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The map label for this gene is macA [H]

Identifier: 225686675

GI number: 225686675

Start: 879557

End: 880675

Strand: Reverse

Name: macA [H]

Synonym: BMEA_B0898

Alternate gene names: 225686675

Gene position: 880675-879557 (Counterclockwise)

Preceding gene: 225686676

Following gene: 225686674

Centisome position: 74.29

GC content: 59.34

Gene sequence:

>1119_bases
ATGCAACGGGCTGCGCGAACAGGCAAATACCTGATTTTGGGCGCATTCGCCGGTCTTGCAACCTGCATTCAGATCCTGTC
GGCCGGAAGTCCGGCATATGCTGATTCACTCAATGTCGTGCCGGTTGCGGTCCGGGAAGCGAAGCTTGTCGATTACCAGC
CGAAATTGACGCTTTCCGGGGCTGTCGCCGCGCGCTCTCTGGTCAATGTATCGTTCCGCGTCAATGGTCAGGTGGTCGAA
CGGCTGGTCGATATCGGGCAGCATGTCGAAAAGGGGCAGCTTCTGGCCCGCATCGACGATGTTGAACAGCGCGCCAATAT
GCGCGTTGCGCAGGCTTCCATGGACGCCGCAGAAGCGCAGCTCGTGCAGGCCGACGCCAATTTCAAGCGCCAGCAGGCGC
TGTTGAAGCAGGGTTTTACCACGCGCAGCCAGTATGACCAGGCCGATCAGGCATTGCGCACCGCGCAAAGTGCGCTTTCC
AGCGCGCAAAGCCAGCTTGGCAATGCACGCGACGAGCTTTCCTATACCGAGCTTCATGCCCCTGTTTCAGGCGTCGTTAC
GGCGCGCAATATCGAAACGGGTCAGGTCGTGCAGGCAGCGCAAACGGCTTTCTCCATTGCGGAAGACGGCTCGCGCGACG
CTATTTTCGATGTGCAGGAAACATTGGTGAATCATGCCCGCATTGGAATGGGCGTAACGGTTGCCCTGCTTGCCGATCCT
TCCATTGAAGCAGAGGGCAATATCCGTGAATTGTCGCCGGTTGTTGACGCACAGACCGGCACAGTGCGGGTCAAGGTAGG
CATTGCGCAGGCAACTGCGCAGATGGCGCTTGGCGCAATCGTCACCGGAACTGTCCATATGGATGCGCGGCAGGTGATCG
TGCTGCCATGGAGCGCGATGACCTCGGAGGCGGGACGAACGGCCGTCTGGCGCGTGGATAGGGACACGCATGTCGCGACA
CTCGTTCCGATCAAGGTGCTGGCCTATGAAAAAGAGCGCGTGATCGTCGAAAGCGGCCTTAATAACGGTGAGCTTATCGT
GACCAAAGGTGCGCAGATGCTGCGCTCCGGCGAGCCGGTAGAGATCATGCAGGGGCCTGAAGGAGCTGGCTCGCAATGA

Upstream 100 bases:

>100_bases
TTTTGATTGCATTCTCACGGCAACCAAACAAACGAGAATCGTGTAAATGGCGGTAATATCGTTCCCTGAGACTATCCGGG
GCGAATGGGGGCGCGTTGCA

Downstream 100 bases:

>100_bases
AAATCCATATGAACCCCATGTTCCGTGCTGCCGGTTGCGCGGTCCTGTTTGGCGCGCTGACGGTGCTTGCCGCTTGCGGC
AAAGAGGATGAAAAGGCGCA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MQRAARTGKYLILGAFAGLATCIQILSAGSPAYADSLNVVPVAVREAKLVDYQPKLTLSGAVAARSLVNVSFRVNGQVVE
RLVDIGQHVEKGQLLARIDDVEQRANMRVAQASMDAAEAQLVQADANFKRQQALLKQGFTTRSQYDQADQALRTAQSALS
SAQSQLGNARDELSYTELHAPVSGVVTARNIETGQVVQAAQTAFSIAEDGSRDAIFDVQETLVNHARIGMGVTVALLADP
SIEAEGNIRELSPVVDAQTGTVRVKVGIAQATAQMALGAIVTGTVHMDARQVIVLPWSAMTSEAGRTAVWRVDRDTHVAT
LVPIKVLAYEKERVIVESGLNNGELIVTKGAQMLRSGEPVEIMQGPEGAGSQ

Sequences:

>Translated_372_residues
MQRAARTGKYLILGAFAGLATCIQILSAGSPAYADSLNVVPVAVREAKLVDYQPKLTLSGAVAARSLVNVSFRVNGQVVE
RLVDIGQHVEKGQLLARIDDVEQRANMRVAQASMDAAEAQLVQADANFKRQQALLKQGFTTRSQYDQADQALRTAQSALS
SAQSQLGNARDELSYTELHAPVSGVVTARNIETGQVVQAAQTAFSIAEDGSRDAIFDVQETLVNHARIGMGVTVALLADP
SIEAEGNIRELSPVVDAQTGTVRVKVGIAQATAQMALGAIVTGTVHMDARQVIVLPWSAMTSEAGRTAVWRVDRDTHVAT
LVPIKVLAYEKERVIVESGLNNGELIVTKGAQMLRSGEPVEIMQGPEGAGSQ
>Mature_372_residues
MQRAARTGKYLILGAFAGLATCIQILSAGSPAYADSLNVVPVAVREAKLVDYQPKLTLSGAVAARSLVNVSFRVNGQVVE
RLVDIGQHVEKGQLLARIDDVEQRANMRVAQASMDAAEAQLVQADANFKRQQALLKQGFTTRSQYDQADQALRTAQSALS
SAQSQLGNARDELSYTELHAPVSGVVTARNIETGQVVQAAQTAFSIAEDGSRDAIFDVQETLVNHARIGMGVTVALLADP
SIEAEGNIRELSPVVDAQTGTVRVKVGIAQATAQMALGAIVTGTVHMDARQVIVLPWSAMTSEAGRTAVWRVDRDTHVAT
LVPIKVLAYEKERVIVESGLNNGELIVTKGAQMLRSGEPVEIMQGPEGAGSQ

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=320, Percent_Identity=25.625, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789929, Length=371, Percent_Identity=25.3369272237197, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081796, Length=314, Percent_Identity=29.6178343949045, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081951, Length=189, Percent_Identity=29.6296296296296, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790519, Length=251, Percent_Identity=25.8964143426295, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786668, Length=317, Percent_Identity=26.1829652996845, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1789665, Length=336, Percent_Identity=23.8095238095238, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39576; Mature: 39576

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRAARTGKYLILGAFAGLATCIQILSAGSPAYADSLNVVPVAVREAKLVDYQPKLTLSG
CCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEECCCCCEEEHH
AVAARSLVNVSFRVNGQVVERLVDIGQHVEKGQLLARIDDVEQRANMRVAQASMDAAEAQ
HHHHHHHEEEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LVQADANFKRQQALLKQGFTTRSQYDQADQALRTAQSALSSAQSQLGNARDELSYTELHA
HHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCC
PVSGVVTARNIETGQVVQAAQTAFSIAEDGSRDAIFDVQETLVNHARIGMGVTVALLADP
CHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECC
SIEAEGNIRELSPVVDAQTGTVRVKVGIAQATAQMALGAIVTGTVHMDARQVIVLPWSAM
CCCCCCCHHHHCHHHCCCCCEEEEEEEHHHHHHHHHHHHHEEEEEEECCCEEEEEECHHH
TSEAGRTAVWRVDRDTHVATLVPIKVLAYEKERVIVESGLNNGELIVTKGAQMLRSGEPV
HCCCCCEEEEEECCCCEEEEEEEEEEEEECCCEEEEECCCCCCCEEEECCHHHHHCCCCE
EIMQGPEGAGSQ
EEEECCCCCCCC
>Mature Secondary Structure
MQRAARTGKYLILGAFAGLATCIQILSAGSPAYADSLNVVPVAVREAKLVDYQPKLTLSG
CCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEECCCCCEEEHH
AVAARSLVNVSFRVNGQVVERLVDIGQHVEKGQLLARIDDVEQRANMRVAQASMDAAEAQ
HHHHHHHEEEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LVQADANFKRQQALLKQGFTTRSQYDQADQALRTAQSALSSAQSQLGNARDELSYTELHA
HHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCC
PVSGVVTARNIETGQVVQAAQTAFSIAEDGSRDAIFDVQETLVNHARIGMGVTVALLADP
CHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECC
SIEAEGNIRELSPVVDAQTGTVRVKVGIAQATAQMALGAIVTGTVHMDARQVIVLPWSAM
CCCCCCCHHHHCHHHCCCCCEEEEEEEHHHHHHHHHHHHHEEEEEEECCCEEEEEECHHH
TSEAGRTAVWRVDRDTHVATLVPIKVLAYEKERVIVESGLNNGELIVTKGAQMLRSGEPV
HCCCCCEEEEEECCCCEEEEEEEEEEEEECCCEEEEECCCCCCCEEEECCHHHHHCCCCE
EIMQGPEGAGSQ
EEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]