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The map label for this gene is iclR [H]

Identifier: 225686912

GI number: 225686912

Start: 1147010

End: 1147792

Strand: Reverse

Name: iclR [H]

Synonym: BMEA_B1164

Alternate gene names: 225686912

Gene position: 1147792-1147010 (Counterclockwise)

Preceding gene: 225686919

Following gene: 225686911

Centisome position: 96.82

GC content: 60.79

Gene sequence:

>783_bases
ATGAGCACCATTGGCAAAGCTCTGACGCTTCTGGATGTCCTGTCGCGGCTGAATACCGAGGCGGGATTGACCGAGATTGC
GCAGGCCTGCGGATATGACAAGGCGACGACCCGCCGTTTTCTGGTCGATCTGGAAAAGCACGGCTTCGTCGAGCAACTGG
CCGAAAGCCGGAAATACCGAATCGGGGCCGAGCCGCTGCGGCTCGCGCGCATTCGCGAAGCCCGCTATCCCTTTCTGGGC
ACGGCCCTTCCATTCGTAAGGCAGCTTGCCGAGCGAACCGGCGAAACCGTGCATCTTTCCGAATTTTCCAACGGGCGGCT
TTCCACCATTCATGTGGAAGAATCACCCCGCGCCCATCGGGTTTTCATCAATGTCGGCATGATCCTGCCTTTCCACGCCA
CGGCATCGGGCCTCGCCTATCTGGCAGCCTGTGCGGACGATGTGGTGGAGGCCACGGTGACGAAATCGCTCGATACATTC
ACGGAATTTACGATCGCTGACCCGGAGGAAGTCCGGCGGCGCGTGCGCGAAGCACGGCAAAACGGCTTTTCCGTTAACCG
GCAGGGGCTGGAAGTGGGCGTGATGAGCACATCGGCGGCGATCCTCACACCCGGATCGAGACCGGTTGGCTGCATTACGG
TGGCCGCACCCCTTGCGCGTGCCGATGACGGGATCGTCATGCGATATGGCGCGGACGCCCATGCCACGGCTGAGGCTATT
TCCGCTGCCCTGTTCGCAGAACACAGGCAAGCCCGTTCCAATCAATCGAAGAGGAACGGTTGA

Upstream 100 bases:

>100_bases
TGCCGTGCGAAGCGCCCTTTGAGAGAGTGGAGAGAAGCTTGCGAAACGCCGCCGCAAGGCGCGTTGGCAGGCATGGGGCT
TGACCTGAGGAGGACGATTG

Downstream 100 bases:

>100_bases
TGACTGCGCATACCAATTCCCCCCGCATTCTGGTGATCGGCACGGGCGACACCAAGAGTGATGAACTGCTTTTCATGGCG
GATGTCATCGAAAGGGCTGG

Product: HTH-type transcriptional repressor AllR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MSTIGKALTLLDVLSRLNTEAGLTEIAQACGYDKATTRRFLVDLEKHGFVEQLAESRKYRIGAEPLRLARIREARYPFLG
TALPFVRQLAERTGETVHLSEFSNGRLSTIHVEESPRAHRVFINVGMILPFHATASGLAYLAACADDVVEATVTKSLDTF
TEFTIADPEEVRRRVREARQNGFSVNRQGLEVGVMSTSAAILTPGSRPVGCITVAAPLARADDGIVMRYGADAHATAEAI
SAALFAEHRQARSNQSKRNG

Sequences:

>Translated_260_residues
MSTIGKALTLLDVLSRLNTEAGLTEIAQACGYDKATTRRFLVDLEKHGFVEQLAESRKYRIGAEPLRLARIREARYPFLG
TALPFVRQLAERTGETVHLSEFSNGRLSTIHVEESPRAHRVFINVGMILPFHATASGLAYLAACADDVVEATVTKSLDTF
TEFTIADPEEVRRRVREARQNGFSVNRQGLEVGVMSTSAAILTPGSRPVGCITVAAPLARADDGIVMRYGADAHATAEAI
SAALFAEHRQARSNQSKRNG
>Mature_259_residues
STIGKALTLLDVLSRLNTEAGLTEIAQACGYDKATTRRFLVDLEKHGFVEQLAESRKYRIGAEPLRLARIREARYPFLGT
ALPFVRQLAERTGETVHLSEFSNGRLSTIHVEESPRAHRVFINVGMILPFHATASGLAYLAACADDVVEATVTKSLDTFT
EFTIADPEEVRRRVREARQNGFSVNRQGLEVGVMSTSAAILTPGSRPVGCITVAAPLARADDGIVMRYGADAHATAEAIS
AALFAEHRQARSNQSKRNG

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=246, Percent_Identity=26.4227642276423, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1786468, Length=247, Percent_Identity=25.9109311740891, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788131, Length=245, Percent_Identity=24.8979591836735, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786715, Length=240, Percent_Identity=24.5833333333333, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28339; Mature: 28207

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIGKALTLLDVLSRLNTEAGLTEIAQACGYDKATTRRFLVDLEKHGFVEQLAESRKYR
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCC
IGAEPLRLARIREARYPFLGTALPFVRQLAERTGETVHLSEFSNGRLSTIHVEESPRAHR
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCEEE
VFINVGMILPFHATASGLAYLAACADDVVEATVTKSLDTFTEFTIADPEEVRRRVREARQ
EEEEECEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHH
NGFSVNRQGLEVGVMSTSAAILTPGSRPVGCITVAAPLARADDGIVMRYGADAHATAEAI
CCCCCCCCCCEEEEEECCCEEECCCCCCCEEEEEHHHHHCCCCCEEEEECCCCHHHHHHH
SAALFAEHRQARSNQSKRNG
HHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
STIGKALTLLDVLSRLNTEAGLTEIAQACGYDKATTRRFLVDLEKHGFVEQLAESRKYR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCC
IGAEPLRLARIREARYPFLGTALPFVRQLAERTGETVHLSEFSNGRLSTIHVEESPRAHR
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCEEE
VFINVGMILPFHATASGLAYLAACADDVVEATVTKSLDTFTEFTIADPEEVRRRVREARQ
EEEEECEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHH
NGFSVNRQGLEVGVMSTSAAILTPGSRPVGCITVAAPLARADDGIVMRYGADAHATAEAI
CCCCCCCCCCEEEEEECCCEEECCCCCCCEEEEEHHHHHCCCCCEEEEECCCCHHHHHHH
SAALFAEHRQARSNQSKRNG
HHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]