BacMap

Definition	Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence.
Accession	NC_012442
Length	1,185,518

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The map label for this gene is hpaE [H]

Identifier: 225686904

GI number: 225686904

Start: 1138837

End: 1140351

Strand: Reverse

Name: hpaE [H]

Synonym: BMEA_B1156

Alternate gene names: 225686904

Gene position: 1140351-1138837 (Counterclockwise)

Preceding gene: 225686905

Following gene: 225686903

Centisome position: 96.19

GC content: 59.93

Gene sequence:

>1515_bases
ATGTCCAAGCTCGACGACAATGTCGCCAAAGCAAAAACCTATCTTGCCCGGTTTGAAAAAGGGGTTCTGAACCGCATTGG
CGGTGAAGACGTGGCCGCTGCCGATGGCGCGACTTTCGAGACGATTTCGCCGGTGGACCTGAAGCCGCTTGCAACCGTGG
CGCTTGGCAAGGCAGCGGATATCGACCGTGCTGCCAGGGCGGCAAAGGCCGCCTTTCCCGAATGGGCCGCAATGTCGGGC
GATGCGCGCAAGAAGCTCCTGCACAAGATTGCCGATGCCATTGTCGCCCGTGCCGAGGAAATCGCCTTCGTGGAATTCAT
GGATACGGGCCAGTCGCTGAAATTCATGGCCAAGGCGGCACTGCGCGGCGCGGAAAATTTCCGCTTCTTCGCAGACCGTG
CACCGGAAGCCCGCGACGGCAAGACGCTTCGCGGCCCCGGCCAGGTCAATATGACAACCCGTGTACCCATCGGGCCGGTC
GGCGTCATCACGCCGTGGAACACACCTTTCATGCTGTCGACATGGAAGATCGCTCCGGCACTTGCGGCAGGATGCACCGT
GGTTCACAAGCCGGCTGAATTTTCACCGCTGACGGCGCGCCTGCTCGTTGAAATTGCCGAGGAAGCCGGTCTGCCGAAAG
GCGTATGGAACCTCGTCAATGGCTTCGGGGAAGATGCGGGCAAGGCCCTGACCGAGCATCCCGACATCAAGGCCATCGGC
TTTGTGGGCGAAAGCCGCACAGGCTCGCTCATCATGAAGCAGGGGGCGGATACGCTGAAGCGCGTGCATTTTGAGCTTGG
CGGCAAAAACCCGGTGGTCGTCTTTGCCGATGCCGATCTGGAGCGCGCTGTCGATGCCGCCGTCTTCATGATCTATTCGC
TGAATGGTGAACGCTGCACGTCTTCCTCGCGCCTGCTGGTGGAAGCAAGCATCTATGAAAAATTCACCGCGCTGGTCGCT
GAAAAGGCAAAGCGTATCAAGGTCGGCCATCCGCTCGATCCTGAAACGGTTGTTGGCCCTCTGATCCATCCGGTTCATGA
AAAGAAAGTGCTGGAATATATCGAGATCGGCCGCAGCGAAGGCGCGACGGTTGCCGCAGGCGGCGCAAAATTCGCAGGGC
CGGGCGGTGGCTGCTATGTGTCGCCGACACTTTTCACCGCCGCCCACAACGGCATGCGCATCGCGCAGGAGGAGATTTTC
GGCCCGGTTCTGACCGCCATTCCTTTCAAGGACGAGGCCGAGGCGCTGGCGCTTGCCAATGATGTGAAGTACGGCCTGAC
CGGCTATCTATGGACCAATGACGTGACCCGCGCTTTCCGTTTCACCGATGCGCTGGAAGCCGGAATGATCTGGGTCAACT
CGGAAAATGTGCGCCATCTGCCAACGCCATTCGGCGGCGTGAAGAATTCCGGCATCGGCCGCGACGGCGGCGACTGGTCG
TTCGATTTCTACATGGAAACCAAGAATATCGCCTTCGCCAACGCTGCGCACGCGATTGCAAAACTCGGCGGCTGA

Upstream 100 bases:

>100_bases
TCATCCCCGCCTGCGCCAGAAGCAGGCCTGATCCACACGCGCACTACAGCGCGTCGCAGCCGGTTGTTTTCACAGCGCGG
CCCACATCACGGAGTAAAGC

Downstream 100 bases:

>100_bases
GCACGGGCATTTAAACCCCGCATCGCCGCATCTGACATATTGAGGAGGAAAATCATGCCCTTGCCGACCCCTAACCTTCA
CCCACCATTCAACATTGTGC

Product: 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase

Products: 5-carboxymethyl-2-hydroxymuconate; NADH; H+

Alternate protein names: CHMS dehydrogenase [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSKLDDNVAKAKTYLARFEKGVLNRIGGEDVAAADGATFETISPVDLKPLATVALGKAADIDRAARAAKAAFPEWAAMSG
DARKKLLHKIADAIVARAEEIAFVEFMDTGQSLKFMAKAALRGAENFRFFADRAPEARDGKTLRGPGQVNMTTRVPIGPV
GVITPWNTPFMLSTWKIAPALAAGCTVVHKPAEFSPLTARLLVEIAEEAGLPKGVWNLVNGFGEDAGKALTEHPDIKAIG
FVGESRTGSLIMKQGADTLKRVHFELGGKNPVVVFADADLERAVDAAVFMIYSLNGERCTSSSRLLVEASIYEKFTALVA
EKAKRIKVGHPLDPETVVGPLIHPVHEKKVLEYIEIGRSEGATVAAGGAKFAGPGGGCYVSPTLFTAAHNGMRIAQEEIF
GPVLTAIPFKDEAEALALANDVKYGLTGYLWTNDVTRAFRFTDALEAGMIWVNSENVRHLPTPFGGVKNSGIGRDGGDWS
FDFYMETKNIAFANAAHAIAKLGG

Sequences:

>Translated_504_residues
MSKLDDNVAKAKTYLARFEKGVLNRIGGEDVAAADGATFETISPVDLKPLATVALGKAADIDRAARAAKAAFPEWAAMSG
DARKKLLHKIADAIVARAEEIAFVEFMDTGQSLKFMAKAALRGAENFRFFADRAPEARDGKTLRGPGQVNMTTRVPIGPV
GVITPWNTPFMLSTWKIAPALAAGCTVVHKPAEFSPLTARLLVEIAEEAGLPKGVWNLVNGFGEDAGKALTEHPDIKAIG
FVGESRTGSLIMKQGADTLKRVHFELGGKNPVVVFADADLERAVDAAVFMIYSLNGERCTSSSRLLVEASIYEKFTALVA
EKAKRIKVGHPLDPETVVGPLIHPVHEKKVLEYIEIGRSEGATVAAGGAKFAGPGGGCYVSPTLFTAAHNGMRIAQEEIF
GPVLTAIPFKDEAEALALANDVKYGLTGYLWTNDVTRAFRFTDALEAGMIWVNSENVRHLPTPFGGVKNSGIGRDGGDWS
FDFYMETKNIAFANAAHAIAKLGG
>Mature_503_residues
SKLDDNVAKAKTYLARFEKGVLNRIGGEDVAAADGATFETISPVDLKPLATVALGKAADIDRAARAAKAAFPEWAAMSGD
ARKKLLHKIADAIVARAEEIAFVEFMDTGQSLKFMAKAALRGAENFRFFADRAPEARDGKTLRGPGQVNMTTRVPIGPVG
VITPWNTPFMLSTWKIAPALAAGCTVVHKPAEFSPLTARLLVEIAEEAGLPKGVWNLVNGFGEDAGKALTEHPDIKAIGF
VGESRTGSLIMKQGADTLKRVHFELGGKNPVVVFADADLERAVDAAVFMIYSLNGERCTSSSRLLVEASIYEKFTALVAE
KAKRIKVGHPLDPETVVGPLIHPVHEKKVLEYIEIGRSEGATVAAGGAKFAGPGGGCYVSPTLFTAAHNGMRIAQEEIFG
PVLTAIPFKDEAEALALANDVKYGLTGYLWTNDVTRAFRFTDALEAGMIWVNSENVRHLPTPFGGVKNSGIGRDGGDWSF
DFYMETKNIAFANAAHAIAKLGG

Specific function: Transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde (CHMS) into 5-carboxymethyl-2-hydroxy-muconic acid (CHM) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI25777730, Length=473, Percent_Identity=40.5919661733615, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI12007648, Length=438, Percent_Identity=38.8127853881278, Blast_Score=330, Evalue=3e-90,
Organism=Homo sapiens, GI153266822, Length=471, Percent_Identity=39.7027600849257, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI238814322, Length=478, Percent_Identity=38.4937238493724, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI21614513, Length=478, Percent_Identity=39.1213389121339, Blast_Score=322, Evalue=4e-88,
Organism=Homo sapiens, GI21361176, Length=466, Percent_Identity=39.6995708154506, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI25777724, Length=471, Percent_Identity=39.0658174097665, Blast_Score=311, Evalue=8e-85,
Organism=Homo sapiens, GI115387104, Length=476, Percent_Identity=36.344537815126, Blast_Score=310, Evalue=3e-84,
Organism=Homo sapiens, GI25777732, Length=459, Percent_Identity=38.1263616557734, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI25777728, Length=416, Percent_Identity=40.3846153846154, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI25777726, Length=470, Percent_Identity=35.9574468085106, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI25952152, Length=438, Percent_Identity=33.7899543378995, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI4507229, Length=473, Percent_Identity=34.6723044397463, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI25777721, Length=486, Percent_Identity=33.7448559670782, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI301500698, Length=279, Percent_Identity=38.7096774193548, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI188035924, Length=471, Percent_Identity=28.6624203821656, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI310128103, Length=471, Percent_Identity=28.6624203821656, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI310128093, Length=470, Percent_Identity=28.2978723404255, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI11095441, Length=475, Percent_Identity=29.6842105263158, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI310128091, Length=462, Percent_Identity=28.5714285714286, Blast_Score=182, Evalue=9e-46,
Organism=Homo sapiens, GI310128089, Length=296, Percent_Identity=31.7567567567568, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI4557303, Length=332, Percent_Identity=29.5180722891566, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI73466520, Length=332, Percent_Identity=29.2168674698795, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI310128097, Length=258, Percent_Identity=32.5581395348837, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI223972651, Length=437, Percent_Identity=26.7734553775744, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI238859541, Length=471, Percent_Identity=28.8747346072187, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI25777736, Length=471, Percent_Identity=28.8747346072187, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI25777734, Length=471, Percent_Identity=28.8747346072187, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI310128095, Length=322, Percent_Identity=28.5714285714286, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI206597441, Length=337, Percent_Identity=29.9703264094956, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI206597439, Length=337, Percent_Identity=29.9703264094956, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI22907049, Length=337, Percent_Identity=29.9703264094956, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI73695881, Length=342, Percent_Identity=28.0701754385965, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI73695879, Length=342, Percent_Identity=28.0701754385965, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI4502043, Length=334, Percent_Identity=28.1437125748503, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI238814371, Length=334, Percent_Identity=28.1437125748503, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI71773324, Length=334, Percent_Identity=28.1437125748503, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI310128087, Length=471, Percent_Identity=24.203821656051, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI223972653, Length=174, Percent_Identity=28.1609195402299, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787558, Length=470, Percent_Identity=41.7021276595745, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI1786504, Length=469, Percent_Identity=38.592750533049, Blast_Score=311, Evalue=6e-86,
Organism=Escherichia coli, GI87081896, Length=459, Percent_Identity=36.6013071895425, Blast_Score=301, Evalue=5e-83,
Organism=Escherichia coli, GI87082295, Length=476, Percent_Identity=38.655462184874, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI1789015, Length=476, Percent_Identity=33.4033613445378, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1787715, Length=426, Percent_Identity=35.9154929577465, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1787684, Length=466, Percent_Identity=32.618025751073, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87081926, Length=435, Percent_Identity=30.8045977011494, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1788042, Length=465, Percent_Identity=27.0967741935484, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1787250, Length=432, Percent_Identity=28.0092592592593, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787653, Length=307, Percent_Identity=24.4299674267101, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133930964, Length=478, Percent_Identity=39.5397489539749, Blast_Score=340, Evalue=9e-94,
Organism=Caenorhabditis elegans, GI17562198, Length=471, Percent_Identity=39.4904458598726, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI25144435, Length=473, Percent_Identity=38.9006342494715, Blast_Score=321, Evalue=5e-88,
Organism=Caenorhabditis elegans, GI25143876, Length=472, Percent_Identity=36.0169491525424, Blast_Score=295, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI25143874, Length=472, Percent_Identity=36.0169491525424, Blast_Score=294, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI71995606, Length=478, Percent_Identity=35.9832635983264, Blast_Score=287, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI32564736, Length=418, Percent_Identity=38.0382775119617, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17551164, Length=481, Percent_Identity=35.3430353430353, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17534119, Length=493, Percent_Identity=33.6713995943205, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71995613, Length=414, Percent_Identity=36.7149758454106, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71986308, Length=473, Percent_Identity=31.7124735729387, Blast_Score=201, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI115534176, Length=480, Percent_Identity=28.5416666666667, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17534447, Length=335, Percent_Identity=28.3582089552239, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI115532534, Length=375, Percent_Identity=28.2666666666667, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17564084, Length=337, Percent_Identity=29.9703264094956, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI32566756, Length=338, Percent_Identity=28.4023668639053, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25146394, Length=338, Percent_Identity=28.4023668639053, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25146391, Length=338, Percent_Identity=28.4023668639053, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32564151, Length=335, Percent_Identity=28.3582089552239, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71990744, Length=178, Percent_Identity=28.6516853932584, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320917, Length=470, Percent_Identity=38.2978723404255, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6324950, Length=476, Percent_Identity=36.9747899159664, Blast_Score=316, Evalue=7e-87,
Organism=Saccharomyces cerevisiae, GI6323822, Length=476, Percent_Identity=36.344537815126, Blast_Score=300, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6323821, Length=476, Percent_Identity=35.2941176470588, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6325196, Length=470, Percent_Identity=34.6808510638298, Blast_Score=276, Evalue=6e-75,
Organism=Saccharomyces cerevisiae, GI6319478, Length=498, Percent_Identity=31.9277108433735, Blast_Score=266, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6321828, Length=460, Percent_Identity=25.8695652173913, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6321826, Length=485, Percent_Identity=25.1546391752577, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323757, Length=353, Percent_Identity=27.7620396600567, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24650465, Length=469, Percent_Identity=41.36460554371, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI20129399, Length=473, Percent_Identity=38.6892177589852, Blast_Score=314, Evalue=9e-86,
Organism=Drosophila melanogaster, GI24585660, Length=474, Percent_Identity=36.7088607594937, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI281362580, Length=466, Percent_Identity=34.9785407725322, Blast_Score=282, Evalue=5e-76,
Organism=Drosophila melanogaster, GI62472918, Length=466, Percent_Identity=34.9785407725322, Blast_Score=282, Evalue=5e-76,
Organism=Drosophila melanogaster, GI62472926, Length=466, Percent_Identity=34.9785407725322, Blast_Score=282, Evalue=5e-76,
Organism=Drosophila melanogaster, GI62472936, Length=466, Percent_Identity=34.9785407725322, Blast_Score=282, Evalue=5e-76,
Organism=Drosophila melanogaster, GI21356737, Length=466, Percent_Identity=34.9785407725322, Blast_Score=282, Evalue=5e-76,
Organism=Drosophila melanogaster, GI24638876, Length=473, Percent_Identity=28.3298097251586, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24638878, Length=473, Percent_Identity=28.3298097251586, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24666674, Length=482, Percent_Identity=26.5560165975104, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24668425, Length=448, Percent_Identity=26.1160714285714, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24668417, Length=448, Percent_Identity=26.1160714285714, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24668413, Length=448, Percent_Identity=26.1160714285714, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI281360299, Length=351, Percent_Identity=26.7806267806268, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281360297, Length=351, Percent_Identity=26.7806267806268, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281360295, Length=351, Percent_Identity=26.7806267806268, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24586250, Length=351, Percent_Identity=26.7806267806268, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281360301, Length=351, Percent_Identity=26.7806267806268, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45552499, Length=349, Percent_Identity=26.647564469914, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360303, Length=349, Percent_Identity=26.647564469914, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571806, Length=464, Percent_Identity=23.7068965517241, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28571802, Length=464, Percent_Identity=23.7068965517241, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28571800, Length=464, Percent_Identity=23.7068965517241, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28571798, Length=464, Percent_Identity=23.7068965517241, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28571796, Length=464, Percent_Identity=23.7068965517241, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28571794, Length=464, Percent_Identity=23.7068965517241, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574525, Length=343, Percent_Identity=26.2390670553936, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016160
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR011985 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: 1.2.1.60

Molecular weight: Translated: 53870; Mature: 53739

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLDDNVAKAKTYLARFEKGVLNRIGGEDVAAADGATFETISPVDLKPLATVALGKAAD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCHHHHHHCCCCCC
IDRAARAAKAAFPEWAAMSGDARKKLLHKIADAIVARAEEIAFVEFMDTGQSLKFMAKAA
HHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHH
LRGAENFRFFADRAPEARDGKTLRGPGQVNMTTRVPIGPVGVITPWNTPFMLSTWKIAPA
HCCCCCCEEECCCCCCCCCCCEECCCCCEEEEEECCCCCEEEECCCCCCEEEEEHHHHHH
LAAGCTVVHKPAEFSPLTARLLVEIAEEAGLPKGVWNLVNGFGEDAGKALTEHPDIKAIG
HHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHCCCCEEEEE
FVGESRTGSLIMKQGADTLKRVHFELGGKNPVVVFADADLERAVDAAVFMIYSLNGERCT
ECCCCCCCCEEECCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHEEEEEECCCCCCC
SSSRLLVEASIYEKFTALVAEKAKRIKVGHPLDPETVVGPLIHPVHEKKVLEYIEIGRSE
CCCCEEEEHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCC
GATVAAGGAKFAGPGGGCYVSPTLFTAAHNGMRIAQEEIFGPVLTAIPFKDEAEALALAN
CCEEEECCCEECCCCCCEEECCHHEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
DVKYGLTGYLWTNDVTRAFRFTDALEAGMIWVNSENVRHLPTPFGGVKNSGIGRDGGDWS
CCCCCCEEEEECCCHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCE
FDFYMETKNIAFANAAHAIAKLGG
EEEEEEECCEEHHHHHHHHHHCCC
>Mature Secondary Structure 
SKLDDNVAKAKTYLARFEKGVLNRIGGEDVAAADGATFETISPVDLKPLATVALGKAAD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCHHHHHHCCCCCC
IDRAARAAKAAFPEWAAMSGDARKKLLHKIADAIVARAEEIAFVEFMDTGQSLKFMAKAA
HHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHH
LRGAENFRFFADRAPEARDGKTLRGPGQVNMTTRVPIGPVGVITPWNTPFMLSTWKIAPA
HCCCCCCEEECCCCCCCCCCCEECCCCCEEEEEECCCCCEEEECCCCCCEEEEEHHHHHH
LAAGCTVVHKPAEFSPLTARLLVEIAEEAGLPKGVWNLVNGFGEDAGKALTEHPDIKAIG
HHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHCCCCEEEEE
FVGESRTGSLIMKQGADTLKRVHFELGGKNPVVVFADADLERAVDAAVFMIYSLNGERCT
ECCCCCCCCEEECCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHEEEEEECCCCCCC
SSSRLLVEASIYEKFTALVAEKAKRIKVGHPLDPETVVGPLIHPVHEKKVLEYIEIGRSE
CCCCEEEEHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCC
GATVAAGGAKFAGPGGGCYVSPTLFTAAHNGMRIAQEEIFGPVLTAIPFKDEAEALALAN
CCEEEECCCEECCCCCCEEECCHHEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
DVKYGLTGYLWTNDVTRAFRFTDALEAGMIWVNSENVRHLPTPFGGVKNSGIGRDGGDWS
CCCCCCEEEEECCCHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCE
FDFYMETKNIAFANAAHAIAKLGG
EEEEEEECCEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-carboxymethyl-2-hydroxymuconate semialdehyde; H2O; NAD+

Specific reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7737515 [H]