Click here to switch to the map view.

The map label for this gene is pntAA [H]

Identifier: 225686732

GI number: 225686732

Start: 939546

End: 940847

Strand: Reverse

Name: pntAA [H]

Synonym: BMEA_B0959

Alternate gene names: 225686732

Gene position: 940847-939546 (Counterclockwise)

Preceding gene: 225686733

Following gene: 225686731

Centisome position: 79.36

GC content: 60.45

Gene sequence:

>1302_bases
TTGGCCCAGACGTTATATATCCCGAAAGAGAGTGACCCCAACGAAACCCGTGTTGCGGGGTCGGCGGAGACGGTGAAGAA
ATTCATCGCGCTTGGTTTTGATGTCGTGGTGGAAAAAGGCGCAGGCGAGAAATCGCGCATTCCCGATGCCGAATTTGCGG
CAGCCGGTGCCCGCATCGGCACGGCGGTGGATGCCAAAACGGCGGATGTCATCTTGAAAGTTCGCCGTCCGGGCGATGCG
GAACTGAAAGCGTATAAATCGGGCGCAGCACTTTTCGCCATGCTGGACCCCTATGGCCATGAAGATGCGGTGGCGGCTCT
TGCCAGGGCTGGAATTTCGGCTTTTACGATGGAATTCATGCCGCGCATAACCCGCGCGCAGGTGATGGACGTTCTGTCTT
CGCAGGCCAATCTTGCCGGTTATCAGGCGGTGATCGATGCGGCGGAAGTCTATGACCGCGCCATGCCGATGATGATGACG
GCAGCGGGCACGGTTCCCGCCGCCAAGGTTTTCGTCATGGGGGCGGGCGTTGCCGGTCTTCAGGCGATTGCGACCGCGCG
CCGTCTGGGTGCAGTCGTGACCGCCACCGATGTTCGCCCGGCGGCGAAGGAACAAGTTGCCTCGCTTGGCGCGAAGTTCA
TCGCGGTCGAGGACGACGAGTTCAAGGCGGCGGAAACCGCCGGCGGCTATGCCAAGGAAATGTCGAAGGACTATCAGGCC
AAACAGGCAGCACTCGTTGCCGACCATATCGCCAAGCAGGATATCGTCATCACCACGGCGCTTATTCCGGGCCGTCCGGC
CCCGCGTCTGGTGTCGAAGGAAATGGTCGCTTCCATGCGCCCGGGTTCGGTGCTGGTCGATCTGGCGGTTGAGCGCGGCG
GCAATGTCGAAGGCGCTGTTCCCGGTGAAATTGCCGACGTGAATGGCGTCAAGATTGTCGGCTATCTCAACGTGCCGGGC
CGCATCGCGGCCAGCGCCTCGCAGCTTTATGCGCGCAACCTGATCGCCTTTGTCGAAACGCTGGTCGATAAGGAAAGCAA
AGTCCTGAAGATTGACCCGGAAGAAGAGCTGGTGAAGGCGACGCTTCTCACCCATCAGGGCAGGATTTTGCATCCGGCTT
TCGCCAAGGCAGAAACGGCACCGGCTGCCGTGACTGAAAAGGCTGAAAAACCGAAGGCCGTACCCAAGGCCCCCCCCAAG
GCCCCCCCCAAGGCTGCTGCAAAGCCTGCGAAAAAAGCCCCGGCAAAAGCGGCGAAGAAACCATCGTCCCCCAAGTCTCC
GGTTGATGGAGGAGAGGCATAA

Upstream 100 bases:

>100_bases
TCTGTAGTTCAGTAATTTTAAAAATAGCTTCTCCCCGGAAGCCCGCATTTGTGCATGACCGGGACCAAACCCGGAAGAAC
GCCACGAAAGGGAAACCAGC

Downstream 100 bases:

>100_bases
TGGCCGATACAAATCTCGATAAAGCCCTTGAGGGCCTCAATCAGGCCGCGGATGCTGTGCGTCAGGCGGCGGAAAATGCT
GGCGGTTTTGGTGATGCGGC

Product: alanine dehydrogenase/PNT domain-containing protein

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MAQTLYIPKESDPNETRVAGSAETVKKFIALGFDVVVEKGAGEKSRIPDAEFAAAGARIGTAVDAKTADVILKVRRPGDA
ELKAYKSGAALFAMLDPYGHEDAVAALARAGISAFTMEFMPRITRAQVMDVLSSQANLAGYQAVIDAAEVYDRAMPMMMT
AAGTVPAAKVFVMGAGVAGLQAIATARRLGAVVTATDVRPAAKEQVASLGAKFIAVEDDEFKAAETAGGYAKEMSKDYQA
KQAALVADHIAKQDIVITTALIPGRPAPRLVSKEMVASMRPGSVLVDLAVERGGNVEGAVPGEIADVNGVKIVGYLNVPG
RIAASASQLYARNLIAFVETLVDKESKVLKIDPEEELVKATLLTHQGRILHPAFAKAETAPAAVTEKAEKPKAVPKAPPK
APPKAAAKPAKKAPAKAAKKPSSPKSPVDGGEA

Sequences:

>Translated_433_residues
MAQTLYIPKESDPNETRVAGSAETVKKFIALGFDVVVEKGAGEKSRIPDAEFAAAGARIGTAVDAKTADVILKVRRPGDA
ELKAYKSGAALFAMLDPYGHEDAVAALARAGISAFTMEFMPRITRAQVMDVLSSQANLAGYQAVIDAAEVYDRAMPMMMT
AAGTVPAAKVFVMGAGVAGLQAIATARRLGAVVTATDVRPAAKEQVASLGAKFIAVEDDEFKAAETAGGYAKEMSKDYQA
KQAALVADHIAKQDIVITTALIPGRPAPRLVSKEMVASMRPGSVLVDLAVERGGNVEGAVPGEIADVNGVKIVGYLNVPG
RIAASASQLYARNLIAFVETLVDKESKVLKIDPEEELVKATLLTHQGRILHPAFAKAETAPAAVTEKAEKPKAVPKAPPK
APPKAAAKPAKKAPAKAAKKPSSPKSPVDGGEA
>Mature_432_residues
AQTLYIPKESDPNETRVAGSAETVKKFIALGFDVVVEKGAGEKSRIPDAEFAAAGARIGTAVDAKTADVILKVRRPGDAE
LKAYKSGAALFAMLDPYGHEDAVAALARAGISAFTMEFMPRITRAQVMDVLSSQANLAGYQAVIDAAEVYDRAMPMMMTA
AGTVPAAKVFVMGAGVAGLQAIATARRLGAVVTATDVRPAAKEQVASLGAKFIAVEDDEFKAAETAGGYAKEMSKDYQAK
QAALVADHIAKQDIVITTALIPGRPAPRLVSKEMVASMRPGSVLVDLAVERGGNVEGAVPGEIADVNGVKIVGYLNVPGR
IAASASQLYARNLIAFVETLVDKESKVLKIDPEEELVKATLLTHQGRILHPAFAKAETAPAAVTEKAEKPKAVPKAPPKA
PPKAAAKPAKKAPAKAAKKPSSPKSPVDGGEA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=423, Percent_Identity=37.3522458628842, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI122939153, Length=423, Percent_Identity=37.3522458628842, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1787887, Length=368, Percent_Identity=43.2065217391304, Blast_Score=296, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17550456, Length=363, Percent_Identity=42.1487603305785, Blast_Score=281, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 45038; Mature: 44907

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTLYIPKESDPNETRVAGSAETVKKFIALGFDVVVEKGAGEKSRIPDAEFAAAGARIG
CCCEEECCCCCCCCHHEECCCHHHHHHHHHHCHHHEEECCCCCCCCCCCHHHHHCCCHHC
TAVDAKTADVILKVRRPGDAELKAYKSGAALFAMLDPYGHEDAVAALARAGISAFTMEFM
CCCCCCCEEEEEEECCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHH
PRITRAQVMDVLSSQANLAGYQAVIDAAEVYDRAMPMMMTAAGTVPAAKVFVMGAGVAGL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHH
QAIATARRLGAVVTATDVRPAAKEQVASLGAKFIAVEDDEFKAAETAGGYAKEMSKDYQA
HHHHHHHHHCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCHHHHCCHHHHHHHHHHHH
KQAALVADHIAKQDIVITTALIPGRPAPRLVSKEMVASMRPGSVLVDLAVERGGNVEGAV
HHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
PGEIADVNGVKIVGYLNVPGRIAASASQLYARNLIAFVETLVDKESKVLKIDPEEELVKA
CCCEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHH
TLLTHQGRILHPAFAKAETAPAAVTEKAEKPKAVPKAPPKAPPKAAAKPAKKAPAKAAKK
HHHHCCCCEECHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHCC
PSSPKSPVDGGEA
CCCCCCCCCCCCC
>Mature Secondary Structure 
AQTLYIPKESDPNETRVAGSAETVKKFIALGFDVVVEKGAGEKSRIPDAEFAAAGARIG
CCEEECCCCCCCCHHEECCCHHHHHHHHHHCHHHEEECCCCCCCCCCCHHHHHCCCHHC
TAVDAKTADVILKVRRPGDAELKAYKSGAALFAMLDPYGHEDAVAALARAGISAFTMEFM
CCCCCCCEEEEEEECCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHH
PRITRAQVMDVLSSQANLAGYQAVIDAAEVYDRAMPMMMTAAGTVPAAKVFVMGAGVAGL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHH
QAIATARRLGAVVTATDVRPAAKEQVASLGAKFIAVEDDEFKAAETAGGYAKEMSKDYQA
HHHHHHHHHCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCHHHHCCHHHHHHHHHHHH
KQAALVADHIAKQDIVITTALIPGRPAPRLVSKEMVASMRPGSVLVDLAVERGGNVEGAV
HHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
PGEIADVNGVKIVGYLNVPGRIAASASQLYARNLIAFVETLVDKESKVLKIDPEEELVKA
CCCEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHH
TLLTHQGRILHPAFAKAETAPAAVTEKAEKPKAVPKAPPKAPPKAAAKPAKKAPAKAAKK
HHHHCCCCEECHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHCC
PSSPKSPVDGGEA
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]