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The map label for this gene is fhs

Identifier: 225859010

GI number: 225859010

Start: 1184421

End: 1186091

Strand: Reverse

Name: fhs

Synonym: SP70585_1275

Alternate gene names: 225859010

Gene position: 1186091-1184421 (Counterclockwise)

Preceding gene: 225859016

Following gene: 225859009

Centisome position: 54.29

GC content: 44.17

Gene sequence:

>1671_bases
ATGAAAACAGATATTGAAATCGCACAGAGTATTGAGTTGAAGCCAATTGTTGATGTTGTAGAGAAACTTGGTATTTCTTA
CGACGATTTGGAGTTGTACGGAAAGTACAAGGCTAAACTCAGCTTTGATAAAATTCGGGCAGTTGAGAGCAATCCAGTCG
GTAAATTGATCTTGGTTACTGCCATCAACCCAACACCTGCAGGTGAAGGAAAGTCGACGCTTACCATTGGTCTTGCGGAT
GCCTTGAACAAGATTGGCAAGAAAACCATGATTGCTATCCGCGAACCGTCTCTTGGTCCAGTCATGGGGATCAAGGGTGG
TGCTGCTGGTGGTGGGTATGCACAAGTTCTGCCAATGGAAGACATCAACCTCCACTTTACTGGAGATATGCATGCTATTA
CAACTGCCAACAATGCCCTTTCTGCCTTGATTGACAACCACTTGCACCAAGGGAATGAGCTGGGAATTGATCAACGTCGT
ATCCTCTGGAAACGCGTTGTGGACTTGAACGACCGTGCGCTCCGCCATGTGACTGTTGGTCTTGGTGGTCCTCTAAACGG
TATTCCACGTGAGGACGGTTTTGATATTACAGTTGCTTCAGAAATCATGGCAATTCTTTGCTTGGCAACGGACATCGAGG
ACTTGAAACGTCGTTTGGCGAATATCGTTATTGGTTATCGCTATGACCGTACGCCTGTTTCTGTAGGTGATTTGCAGGTT
GAGGGTGCCTTGGCTTTGATTTTGAAGGATGCTATTAAGCCAAACTTGGTTCAGACAATTTACGGTACACCTGCCTTTGT
ACACGGTGGTCCATTTGCCAATATCGCTCATGGCTGTAACTCTGTTTTGGCGACGACAACAGCCCTTCACTTGGCTGATT
ACACTGTTACTGAAGCTGGTTTTGGTGCGGATCTTGGTGCTGAGAAATTCCTTGATATCAAGACACCAAACTTGCCAACA
TCTCCAGATGCAGTTGTTATTGTCGCAACCCTTCGTGCCCTTAAGATGAATGGTGGTGTGGCTAAAGACGCTCTGACTGA
AGAAAATGTAGAGGCAGTTCGTGCAGGTTTTGCTAACTTGAAACGCCACGTTGAAAATATCCGTAAGTTCGGTATTCCAG
CAGTTGTAGCTATTAACGAATTTGTATCTGATACAGAAGCTGAAATTGCAGTCTTAAAAGAACTCTGTGCCTCAATCGAT
GTACCAGTTGAATTGGCTAGTGTCTGGGCTGATGGAGCAGAAGGTGGAGTAGCACTTGCCGAAACAGTTGTTAAGACAAT
TGCTGAAAATCCAGCTAACTATAAACGTTTGTACGATAATGACCTTTCTGTCCAAGAAAAGATTGAAAAAATTGTCACTG
AAATCTATCGTGGTAGCAAAGTGAACTTTGAGAAGAAAGCTCAAACACAAATTGCTCAAATCGTTCAAAACGGTTGGGAC
AAATTGCCAATTTGTATGGCTAAAACTCAATACAGTTTCTCAGACAATCCAAATGCGCTTGGAGCACCAGAAAACTTTGA
AATTACCATTCGTGAATTGGTACCAAAATTAGGTGCAGGCTTCATCGTTGCCTTAACTGGTGATGTTATGACCATGCCAG
GTCTTCCAAAACGTCCAGCAGCTCTCAACATGGATGTTGAAAGCGATGGAACTGTGCTAGGCTTGTTCTAG

Upstream 100 bases:

>100_bases
AAAACAGAGATATTTACGAACGTTTAGAGAGTTTTAAGATGTTAAAAATCTTGTTTTGTGATATAATGAATTATCATATA
AGAGGTTAGAGGAATTTTGA

Downstream 100 bases:

>100_bases
TGGATTGAAATTGACTTTAAGTGAGTTTGGAAATAATATCCAAGCTCATTTTTTCTCAGACTGCAAGCAGTTCATCAATA
AGATTTATACTCTTCGAAAA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase 2; FHS 2; FTHFS 2 [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLAD
ALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRR
ILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQV
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPT
SPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASID
VPVELASVWADGAEGGVALAETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKAQTQIAQIVQNGWD
KLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF

Sequences:

>Translated_556_residues
MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLAD
ALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRR
ILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQV
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPT
SPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASID
VPVELASVWADGAEGGVALAETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKAQTQIAQIVQNGWD
KLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF
>Mature_556_residues
MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLAD
ALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRR
ILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQV
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPT
SPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASID
VPVELASVWADGAEGGVALAETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKAQTQIAQIVQNGWD
KLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=42.1900161030596, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI36796743, Length=622, Percent_Identity=41.6398713826367, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17568737, Length=625, Percent_Identity=42.08, Blast_Score=430, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17568739, Length=625, Percent_Identity=42.08, Blast_Score=430, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=41.9968304278922, Blast_Score=445, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=41.2140575079872, Blast_Score=426, Evalue=1e-120,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=40.8064516129032, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=40.8064516129032, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=40.8064516129032, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=40.8064516129032, Blast_Score=440, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59614; Mature: 59614

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00721 FTHFS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVT
CCCCHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHEEEEECHHHHHCCCCCCCCEEEEEE
AINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPME
EECCCCCCCCCCEEEEEHHHHHHHCCCEEEEEEECCCCCCEEECCCCCCCCCCEEEEEEC
DINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRRILWKRVVDLNDRALRHVTVG
CCEEEECCCEEEEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEE
LGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQV
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHEEEEEEECCCCCCCCCEEE
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAG
CHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCEEECCC
FGADLGAEKFLDIKTPNLPTSPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANL
CCCCCCCCCEEEEECCCCCCCCCCEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
KRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASIDVPVELASVWADGAEGGVALA
HHHHHHHHHHCCCCEEEHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHH
ETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKAQTQIAQIVQNGWD
HHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
KLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPA
CCCEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEEEECCEEECCCCCCCCC
ALNMDVESDGTVLGLF
EEEEEECCCCCEEECC
>Mature Secondary Structure
MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDKIRAVESNPVGKLILVT
CCCCHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHEEEEECHHHHHCCCCCCCCEEEEEE
AINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPME
EECCCCCCCCCCEEEEEHHHHHHHCCCEEEEEEECCCCCCEEECCCCCCCCCCEEEEEEC
DINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRRILWKRVVDLNDRALRHVTVG
CCEEEECCCEEEEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEE
LGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRRLANIVIGYRYDRTPVSVGDLQV
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHEEEEEEECCCCCCCCCEEE
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATTTALHLADYTVTEAG
CHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCEEECCC
FGADLGAEKFLDIKTPNLPTSPDAVVIVATLRALKMNGGVAKDALTEENVEAVRAGFANL
CCCCCCCCCEEEEECCCCCCCCCCEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
KRHVENIRKFGIPAVVAINEFVSDTEAEIAVLKELCASIDVPVELASVWADGAEGGVALA
HHHHHHHHHHCCCCEEEHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHH
ETVVKTIAENPANYKRLYDNDLSVQEKIEKIVTEIYRGSKVNFEKKAQTQIAQIVQNGWD
HHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
KLPICMAKTQYSFSDNPNALGAPENFEITIRELVPKLGAGFIVALTGDVMTMPGLPKRPA
CCCEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEEEECCEEECCCCCCCCC
ALNMDVESDGTVLGLF
EEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA