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The map label for this gene is betA [H]

Identifier: 225686718

GI number: 225686718

Start: 926269

End: 927867

Strand: Direct

Name: betA [H]

Synonym: BMEA_B0944

Alternate gene names: 225686718

Gene position: 926269-927867 (Clockwise)

Preceding gene: 225686717

Following gene: 225686719

Centisome position: 78.13

GC content: 59.66

Gene sequence:

>1599_bases
ATGACCGACACCTACGATTACATCGTGGTTGGCGCGGGCACGGCAGGTTGCGCGCTTGCAAACCGTCTTTCCGCCGATCA
AAACCGTTCCGTACTGCTGCTCGAAGCTGGCGGAAAAGACAATTACGCCTGGATTCACATTCCGGTCGGCTATCTCTACT
GCATCGGCAATCCGCGCACCGACTGGTGCTTCACCACCGAGGCTGAACCGGGCCTCAACGGGCGCTCGCTCAACTATCCG
CGCGGCAAGGTGCTGGGCGGCTGTTCATCGATCAATGGCATGATCTATATGCGCGGCCAGGCATGCGATTATGATCTGTG
GCGGCAGGCTGGTTGCGATGGCTGGGGCTGGGACGATGTTCTGCCGCTCTTCAAGAAATCCGAGGATTATTTCGCAGGCG
CCAGCGCCCTTCATGGCATGGGCGGTGAATGGCGCGTGGAAAATGCCCGCCTCCATTGGGATATTCTGGATGCCTTCCGC
GATGCCGCCCTTGCTGCCGGCATTCCCGCGACCGACGATTTCAACCGGGGCGACAATGAAGGTGTTTCCTATTTCAAGGT
GAACCAGAAGCACGGTATCCGCTGGAACACCGCCAAGGCCTTTCTGCGCCCGGCACTGGATCGCAAAAACCTGACGGTTG
AGACCGGCGCGCATGTCCGGTGCATTGAAATCGAGGGGCTGCGCGCAACTGGCGTTACTTTCGATCAGGATGGCAATATC
CGCACGGTGAAGGCAAGGCGGGAAGTCATTCTCGCTGCCGGGGCTGTGGGATCGCCGCAGATTCTGGAATTGTCGGGCAT
CGGGCGCGGCGATGTGCTGCAACAGGCAGGCATTCCGCTCAAGCTGGAGCGCAGGCAATTGGGTGAAAACCTGCAAGACC
ATCTGCAATTGCGCTGCGCCTATAAAGTCACCGGCATTGCGACACTCAACGAGAAGGCAAGTACGCTTGTGGGCAAGGCC
ATGATCGGGCTGGAATATCTGCTCCGCCGTTCCGGGCCGATGGCCATGGCGCCAAGCCAGCTTGGCGTCTTCACCCGCTC
CGACCCCTCCTACGAGACTGCGAATCTGCAATATCATGTGCAGCCGCTCAGCCTCGAAAAATTCGGCGATGCCGTCCATC
CCTTCCCCGCCTTCACGGCAAGCGTGTGCAATCTGCGTCCTGAAAGCCGGGGTTCGATCCACATCAAGTCGCCTGACCAT
CGCGCGCAACCGGCCATCCGGCCGAATTATCTGGCCACCGAAACCGACCGCCGCATCGCTGCCGATGCGATCCGCCTCAC
CCGCCATATCGTTTCACAAGCGCCCTTGCAGAAATATCGTCCGGAAGAATTCAAACCCGGCCCGAATTATGCAACGCAGG
AAGATCTGGAAAAGGCGGCAGGCGATATCGGCACCACGATTTTCCACCCCGTCGGCACCTGCCGCATGGGGCAGGACGCA
GAGGCAATCGTCGATCCGCGCCTGCGGTTTAACGGCATTGCGGGCCTGCGCGTTGTGGATGCTTCGATCATGCCAGCCAT
CACGTCCGGCAACACCAATTCGCCGACGCTCATGATCGCCGAGAAGGCTGCACAGATGATTATCGCCGACAATCGGTGA

Upstream 100 bases:

>100_bases
CTATACATCGCGAATTGGAAAGAAACTCTTCGGCTAACCAAAATTTCGGGAGCCGCACGCTCGTTCGATAGCGGCTCCGC
CTTTTACTGGATATAGAATC

Downstream 100 bases:

>100_bases
ACGGGTTTTCCATCGCGGCGGCAGCGGAAATGGCAATCCGCTCCCCCTTGCGCGAACGCAATTTCACAATTGCCGACCTG
ACCTTTTCGGAAATAATTTT

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MTDTYDYIVVGAGTAGCALANRLSADQNRSVLLLEAGGKDNYAWIHIPVGYLYCIGNPRTDWCFTTEAEPGLNGRSLNYP
RGKVLGGCSSINGMIYMRGQACDYDLWRQAGCDGWGWDDVLPLFKKSEDYFAGASALHGMGGEWRVENARLHWDILDAFR
DAALAAGIPATDDFNRGDNEGVSYFKVNQKHGIRWNTAKAFLRPALDRKNLTVETGAHVRCIEIEGLRATGVTFDQDGNI
RTVKARREVILAAGAVGSPQILELSGIGRGDVLQQAGIPLKLERRQLGENLQDHLQLRCAYKVTGIATLNEKASTLVGKA
MIGLEYLLRRSGPMAMAPSQLGVFTRSDPSYETANLQYHVQPLSLEKFGDAVHPFPAFTASVCNLRPESRGSIHIKSPDH
RAQPAIRPNYLATETDRRIAADAIRLTRHIVSQAPLQKYRPEEFKPGPNYATQEDLEKAAGDIGTTIFHPVGTCRMGQDA
EAIVDPRLRFNGIAGLRVVDASIMPAITSGNTNSPTLMIAEKAAQMIIADNR

Sequences:

>Translated_532_residues
MTDTYDYIVVGAGTAGCALANRLSADQNRSVLLLEAGGKDNYAWIHIPVGYLYCIGNPRTDWCFTTEAEPGLNGRSLNYP
RGKVLGGCSSINGMIYMRGQACDYDLWRQAGCDGWGWDDVLPLFKKSEDYFAGASALHGMGGEWRVENARLHWDILDAFR
DAALAAGIPATDDFNRGDNEGVSYFKVNQKHGIRWNTAKAFLRPALDRKNLTVETGAHVRCIEIEGLRATGVTFDQDGNI
RTVKARREVILAAGAVGSPQILELSGIGRGDVLQQAGIPLKLERRQLGENLQDHLQLRCAYKVTGIATLNEKASTLVGKA
MIGLEYLLRRSGPMAMAPSQLGVFTRSDPSYETANLQYHVQPLSLEKFGDAVHPFPAFTASVCNLRPESRGSIHIKSPDH
RAQPAIRPNYLATETDRRIAADAIRLTRHIVSQAPLQKYRPEEFKPGPNYATQEDLEKAAGDIGTTIFHPVGTCRMGQDA
EAIVDPRLRFNGIAGLRVVDASIMPAITSGNTNSPTLMIAEKAAQMIIADNR
>Mature_531_residues
TDTYDYIVVGAGTAGCALANRLSADQNRSVLLLEAGGKDNYAWIHIPVGYLYCIGNPRTDWCFTTEAEPGLNGRSLNYPR
GKVLGGCSSINGMIYMRGQACDYDLWRQAGCDGWGWDDVLPLFKKSEDYFAGASALHGMGGEWRVENARLHWDILDAFRD
AALAAGIPATDDFNRGDNEGVSYFKVNQKHGIRWNTAKAFLRPALDRKNLTVETGAHVRCIEIEGLRATGVTFDQDGNIR
TVKARREVILAAGAVGSPQILELSGIGRGDVLQQAGIPLKLERRQLGENLQDHLQLRCAYKVTGIATLNEKASTLVGKAM
IGLEYLLRRSGPMAMAPSQLGVFTRSDPSYETANLQYHVQPLSLEKFGDAVHPFPAFTASVCNLRPESRGSIHIKSPDHR
AQPAIRPNYLATETDRRIAADAIRLTRHIVSQAPLQKYRPEEFKPGPNYATQEDLEKAAGDIGTTIFHPVGTCRMGQDAE
AIVDPRLRFNGIAGLRVVDASIMPAITSGNTNSPTLMIAEKAAQMIIADNR

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=534, Percent_Identity=40.6367041198502, Blast_Score=389, Evalue=1e-108,
Organism=Escherichia coli, GI1786503, Length=531, Percent_Identity=40.4896421845574, Blast_Score=349, Evalue=3e-97,
Organism=Caenorhabditis elegans, GI17532301, Length=546, Percent_Identity=34.2490842490842, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI24642042, Length=570, Percent_Identity=35.2631578947368, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24642048, Length=572, Percent_Identity=35.6643356643357, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24642055, Length=577, Percent_Identity=35.7019064124783, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI45551458, Length=569, Percent_Identity=34.0949033391916, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI45549471, Length=569, Percent_Identity=33.9191564147627, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24642059, Length=573, Percent_Identity=34.5549738219895, Blast_Score=274, Evalue=9e-74,
Organism=Drosophila melanogaster, GI18859995, Length=567, Percent_Identity=36.5079365079365, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI18859993, Length=569, Percent_Identity=34.0949033391916, Blast_Score=257, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24650267, Length=563, Percent_Identity=33.0373001776199, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI17137792, Length=561, Percent_Identity=34.7593582887701, Blast_Score=254, Evalue=7e-68,
Organism=Drosophila melanogaster, GI24642035, Length=575, Percent_Identity=33.7391304347826, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24642039, Length=579, Percent_Identity=33.8514680483592, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI24642051, Length=571, Percent_Identity=30.9982486865149, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24642037, Length=570, Percent_Identity=32.280701754386, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI24645930, Length=578, Percent_Identity=29.9307958477509, Blast_Score=162, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24642057, Length=596, Percent_Identity=26.6778523489933, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 58226; Mature: 58095

