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The map label for this gene is ubiB [H]

Identifier: 225686817

GI number: 225686817

Start: 1028574

End: 1030157

Strand: Reverse

Name: ubiB [H]

Synonym: BMEA_B1052

Alternate gene names: 225686817

Gene position: 1030157-1028574 (Counterclockwise)

Preceding gene: 225686818

Following gene: 225686816

Centisome position: 86.9

GC content: 58.9

Gene sequence:

>1584_bases
ATGAGTAACCTTTCCGCCGTTTTCCGGCTGATGCGGGCCGGATGGATATTGACGCGCGAGGGCGTGATCAGCGCGCTTCC
CGTAGAAGGACTTTCCGGCCTCCCGGCGCTCGGACACAGGATTGCCGGTTTTCTGGCCCGTCCACGCGCGCGTCAGATGG
AGCGTTCCGAACGCATGTCACGGGCCATGAACAAGCTTGGCCCTTCCTATGTGAAGCTTGGCCAGTTTCTGGCGACGCGC
CCCGATATTGTCGGGCATGACGTTGCCGCTGATCTGGAATTGTTGCAAGATCGGCTCGACTTCTTTCCGCAGGCTGGAGC
GGTTGCGGCCATTGAAGGTTCGCTTGGCCGCAAGATCGATGATCTTTATGTGCGTTTCGATGCGCCGATCGCGGCGGCGT
CGATGGCGCAGGTGCATCCGGCCGAGGTGATGAAGGATGGTGCGCCGCAAAAGGTTGCGGTGAAGGTCATCCGCCCCGGC
GTGCGCCAGCGTTTTGCGCGCGATCTGGAAAGTTTCTTTATGGTCGCCCGTATGCAGGAGCGCCATATGCCTTTCACGCG
CCGCCTGCGCCCGGTGCAGGTGGTCGAAACCCTGTCGCAGACCACGCGCATCGAAATGGATTTGCGGCTTGAAGCGGCTG
CCCTTTCTGAAATTGCCGAGAATATCAAGGGAGATGAGGGGTTCCGGGTTCCCAAGGTGGACTGGGAGCGCACGGGCCGC
GATGTGCTGACGCTCGAATGGATCGACGGTATCAAGATGTCGGACATTCCCGCACTTGAAGCTGCCGGTTTCGACCTCAA
GAAGCTTGCCGAAACGCTGATCCAGTCGTTTTTGCGCCATACGCTGCGTGATGGTTTCTTCCATGCCGACATGCATCCGG
GCAATCTGTTCGTGGATCATCAGGGACTGGTGGTGGCGGTCGATTTCGGCATCACGGGCCGGCTCGACAAGCAGCAGCGG
CGGTTCCTTGCCGAAATTCTCTATGGCTTCATCACACGCGATTATATGCGCGTGGCAGAGGTCCATTTCGAGGCAGGTTA
TGTGCCTTACACGCATGATGTGGCAAGTTTTGCGCAGGCCATCCGCGCAATTGGCGAGCCGATCCATGACCAGCCCGCCG
AAACCATTTCCATGGCCAAGCTTCTGACGCTCCTGTTTGAAGTGACCGAGCTTTTTGACATGGAAACGCGGCCCGAGCTT
TTGATGCTCCAGAAGACCATGGTGGTGGTGGAGGGCGTGTCGCGCACGCTTGATCCGCATTTCAACATGTGGAAGGCGGC
GGAACCTGTCGTGGGCGACTGGATCCGGAAGAATCTTGGTCCGCAGGGCATGGTGCTGGATGCGAAGGAGAGTGCTTACG
CATTGCTGCATTTCACGCGCAAGACGCCGGAATTGTTGCAGCGCATCGATCGCATCTCGGTCGCTCTGGACACTATGGCG
GCCAATGGATTGCGCTTTGACGATGCGACGGCAGAGGCCATTGGCCGCGCTGAAGCGCAGCATTCTCGCTGGGGCCGCAT
CGCGCAGGTGGTGATTGCGGTTTCCATGGCCGCGATAGCAATAAAGCTCTATATCTGGCTGTAA

Upstream 100 bases:

>100_bases
TCGCAATTTCACCGGCGGCATTGCCGCGCTCCATTCCGGCTGGAAGCTTTGATCGTGCCTGTGATGAGTTCGGGTCGCAA
CCAGCGTGAGGCATCGGCGC

Downstream 100 bases:

>100_bases
AACTATTCTCTTTTGAGAGGTCGGCAACACATGGCATTGCTGGACGGTAAGCGCATCCTCCTCATCATTGGCGGTGGCAT
TGCCGCCTATAAGACGCCGG

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MSNLSAVFRLMRAGWILTREGVISALPVEGLSGLPALGHRIAGFLARPRARQMERSERMSRAMNKLGPSYVKLGQFLATR
PDIVGHDVAADLELLQDRLDFFPQAGAVAAIEGSLGRKIDDLYVRFDAPIAAASMAQVHPAEVMKDGAPQKVAVKVIRPG
VRQRFARDLESFFMVARMQERHMPFTRRLRPVQVVETLSQTTRIEMDLRLEAAALSEIAENIKGDEGFRVPKVDWERTGR
DVLTLEWIDGIKMSDIPALEAAGFDLKKLAETLIQSFLRHTLRDGFFHADMHPGNLFVDHQGLVVAVDFGITGRLDKQQR
RFLAEILYGFITRDYMRVAEVHFEAGYVPYTHDVASFAQAIRAIGEPIHDQPAETISMAKLLTLLFEVTELFDMETRPEL
LMLQKTMVVVEGVSRTLDPHFNMWKAAEPVVGDWIRKNLGPQGMVLDAKESAYALLHFTRKTPELLQRIDRISVALDTMA
ANGLRFDDATAEAIGRAEAQHSRWGRIAQVVIAVSMAAIAIKLYIWL

Sequences:

>Translated_527_residues
MSNLSAVFRLMRAGWILTREGVISALPVEGLSGLPALGHRIAGFLARPRARQMERSERMSRAMNKLGPSYVKLGQFLATR
PDIVGHDVAADLELLQDRLDFFPQAGAVAAIEGSLGRKIDDLYVRFDAPIAAASMAQVHPAEVMKDGAPQKVAVKVIRPG
VRQRFARDLESFFMVARMQERHMPFTRRLRPVQVVETLSQTTRIEMDLRLEAAALSEIAENIKGDEGFRVPKVDWERTGR
DVLTLEWIDGIKMSDIPALEAAGFDLKKLAETLIQSFLRHTLRDGFFHADMHPGNLFVDHQGLVVAVDFGITGRLDKQQR
RFLAEILYGFITRDYMRVAEVHFEAGYVPYTHDVASFAQAIRAIGEPIHDQPAETISMAKLLTLLFEVTELFDMETRPEL
LMLQKTMVVVEGVSRTLDPHFNMWKAAEPVVGDWIRKNLGPQGMVLDAKESAYALLHFTRKTPELLQRIDRISVALDTMA
ANGLRFDDATAEAIGRAEAQHSRWGRIAQVVIAVSMAAIAIKLYIWL
>Mature_526_residues
SNLSAVFRLMRAGWILTREGVISALPVEGLSGLPALGHRIAGFLARPRARQMERSERMSRAMNKLGPSYVKLGQFLATRP
DIVGHDVAADLELLQDRLDFFPQAGAVAAIEGSLGRKIDDLYVRFDAPIAAASMAQVHPAEVMKDGAPQKVAVKVIRPGV
RQRFARDLESFFMVARMQERHMPFTRRLRPVQVVETLSQTTRIEMDLRLEAAALSEIAENIKGDEGFRVPKVDWERTGRD
VLTLEWIDGIKMSDIPALEAAGFDLKKLAETLIQSFLRHTLRDGFFHADMHPGNLFVDHQGLVVAVDFGITGRLDKQQRR
FLAEILYGFITRDYMRVAEVHFEAGYVPYTHDVASFAQAIRAIGEPIHDQPAETISMAKLLTLLFEVTELFDMETRPELL
MLQKTMVVVEGVSRTLDPHFNMWKAAEPVVGDWIRKNLGPQGMVLDAKESAYALLHFTRKTPELLQRIDRISVALDTMAA
NGLRFDDATAEAIGRAEAQHSRWGRIAQVVIAVSMAAIAIKLYIWL

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=288, Percent_Identity=29.8611111111111, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI40254938, Length=342, Percent_Identity=24.5614035087719, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI217035081, Length=232, Percent_Identity=28.0172413793103, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI34147522, Length=303, Percent_Identity=28.3828382838284, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI27363457, Length=263, Percent_Identity=26.9961977186312, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI32261307, Length=317, Percent_Identity=24.6056782334385, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI217416386, Length=226, Percent_Identity=28.7610619469027, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI2367309, Length=442, Percent_Identity=36.8778280542986, Blast_Score=283, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17559152, Length=342, Percent_Identity=22.8070175438596, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325148, Length=440, Percent_Identity=23.1818181818182, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=261, Percent_Identity=24.5210727969349, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24662575, Length=310, Percent_Identity=30.3225806451613, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI22024280, Length=256, Percent_Identity=25.390625, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 59088; Mature: 58957

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLSAVFRLMRAGWILTREGVISALPVEGLSGLPALGHRIAGFLARPRARQMERSERMS
CCCHHHHHHHHHHCCEEECCCCHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
RAMNKLGPSYVKLGQFLATRPDIVGHDVAADLELLQDRLDFFPQAGAVAAIEGSLGRKID
HHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCHHCCCHH
DLYVRFDAPIAAASMAQVHPAEVMKDGAPQKVAVKVIRPGVRQRFARDLESFFMVARMQE
HEEEEECCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHMPFTRRLRPVQVVETLSQTTRIEMDLRLEAAALSEIAENIKGDEGFRVPKVDWERTGR
HCCCHHHCCCHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCC
DVLTLEWIDGIKMSDIPALEAAGFDLKKLAETLIQSFLRHTLRDGFFHADMHPGNLFVDH
CEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEC
QGLVVAVDFGITGRLDKQQRRFLAEILYGFITRDYMRVAEVHFEAGYVPYTHDVASFAQA
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IRAIGEPIHDQPAETISMAKLLTLLFEVTELFDMETRPELLMLQKTMVVVEGVSRTLDPH
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
FNMWKAAEPVVGDWIRKNLGPQGMVLDAKESAYALLHFTRKTPELLQRIDRISVALDTMA
CCHHHHCCCHHHHHHHHCCCCCCEEEECCCHHEEHHHHHCCCHHHHHHHHHHHHHHHHHH
ANGLRFDDATAEAIGRAEAQHSRWGRIAQVVIAVSMAAIAIKLYIWL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
>Mature Secondary Structure 
SNLSAVFRLMRAGWILTREGVISALPVEGLSGLPALGHRIAGFLARPRARQMERSERMS
CCHHHHHHHHHHCCEEECCCCHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
RAMNKLGPSYVKLGQFLATRPDIVGHDVAADLELLQDRLDFFPQAGAVAAIEGSLGRKID
HHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCHHCCCHH
DLYVRFDAPIAAASMAQVHPAEVMKDGAPQKVAVKVIRPGVRQRFARDLESFFMVARMQE
HEEEEECCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHMPFTRRLRPVQVVETLSQTTRIEMDLRLEAAALSEIAENIKGDEGFRVPKVDWERTGR
HCCCHHHCCCHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCC
DVLTLEWIDGIKMSDIPALEAAGFDLKKLAETLIQSFLRHTLRDGFFHADMHPGNLFVDH
CEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEC
QGLVVAVDFGITGRLDKQQRRFLAEILYGFITRDYMRVAEVHFEAGYVPYTHDVASFAQA
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IRAIGEPIHDQPAETISMAKLLTLLFEVTELFDMETRPELLMLQKTMVVVEGVSRTLDPH
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
FNMWKAAEPVVGDWIRKNLGPQGMVLDAKESAYALLHFTRKTPELLQRIDRISVALDTMA
CCHHHHCCCHHHHHHHHCCCCCCEEEECCCHHEEHHHHHCCCHHHHHHHHHHHHHHHHHH
ANGLRFDDATAEAIGRAEAQHSRWGRIAQVVIAVSMAAIAIKLYIWL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA