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The map label for this gene is acoC [H]

Identifier: 225686853

GI number: 225686853

Start: 1070915

End: 1072201

Strand: Reverse

Name: acoC [H]

Synonym: BMEA_B1093

Alternate gene names: 225686853

Gene position: 1072201-1070915 (Counterclockwise)

Preceding gene: 225686854

Following gene: 225686848

Centisome position: 90.44

GC content: 59.75

Gene sequence:

>1287_bases
ATGGCCACTGAAATTCTATATCCAAAAGTCAGTCTGGAAACCAATTCCGGAACGATTTCGCGTTGGCACGTCCAGGATGG
TGACGCGGTCGAACAGGGCCAGATCCTGTTCGAGATAGACAATGACAAGACAGTCGTGGAGGTTGATGCGCCGCATGCCG
GAACGGTAAAGATACTGAAATCTTCCACCACCGATGAAATCGAGGTCGGCCAGAGCGTCGCCAGCCTGTTTGCCAAGGGA
GAAACGATCACCGCGCCTCCCGCACCGGCCGCAGCGCAAAATGCATCGGCGCCAAAAACGGCGGATATATTGGCGGTCGT
CAATAAAGGTCAAAATGGCAGGGCCATTGCGACACCTCTTGCCAGGCGCCTGGCCAATGATGCCGGGATCGACCTTGACC
GGATCGGCGGCACCGGCCCAGGCGGGCGCATCCAGAAGAAGGATGTCATTGCAGCATTGCAAAGCTGCCCATCCATTCCC
GAAACCATTGCTGCTTCGAGGCAGGCGCGGCCGGAAGGCGATTGCCTGCTTAATGCCGTGTGGCTGCGCAAGGGCGAAGG
GACGCCGCTTGTGCTGTTGCACGGCTTTGCCTCGGACCACAACAACTGGCGGGGGCTTTTTGCCGGCACACAATGGCAAC
AGCCCTTGCTGGCGATTGATCTGCCCTCCCATGGCGCTTCCCCGCTCGTCGCCGTCACGAGCCTTGATGCGATTGCCGCG
ATGATCGAGGCCACACTCAAGGCCCTCGATATCCAGCGTGCGATCCTTGTGGGCCATTCCTTTGGCGCAGCCGTCAGTGC
TCGCCTTGCCAATCGCGGCAATATCGACATCCGCGCCTTGGGCCTGTTTTCGCCAGCCGGGCTCGGTCCGGAAATCAATG
TCGGGTTCGTCCAGAACTTCGTTCGGGCAAGGGCGAGGGAAAGTGTGACCCCGTGGCTGCACGAGCTTGTGCACGACAAG
GCCAGCATTTCCGATACTTTCATCAAGGCCGTCGTGCAGCAGCGCCAGGATAACGATCTGAGCGACGCCATGATGGCATT
TTCCGAACATTTCTTCGCCGACGGCACGCAGACCGTCTCCATTCTCGACGATCTCGCCTCGCTCGAAATTCCCGTCCGCG
TCATTTACGGCAGGCAGGACAGGATATTGCCGTTCCGCTACACCCGGAACCTGCCCGACAATGTCGCGCTGTATGCGTTC
GATGCTTGCGGGCACATGCCGCATCTGGAAAAGCGCGGCCTGAGCCTGCGCATCCTGGCGGAGGTTTCCGCCTCCGCGGC
AGGCTGA

Upstream 100 bases:

>100_bases
TGCAGGAGCGGCTCCTAGGCAATTCCAGAGAGGCGCCTTGAGAGCATATTTTCCGTGAAATTCTGAAGGCTGCGAAAGCC
CAATTGTTGCAGGACACCCT

Downstream 100 bases:

>100_bases
GCGACACAAAAGCCTGCCATAGCAAAAAGCCACCGATGCGGGATCGGTGGCTTTTTCTTTTCAAAAACAGGTTCCCGTCA
TGCCTATCTGGATACGGAAA

Product: branched-chain alpha-keto acid dehydrogenase subunit E2

Products: NA

Alternate protein names: Acetoin dehydrogenase E2 component; Dihydrolipoamide acetyltransferase component of acetoin cleaving system [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MATEILYPKVSLETNSGTISRWHVQDGDAVEQGQILFEIDNDKTVVEVDAPHAGTVKILKSSTTDEIEVGQSVASLFAKG
ETITAPPAPAAAQNASAPKTADILAVVNKGQNGRAIATPLARRLANDAGIDLDRIGGTGPGGRIQKKDVIAALQSCPSIP
ETIAASRQARPEGDCLLNAVWLRKGEGTPLVLLHGFASDHNNWRGLFAGTQWQQPLLAIDLPSHGASPLVAVTSLDAIAA
MIEATLKALDIQRAILVGHSFGAAVSARLANRGNIDIRALGLFSPAGLGPEINVGFVQNFVRARARESVTPWLHELVHDK
ASISDTFIKAVVQQRQDNDLSDAMMAFSEHFFADGTQTVSILDDLASLEIPVRVIYGRQDRILPFRYTRNLPDNVALYAF
DACGHMPHLEKRGLSLRILAEVSASAAG

Sequences:

>Translated_428_residues
MATEILYPKVSLETNSGTISRWHVQDGDAVEQGQILFEIDNDKTVVEVDAPHAGTVKILKSSTTDEIEVGQSVASLFAKG
ETITAPPAPAAAQNASAPKTADILAVVNKGQNGRAIATPLARRLANDAGIDLDRIGGTGPGGRIQKKDVIAALQSCPSIP
ETIAASRQARPEGDCLLNAVWLRKGEGTPLVLLHGFASDHNNWRGLFAGTQWQQPLLAIDLPSHGASPLVAVTSLDAIAA
MIEATLKALDIQRAILVGHSFGAAVSARLANRGNIDIRALGLFSPAGLGPEINVGFVQNFVRARARESVTPWLHELVHDK
ASISDTFIKAVVQQRQDNDLSDAMMAFSEHFFADGTQTVSILDDLASLEIPVRVIYGRQDRILPFRYTRNLPDNVALYAF
DACGHMPHLEKRGLSLRILAEVSASAAG
>Mature_427_residues
ATEILYPKVSLETNSGTISRWHVQDGDAVEQGQILFEIDNDKTVVEVDAPHAGTVKILKSSTTDEIEVGQSVASLFAKGE
TITAPPAPAAAQNASAPKTADILAVVNKGQNGRAIATPLARRLANDAGIDLDRIGGTGPGGRIQKKDVIAALQSCPSIPE
TIAASRQARPEGDCLLNAVWLRKGEGTPLVLLHGFASDHNNWRGLFAGTQWQQPLLAIDLPSHGASPLVAVTSLDAIAAM
IEATLKALDIQRAILVGHSFGAAVSARLANRGNIDIRALGLFSPAGLGPEINVGFVQNFVRARARESVTPWLHELVHDKA
SISDTFIKAVVQQRQDNDLSDAMMAFSEHFFADGTQTVSILDDLASLEIPVRVIYGRQDRILPFRYTRNLPDNVALYAFD
ACGHMPHLEKRGLSLRILAEVSASAAG

Specific function: The 2-Oxoglutarate Dehydrogenase Complex Catalyzes The Overall Conversion Of 2-Oxoglutarate To Succinyl-CoA And Co(2). It Contains Multiple Copies Of Three Enzymatic Components: 2- Oxoglutarate Dehydrogenase (E1), Dihydrolipoamide Succinyltransferase (E2)

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=170, Percent_Identity=28.2352941176471, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537937, Length=142, Percent_Identity=30.9859154929577, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000073
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF00364 Biotin_lipoyl [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 45697; Mature: 45566

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATEILYPKVSLETNSGTISRWHVQDGDAVEQGQILFEIDNDKTVVEVDAPHAGTVKILK
CCCCEECCEEEEECCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEE
SSTTDEIEVGQSVASLFAKGETITAPPAPAAAQNASAPKTADILAVVNKGQNGRAIATPL
CCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCHHEEEEEEECCCCCCCHHHHH
ARRLANDAGIDLDRIGGTGPGGRIQKKDVIAALQSCPSIPETIAASRQARPEGDCLLNAV
HHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEE
WLRKGEGTPLVLLHGFASDHNNWRGLFAGTQWQQPLLAIDLPSHGASPLVAVTSLDAIAA
EEECCCCCCEEEEEEECCCCCCCEEEECCCCCCCCEEEEECCCCCCCCEEEEHHHHHHHH
MIEATLKALDIQRAILVGHSFGAAVSARLANRGNIDIRALGLFSPAGLGPEINVGFVQNF
HHHHHHHHHHHHHHEEEECCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHHHHH
VRARARESVTPWLHELVHDKASISDTFIKAVVQQRQDNDLSDAMMAFSEHFFADGTQTVS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHH
ILDDLASLEIPVRVIYGRQDRILPFRYTRNLPDNVALYAFDACGHMPHLEKRGLSLRILA
HHHHHHHCCCCEEEEECCCCCEEEEHCCCCCCCCEEEEEECCCCCCCCHHHCCCEEEEEE
EVSASAAG
ECCCCCCC
>Mature Secondary Structure 
ATEILYPKVSLETNSGTISRWHVQDGDAVEQGQILFEIDNDKTVVEVDAPHAGTVKILK
CCCEECCEEEEECCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEE
SSTTDEIEVGQSVASLFAKGETITAPPAPAAAQNASAPKTADILAVVNKGQNGRAIATPL
CCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCHHEEEEEEECCCCCCCHHHHH
ARRLANDAGIDLDRIGGTGPGGRIQKKDVIAALQSCPSIPETIAASRQARPEGDCLLNAV
HHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEE
WLRKGEGTPLVLLHGFASDHNNWRGLFAGTQWQQPLLAIDLPSHGASPLVAVTSLDAIAA
EEECCCCCCEEEEEEECCCCCCCEEEECCCCCCCCEEEEECCCCCCCCEEEEHHHHHHHH
MIEATLKALDIQRAILVGHSFGAAVSARLANRGNIDIRALGLFSPAGLGPEINVGFVQNF
HHHHHHHHHHHHHHEEEECCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHHHHH
VRARARESVTPWLHELVHDKASISDTFIKAVVQQRQDNDLSDAMMAFSEHFFADGTQTVS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHH
ILDDLASLEIPVRVIYGRQDRILPFRYTRNLPDNVALYAFDACGHMPHLEKRGLSLRILA
HHHHHHHCCCCEEEEECCCCCEEEEHCCCCCCCCEEEEEECCCCCCCCHHHCCCEEEEEE
EVSASAAG
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7813883 [H]