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The map label for this gene is yciC [H]

Identifier: 225686744

GI number: 225686744

Start: 952457

End: 953590

Strand: Direct

Name: yciC [H]

Synonym: BMEA_B0972

Alternate gene names: 225686744

Gene position: 952457-953590 (Clockwise)

Preceding gene: 225686743

Following gene: 225686745

Centisome position: 80.34

GC content: 58.99

Gene sequence:

>1134_bases
ATGGCCGAAGCCGAGGCAACAGCAACCACTGAAGCTGGCCGCATTCCCGTTACCGTTCTGACCGGATATCTGGGCTCGGG
GAAAACGACCCTTCTCAATCGCATCCTGACCGAAAACCACGGCAAGCGCTATGCCGTCATCGTCAATGAGTTCGGCGAAA
TCGGCATCGATAACGACCTCATCGTCGAATCGGACGAAGAAATCTACGAGATGAACAATGGCTGCATCTGCTGCACCGTG
CGCGGCGACCTGATCCGCGTGGTGGAAGGCCTGATGCGCCGCCCCGGACGTTTTGACGCCATTGTGGTGGAGACGACGGG
CCTTGCCGATCCGGTTCCGGTTGCGCAGACTTTTTTCATGGATGACGACGTGCGCGCCAAGACCGGGCTTGATGCCGTTG
TCGCCCTTGTGGATGCCAAGCACCTGCCGCTGCGCCTGAAGGACAGCCGCGAGGCGGAAGACCAGATCGCATTTGCCGAT
GTCGTGCTCATCAACAAGACCGACCTCGTGACGCCGGAAGAACTGGCGGCGGTCGAAGCCACCGTGCGCGCCATCAACCC
GCACGCAATCATCCACCGTACCGAGCGCGCATCGATTCCGCTCGACCGCGTGCTGGACCGTGGCGCCTTCGACCTGAAGC
GCGTTCTGGACAATGATCCGCACTTCCTCGACCATGACGACCCGGACCATGTCTGTGGCCCCGATTGCGACCACGATCAT
CATCACCATGGGCATCATCACCATGGGCATGACCATCACCATCATGATCATCACGATCACGACCATGTTTGCGGGCCGGA
CTGCGACCACGATCACGATCATGCCTCGCCCATCCACGACGTTACGGTGAAGTCCGTTTCGCTGCGAACAGGTGAAATTG
ATCCGGCGAAATTTTTCCCATGGATCCAGAACATTACCCAGACGCAAGGCCCGAATATCCTACGCCTGAAAGGCATCATC
GCCTTCAAGGACGATCCGGACCGCTATGTCGTGCAGGGCGTGCACATGATTATCGAAGGCGATCACCAGCGCGCGTGGAA
GCTGGAAGAAAAGCATGAAAGCCGCCTCGTCTTCATCGGGCGCGAGCTTGATCCGGCGGCATTGAAAGCCGGTTTTGAGA
ACTGCCGGGCCTGA

Upstream 100 bases:

>100_bases
AAGAGCGGTCCCAACAACTCCGCTTAACCGGAACCGCTCTGACGCCATATTGCACGCGTGATCTTGTTCGGGATCACGCT
AACTCCAAGAGGTACGAACC

Downstream 100 bases:

>100_bases
ACATCCAGAGCGGTTCTAACAATTTGTTCTGTCGCATTATCCGACGAAAAACTGCTTCGCATTTTTGCTGGAAATGCTCC
AGGCTCAGAACCTGTTAAAA

Product: cobalamin synthesis protein P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAEAEATATTEAGRIPVTVLTGYLGSGKTTLLNRILTENHGKRYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCICCTV
RGDLIRVVEGLMRRPGRFDAIVVETTGLADPVPVAQTFFMDDDVRAKTGLDAVVALVDAKHLPLRLKDSREAEDQIAFAD
VVLINKTDLVTPEELAAVEATVRAINPHAIIHRTERASIPLDRVLDRGAFDLKRVLDNDPHFLDHDDPDHVCGPDCDHDH
HHHGHHHHGHDHHHHDHHDHDHVCGPDCDHDHDHASPIHDVTVKSVSLRTGEIDPAKFFPWIQNITQTQGPNILRLKGII
AFKDDPDRYVVQGVHMIIEGDHQRAWKLEEKHESRLVFIGRELDPAALKAGFENCRA

Sequences:

>Translated_377_residues
MAEAEATATTEAGRIPVTVLTGYLGSGKTTLLNRILTENHGKRYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCICCTV
RGDLIRVVEGLMRRPGRFDAIVVETTGLADPVPVAQTFFMDDDVRAKTGLDAVVALVDAKHLPLRLKDSREAEDQIAFAD
VVLINKTDLVTPEELAAVEATVRAINPHAIIHRTERASIPLDRVLDRGAFDLKRVLDNDPHFLDHDDPDHVCGPDCDHDH
HHHGHHHHGHDHHHHDHHDHDHVCGPDCDHDHDHASPIHDVTVKSVSLRTGEIDPAKFFPWIQNITQTQGPNILRLKGII
AFKDDPDRYVVQGVHMIIEGDHQRAWKLEEKHESRLVFIGRELDPAALKAGFENCRA
>Mature_376_residues
AEAEATATTEAGRIPVTVLTGYLGSGKTTLLNRILTENHGKRYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCICCTVR
GDLIRVVEGLMRRPGRFDAIVVETTGLADPVPVAQTFFMDDDVRAKTGLDAVVALVDAKHLPLRLKDSREAEDQIAFADV
VLINKTDLVTPEELAAVEATVRAINPHAIIHRTERASIPLDRVLDRGAFDLKRVLDNDPHFLDHDDPDHVCGPDCDHDHH
HHGHHHHGHDHHHHDHHDHDHVCGPDCDHDHDHASPIHDVTVKSVSLRTGEIDPAKFFPWIQNITQTQGPNILRLKGIIA
FKDDPDRYVVQGVHMIIEGDHQRAWKLEEKHESRLVFIGRELDPAALKAGFENCRA

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=211, Percent_Identity=46.4454976303318, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI126722884, Length=211, Percent_Identity=45.9715639810426, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI148727351, Length=211, Percent_Identity=45.4976303317536, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI146231952, Length=211, Percent_Identity=45.4976303317536, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI223941779, Length=199, Percent_Identity=45.7286432160804, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI223941776, Length=198, Percent_Identity=44.9494949494949, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI119120938, Length=135, Percent_Identity=48.1481481481481, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI87082430, Length=367, Percent_Identity=30.2452316076294, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1788499, Length=172, Percent_Identity=34.3023255813954, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324356, Length=239, Percent_Identity=33.4728033472803, Blast_Score=140, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 42144; Mature: 42013

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAEATATTEAGRIPVTVLTGYLGSGKTTLLNRILTENHGKRYAVIVNEFGEIGIDNDL
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCE
IVESDEEIYEMNNGCICCTVRGDLIRVVEGLMRRPGRFDAIVVETTGLADPVPVAQTFFM
EEECCHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHEEEC
DDDVRAKTGLDAVVALVDAKHLPLRLKDSREAEDQIAFADVVLINKTDLVTPEELAAVEA
CCCCHHHHCHHHHHHHHCCCCCCEEECCCCCHHHHEEEEEEEEECCCCCCCHHHHHHHHH
TVRAINPHAIIHRTERASIPLDRVLDRGAFDLKRVLDNDPHFLDHDDPDHVCGPDCDHDH
HHHHCCCHHEEEECCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
HHHGHHHHGHDHHHHDHHDHDHVCGPDCDHDHDHASPIHDVTVKSVSLRTGEIDPAKFFP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEEEECCCCCHHHHHH
WIQNITQTQGPNILRLKGIIAFKDDPDRYVVQGVHMIIEGDHQRAWKLEEKHESRLVFIG
HHHHHHHCCCCCEEEEEEEEEECCCCCHHHHEEEEEEEECCCHHHCCCCCCCCCEEEEEE
RELDPAALKAGFENCRA
CCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AEAEATATTEAGRIPVTVLTGYLGSGKTTLLNRILTENHGKRYAVIVNEFGEIGIDNDL
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCE
IVESDEEIYEMNNGCICCTVRGDLIRVVEGLMRRPGRFDAIVVETTGLADPVPVAQTFFM
EEECCHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHEEEC
DDDVRAKTGLDAVVALVDAKHLPLRLKDSREAEDQIAFADVVLINKTDLVTPEELAAVEA
CCCCHHHHCHHHHHHHHCCCCCCEEECCCCCHHHHEEEEEEEEECCCCCCCHHHHHHHHH
TVRAINPHAIIHRTERASIPLDRVLDRGAFDLKRVLDNDPHFLDHDDPDHVCGPDCDHDH
HHHHCCCHHEEEECCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
HHHGHHHHGHDHHHHDHHDHDHVCGPDCDHDHDHASPIHDVTVKSVSLRTGEIDPAKFFP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEEEECCCCCHHHHHH
WIQNITQTQGPNILRLKGIIAFKDDPDRYVVQGVHMIIEGDHQRAWKLEEKHESRLVFIG
HHHHHHHCCCCCEEEEEEEEEECCCCCHHHHEEEEEEEECCCHHHCCCCCCCCCEEEEEE
RELDPAALKAGFENCRA
CCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]