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The map label for this gene is livM [H]

Identifier: 225686717

GI number: 225686717

Start: 925210

End: 926205

Strand: Direct

Name: livM [H]

Synonym: BMEA_B0943

Alternate gene names: 225686717

Gene position: 925210-926205 (Clockwise)

Preceding gene: 225686716

Following gene: 225686718

Centisome position: 78.04

GC content: 57.43

Gene sequence:

>996_bases
ATGGTCGATACCACTCTCAAGCCCACTCTCAAGGCAAATGCGGCTTACAGCAAGGCGCCTGCCCTCAACAGCCTCTCGGC
CATCGTTCTCGGCATTGCCCTTGTCGGGCTGATTGCCGCCCCCTTCATGGTCTATCCGATCTTCCTCATGAAGATGCTGT
GCTTTGCGCTGTTTGCCTCCGCATTCAATCTTCTTCTGGGCTATACCGGCATTCTCTCCTTCGGCCATGCGGCTTTCTTC
GGGGCGGCGGCCTACGTGACAGCCCATGCGGTCAAGGAATGGGGCGTCTCACCGGAACTGGGCCTCGTGCTCGGTATTCT
GGCCGCAGCCGCCCTTGGCCTCGTCATCGGCTATCTCGCCATTCGCCGTCAGGGCATCTATTCAACGATGATTACGCTGG
CCCTTGCGCAGATGTTCTTTTTCTTCTGCCTGCAAGCCTCCTTCACCCATGGCGAGGACGGATTGCAGGGTGTGCCGCGC
GGGTTTCTCTTTGGCTTCATCGACCTCAACCAGCCGATGAACATGTATTATTTTGTGCTGGCCGTGTTTGTGCTTGGGGT
CTTCGCTATCTGGCGCATTACCAACTCACCCTTCGGCATGATCCTGAAATCGGTGCGCGAGAATGAAAACCGCGCCATAT
CGCTTGGGTTTTCCGTCAATCACTACAAGCTCGCAGCCTTCGTCATGTCGGCAGGGCTTGCAGGTCTTGCGGGCGGCATG
AAGGCGCTTGTCTTCCAGTTCGCAACGCTCACCGATGTCAGTTGGCAGATGTCGGGCGAGGTCATCCTGATGACGCTGCT
CGGCGGCATCGGCACCCTCATCGGCCCCATTGTCGGCGCGGCCTTCGTCGTCGCACTCCAGAACTGGCTTGCAACATCCG
ACTTCCCCGTCACCATCGTCACGGGCCTTATCTTCATGGCCTGTGTCCTGCTGTTCCGCAAAGGTATCATCGGGGAGTTC
TATACATCGCGAATTGGAAAGAAACTCTTCGGCTAA

Upstream 100 bases:

>100_bases
AAGGTCTTCTACCCGGAGGCTTCCAGCATCGTCGTCTTCGTTATCATGGCAATCGTCCTTCTGGTTCGACCCGCCGGACT
GTTCGGGAAGGAGGCCTGAT

Downstream 100 bases:

>100_bases
CCAAAATTTCGGGAGCCGCACGCTCGTTCGATAGCGGCTCCGCCTTTTACTGGATATAGAATCATGACCGACACCTACGA
TTACATCGTGGTTGGCGCGG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MVDTTLKPTLKANAAYSKAPALNSLSAIVLGIALVGLIAAPFMVYPIFLMKMLCFALFASAFNLLLGYTGILSFGHAAFF
GAAAYVTAHAVKEWGVSPELGLVLGILAAAALGLVIGYLAIRRQGIYSTMITLALAQMFFFFCLQASFTHGEDGLQGVPR
GFLFGFIDLNQPMNMYYFVLAVFVLGVFAIWRITNSPFGMILKSVRENENRAISLGFSVNHYKLAAFVMSAGLAGLAGGM
KALVFQFATLTDVSWQMSGEVILMTLLGGIGTLIGPIVGAAFVVALQNWLATSDFPVTIVTGLIFMACVLLFRKGIIGEF
YTSRIGKKLFG

Sequences:

>Translated_331_residues
MVDTTLKPTLKANAAYSKAPALNSLSAIVLGIALVGLIAAPFMVYPIFLMKMLCFALFASAFNLLLGYTGILSFGHAAFF
GAAAYVTAHAVKEWGVSPELGLVLGILAAAALGLVIGYLAIRRQGIYSTMITLALAQMFFFFCLQASFTHGEDGLQGVPR
GFLFGFIDLNQPMNMYYFVLAVFVLGVFAIWRITNSPFGMILKSVRENENRAISLGFSVNHYKLAAFVMSAGLAGLAGGM
KALVFQFATLTDVSWQMSGEVILMTLLGGIGTLIGPIVGAAFVVALQNWLATSDFPVTIVTGLIFMACVLLFRKGIIGEF
YTSRIGKKLFG
>Mature_331_residues
MVDTTLKPTLKANAAYSKAPALNSLSAIVLGIALVGLIAAPFMVYPIFLMKMLCFALFASAFNLLLGYTGILSFGHAAFF
GAAAYVTAHAVKEWGVSPELGLVLGILAAAALGLVIGYLAIRRQGIYSTMITLALAQMFFFFCLQASFTHGEDGLQGVPR
GFLFGFIDLNQPMNMYYFVLAVFVLGVFAIWRITNSPFGMILKSVRENENRAISLGFSVNHYKLAAFVMSAGLAGLAGGM
KALVFQFATLTDVSWQMSGEVILMTLLGGIGTLIGPIVGAAFVVALQNWLATSDFPVTIVTGLIFMACVLLFRKGIIGEF
YTSRIGKKLFG

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=275, Percent_Identity=26.5454545454545, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 35461; Mature: 35461

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDTTLKPTLKANAAYSKAPALNSLSAIVLGIALVGLIAAPFMVYPIFLMKMLCFALFAS
CCCCCCCCCHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFNLLLGYTGILSFGHAAFFGAAAYVTAHAVKEWGVSPELGLVLGILAAAALGLVIGYLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
IRRQGIYSTMITLALAQMFFFFCLQASFTHGEDGLQGVPRGFLFGFIDLNQPMNMYYFVL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEEEECCCCHHHHHHHH
AVFVLGVFAIWRITNSPFGMILKSVRENENRAISLGFSVNHYKLAAFVMSAGLAGLAGGM
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
KALVFQFATLTDVSWQMSGEVILMTLLGGIGTLIGPIVGAAFVVALQNWLATSDFPVTIV
HHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
TGLIFMACVLLFRKGIIGEFYTSRIGKKLFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDTTLKPTLKANAAYSKAPALNSLSAIVLGIALVGLIAAPFMVYPIFLMKMLCFALFAS
CCCCCCCCCHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFNLLLGYTGILSFGHAAFFGAAAYVTAHAVKEWGVSPELGLVLGILAAAALGLVIGYLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
IRRQGIYSTMITLALAQMFFFFCLQASFTHGEDGLQGVPRGFLFGFIDLNQPMNMYYFVL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEEEECCCCHHHHHHHH
AVFVLGVFAIWRITNSPFGMILKSVRENENRAISLGFSVNHYKLAAFVMSAGLAGLAGGM
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
KALVFQFATLTDVSWQMSGEVILMTLLGGIGTLIGPIVGAAFVVALQNWLATSDFPVTIV
HHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
TGLIFMACVLLFRKGIIGEFYTSRIGKKLFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]