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The map label for this gene is mtaD [H]

Identifier: 225859123

GI number: 225859123

Start: 1288669

End: 1289928

Strand: Reverse

Name: mtaD [H]

Synonym: SP70585_1395

Alternate gene names: 225859123

Gene position: 1289928-1288669 (Counterclockwise)

Preceding gene: 225859124

Following gene: 225859121

Centisome position: 59.04

GC content: 43.17

Gene sequence:

>1260_bases
ATGAAAGTCTTTCAGCATGTAAATATCGTGACTTGTGATCAAAATTTCCATGTTTATCTTGATGGAATCTTAGCAGTCAA
GGATTCTCAAATCGTCTATGTCGGTCAAGATAAGCCAGCGTTTTTAGAACAAGCTGAGCAGATTGTAGACTATCAGGGAG
CTTGGATTATGCCTGGTTTGGTCAATTGTCACACCCATTCTGCAATGACAGGTCTGAGAGGGATCCGAGATGACAGCAAT
CTCCATGAATGGCTCAATGACTATATCTGGCCAGCAGAATCTGAGTTTACTCCCGACATGACTACCAATGCGGTCAAAGA
AGCCCTGACAGAGATGCTCCAGTCAGGAACAACAACCTTTAACGATATGTATAATCCCAATGGTGTGGATATTCAGCAAA
TTTATCAGGTGGTGAAAACTTCCAAGATGCGTTGTTATTTTTCTCCGACTCTCTTTTCTTCAGAGACAGAAACAACTGCT
GAGACTATAAGCAGAACTCGATCCATCATAGACGAAATCTTAAAATATAAAAATCCAAATTTCAAGGTTATGGTAGCACC
TCATTCTCCGTATAGCTGCAGTAGAGACTTGCTGGAAGCGAGTTTGGAAATGGCAAAAGAGCTAAATATTCCGCTCCATG
TCCATGTGGCGGAGACCAAGGAGGAGTCAGGAATTATCCTCAAACGATACGGCAAACGCCCCCTTGCTTTTCTTGAAGAA
CTGGGTTATTTAGATCATCCGTCCGTATTTGCTCACGGGGTCGAATTAAACGAGAGAGAAATTGAACGCTTGGCATCTTC
TCAAGTGGCTATCGCCCACAATCCTATCAGTAACCTCAAACTGGCATCAGGAATTGCTCCAATTATCCAGCTCCAAAAAG
CGGGAGTAGCAGTCGGAATTGCGACTGACTCGGTTGCTTCCAATAACAATCTAGATATGTTTGAGGAAGGAAGGACTGCA
GCTCTTCTTCAGAAGATGAAAAGTGGGGATGCCAGCCAGTTTCCAATCGAAACAGCTCTCAAGGTACTGACAATCGAAGG
GGCTAAGGCCCTTGGAATGGAAAATCAGATAGGAAGTCTGGAAGTCGGCAAGCAAGCAGATTTTCTGGTCATTCAACCAC
AAGGGAAAATTCATCTCCAACCTCAGGAAAATATGCTGTCTCACCTGGTTTATGCAGTTAAATCTAATGATGTAGATGAT
GTTTATATCGCCGGAGAACAGGTTGTTAAGCAAGGTCAAGTCCTGACAGTAGAACTTTAA

Upstream 100 bases:

>100_bases
TGCAGATAGAACTGACGAAGTCAGTAACCACACCTACGGCAAAGTGAATCTGAAGTGGTTTGAAGAGAGTACAACTTGTC
TTTTAGAAAAGGAGCCTATA

Downstream 100 bases:

>100_bases
AAGAAAAATCACGAAAAATTTTAAAAAAAGTTTGCAAAAATCTTGCATTCTTTTTTTGACTATGCTATACTTATATACGG
TTTAAAAAAACTGCCTAAGA

Product: chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKVFQHVNIVTCDQNFHVYLDGILAVKDSQIVYVGQDKPAFLEQAEQIVDYQGAWIMPGLVNCHTHSAMTGLRGIRDDSN
LHEWLNDYIWPAESEFTPDMTTNAVKEALTEMLQSGTTTFNDMYNPNGVDIQQIYQVVKTSKMRCYFSPTLFSSETETTA
ETISRTRSIIDEILKYKNPNFKVMVAPHSPYSCSRDLLEASLEMAKELNIPLHVHVAETKEESGIILKRYGKRPLAFLEE
LGYLDHPSVFAHGVELNEREIERLASSQVAIAHNPISNLKLASGIAPIIQLQKAGVAVGIATDSVASNNNLDMFEEGRTA
ALLQKMKSGDASQFPIETALKVLTIEGAKALGMENQIGSLEVGKQADFLVIQPQGKIHLQPQENMLSHLVYAVKSNDVDD
VYIAGEQVVKQGQVLTVEL

Sequences:

>Translated_419_residues
MKVFQHVNIVTCDQNFHVYLDGILAVKDSQIVYVGQDKPAFLEQAEQIVDYQGAWIMPGLVNCHTHSAMTGLRGIRDDSN
LHEWLNDYIWPAESEFTPDMTTNAVKEALTEMLQSGTTTFNDMYNPNGVDIQQIYQVVKTSKMRCYFSPTLFSSETETTA
ETISRTRSIIDEILKYKNPNFKVMVAPHSPYSCSRDLLEASLEMAKELNIPLHVHVAETKEESGIILKRYGKRPLAFLEE
LGYLDHPSVFAHGVELNEREIERLASSQVAIAHNPISNLKLASGIAPIIQLQKAGVAVGIATDSVASNNNLDMFEEGRTA
ALLQKMKSGDASQFPIETALKVLTIEGAKALGMENQIGSLEVGKQADFLVIQPQGKIHLQPQENMLSHLVYAVKSNDVDD
VYIAGEQVVKQGQVLTVEL
>Mature_419_residues
MKVFQHVNIVTCDQNFHVYLDGILAVKDSQIVYVGQDKPAFLEQAEQIVDYQGAWIMPGLVNCHTHSAMTGLRGIRDDSN
LHEWLNDYIWPAESEFTPDMTTNAVKEALTEMLQSGTTTFNDMYNPNGVDIQQIYQVVKTSKMRCYFSPTLFSSETETTA
ETISRTRSIIDEILKYKNPNFKVMVAPHSPYSCSRDLLEASLEMAKELNIPLHVHVAETKEESGIILKRYGKRPLAFLEE
LGYLDHPSVFAHGVELNEREIERLASSQVAIAHNPISNLKLASGIAPIIQLQKAGVAVGIATDSVASNNNLDMFEEGRTA
ALLQKMKSGDASQFPIETALKVLTIEGAKALGMENQIGSLEVGKQADFLVIQPQGKIHLQPQENMLSHLVYAVKSNDVDD
VYIAGEQVVKQGQVLTVEL

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=429, Percent_Identity=26.5734265734266, Blast_Score=145, Evalue=9e-35,
Organism=Escherichia coli, GI1789249, Length=374, Percent_Identity=25.9358288770053, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI87082177, Length=404, Percent_Identity=22.2772277227723, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540282, Length=400, Percent_Identity=22.75, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319963, Length=365, Percent_Identity=25.2054794520548, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24643849, Length=438, Percent_Identity=25.7990867579909, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 46522; Mature: 46522

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFQHVNIVTCDQNFHVYLDGILAVKDSQIVYVGQDKPAFLEQAEQIVDYQGAWIMPGL
CCCEEECEEEEECCCCEEEEEEEEEEECCEEEEECCCCCHHHHHHHHHHHCCCCEECCCC
VNCHTHSAMTGLRGIRDDSNLHEWLNDYIWPAESEFTPDMTTNAVKEALTEMLQSGTTTF
CCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCH
NDMYNPNGVDIQQIYQVVKTSKMRCYFSPTLFSSETETTAETISRTRSIIDEILKYKNPN
HCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
FKVMVAPHSPYSCSRDLLEASLEMAKELNIPLHVHVAETKEESGIILKRYGKRPLAFLEE
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHH
LGYLDHPSVFAHGVELNEREIERLASSQVAIAHNPISNLKLASGIAPIIQLQKAGVAVGI
CCCCCCCHHHEECCCCCHHHHHHHHCCCEEEEECCCCCCCHHHCCHHHHHHHHCCEEEEE
ATDSVASNNNLDMFEEGRTAALLQKMKSGDASQFPIETALKVLTIEGAKALGMENQIGSL
EECCCCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCHHHHEEEEEECCCHHCCCCCCCCCE
EVGKQADFLVIQPQGKIHLQPQENMLSHLVYAVKSNDVDDVYIAGEQVVKQGQVLTVEL
ECCCCCCEEEECCCCCEEECCHHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCEEEEEC
>Mature Secondary Structure
MKVFQHVNIVTCDQNFHVYLDGILAVKDSQIVYVGQDKPAFLEQAEQIVDYQGAWIMPGL
CCCEEECEEEEECCCCEEEEEEEEEEECCEEEEECCCCCHHHHHHHHHHHCCCCEECCCC
VNCHTHSAMTGLRGIRDDSNLHEWLNDYIWPAESEFTPDMTTNAVKEALTEMLQSGTTTF
CCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCH
NDMYNPNGVDIQQIYQVVKTSKMRCYFSPTLFSSETETTAETISRTRSIIDEILKYKNPN
HCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
FKVMVAPHSPYSCSRDLLEASLEMAKELNIPLHVHVAETKEESGIILKRYGKRPLAFLEE
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHHHHH
LGYLDHPSVFAHGVELNEREIERLASSQVAIAHNPISNLKLASGIAPIIQLQKAGVAVGI
CCCCCCCHHHEECCCCCHHHHHHHHCCCEEEEECCCCCCCHHHCCHHHHHHHHCCEEEEE
ATDSVASNNNLDMFEEGRTAALLQKMKSGDASQFPIETALKVLTIEGAKALGMENQIGSL
EECCCCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCHHHHEEEEEECCCHHCCCCCCCCCE
EVGKQADFLVIQPQGKIHLQPQENMLSHLVYAVKSNDVDDVYIAGEQVVKQGQVLTVEL
ECCCCCCEEEECCCCCEEECCHHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA