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The map label for this gene is msrA [H]

Identifier: 225686821

GI number: 225686821

Start: 1032282

End: 1032938

Strand: Reverse

Name: msrA [H]

Synonym: BMEA_B1056

Alternate gene names: 225686821

Gene position: 1032938-1032282 (Counterclockwise)

Preceding gene: 225686822

Following gene: 225686818

Centisome position: 87.13

GC content: 56.77

Gene sequence:

>657_bases
ATGAGTTTCTTCGACAGCTACCGCAAGAAGATGCAGATGCCTTCAAAAGAAGAAGTATTGCCAGGGCGTGTTCAACCGAT
CCCGACGGCTGCGGCGCATTTCGTTTCCGGCCATCCGCTAAAGGGGCCATGGCCTGACGGGATGAAGCAGGTTCTGTTTG
GCATGGGCTGCTTCTGGGGTGCGGAGCGGCTTTTCTGGCAGGTGCCGGGCGTGTATGTGACGGCTGTAGGCTATGCAGGC
GGCATCACACCCAATCCGACCTATGAGGAAACCTGCACGGGGCTGACCGGCCATGCGGAAGTGGTGCTGGTGGTCTATGA
CCCGAAGGTTGTGACGCTCAATGAATTGCTGGCCCTTTTCTGGGAAGAACATGATCCGACCCAGGGGATGCGGCAGGGCA
ATGATATCGGCACGACCTATCGCTCGGTGATCTATACGTTTAATGCGGTCGATCGTGCGGTTGCGGAAAAGAGCCGCGAT
GCTTATTCGCAGGCACTCGCCTCACGCGGCCTTGGTCCTGTCACGACGCAAATCACCGAGGCGCCCGATTTCTATTATGC
TGAGGATTATCATCAGCAATATCTGGCGAAAAATCCGGATGGCTATTGCGGGTTGCGCGGAACCGGTGTGAGTTGCCCGA
TCCCTCTTGCGCATTGA

Upstream 100 bases:

>100_bases
TTCGGTGTGCTTGCGCTTCTGTTCTATGCCATCGGTCATCGCCGGGAGCGGCCTCTTGGCCGCTTCACTGCCCGGTAATT
AAATTCAGGAGGAAGGGGCC

Downstream 100 bases:

>100_bases
TCAGGCGCGCGCTTACCAGTGCGGCGGCTTGGTGACGGGCACGTCCGGCGCAGCCTGTTCTTCCAGTTCCAGAAAGCGGT
TGGTAAGGGCGTTCAGCTTC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MSFFDSYRKKMQMPSKEEVLPGRVQPIPTAAAHFVSGHPLKGPWPDGMKQVLFGMGCFWGAERLFWQVPGVYVTAVGYAG
GITPNPTYEETCTGLTGHAEVVLVVYDPKVVTLNELLALFWEEHDPTQGMRQGNDIGTTYRSVIYTFNAVDRAVAEKSRD
AYSQALASRGLGPVTTQITEAPDFYYAEDYHQQYLAKNPDGYCGLRGTGVSCPIPLAH

Sequences:

>Translated_218_residues
MSFFDSYRKKMQMPSKEEVLPGRVQPIPTAAAHFVSGHPLKGPWPDGMKQVLFGMGCFWGAERLFWQVPGVYVTAVGYAG
GITPNPTYEETCTGLTGHAEVVLVVYDPKVVTLNELLALFWEEHDPTQGMRQGNDIGTTYRSVIYTFNAVDRAVAEKSRD
AYSQALASRGLGPVTTQITEAPDFYYAEDYHQQYLAKNPDGYCGLRGTGVSCPIPLAH
>Mature_217_residues
SFFDSYRKKMQMPSKEEVLPGRVQPIPTAAAHFVSGHPLKGPWPDGMKQVLFGMGCFWGAERLFWQVPGVYVTAVGYAGG
ITPNPTYEETCTGLTGHAEVVLVVYDPKVVTLNELLALFWEEHDPTQGMRQGNDIGTTYRSVIYTFNAVDRAVAEKSRDA
YSQALASRGLGPVTTQITEAPDFYYAEDYHQQYLAKNPDGYCGLRGTGVSCPIPLAH

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=200, Percent_Identity=59.5, Blast_Score=258, Evalue=3e-69,
Organism=Homo sapiens, GI208609995, Length=184, Percent_Identity=59.7826086956522, Blast_Score=240, Evalue=5e-64,
Organism=Homo sapiens, GI208609993, Length=200, Percent_Identity=45.5, Blast_Score=176, Evalue=1e-44,
Organism=Escherichia coli, GI1790665, Length=200, Percent_Identity=55.5, Blast_Score=222, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=36.0544217687075, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=36.144578313253, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=40.1408450704225, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24664631, Length=142, Percent_Identity=39.4366197183099, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=39.2857142857143, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24061; Mature: 23930

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFDSYRKKMQMPSKEEVLPGRVQPIPTAAAHFVSGHPLKGPWPDGMKQVLFGMGCFWG
CCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AERLFWQVPGVYVTAVGYAGGITPNPTYEETCTGLTGHAEVVLVVYDPKVVTLNELLALF
HHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCEEEHHHHHHHH
WEEHDPTQGMRQGNDIGTTYRSVIYTFNAVDRAVAEKSRDAYSQALASRGLGPVTTQITE
HHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
APDFYYAEDYHQQYLAKNPDGYCGLRGTGVSCPIPLAH
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SFFDSYRKKMQMPSKEEVLPGRVQPIPTAAAHFVSGHPLKGPWPDGMKQVLFGMGCFWG
CHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AERLFWQVPGVYVTAVGYAGGITPNPTYEETCTGLTGHAEVVLVVYDPKVVTLNELLALF
HHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCEEEHHHHHHHH
WEEHDPTQGMRQGNDIGTTYRSVIYTFNAVDRAVAEKSRDAYSQALASRGLGPVTTQITE
HHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
APDFYYAEDYHQQYLAKNPDGYCGLRGTGVSCPIPLAH
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA