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The map label for this gene is ubiE

Identifier: 225686818

GI number: 225686818

Start: 1030206

End: 1031015

Strand: Reverse

Name: ubiE

Synonym: BMEA_B1053

Alternate gene names: 225686818

Gene position: 1031015-1030206 (Counterclockwise)

Preceding gene: 225686821

Following gene: 225686817

Centisome position: 86.97

GC content: 56.79

Gene sequence:

>810_bases
ATGAGCCAGCAAAACGGCAATGTGAACCGCGTGGGCGCACAAGATCGTGTTGGTGCATCGGGCGGCATGGAGCATTCATT
CGGCTTCAAGGCGGTGGACGAAAACGAAAAGCAGGGGCTGGTCAACGACGTTTTCCATAAGGTTGCCAAGCGTTACGACA
TCATGAACGATCTGATGTCTGCCGGTATGCACCGCGTCTGGAAAGATGCGATGGTGGCCTGGCTTGCGCCCTCGAAGCGC
CCCGGCTGGACCTCGCTTGATGTTGCAGGCGGCACGGGCGACATTGCCTTTCGCATCGTGGAAGCTTCGGGCCGCCAGGC
ACATGTCACCATTCTCGATATCAACGGGTCGATGCTCGGCGTCGGGCGTGAACGCGCCATCAAGAAGGGCCTCATCGACA
ATCTTGAATTCGTCGAGGCCAATGCGGAGGAATTGCCGTTCGAGGACAATAGTTTCGATGCCTATACGATCGCCTTCGGC
ATTCGCAATGTGCCGCATATCGACAAGGCGCTGAGCGAGGCTTATCGCGTGCTCAAGCCGGGCGGGCGTTTCCTGTGCCT
TGAATTTTCAGAAGTTGAATTGCCGGTTCTCGACAAGGTTTATGACGAATGGTCGTTCCGGGCCATTCCGCGCATCGGCA
AGATGATTACAGGTGACGCGGACTCCTATAGCTATCTGGTCGAATCGATCCGCAAATTCCCCAAGCAGCAGGATTTTGCC
GCGATGATCGAGAAGGCCGGTTTCGAGCGCGTCAGCTATCGCAATTTCACCGGCGGCATTGCCGCGCTCCATTCCGGCTG
GAAGCTTTGA

Upstream 100 bases:

>100_bases
CTGATCCAAAAGTCACCATGCCGGGGCTATACGTGGCTTGCCGCTTTTTGATTCAGGCAGCAGTATCGTTTTCGTAATAA
ACCAAGAAGCAGGATGAGCT

Downstream 100 bases:

>100_bases
TCGTGCCTGTGATGAGTTCGGGTCGCAACCAGCGTGAGGCATCGGCGCATGAGTAACCTTTCCGCCGTTTTCCGGCTGAT
GCGGGCCGGATGGATATTGA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MSQQNGNVNRVGAQDRVGASGGMEHSFGFKAVDENEKQGLVNDVFHKVAKRYDIMNDLMSAGMHRVWKDAMVAWLAPSKR
PGWTSLDVAGGTGDIAFRIVEASGRQAHVTILDINGSMLGVGRERAIKKGLIDNLEFVEANAEELPFEDNSFDAYTIAFG
IRNVPHIDKALSEAYRVLKPGGRFLCLEFSEVELPVLDKVYDEWSFRAIPRIGKMITGDADSYSYLVESIRKFPKQQDFA
AMIEKAGFERVSYRNFTGGIAALHSGWKL

Sequences:

>Translated_269_residues
MSQQNGNVNRVGAQDRVGASGGMEHSFGFKAVDENEKQGLVNDVFHKVAKRYDIMNDLMSAGMHRVWKDAMVAWLAPSKR
PGWTSLDVAGGTGDIAFRIVEASGRQAHVTILDINGSMLGVGRERAIKKGLIDNLEFVEANAEELPFEDNSFDAYTIAFG
IRNVPHIDKALSEAYRVLKPGGRFLCLEFSEVELPVLDKVYDEWSFRAIPRIGKMITGDADSYSYLVESIRKFPKQQDFA
AMIEKAGFERVSYRNFTGGIAALHSGWKL
>Mature_268_residues
SQQNGNVNRVGAQDRVGASGGMEHSFGFKAVDENEKQGLVNDVFHKVAKRYDIMNDLMSAGMHRVWKDAMVAWLAPSKRP
GWTSLDVAGGTGDIAFRIVEASGRQAHVTILDINGSMLGVGRERAIKKGLIDNLEFVEANAEELPFEDNSFDAYTIAFGI
RNVPHIDKALSEAYRVLKPGGRFLCLEFSEVELPVLDKVYDEWSFRAIPRIGKMITGDADSYSYLVESIRKFPKQQDFAA
MIEKAGFERVSYRNFTGGIAALHSGWKL

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=293, Percent_Identity=49.1467576791809, Blast_Score=276, Evalue=1e-74,
Organism=Escherichia coli, GI48994983, Length=243, Percent_Identity=51.8518518518518, Blast_Score=257, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI17557039, Length=264, Percent_Identity=49.6212121212121, Blast_Score=244, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI25143945, Length=101, Percent_Identity=31.6831683168317, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323526, Length=256, Percent_Identity=47.265625, Blast_Score=229, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24641702, Length=279, Percent_Identity=50.8960573476703, Blast_Score=276, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_BRUA1 (B2SC50)

Other databases:

- EMBL:   CP000888
- RefSeq:   YP_001932883.1
- ProteinModelPortal:   B2SC50
- GeneID:   6325868
- GenomeReviews:   CP000888_GR
- KEGG:   bmc:BAbS19_II09540
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- ProtClustDB:   PRK00216
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 29898; Mature: 29767

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQNGNVNRVGAQDRVGASGGMEHSFGFKAVDENEKQGLVNDVFHKVAKRYDIMNDLMS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGMHRVWKDAMVAWLAPSKRPGWTSLDVAGGTGDIAFRIVEASGRQAHVTILDINGSMLG
HHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEEECCCCEEEEEEEEECCCEEC
VGRERAIKKGLIDNLEFVEANAEELPFEDNSFDAYTIAFGIRNVPHIDKALSEAYRVLKP
CCHHHHHHHHHHCCHHHHCCCHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
GGRFLCLEFSEVELPVLDKVYDEWSFRAIPRIGKMITGDADSYSYLVESIRKFPKQQDFA
CCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHH
AMIEKAGFERVSYRNFTGGIAALHSGWKL
HHHHHHCCHHHHCCCCCCHHHHHHCCCCC
>Mature Secondary Structure 
SQQNGNVNRVGAQDRVGASGGMEHSFGFKAVDENEKQGLVNDVFHKVAKRYDIMNDLMS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGMHRVWKDAMVAWLAPSKRPGWTSLDVAGGTGDIAFRIVEASGRQAHVTILDINGSMLG
HHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEEECCCCEEEEEEEEECCCEEC
VGRERAIKKGLIDNLEFVEANAEELPFEDNSFDAYTIAFGIRNVPHIDKALSEAYRVLKP
CCHHHHHHHHHHCCHHHHCCCHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
GGRFLCLEFSEVELPVLDKVYDEWSFRAIPRIGKMITGDADSYSYLVESIRKFPKQQDFA
CCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHH
AMIEKAGFERVSYRNFTGGIAALHSGWKL
HHHHHHCCHHHHCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA