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The map label for this gene is ffh

Identifier: 225859083

GI number: 225859083

Start: 1257035

End: 1258606

Strand: Reverse

Name: ffh

Synonym: SP70585_1352

Alternate gene names: 225859083

Gene position: 1258606-1257035 (Counterclockwise)

Preceding gene: 225859084

Following gene: 225859080

Centisome position: 57.61

GC content: 43.45

Gene sequence:

>1572_bases
ATGGCATTTGAAAGTTTAACAGAACGTTTGCAGAACGTCTTTAAAAATCTACGTAAAAAAGGAAAAATCTCTGAATCTGA
TGTCCAAGAGGCAACCAAAGAAATTCGCTTGGCCTTGCTCGAGGCCGACGTTGCCTTGCCTGTTGTAAAGGACTTTATCA
AGAAAGTTCGTGAGCGTGCAGTCGGGCATGAGGTCATTGATACACTTAATCCTGCGCAACAGATTATTAAAATCGTTGAT
GAGGAACTGACAGCCGTTTTAGGTTCTGATACGGCAGAAATTATCAAGTCACCTAAGATTCCAACCATCATCATGATGGT
TGGTTTACAAGGGGCTGGTAAAACAACCTTTGCTGGTAAATTGGCCAACAAACTCAAGAAAGAAGAAAATGCTCGTCCTT
TGATGATTGCGGCGGATATTTATCGTCCAGCTGCCATTGACCAGCTTAAGACCTTGGGACAACAGATTGATGTGCCTGTC
TTTGCACTTGGAACAGAAGTACCAGCTGTTGAGATTGTACGTCAAGGTTTGGAGCAAGCCCAAACTAATCATAACGACTA
TGTCTTGATTGATACTGCGGGTCGTTTGCAGATTGATGAGCTCCTCATGAATGAGCTTCGTGATGTGAAAGCATTGGCTC
AACCAAATGAAATCTTGCTTGTCGTTGATGCTATGATTGGTCAGGAAGCAGCCAATGTTGCGCGTGAGTTTAATGCTCAG
TTGGAAGTGACTGGGGTCATCCTTACCAAGATTGATGGCGATACTCGTGGTGGTGCTGCTCTGTCTGTTCGTCACATTAC
TGGAAAACCAATCAAGTTCACTGGTACAGGTGAAAAGATTACGGACATTGAAACCTTCCACCCAGACCGCATGTCTAGCC
GTATCCTTGGTATGGGGGATATGCTCACTTTGATTGAGAAAGCTTCTCAGGAATACGATGAACAAAAAGCCCTTGAAATG
GCTGAGAAGATGCGCGAAAACACCTTTGATTTTAATGATTTCATCGATCAATTAGATCAGGTGCAAAATATGGGGCCGAT
GGAAGACTTGCTCAAGATGATTCCAGGTATGGCAAACAATCCAGCCCTTCAAAACATGAAGGTGGATGAACGCCAGATTG
CTCGTAAACGTGCCATTGTGTCTTCGATGACACCTGAAGAGCGTGAAAACCCAGATTTGTTAAATCCAAGCCGTCGCCGT
CGTATTGCTGCTGGTTCTGGAAATACATTCGTCGAAGTCAATAAATTCATCAAGGACTTTAACCAGGCTAAACAGCTCAT
GCAGGGTGTTATGTCTGGGGATATGAATAAAATGATGAAGCAAATGGGGATTAATCCAAATAACCTTCCTAAAAATATGC
CAAATATGGGAGGAATGGATATGTCTGCCCTTGAAGGAATGATGGGACAAGGCGGTATGCCTGACTTATCAGCTCTCGGA
GGAGCAGGAATGCCAGATATGAGCCAGATGTTTGGTGGCGGTTTGAAAGGTAAAATTGGTGAATTTGCTATGAAACAGTC
CATGAAACGTATGGCTAACAAAATGAAGAAAGCGAAGAAGAAACGCAAGTAA

Upstream 100 bases:

>100_bases
TTTTTGACCAAATCTTGGAGCGCTATCCCAAGGATGATTTTCTGCAGGAGCAGATAGAAATTTTAACAAGCATTGATAAT
AGAGAATAAGAGGAAGAAAA

Downstream 100 bases:

>100_bases
GACAAGAGATTGATGCAAATCTCATTTGATGAGAAAATAAAGTAAAAATTTCTATGATAAAACGTACAGTATCAAGGTTT
TAGAATATCTGATATTATAC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MAFESLTERLQNVFKNLRKKGKISESDVQEATKEIRLALLEADVALPVVKDFIKKVRERAVGHEVIDTLNPAQQIIKIVD
EELTAVLGSDTAEIIKSPKIPTIIMMVGLQGAGKTTFAGKLANKLKKEENARPLMIAADIYRPAAIDQLKTLGQQIDVPV
FALGTEVPAVEIVRQGLEQAQTNHNDYVLIDTAGRLQIDELLMNELRDVKALAQPNEILLVVDAMIGQEAANVAREFNAQ
LEVTGVILTKIDGDTRGGAALSVRHITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGDMLTLIEKASQEYDEQKALEM
AEKMRENTFDFNDFIDQLDQVQNMGPMEDLLKMIPGMANNPALQNMKVDERQIARKRAIVSSMTPEERENPDLLNPSRRR
RIAAGSGNTFVEVNKFIKDFNQAKQLMQGVMSGDMNKMMKQMGINPNNLPKNMPNMGGMDMSALEGMMGQGGMPDLSALG
GAGMPDMSQMFGGGLKGKIGEFAMKQSMKRMANKMKKAKKKRK

Sequences:

>Translated_523_residues
MAFESLTERLQNVFKNLRKKGKISESDVQEATKEIRLALLEADVALPVVKDFIKKVRERAVGHEVIDTLNPAQQIIKIVD
EELTAVLGSDTAEIIKSPKIPTIIMMVGLQGAGKTTFAGKLANKLKKEENARPLMIAADIYRPAAIDQLKTLGQQIDVPV
FALGTEVPAVEIVRQGLEQAQTNHNDYVLIDTAGRLQIDELLMNELRDVKALAQPNEILLVVDAMIGQEAANVAREFNAQ
LEVTGVILTKIDGDTRGGAALSVRHITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGDMLTLIEKASQEYDEQKALEM
AEKMRENTFDFNDFIDQLDQVQNMGPMEDLLKMIPGMANNPALQNMKVDERQIARKRAIVSSMTPEERENPDLLNPSRRR
RIAAGSGNTFVEVNKFIKDFNQAKQLMQGVMSGDMNKMMKQMGINPNNLPKNMPNMGGMDMSALEGMMGQGGMPDLSALG
GAGMPDMSQMFGGGLKGKIGEFAMKQSMKRMANKMKKAKKKRK
>Mature_522_residues
AFESLTERLQNVFKNLRKKGKISESDVQEATKEIRLALLEADVALPVVKDFIKKVRERAVGHEVIDTLNPAQQIIKIVDE
ELTAVLGSDTAEIIKSPKIPTIIMMVGLQGAGKTTFAGKLANKLKKEENARPLMIAADIYRPAAIDQLKTLGQQIDVPVF
ALGTEVPAVEIVRQGLEQAQTNHNDYVLIDTAGRLQIDELLMNELRDVKALAQPNEILLVVDAMIGQEAANVAREFNAQL
EVTGVILTKIDGDTRGGAALSVRHITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGDMLTLIEKASQEYDEQKALEMA
EKMRENTFDFNDFIDQLDQVQNMGPMEDLLKMIPGMANNPALQNMKVDERQIARKRAIVSSMTPEERENPDLLNPSRRRR
IAAGSGNTFVEVNKFIKDFNQAKQLMQGVMSGDMNKMMKQMGINPNNLPKNMPNMGGMDMSALEGMMGQGGMPDLSALGG
AGMPDMSQMFGGGLKGKIGEFAMKQSMKRMANKMKKAKKKRK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=493, Percent_Identity=31.237322515213, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI226371618, Length=430, Percent_Identity=31.8604651162791, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI89061728, Length=163, Percent_Identity=38.0368098159509, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI23308697, Length=308, Percent_Identity=27.2727272727273, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI295424842, Length=308, Percent_Identity=27.2727272727273, Blast_Score=100, Evalue=6e-21,
Organism=Escherichia coli, GI1788963, Length=420, Percent_Identity=48.0952380952381, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1789874, Length=269, Percent_Identity=33.457249070632, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=490, Percent_Identity=28.7755102040816, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI193206261, Length=302, Percent_Identity=28.1456953642384, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=464, Percent_Identity=31.8965517241379, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6320498, Length=308, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17647949, Length=492, Percent_Identity=31.5040650406504, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24641198, Length=310, Percent_Identity=27.741935483871, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 57758; Mature: 57627

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.1 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.9 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFESLTERLQNVFKNLRKKGKISESDVQEATKEIRLALLEADVALPVVKDFIKKVRERA
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGHEVIDTLNPAQQIIKIVDEELTAVLGSDTAEIIKSPKIPTIIMMVGLQGAGKTTFAGK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEECCCCCCCCHHHHH
LANKLKKEENARPLMIAADIYRPAAIDQLKTLGQQIDVPVFALGTEVPAVEIVRQGLEQA
HHHHHHHHCCCCCEEEEHHHHCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHH
QTNHNDYVLIDTAGRLQIDELLMNELRDVKALAQPNEILLVVDAMIGQEAANVAREFNAQ
HCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCC
LEVTGVILTKIDGDTRGGAALSVRHITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGD
EEEEEEEEEEECCCCCCCCEEEEEECCCCCEEECCCCCEECCCHHCCCHHHHHHHHCCHH
MLTLIEKASQEYDEQKALEMAEKMRENTFDFNDFIDQLDQVQNMGPMEDLLKMIPGMANN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PALQNMKVDERQIARKRAIVSSMTPEERENPDLLNPSRRRRIAAGSGNTFVEVNKFIKDF
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCEEECCCCCCHHHHHHHHHHH
NQAKQLMQGVMSGDMNKMMKQMGINPNNLPKNMPNMGGMDMSALEGMMGQGGMPDLSALG
HHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHC
GAGMPDMSQMFGGGLKGKIGEFAMKQSMKRMANKMKKAKKKRK
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFESLTERLQNVFKNLRKKGKISESDVQEATKEIRLALLEADVALPVVKDFIKKVRERA
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGHEVIDTLNPAQQIIKIVDEELTAVLGSDTAEIIKSPKIPTIIMMVGLQGAGKTTFAGK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEECCCCCCCCHHHHH
LANKLKKEENARPLMIAADIYRPAAIDQLKTLGQQIDVPVFALGTEVPAVEIVRQGLEQA
HHHHHHHHCCCCCEEEEHHHHCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHH
QTNHNDYVLIDTAGRLQIDELLMNELRDVKALAQPNEILLVVDAMIGQEAANVAREFNAQ
HCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCC
LEVTGVILTKIDGDTRGGAALSVRHITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGD
EEEEEEEEEEECCCCCCCCEEEEEECCCCCEEECCCCCEECCCHHCCCHHHHHHHHCCHH
MLTLIEKASQEYDEQKALEMAEKMRENTFDFNDFIDQLDQVQNMGPMEDLLKMIPGMANN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PALQNMKVDERQIARKRAIVSSMTPEERENPDLLNPSRRRRIAAGSGNTFVEVNKFIKDF
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCEEECCCCCCHHHHHHHHHHH
NQAKQLMQGVMSGDMNKMMKQMGINPNNLPKNMPNMGGMDMSALEGMMGQGGMPDLSALG
HHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHC
GAGMPDMSQMFGGGLKGKIGEFAMKQSMKRMANKMKKAKKKRK
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]