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The map label for this gene is hutU [H]

Identifier: 225686692

GI number: 225686692

Start: 897349

End: 899022

Strand: Direct

Name: hutU [H]

Synonym: BMEA_B0916

Alternate gene names: 225686692

Gene position: 897349-899022 (Clockwise)

Preceding gene: 225686691

Following gene: 225686693

Centisome position: 75.69

GC content: 61.05

Gene sequence:

>1674_bases
ATGTCCAATCCACGACATAACGAGCGCGAAGTGCGCAGCCCCCGCGGTGACGAACTGAATGCCAAAAGCTGGCTGACCGA
AGCGCCGCTGCGTATGCTGATGAACAATCTCGACCCCGATGTGGCCGAGCGTCCGCATGAACTGGTGGTCTATGGCGGCA
TTGGCCGCGCTGCCCGCACATGGGACGATTTCGACCGCATCGTCGCCACGCTCAAGACGCTCAACGACGACGAAACCCTG
CTGGTGCAGTCGGGCAAGCCGGTTGGCGTGTTCCGCACTCACAAGGACGCCCCCCGCGTTTTGATCGCCAATTCCAACCT
CGTGCCGCATTGGGCAAACTGGGATCATTTCAACGAACTGGATAAGAAGGGTCTTGCCATGTACGGCCAGATGACCGCCG
GTTCATGGATCTATATCGGCGCGCAGGGTATTGTTCAGGGCACTTACGAGACCTTCGTGGAAGCCGGTCGCCAGCATTAT
GGCGGCAACCTCAAGGGCAGGTGGATCTTGACCGGTGGCCTTGGCGGCATGGGTGGCGCGCAGCCGCTTGCCGCCGTCAT
GGCGGGCGCCTGCTGCCTTGCGGTCGAATGTGATGAAACCCGCGCCGATTTCCGCCTGCGCACCCGCTATGTCGATGAGA
AGACCCACAGCCTTGATGAGGCACTGGCCAAAATCGACGCCTGGACCAAGGCAGGCGAGGCAAAATCCATTGCGCTCATC
GGCAATGCGGCTGAGATTTTCCCGGAACTCGTCAAGCGTGGCGTGAAGCCGGATATCGTCACCGACCAGACCTCGGCGCA
TGATCCGGTGCATGGCTACCTGCCGCTTGGCTGGACCGTCGCGGAATGGCGCGCCAAGCAGGAAAATGACCCGAAGGCGG
TTGAAAAGGCGGCGCGCGCCTCCATGAAGGTGCAGGTTCAGGCCATGCTCGATTTCTGGAATGCCGGAATTCCAACCGTC
GATTACGGCAACAATATTCGCCAGATGGCACTGGAAGAAGGGCTTGAAAACGCCTTTGCCTTCCCCGGCTTCGTGCCTGC
CTATATCCGCCCGCTGTTCTGCCGCGGCATCGGCCCGTTCCGCTGGGCGGCGTTGTCCGGCGATCCGGAAGATATCGCCA
AAACAGACGCCAAGGTGAAGGAGCTGCTGCCCGACAACAAGCACCTGCACAACTGGCTTGATATGGCAAAGGAACGTATC
GCCTTTCAGGGCCTGCCGGCGCGCATCTGCTGGGTCGGCCTTGGCGATCGCCACCGCCTCGGCCTTGCCTTCAACGAGAT
GGTTCGCAACGGCGAATTGAAAGCCCCGATCGTCATCGGTCGCGACCATCTCGATAGCGGCTCGGTCGCCTCGCCCAACC
GCAAAACAGAGGCCATGAAGGATGGTTCGGATGCCGTGTCCGACTGGCCGCTCTTGAACGCGCTTCTCAATACGGCTTCG
GGCGCAACATGGGTTTCGCTGCATCACGGCGGCGGCGTCGGCATGGGCTTCTCGCAGCACGCGGGCATGGTTATCTGCTG
CGATGGCACCGAAGATGCGGATCGCCGGCTGGAACGCGTTCTGTGGAACGATCCGGCAACCGGGGTCATGCGCCATGCAG
ATGCGGGTTACGACATCGCGCTGGACTGGGCAAGGAAACAAGGCCTGCGCCTTCCAGCTATTCTCGGAAATTAA

Upstream 100 bases:

>100_bases
TATGACGAAGCCAAAGCGGACACGCTTCGCGTGCATCTCAAAACCCTTTTGCAGCGGCTGGAAACAATTGCCGCAGAACT
AAAATCCTGAGGAGAACACT

Downstream 100 bases:

>100_bases
GGTCATATGGCAATCACTATCCTCAAGGCCGAAAATCATCGCCGCATGCCGTGGAAAAACGGCGGCGGCCTCACGGCTGA
AATTGCCGTGCACCCACAAG

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MSNPRHNEREVRSPRGDELNAKSWLTEAPLRMLMNNLDPDVAERPHELVVYGGIGRAARTWDDFDRIVATLKTLNDDETL
LVQSGKPVGVFRTHKDAPRVLIANSNLVPHWANWDHFNELDKKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEAGRQHY
GGNLKGRWILTGGLGGMGGAQPLAAVMAGACCLAVECDETRADFRLRTRYVDEKTHSLDEALAKIDAWTKAGEAKSIALI
GNAAEIFPELVKRGVKPDIVTDQTSAHDPVHGYLPLGWTVAEWRAKQENDPKAVEKAARASMKVQVQAMLDFWNAGIPTV
DYGNNIRQMALEEGLENAFAFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIAKTDAKVKELLPDNKHLHNWLDMAKERI
AFQGLPARICWVGLGDRHRLGLAFNEMVRNGELKAPIVIGRDHLDSGSVASPNRKTEAMKDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHAGMVICCDGTEDADRRLERVLWNDPATGVMRHADAGYDIALDWARKQGLRLPAILGN

Sequences:

>Translated_557_residues
MSNPRHNEREVRSPRGDELNAKSWLTEAPLRMLMNNLDPDVAERPHELVVYGGIGRAARTWDDFDRIVATLKTLNDDETL
LVQSGKPVGVFRTHKDAPRVLIANSNLVPHWANWDHFNELDKKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEAGRQHY
GGNLKGRWILTGGLGGMGGAQPLAAVMAGACCLAVECDETRADFRLRTRYVDEKTHSLDEALAKIDAWTKAGEAKSIALI
GNAAEIFPELVKRGVKPDIVTDQTSAHDPVHGYLPLGWTVAEWRAKQENDPKAVEKAARASMKVQVQAMLDFWNAGIPTV
DYGNNIRQMALEEGLENAFAFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIAKTDAKVKELLPDNKHLHNWLDMAKERI
AFQGLPARICWVGLGDRHRLGLAFNEMVRNGELKAPIVIGRDHLDSGSVASPNRKTEAMKDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHAGMVICCDGTEDADRRLERVLWNDPATGVMRHADAGYDIALDWARKQGLRLPAILGN
>Mature_556_residues
SNPRHNEREVRSPRGDELNAKSWLTEAPLRMLMNNLDPDVAERPHELVVYGGIGRAARTWDDFDRIVATLKTLNDDETLL
VQSGKPVGVFRTHKDAPRVLIANSNLVPHWANWDHFNELDKKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEAGRQHYG
GNLKGRWILTGGLGGMGGAQPLAAVMAGACCLAVECDETRADFRLRTRYVDEKTHSLDEALAKIDAWTKAGEAKSIALIG
NAAEIFPELVKRGVKPDIVTDQTSAHDPVHGYLPLGWTVAEWRAKQENDPKAVEKAARASMKVQVQAMLDFWNAGIPTVD
YGNNIRQMALEEGLENAFAFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIAKTDAKVKELLPDNKHLHNWLDMAKERIA
FQGLPARICWVGLGDRHRLGLAFNEMVRNGELKAPIVIGRDHLDSGSVASPNRKTEAMKDGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGFSQHAGMVICCDGTEDADRRLERVLWNDPATGVMRHADAGYDIALDWARKQGLRLPAILGN

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=555, Percent_Identity=33.1531531531532, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI260306182, Length=217, Percent_Identity=38.7096774193548, Blast_Score=163, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71997891, Length=574, Percent_Identity=34.4947735191638, Blast_Score=307, Evalue=8e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61213; Mature: 61082

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPRHNEREVRSPRGDELNAKSWLTEAPLRMLMNNLDPDVAERPHELVVYGGIGRAART
CCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCCCCCC
WDDFDRIVATLKTLNDDETLLVQSGKPVGVFRTHKDAPRVLIANSNLVPHWANWDHFNEL
HHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHH
DKKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEAGRQHYGGNLKGRWILTGGLGGMGGA
HHCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCH
QPLAAVMAGACCLAVECDETRADFRLRTRYVDEKTHSLDEALAKIDAWTKAGEAKSIALI
HHHHHHHHCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
GNAAEIFPELVKRGVKPDIVTDQTSAHDPVHGYLPLGWTVAEWRAKQENDPKAVEKAARA
CCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCEEHHHHHCCCCCCHHHHHHHHHH
SMKVQVQAMLDFWNAGIPTVDYGNNIRQMALEEGLENAFAFPGFVPAYIRPLFCRGIGPF
HHEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCC
RWAALSGDPEDIAKTDAKVKELLPDNKHLHNWLDMAKERIAFQGLPARICWVGLGDRHRL
EEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEE
GLAFNEMVRNGELKAPIVIGRDHLDSGSVASPNRKTEAMKDGSDAVSDWPLLNALLNTAS
CHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHAGMVICCDGTEDADRRLERVLWNDPATGVMRHADAGYDIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHCCCCCEEE
LDWARKQGLRLPAILGN
EEHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SNPRHNEREVRSPRGDELNAKSWLTEAPLRMLMNNLDPDVAERPHELVVYGGIGRAART
CCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCCCCCC
WDDFDRIVATLKTLNDDETLLVQSGKPVGVFRTHKDAPRVLIANSNLVPHWANWDHFNEL
HHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHH
DKKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEAGRQHYGGNLKGRWILTGGLGGMGGA
HHCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCH
QPLAAVMAGACCLAVECDETRADFRLRTRYVDEKTHSLDEALAKIDAWTKAGEAKSIALI
HHHHHHHHCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
GNAAEIFPELVKRGVKPDIVTDQTSAHDPVHGYLPLGWTVAEWRAKQENDPKAVEKAARA
CCHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCEEHHHHHCCCCCCHHHHHHHHHH
SMKVQVQAMLDFWNAGIPTVDYGNNIRQMALEEGLENAFAFPGFVPAYIRPLFCRGIGPF
HHEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCC
RWAALSGDPEDIAKTDAKVKELLPDNKHLHNWLDMAKERIAFQGLPARICWVGLGDRHRL
EEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEE
GLAFNEMVRNGELKAPIVIGRDHLDSGSVASPNRKTEAMKDGSDAVSDWPLLNALLNTAS
CHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHAGMVICCDGTEDADRRLERVLWNDPATGVMRHADAGYDIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHCCCCCEEE
LDWARKQGLRLPAILGN
EEHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA