCGGTGACTACTCTATTGA ACTTTGTGGTGGTACTCATGTTGGCAACACTTCTGAGATTGGTCTCTTCAAAATTGTCAAAGAAGAAGGAATCGGTTCAG GAACTCGCCGTATCTTGGCAGTGACTGGTAAGGAAGCCTTTGAAGCCTATCGTGAACAAGAGGATGCTCTTAAAGCTGTC GCAGCAACCTTGAAAGCACCTCAAGTCAAGGAAGTACCTCACAAGGTAGAAGGACTTCAAGAACAACTTCGTCAACTTCA AAAAGAAAATGCTGAGTTGAAAGAAAAAGCCGCAGCTGCAGCCGCAGGCGATATCTTCAAAGATGCTAAGGAAGTCAACG GTCATCGTTACATTGCTAGTCAAGTGTCTGTATCCGATGCCGGTGCCCTTCGTACTTTTGCAGATAACTGGAAACAAAAA GACTACTCTGATCTTCTTGTCCTAGTTGCCGCTATCGGTGACAAAGTCAATGTCCTTGTAGCAAGCAAGACAAAAGACCT TCATGCAGGAAACCTTGTCAAAGAATTAGCACCAATCATCGATGGACGTGGTGGTGGTAAACCAGACATGGCCATGGCAG GAGGAAGCAACCAAGCTAAGATCCAAGAATTGTTGGATGCAGTAGCAGGTAAATTGTAA
Upstream 100 bases:
>100_bases GGACGCTTATGCAGACCTAGTCATTTCCCTCTGTGTCGCGATTGACTATGTGGAAATGCTGGAAAGCCAATCACATTAAA CAAGTAAATAAGGAGACAAT
Downstream 100 bases:
>100_bases TCAAGTAAAGATCTATCCATTTGGGTAGGTCTTTTTGTGAATACAAAAAAGCCAAATCCGCTTGGACCTAGCTTGGTTAT TATGAGCTATTAGATGGTAT
Product: alanyl-tRNA synthetase
Products: NA
Alternate protein names: Alanine--tRNA ligase; AlaRS [H]
Number of amino acids: Translated: 872; Mature: 872
Protein sequence:
>872_residues MKQLSSAQVRQMWLDFWATKAHSVEPSVSLVPVNDPTLLWINSGVATLKKYFDGTIIPENPRITNAQKAIRTNDIENVGK TARHHTMFEMLGNFSIGDYFRDEAITWAYELLTSPEWFDFPAEKLYMTYYPDDKDSYNRWIEVGVDPSHLIPIEDNFWEI GAGPSGPDTEIFFDRGEAFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPHKNIDTGAGLERLVAV IQGAKTNFETDLFMPIIREVEKLSGKVYDQDGDNMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRASMHGQKL GINEPFLYKLVPTVGKIMESYYPEVLEKRDFIEKIVKSEEESFARTLHSGQHFAQGIVADLKEKGQSVIAGQDVFKLYDT YGFPVELTEEIAEEAGMTVDREGFEAAMKEQQERARASAVKGGSMGMQNETLQNITVESVFNYNTSQLSSKLVAIVADNA EVGAVSEGTASLIFAETSFYAEMGGQVADYGQILDESGKIVATVTNVQKAPNGQALHTVEVLAPLALNQEYILAIDSNRR HRVMKNHTATHLLHAALHNILGNHATQAGSLNEVEFLRFDFTHFQAVTAEELRAIEQQVNEKIWEALEVKTVETDIDTAK EMGAMALFGEKYGKEVRVVTIGDYSIELCGGTHVGNTSEIGLFKIVKEEGIGSGTRRILAVTGKEAFEAYREQEDALKAV AATLKAPQVKEVPHKVEGLQEQLRQLQKENAELKEKAAAAAAGDIFKDAKEVNGHRYIASQVSVSDAGALRTFADNWKQK DYSDLLVLVAAIGDKVNVLVASKTKDLHAGNLVKELAPIIDGRGGGKPDMAMAGGSNQAKIQELLDAVAGKL
Sequences:
>Translated_872_residues MKQLSSAQVRQMWLDFWATKAHSVEPSVSLVPVNDPTLLWINSGVATLKKYFDGTIIPENPRITNAQKAIRTNDIENVGK TARHHTMFEMLGNFSIGDYFRDEAITWAYELLTSPEWFDFPAEKLYMTYYPDDKDSYNRWIEVGVDPSHLIPIEDNFWEI GAGPSGPDTEIFFDRGEAFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPHKNIDTGAGLERLVAV IQGAKTNFETDLFMPIIREVEKLSGKVYDQDGDNMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRASMHGQKL GINEPFLYKLVPTVGKIMESYYPEVLEKRDFIEKIVKSEEESFARTLHSGQHFAQGIVADLKEKGQSVIAGQDVFKLYDT YGFPVELTEEIAEEAGMTVDREGFEAAMKEQQERARASAVKGGSMGMQNETLQNITVESVFNYNTSQLSSKLVAIVADNA EVGAVSEGTASLIFAETSFYAEMGGQVADYGQILDESGKIVATVTNVQKAPNGQALHTVEVLAPLALNQEYILAIDSNRR HRVMKNHTATHLLHAALHNILGNHATQAGSLNEVEFLRFDFTHFQAVTAEELRAIEQQVNEKIWEALEVKTVETDIDTAK EMGAMALFGEKYGKEVRVVTIGDYSIELCGGTHVGNTSEIGLFKIVKEEGIGSGTRRILAVTGKEAFEAYREQEDALKAV AATLKAPQVKEVPHKVEGLQEQLRQLQKENAELKEKAAAAAAGDIFKDAKEVNGHRYIASQVSVSDAGALRTFADNWKQK DYSDLLVLVAAIGDKVNVLVASKTKDLHAGNLVKELAPIIDGRGGGKPDMAMAGGSNQAKIQELLDAVAGKL >Mature_872_residues MKQLSSAQVRQMWLDFWATKAHSVEPSVSLVPVNDPTLLWINSGVATLKKYFDGTIIPENPRITNAQKAIRTNDIENVGK TARHHTMFEMLGNFSIGDYFRDEAITWAYELLTSPEWFDFPAEKLYMTYYPDDKDSYNRWIEVGVDPSHLIPIEDNFWEI GAGPSGPDTEIFFDRGEAFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPHKNIDTGAGLERLVAV IQGAKTNFETDLFMPIIREVEKLSGKVYDQDGDNMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRASMHGQKL GINEPFLYKLVPTVGKIMESYYPEVLEKRDFIEKIVKSEEESFARTLHSGQHFAQGIVADLKEKGQSVIAGQDVFKLYDT YGFPVELTEEIAEEAGMTVDREGFEAAMKEQQERARASAVKGGSMGMQNETLQNITVESVFNYNTSQLSSKLVAIVADNA EVGAVSEGTASLIFAETSFYAEMGGQVADYGQILDESGKIVATVTNVQKAPNGQALHTVEVLAPLALNQEYILAIDSNRR HRVMKNHTATHLLHAALHNILGNHATQAGSLNEVEFLRFDFTHFQAVTAEELRAIEQQVNEKIWEALEVKTVETDIDTAK EMGAMALFGEKYGKEVRVVTIGDYSIELCGGTHVGNTSEIGLFKIVKEEGIGSGTRRILAVTGKEAFEAYREQEDALKAV AATLKAPQVKEVPHKVEGLQEQLRQLQKENAELKEKAAAAAAGDIFKDAKEVNGHRYIASQVSVSDAGALRTFADNWKQK DYSDLLVLVAAIGDKVNVLVASKTKDLHAGNLVKELAPIIDGRGGGKPDMAMAGGSNQAKIQELLDAVAGKL
Specific function: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction:alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editin
COG id: COG0013
COG function: function code J; Alanyl-tRNA synthetase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]
Homologues:
Organism=Homo sapiens, GI109148542, Length=967, Percent_Identity=34.6432264736298, Blast_Score=472, Evalue=1e-133, Organism=Homo sapiens, GI38569417, Length=768, Percent_Identity=32.6822916666667, Blast_Score=345, Evalue=1e-94, Organism=Homo sapiens, GI217416402, Length=266, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-14, Organism=Homo sapiens, GI13376886, Length=275, Percent_Identity=28.3636363636364, Blast_Score=79, Evalue=2e-14, Organism=Escherichia coli, GI1789048, Length=896, Percent_Identity=42.5223214285714, Blast_Score=655, Evalue=0.0, Organism=Caenorhabditis elegans, GI17506981, Length=977, Percent_Identity=32.9580348004094, Blast_Score=441, Evalue=1e-124, Organism=Caenorhabditis elegans, GI17536681, Length=742, Percent_Identity=32.0754716981132, Blast_Score=355, Evalue=4e-98, Organism=Saccharomyces cerevisiae, GI6324911, Length=807, Percent_Identity=38.2899628252788, Blast_Score=498, Evalue=1e-141, Organism=Drosophila melanogaster, GI24582809, Length=974, Percent_Identity=33.3675564681725, Blast_Score=469, Evalue=1e-132, Organism=Drosophila melanogaster, GI45552267, Length=974, Percent_Identity=33.3675564681725, Blast_Score=469, Evalue=1e-132, Organism=Drosophila melanogaster, GI24658214, Length=859, Percent_Identity=28.4051222351572, Blast_Score=284, Evalue=2e-76, Organism=Drosophila melanogaster, GI18543305, Length=389, Percent_Identity=26.2210796915167, Blast_Score=78, Evalue=2e-14,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002318 - InterPro: IPR018162 - InterPro: IPR018165 - InterPro: IPR018164 - InterPro: IPR023033 - InterPro: IPR003156 - InterPro: IPR018163 - InterPro: IPR012947 [H]
Pfam domain/function: PF02272 DHHA1; PF01411 tRNA-synt_2c; PF07973 tRNA_SAD [H]
EC number: =6.1.1.7 [H]
Molecular weight: Translated: 96426; Mature: 96426
Theoretical pI: Translated: 4.81; Mature: 4.81
Prosite motif: PS50860 AA_TRNA_LIGASE_II_ALA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.1 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 0.1 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKQLSSAQVRQMWLDFWATKAHSVEPSVSLVPVNDPTLLWINSGVATLKKYFDGTIIPEN CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHCCCCCCCC PRITNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRDEAITWAYELLTSPEWFDF CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCC PAEKLYMTYYPDDKDSYNRWIEVGVDPSHLIPIEDNFWEIGAGPSGPDTEIFFDRGEAFD CCHHEEEEECCCCCCCCCCEEEECCCCCEEEECCCCCEEECCCCCCCCCCEEEECCCCCC PENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPHKNIDTGAGLERLVAV CCCCCCEEEEHHCCCCCEEHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHH IQGAKTNFETDLFMPIIREVEKLSGKVYDQDGDNMSFKVIADHIRSLSFAIGDGALPGNE HHCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHEECCCCCCCCC GRGYVLRRLLRRASMHGQKLGINEPFLYKLVPTVGKIMESYYPEVLEKRDFIEKIVKSEE CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH ESFARTLHSGQHFAQGIVADLKEKGQSVIAGQDVFKLYDTYGFPVELTEEIAEEAGMTVD HHHHHHHHCCHHHHHHHHHHHHHCCCCEECHHHHHHHHHCCCCCHHHHHHHHHHHCCEEC REGFEAAMKEQQERARASAVKGGSMGMQNETLQNITVESVFNYNTSQLSSKLVAIVADNA CHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHCCCHHHHHCCEEEEEECCC EVGAVSEGTASLIFAETSFYAEMGGQVADYGQILDESGKIVATVTNVQKAPNGQALHTVE CCCCCCCCCEEEEEEEHHHHHHHCCCHHHHHHHHCCCCCEEEEEECHHCCCCCCCEEHHH VLAPLALNQEYILAIDSNRRHRVMKNHTATHLLHAALHNILGNHATQAGSLNEVEFLRFD HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEE FTHFQAVTAEELRAIEQQVNEKIWEALEVKTVETDIDTAKEMGAMALFGEKYGKEVRVVT HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHCCEEEEEE IGDYSIELCGGTHVGNTSEIGLFKIVKEEGIGSGTRRILAVTGKEAFEAYREQEDALKAV ECCEEEEEECCCCCCCCCCCHHEEEEHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHH AATLKAPQVKEVPHKVEGLQEQLRQLQKENAELKEKAAAAAAGDIFKDAKEVNGHRYIAS HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE QVSVSDAGALRTFADNWKQKDYSDLLVLVAAIGDKVNVLVASKTKDLHAGNLVKELAPII CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHH DGRGGGKPDMAMAGGSNQAKIQELLDAVAGKL CCCCCCCCCCEECCCCCHHHHHHHHHHHHCCC >Mature Secondary Structure MKQLSSAQVRQMWLDFWATKAHSVEPSVSLVPVNDPTLLWINSGVATLKKYFDGTIIPEN CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHCCCCCCCC PRITNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRDEAITWAYELLTSPEWFDF CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCC PAEKLYMTYYPDDKDSYNRWIEVGVDPSHLIPIEDNFWEIGAGPSGPDTEIFFDRGEAFD CCHHEEEEECCCCCCCCCCEEEECCCCCEEEECCCCCEEECCCCCCCCCCEEEECCCCCC PENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPHKNIDTGAGLERLVAV CCCCCCEEEEHHCCCCCEEHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHH IQGAKTNFETDLFMPIIREVEKLSGKVYDQDGDNMSFKVIADHIRSLSFAIGDGALPGNE HHCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHEECCCCCCCCC GRGYVLRRLLRRASMHGQKLGINEPFLYKLVPTVGKIMESYYPEVLEKRDFIEKIVKSEE CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH ESFARTLHSGQHFAQGIVADLKEKGQSVIAGQDVFKLYDTYGFPVELTEEIAEEAGMTVD HHHHHHHHCCHHHHHHHHHHHHHCCCCEECHHHHHHHHHCCCCCHHHHHHHHHHHCCEEC REGFEAAMKEQQERARASAVKGGSMGMQNETLQNITVESVFNYNTSQLSSKLVAIVADNA CHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHCCCHHHHHCCEEEEEECCC EVGAVSEGTASLIFAETSFYAEMGGQVADYGQILDESGKIVATVTNVQKAPNGQALHTVE CCCCCCCCCEEEEEEEHHHHHHHCCCHHHHHHHHCCCCCEEEEEECHHCCCCCCCEEHHH VLAPLALNQEYILAIDSNRRHRVMKNHTATHLLHAALHNILGNHATQAGSLNEVEFLRFD HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEE FTHFQAVTAEELRAIEQQVNEKIWEALEVKTVETDIDTAKEMGAMALFGEKYGKEVRVVT HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHCCEEEEEE IGDYSIELCGGTHVGNTSEIGLFKIVKEEGIGSGTRRILAVTGKEAFEAYREQEDALKAV ECCEEEEEECCCCCCCCCCCHHEEEEHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHH AATLKAPQVKEVPHKVEGLQEQLRQLQKENAELKEKAAAAAAGDIFKDAKEVNGHRYIAS HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE QVSVSDAGALRTFADNWKQKDYSDLLVLVAAIGDKVNVLVASKTKDLHAGNLVKELAPII CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHH DGRGGGKPDMAMAGGSNQAKIQELLDAVAGKL CCCCCCCCCCEECCCCCHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA