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The map label for this gene is msrAB1 [H]

Identifier: 225859126

GI number: 225859126

Start: 1293762

End: 1294700

Strand: Reverse

Name: msrAB1 [H]

Synonym: SP70585_1398

Alternate gene names: 225859126

Gene position: 1294700-1293762 (Counterclockwise)

Preceding gene: 225859127

Following gene: 225859125

Centisome position: 59.26

GC content: 43.77

Gene sequence:

>939_bases
ATGGCAGAAATTTATCTAGCAGGTGGTTGTTTTTGGGGCCTAGAGGAATATTTTTCACGCATTTCTGGAGTGCTAGAAAC
CAGTGTTGGCTACGCTAATGGTCAAGTCGAAACGACCAATTACCAGTTGATCAAGGAAACAGACCATGCAGAAACGGTCC
AAGTGATTTACGATGAGAAGGAAGTGTCACTCAGAGAGATTTTACTTTATTATTTCCGAGTTATCGATCCTCTATCTATC
AATCAACAAGGGAATGACCGTGGTCGCCAATATCGAACTGGGATTTATTATCAGGATGAAGCAGATTTGCCAGCTATCTA
CACAGTGGTACAGGAGCAGGAACGCATGCTGGGTCGAAAGATTGCAGTAGAAGTGGAGCAATTACGCCACTACATTCTGG
CTGAAGACTACCACCAAGACTATCTCAGGAAGAATCCTTCAGGTTACTGTCATATCGATGTGACCGATGCTGATAAGCCA
TTGATTGATGCAGCAAACTATGAAAAGCCTAGTCAAGAGGTGTTGAAGGCCAGTCTATCTGAAGAGTCTTATCGTGTCAC
ACAAGAAGCTGCTACAGAGGCTCCATTTACCAATGCCTATGACCAAACCTTTGAAGAGGGGATTTATGTAGATATTACGA
CAGGTGAGCCACTCTTTTTTGCCAAGGATAAGTTTGCTTCAGGTTGTGGTTGGCCAAGTTTTAGCCGTCCGATTTCCAAA
GAGTTGATTCATTATTACAAGGATCTGAGCCATGGAATGGAGCGAATTGAAGTTCGTTCTCGTTCAGGCAGTGCTCACTT
GGGTCATGTTTTCACAGATGGACCGCGGGAGTTAGGCGGCCTCCGTTACTGTATCAATTCTGCTTCTTTACGCTTTGTGG
CCAAGGATGAGATGGAAAAAGCAGGATATGGCTATCTATTGCCTTACTTAAACAAATAA

Upstream 100 bases:

>100_bases
TGACGAAGTCAGTAACATATATACGGTAAGGTGACGCTGACGTGGTTTGAAGAGATTTTCGAAGAGTATTAGTTAAAAAC
GTGATAAAGGAGAAATAAAG

Downstream 100 bases:

>100_bases
AACAGAGAGTGGGGCTTCCCACTTTCTTCATTTCTAGAATATGAATAGAAGGGATTTATGAAACACCTATTATCTTACTT
CAAACCCTACATCAAGGAAT

Product: peptide methionine sulfoxide reductase MsrA/msrB

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLIKETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSI
NQQGNDRGRQYRTGIYYQDEADLPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKP
LIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPISK
ELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNK

Sequences:

>Translated_312_residues
MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLIKETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSI
NQQGNDRGRQYRTGIYYQDEADLPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKP
LIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPISK
ELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNK
>Mature_311_residues
AEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLIKETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSIN
QQGNDRGRQYRTGIYYQDEADLPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKPL
IDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPISKE
LIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=140, Percent_Identity=45, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI301336162, Length=140, Percent_Identity=45, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI73089054, Length=140, Percent_Identity=45, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI37620216, Length=140, Percent_Identity=45, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=35.2201257861635, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=35.2201257861635, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI117606353, Length=121, Percent_Identity=42.1487603305785, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI208609993, Length=129, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788077, Length=132, Percent_Identity=52.2727272727273, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790665, Length=148, Percent_Identity=37.1621621621622, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI115532676, Length=132, Percent_Identity=46.2121212121212, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17553450, Length=132, Percent_Identity=46.2121212121212, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6320881, Length=156, Percent_Identity=39.1025641025641, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319816, Length=120, Percent_Identity=38.3333333333333, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221378664, Length=132, Percent_Identity=44.6969696969697, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45553335, Length=127, Percent_Identity=44.0944881889764, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356369, Length=127, Percent_Identity=44.0944881889764, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221378662, Length=139, Percent_Identity=42.4460431654676, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645799, Length=127, Percent_Identity=44.0944881889764, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24645804, Length=138, Percent_Identity=40.5797101449275, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24645801, Length=138, Percent_Identity=40.5797101449275, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24664627, Length=139, Percent_Identity=32.3741007194245, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=33.0935251798561, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664631, Length=139, Percent_Identity=30.9352517985612, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 35703; Mature: 35572

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLIKETDHAETVQVIYDEK
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEEECCCCCCEEEEEECCC
EVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDEADLPAIYTVVQEQERMLGRK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCEEEECCCCCHHHHHHHHHHHHHHHHH
IAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKPLIDAANYEKPSQEVLKASLS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHC
EESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPISK
HHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHH
ELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEK
HHHHHHHHHHHHHHHHHHHCCCCCCEECCEECCCHHHHHHHHHHHCCCCEEEEEHHHHHH
AGYGYLLPYLNK
CCCCEECCCCCC
>Mature Secondary Structure 
AEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLIKETDHAETVQVIYDEK
CEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEEECCCCCCEEEEEECCC
EVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDEADLPAIYTVVQEQERMLGRK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCEEEECCCCCHHHHHHHHHHHHHHHHH
IAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKPLIDAANYEKPSQEVLKASLS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHC
EESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPISK
HHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHH
ELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEK
HHHHHHHHHHHHHHHHHHHCCCCCCEECCEECCCHHHHHHHHHHHCCCCEEEEEHHHHHH
AGYGYLLPYLNK
CCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]