BacMap

Definition	Streptococcus pneumoniae 70585, complete genome.
Accession	NC_012468
Length	2,184,682

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The map label for this gene is ppiB [C]

Identifier: 225858579

GI number: 225858579

Start: 747088

End: 747891

Strand: Reverse

Name: ppiB [C]

Synonym: SP70585_0814

Alternate gene names: 225858579

Gene position: 747891-747088 (Counterclockwise)

Preceding gene: 225858580

Following gene: 225858553

Centisome position: 34.23

GC content: 43.16

Gene sequence:

>804_bases
ATGAAAAAACTAGCAACCCTTCTTTTACTGTCTACTGTAGCCCTAGCTGGGTGTAGCAGCGTCCAACGCAGTCTGCGTGG
TGATGATTATGTTGATTCCAGTCTTGCTGCTGAAGAAAGTTCCAAAGTAGCTGCCCAATCTGCCAAGGAGTTAAACGATG
CTTTAACAAACGAAAACGCCAATTTCCCACAACTATCTAAGGAAGTTGCTGAAGATGAAGCCGAAGTGATTCTCCACACA
AGCCAAGGTGATATTCGCATTAAACTCTTCCCTAAACTCGCTCCTCTAGCGGTTGAAAATTTCCTCACTCACGCCAAAGA
AGGCTACTATAACGGTATTACCTTCCACCGTGTCATCGATGGCTTTATGGTCCAAACTGGAGATCCAAAAGGGGACGGTA
CAGGTGGTCAGTCCATCTGGCATGACAAGGATAAGACTAAAGACAAAGGAACTGGTTTCAAGAACGAGATTACTCCTTAT
TTGTATAACATCCGTGGTGCTCTTGCTATGGCTAATACTGGTCAACCAAACACCAATGGCAGCCAGTTCTTCATCAACCA
AAACTCTACAGATACCTCTTCTAAACTCCCTACAAGCAAGTATCCACAGAAAATTATCGAAGCCTACAAAGAAGGTGGAA
ACCCTAGTCTAGATGGCAAACACCCAGTCTTTGGTCAAGTGATTGACGGTATGGATGTTGTGGATAAGATTGCTAAAGCC
GAAAAAGATGAAAAAGACAAGCCAACTACTGCTATCACAATCAACAGCATCGAAGTGGTGAAAGACTACGATTTTAAATC
TTAA

Upstream 100 bases:

>100_bases
ATCCCAACTATTATCTAATCCAGTTCTGTAAACTACTAATATTTGAAATCCACTTCCTTTTAGGGTACAATGGTATAAAT
GAATTTTTGAGAGGATCAGA

Downstream 100 bases:

>100_bases
AAACCAAAAAAAATACAGTATCCACATTCGGTACTGTATTTCTTTTACTCTCATTCTTAAGTTAAATTATTAAAATCCCA
TATTTGGTCTATCCAACCTT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MKKLATLLLLSTVALAGCSSVQRSLRGDDYVDSSLAAEESSKVAAQSAKELNDALTNENANFPQLSKEVAEDEAEVILHT
SQGDIRIKLFPKLAPLAVENFLTHAKEGYYNGITFHRVIDGFMVQTGDPKGDGTGGQSIWHDKDKTKDKGTGFKNEITPY
LYNIRGALAMANTGQPNTNGSQFFINQNSTDTSSKLPTSKYPQKIIEAYKEGGNPSLDGKHPVFGQVIDGMDVVDKIAKA
EKDEKDKPTTAITINSIEVVKDYDFKS

Sequences:

>Translated_267_residues
MKKLATLLLLSTVALAGCSSVQRSLRGDDYVDSSLAAEESSKVAAQSAKELNDALTNENANFPQLSKEVAEDEAEVILHT
SQGDIRIKLFPKLAPLAVENFLTHAKEGYYNGITFHRVIDGFMVQTGDPKGDGTGGQSIWHDKDKTKDKGTGFKNEITPY
LYNIRGALAMANTGQPNTNGSQFFINQNSTDTSSKLPTSKYPQKIIEAYKEGGNPSLDGKHPVFGQVIDGMDVVDKIAKA
EKDEKDKPTTAITINSIEVVKDYDFKS
>Mature_267_residues
MKKLATLLLLSTVALAGCSSVQRSLRGDDYVDSSLAAEESSKVAAQSAKELNDALTNENANFPQLSKEVAEDEAEVILHT
SQGDIRIKLFPKLAPLAVENFLTHAKEGYYNGITFHRVIDGFMVQTGDPKGDGTGGQSIWHDKDKTKDKGTGFKNEITPY
LYNIRGALAMANTGQPNTNGSQFFINQNSTDTSSKLPTSKYPQKIIEAYKEGGNPSLDGKHPVFGQVIDGMDVVDKIAKA
EKDEKDKPTTAITINSIEVVKDYDFKS

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=185, Percent_Identity=45.4054054054054, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI19557636, Length=186, Percent_Identity=42.4731182795699, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI7706339, Length=189, Percent_Identity=37.037037037037, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI64276486, Length=187, Percent_Identity=35.8288770053476, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI22547212, Length=261, Percent_Identity=33.7164750957854, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI7657473, Length=261, Percent_Identity=33.7164750957854, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI22547215, Length=259, Percent_Identity=33.976833976834, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4505991, Length=176, Percent_Identity=42.0454545454545, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4758950, Length=188, Percent_Identity=36.1702127659575, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI20911035, Length=181, Percent_Identity=34.8066298342541, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI42560244, Length=184, Percent_Identity=34.2391304347826, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4826932, Length=194, Percent_Identity=34.5360824742268, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI45439316, Length=164, Percent_Identity=37.1951219512195, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI5174637, Length=175, Percent_Identity=37.1428571428571, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI5454154, Length=182, Percent_Identity=35.1648351648352, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI5031987, Length=159, Percent_Identity=40.251572327044, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI303305009, Length=162, Percent_Identity=37.037037037037, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI6631100, Length=184, Percent_Identity=32.6086956521739, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI10863927, Length=161, Percent_Identity=36.6459627329193, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI150418007, Length=159, Percent_Identity=38.3647798742138, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI14277126, Length=191, Percent_Identity=32.4607329842932, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI256017253, Length=157, Percent_Identity=36.9426751592357, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI221139811, Length=157, Percent_Identity=36.9426751592357, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI256017251, Length=157, Percent_Identity=36.9426751592357, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI310129267, Length=159, Percent_Identity=35.8490566037736, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI310120620, Length=159, Percent_Identity=35.8490566037736, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI209417936, Length=159, Percent_Identity=35.8490566037736, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI30102944, Length=159, Percent_Identity=35.8490566037736, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI219842199, Length=159, Percent_Identity=35.8490566037736, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI310110104, Length=159, Percent_Identity=35.2201257861635, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI178057341, Length=159, Percent_Identity=35.8490566037736, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI169163387, Length=160, Percent_Identity=35, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI169164185, Length=160, Percent_Identity=35, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI169163623, Length=160, Percent_Identity=35, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786736, Length=189, Percent_Identity=37.037037037037, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789763, Length=195, Percent_Identity=32.3076923076923, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17506311, Length=187, Percent_Identity=43.3155080213904, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17532641, Length=235, Percent_Identity=36.1702127659575, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71980594, Length=185, Percent_Identity=38.9189189189189, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17539496, Length=180, Percent_Identity=40, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71980590, Length=174, Percent_Identity=40.8045977011494, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71997782, Length=153, Percent_Identity=39.8692810457516, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17506307, Length=177, Percent_Identity=40.1129943502825, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17552780, Length=177, Percent_Identity=37.8531073446328, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17551282, Length=193, Percent_Identity=37.3056994818653, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17551284, Length=193, Percent_Identity=37.3056994818653, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI32563659, Length=189, Percent_Identity=32.2751322751323, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17539498, Length=176, Percent_Identity=36.9318181818182, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17565860, Length=183, Percent_Identity=37.1584699453552, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17532643, Length=181, Percent_Identity=36.4640883977901, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17566266, Length=169, Percent_Identity=36.094674556213, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17559074, Length=188, Percent_Identity=33.5106382978723, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321848, Length=178, Percent_Identity=40.4494382022472, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320510, Length=178, Percent_Identity=38.7640449438202, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320359, Length=159, Percent_Identity=39.622641509434, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323562, Length=195, Percent_Identity=35.8974358974359, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323246, Length=196, Percent_Identity=36.2244897959184, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322492, Length=208, Percent_Identity=31.25, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922376, Length=185, Percent_Identity=40, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI19922912, Length=186, Percent_Identity=48.9247311827957, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI17986117, Length=187, Percent_Identity=38.5026737967914, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24652460, Length=186, Percent_Identity=37.0967741935484, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21357249, Length=191, Percent_Identity=36.1256544502618, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20130249, Length=177, Percent_Identity=37.8531073446328, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21355677, Length=188, Percent_Identity=32.9787234042553, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136360, Length=179, Percent_Identity=36.8715083798883, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24650807, Length=192, Percent_Identity=33.8541666666667, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17647301, Length=183, Percent_Identity=36.6120218579235, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24664125, Length=159, Percent_Identity=37.7358490566038, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357783, Length=159, Percent_Identity=37.7358490566038, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24661775, Length=195, Percent_Identity=29.7435897435897, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21355237, Length=195, Percent_Identity=29.7435897435897, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24661771, Length=195, Percent_Identity=29.7435897435897, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 29066; Mature: 29066

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLATLLLLSTVALAGCSSVQRSLRGDDYVDSSLAAEESSKVAAQSAKELNDALTNENA
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NFPQLSKEVAEDEAEVILHTSQGDIRIKLFPKLAPLAVENFLTHAKEGYYNGITFHRVID
CCHHHHHHHHCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
GFMVQTGDPKGDGTGGQSIWHDKDKTKDKGTGFKNEITPYLYNIRGALAMANTGQPNTNG
HHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCCCCC
SQFFINQNSTDTSSKLPTSKYPQKIIEAYKEGGNPSLDGKHPVFGQVIDGMDVVDKIAKA
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHH
EKDEKDKPTTAITINSIEVVKDYDFKS
CCCCCCCCCEEEEECCEEEEECCCCCC
>Mature Secondary Structure
MKKLATLLLLSTVALAGCSSVQRSLRGDDYVDSSLAAEESSKVAAQSAKELNDALTNENA
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NFPQLSKEVAEDEAEVILHTSQGDIRIKLFPKLAPLAVENFLTHAKEGYYNGITFHRVID
CCHHHHHHHHCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
GFMVQTGDPKGDGTGGQSIWHDKDKTKDKGTGFKNEITPYLYNIRGALAMANTGQPNTNG
HHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCCCCC
SQFFINQNSTDTSSKLPTSKYPQKIIEAYKEGGNPSLDGKHPVFGQVIDGMDVVDKIAKA
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHH
EKDEKDKPTTAITINSIEVVKDYDFKS
CCCCCCCCCEEEEECCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA