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The map label for this gene is mutY

Identifier: 225859009

GI number: 225859009

Start: 1182918

End: 1184093

Strand: Reverse

Name: mutY

Synonym: SP70585_1274

Alternate gene names: 225859009

Gene position: 1184093-1182918 (Counterclockwise)

Preceding gene: 225859010

Following gene: 225859008

Centisome position: 54.2

GC content: 42.43

Gene sequence:

>1176_bases
ATGTTAGATTTGAAAGAATACGGTATCGTCATGTGGCCGGAGGAGAAAGTCATTTCTTTCCGTGAGAAACTTCTCGCTTG
GTATGATGAAAACAAAAGAGATTTGCCTTGGAGGAGAAGTAAAAATCCTTATCACATCTGGGTATCTGAAATCATGCTTC
AGCAGACCAGGGTGGATACAGTTATCCCTTACTACGAAAGATTTTTGGACTGGTTTCCAACTGTCGAAAGTCTGGCAACT
GCGCCTGAGGAGAGTTTACTGAAAGCTTGGGAGGGCTTGGGCTATTATTCTCGAGTTCGCAATATGCAGGCTGCAGCCCA
GCAGATTATGACTGACTTTGGTGGCCAATTTCCAAATACCTATGAAGGAATTTCCAGCTTGAAAGGGATTGGACCTTACA
CAGCAGGAGCCATTTCCAGTATTGCTTTTAACTTGCCTGAGCCAGCTGTAGATGGTAATGTCATGCGGGTCTTGGCGCGT
CTGTTTGAAGTCAACCACGATATTGGGATTCCAAGTAATCGAAAAATTTTTCAGGCAATGATGGAGATCTTGATTAATCC
AGATCGTCCAGGTGATTTTAATCAAGCCTTGATGGACTTAGGGTCTGATATTGAGTCTCCTGTAAATCCCAGACCTGAAG
AAAGCCCAGTCAAGGACTTTAGTGCGGCATATCAGAATGGAACCATGGACCGTTATCCAATTAAATCTCCTAAGAAAAAG
CCGGTTCCTATTTATCTTAAAGCCTTAGTTGTGAAAAATTCTCAAGGACAATTTTTACTTGAAAAAAATGAAAGCGAAAA
GCTCTTGGCAGGTTTTTGGCATTTCCCCTTTATAGAAGTTGATAACTTTTCGCAAGAAGAGCAGTTTGACCTCTTTCATC
AGGTTGCGGAAGAAAGTGTGAACTTTGGCCCCAGTCCAGAAGAGAGTTTCCAGCAGGACTATGACCTAGATGTTGATTGG
CTTGATGTTTGTTTTGATACAGTCCAGCATGTTTTTAGTCATCGAAAATGGCATGTACAGATTGTAGCAGGTCAGGTGAG
TGACTTCCATGATTTTTCAGATAGGGAAGTTCGTTGGCTTTCACCAGAAGAATTCAAGAATTACCCACTTGCCAAACCCC
AACAAAAAATCTGGCAGGCTTATGCACAAGCCAACTTAGACAGTAGCCAAGACTAG

Upstream 100 bases:

>100_bases
TCATTGAGTATAAGTAGATAGAAAAGTTATATACTATCTATTGAAAATATTATAAATCAGATACAAAGACAGGTGAAACC
TTCTGTGTTATACTAGAGAT

Downstream 100 bases:

>100_bases
CTATTGTGTCTTCTGACTATTTTTTGGTATAATAGTAGAGAAAAAGGTGAACATATGAAAAAAATACTAATTGTAGATGA
TGAGAAACCAATCTCGGATA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MLDLKEYGIVMWPEEKVISFREKLLAWYDENKRDLPWRRSKNPYHIWVSEIMLQQTRVDTVIPYYERFLDWFPTVESLAT
APEESLLKAWEGLGYYSRVRNMQAAAQQIMTDFGGQFPNTYEGISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLAR
LFEVNHDIGIPSNRKIFQAMMEILINPDRPGDFNQALMDLGSDIESPVNPRPEESPVKDFSAAYQNGTMDRYPIKSPKKK
PVPIYLKALVVKNSQGQFLLEKNESEKLLAGFWHFPFIEVDNFSQEEQFDLFHQVAEESVNFGPSPEESFQQDYDLDVDW
LDVCFDTVQHVFSHRKWHVQIVAGQVSDFHDFSDREVRWLSPEEFKNYPLAKPQQKIWQAYAQANLDSSQD

Sequences:

>Translated_391_residues
MLDLKEYGIVMWPEEKVISFREKLLAWYDENKRDLPWRRSKNPYHIWVSEIMLQQTRVDTVIPYYERFLDWFPTVESLAT
APEESLLKAWEGLGYYSRVRNMQAAAQQIMTDFGGQFPNTYEGISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLAR
LFEVNHDIGIPSNRKIFQAMMEILINPDRPGDFNQALMDLGSDIESPVNPRPEESPVKDFSAAYQNGTMDRYPIKSPKKK
PVPIYLKALVVKNSQGQFLLEKNESEKLLAGFWHFPFIEVDNFSQEEQFDLFHQVAEESVNFGPSPEESFQQDYDLDVDW
LDVCFDTVQHVFSHRKWHVQIVAGQVSDFHDFSDREVRWLSPEEFKNYPLAKPQQKIWQAYAQANLDSSQD
>Mature_391_residues
MLDLKEYGIVMWPEEKVISFREKLLAWYDENKRDLPWRRSKNPYHIWVSEIMLQQTRVDTVIPYYERFLDWFPTVESLAT
APEESLLKAWEGLGYYSRVRNMQAAAQQIMTDFGGQFPNTYEGISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLAR
LFEVNHDIGIPSNRKIFQAMMEILINPDRPGDFNQALMDLGSDIESPVNPRPEESPVKDFSAAYQNGTMDRYPIKSPKKK
PVPIYLKALVVKNSQGQFLLEKNESEKLLAGFWHFPFIEVDNFSQEEQFDLFHQVAEESVNFGPSPEESFQQDYDLDVDW
LDVCFDTVQHVFSHRKWHVQIVAGQVSDFHDFSDREVRWLSPEEFKNYPLAKPQQKIWQAYAQANLDSSQD

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=424, Percent_Identity=32.0754716981132, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI115298654, Length=424, Percent_Identity=32.0754716981132, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI115298652, Length=424, Percent_Identity=32.0754716981132, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI6912520, Length=424, Percent_Identity=32.0754716981132, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI115298650, Length=424, Percent_Identity=32.0754716981132, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI115298648, Length=424, Percent_Identity=32.0754716981132, Blast_Score=208, Evalue=7e-54,
Organism=Escherichia coli, GI1789331, Length=330, Percent_Identity=37.5757575757576, Blast_Score=197, Evalue=7e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 45295; Mature: 45295

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKEYGIVMWPEEKVISFREKLLAWYDENKRDLPWRRSKNPYHIWVSEIMLQQTRVDT
CCCCHHCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHH
VIPYYERFLDWFPTVESLATAPEESLLKAWEGLGYYSRVRNMQAAAQQIMTDFGGQFPNT
HHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
YEGISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLARLFEVNHDIGIPSNRKIFQAM
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
MEILINPDRPGDFNQALMDLGSDIESPVNPRPEESPVKDFSAAYQNGTMDRYPIKSPKKK
HHHHCCCCCCCCHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
PVPIYLKALVVKNSQGQFLLEKNESEKLLAGFWHFPFIEVDNFSQEEQFDLFHQVAEESV
CCCEEEEEEEEECCCCCEEEECCCCCHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHC
NFGPSPEESFQQDYDLDVDWLDVCFDTVQHVFSHRKWHVQIVAGQVSDFHDFSDREVRWL
CCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHCCCCCCCCEEEC
SPEEFKNYPLAKPQQKIWQAYAQANLDSSQD
CHHHHCCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLDLKEYGIVMWPEEKVISFREKLLAWYDENKRDLPWRRSKNPYHIWVSEIMLQQTRVDT
CCCCHHCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHH
VIPYYERFLDWFPTVESLATAPEESLLKAWEGLGYYSRVRNMQAAAQQIMTDFGGQFPNT
HHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
YEGISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLARLFEVNHDIGIPSNRKIFQAM
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
MEILINPDRPGDFNQALMDLGSDIESPVNPRPEESPVKDFSAAYQNGTMDRYPIKSPKKK
HHHHCCCCCCCCHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
PVPIYLKALVVKNSQGQFLLEKNESEKLLAGFWHFPFIEVDNFSQEEQFDLFHQVAEESV
CCCEEEEEEEEECCCCCEEEECCCCCHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHC
NFGPSPEESFQQDYDLDVDWLDVCFDTVQHVFSHRKWHVQIVAGQVSDFHDFSDREVRWL
CCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHCCCCCCCCEEEC
SPEEFKNYPLAKPQQKIWQAYAQANLDSSQD
CHHHHCCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]