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTYDYIVVGAGTAGCALANRLSADQNRSVLLLEAGGKDNYAWIHIPVGYLYCIGNPRT
CCCCEEEEEEECCCHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEEEEEEEECCCCCC
DWCFTTEAEPGLNGRSLNYPRGKVLGGCSSINGMIYMRGQACDYDLWRQAGCDGWGWDDV
CEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCEEEECCCCCCHHHHHHCCCCCCCHHHH
LPLFKKSEDYFAGASALHGMGGEWRVENARLHWDILDAFRDAALAAGIPATDDFNRGDNE
HHHHHCCCCHHCCHHHHHCCCCCEEEECCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GVSYFKVNQKHGIRWNTAKAFLRPALDRKNLTVETGAHVRCIEIEGLRATGVTFDQDGNI
CCEEEEECCCCCCEECHHHHHHHHCCCCCCEEEECCCEEEEEEECCCEEECEEECCCCCE
RTVKARREVILAAGAVGSPQILELSGIGRGDVLQQAGIPLKLERRQLGENLQDHLQLRCA
EEEEECEEEEEEECCCCCCCEEEEECCCCCHHHHHCCCCEEEHHHHHCCCHHHHHEEEEE
YKVTGIATLNEKASTLVGKAMIGLEYLLRRSGPMAMAPSQLGVFTRSDPSYETANLQYHV
EEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEECCHHCCEEECCCCCCEECCEEEEE
QPLSLEKFGDAVHPFPAFTASVCNLRPESRGSIHIKSPDHRAQPAIRPNYLATETDRRIA
EECCHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCHHH
ADAIRLTRHIVSQAPLQKYRPEEFKPGPNYATQEDLEKAAGDIGTTIFHPVGTCRMGQDA
HHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCC
EAIVDPRLRFNGIAGLRVVDASIMPAITSGNTNSPTLMIAEKAAQMIIADNR
HHHCCCCEEECCCCCEEEECCCCCCEEECCCCCCCEEEEEECCCEEEEECCC
>Mature Secondary Structure 
TDTYDYIVVGAGTAGCALANRLSADQNRSVLLLEAGGKDNYAWIHIPVGYLYCIGNPRT
CCCEEEEEEECCCHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEEEEEEEECCCCCC
DWCFTTEAEPGLNGRSLNYPRGKVLGGCSSINGMIYMRGQACDYDLWRQAGCDGWGWDDV
CEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCEEEECCCCCCHHHHHHCCCCCCCHHHH
LPLFKKSEDYFAGASALHGMGGEWRVENARLHWDILDAFRDAALAAGIPATDDFNRGDNE
HHHHHCCCCHHCCHHHHHCCCCCEEEECCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GVSYFKVNQKHGIRWNTAKAFLRPALDRKNLTVETGAHVRCIEIEGLRATGVTFDQDGNI
CCEEEEECCCCCCEECHHHHHHHHCCCCCCEEEECCCEEEEEEECCCEEECEEECCCCCE
RTVKARREVILAAGAVGSPQILELSGIGRGDVLQQAGIPLKLERRQLGENLQDHLQLRCA
EEEEECEEEEEEECCCCCCCEEEEECCCCCHHHHHCCCCEEEHHHHHCCCHHHHHEEEEE
YKVTGIATLNEKASTLVGKAMIGLEYLLRRSGPMAMAPSQLGVFTRSDPSYETANLQYHV
EEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEECCHHCCEEECCCCCCEECCEEEEE
QPLSLEKFGDAVHPFPAFTASVCNLRPESRGSIHIKSPDHRAQPAIRPNYLATETDRRIA
EECCHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCCHHH
ADAIRLTRHIVSQAPLQKYRPEEFKPGPNYATQEDLEKAAGDIGTTIFHPVGTCRMGQDA
HHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCC
EAIVDPRLRFNGIAGLRVVDASIMPAITSGNTNSPTLMIAEKAAQMIIADNR
HHHCCCCEEECCCCCEEEECCCCCCEEECCCCCCCEEEEEECCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA