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The map label for this gene is hsdM [C]

Identifier: 225686602

GI number: 225686602

Start: 802002

End: 803528

Strand: Direct

Name: hsdM [C]

Synonym: BMEA_B0819

Alternate gene names: 225686602

Gene position: 802002-803528 (Clockwise)

Preceding gene: 225686601

Following gene: 225686603

Centisome position: 67.65

GC content: 55.53

Gene sequence:

>1527_bases
ATGGCCAAACTCACACGTACCGAACTGGAAAATCATCTTTGGAAATCCGCTGACATTCTTCGCGGCTCCATCGATAGCTC
CGACTACAAGATCTACATCTTTGGCTTTCTATTTCTGAAGCGACTTTCTGATCGTTTCGAGGAAGAGGCCAAGGAGTCCA
TACGTCAGGGGCTGCCGGAAAATGTCGCCTACAGCGACCCAGACGAGCATGAGTTCTTTCTCGTTGAACGCGCGCGCTGG
TCGTCGATCAAAAAGCTGACGACGGGTATTGGCGACCACCTCAACAAAGCATGCGCCGCGATTGAGGACGCCAATCCTTC
AATCGAAGGTGTGCTGGCCAATATCGACTTCAACTCCGAATCGCGCCTTGGCGATGCCAAGAACCGCGAAGGCGTTCTGT
CGCGTCTGATCGACCATTTCTCACGCATCGACCTGTCGAACGCTTCTCTGTCCGAACCGGATATGCTTGGTCGCGCATAT
GAATACTTGATCGACAAGTTCGCAGACGATGCAGGCAAGAAGGGCGGCGAGTTCTATACCCCCCACCATGTCGTGCGGCT
GATTGTCGAGTTGCTGGCCCCCAAGCCAGGTATGCGCATCAGCGACCCAACATGTGGCTCAGGCGGCATGCTGGTTCAGG
TCGCGGAGCATGTGGCGAAGCTCGAAGGCAAGCGGCTCGGCGAAGCGCTCAACATCACGCTGCACGGGCAGGAAAAGAAC
CTTGGCACATGGGCCATCGCCAAGATGAACTTGCTGCTGCACGGGCTACGCGATGCGCGAATTGAAAAAGGCGATACAAT
CCGCAATCCGCGCCTGTTGGATCAGGACGGCAACCTGTTCCTTTATGATCGAGTAATCGCCAACCCGCCCTTCTCGCTGG
ATAGCTGGGGTGCGGAGGACGTGTCAGGCGACACCGAGAAGAAGGGCCACAATCGCTTCATCTACGGCATTCCCCCAAAG
AACATGGGCGATCTAGCCTTCGTTCAGCACATGGTGGCCACGCTCAACACTAAAGGTGTTTGCGGCGTAGTGATGCCGCA
TGGGGTGCTGTTCCGCGGCTCAGGCGACGGCCGTATTCGCGAGTCGATGCTGAAAGCCGATCTGTTCGAAGCGATTATCG
GCCTGCCAGAAAACCTGTTCGCAGGAACCGGCATTCCAGCAACCGTTTTGATCCTCAACAAGGCAAAAGCGACTGAGCGC
AAGGGAAGAGTACTGTTCATTCACGGCGCAAAGGAATTCGAGGAACGGCCTAAAAAGAACATCTTGGGCGAGGGCAACAT
CACGCGCATCGTTAATGCCTTCAATGCTTGGAAGGATGAGGATCGCTTCTGCCGCATCGTCGACATGAAGGAGATCGAAG
AGAATGATTTCAATCTCAACATCTCCCGCTACATCGATACGCTCGAGCCCGAAAAGCCGATCGATGTGCAGGCCGAACTT
GCCAAGCTGTGGGACGCTGAGACGGCCCGGGACGAAGCTGCGGCCCGCATGAACGCCCTTCTCAAGGAGATGGGTTATGT
CGGTTGA

Upstream 100 bases:

>100_bases
TACCGCACCGCCTTGGAGGCCGCTAAAATCCGCCGCTCACTCGCGCGGCGTCTGATTGACGCGCGCCTGTTTGGCGACGA
CCAGAATCATTGAGGTAAAC

Downstream 100 bases:

>100_bases
AGTGCCCAAAGGCTGGCGCGAGGTGCGCATCGGTCAAATTGCCCGCGAAATCTCGAATAGAAACCATGCGAGCGCTGACA
TCCCCGTCCTAAGCATGACA

Product: type I restriction-modification system, M subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MAKLTRTELENHLWKSADILRGSIDSSDYKIYIFGFLFLKRLSDRFEEEAKESIRQGLPENVAYSDPDEHEFFLVERARW
SSIKKLTTGIGDHLNKACAAIEDANPSIEGVLANIDFNSESRLGDAKNREGVLSRLIDHFSRIDLSNASLSEPDMLGRAY
EYLIDKFADDAGKKGGEFYTPHHVVRLIVELLAPKPGMRISDPTCGSGGMLVQVAEHVAKLEGKRLGEALNITLHGQEKN
LGTWAIAKMNLLLHGLRDARIEKGDTIRNPRLLDQDGNLFLYDRVIANPPFSLDSWGAEDVSGDTEKKGHNRFIYGIPPK
NMGDLAFVQHMVATLNTKGVCGVVMPHGVLFRGSGDGRIRESMLKADLFEAIIGLPENLFAGTGIPATVLILNKAKATER
KGRVLFIHGAKEFEERPKKNILGEGNITRIVNAFNAWKDEDRFCRIVDMKEIEENDFNLNISRYIDTLEPEKPIDVQAEL
AKLWDAETARDEAAARMNALLKEMGYVG

Sequences:

>Translated_508_residues
MAKLTRTELENHLWKSADILRGSIDSSDYKIYIFGFLFLKRLSDRFEEEAKESIRQGLPENVAYSDPDEHEFFLVERARW
SSIKKLTTGIGDHLNKACAAIEDANPSIEGVLANIDFNSESRLGDAKNREGVLSRLIDHFSRIDLSNASLSEPDMLGRAY
EYLIDKFADDAGKKGGEFYTPHHVVRLIVELLAPKPGMRISDPTCGSGGMLVQVAEHVAKLEGKRLGEALNITLHGQEKN
LGTWAIAKMNLLLHGLRDARIEKGDTIRNPRLLDQDGNLFLYDRVIANPPFSLDSWGAEDVSGDTEKKGHNRFIYGIPPK
NMGDLAFVQHMVATLNTKGVCGVVMPHGVLFRGSGDGRIRESMLKADLFEAIIGLPENLFAGTGIPATVLILNKAKATER
KGRVLFIHGAKEFEERPKKNILGEGNITRIVNAFNAWKDEDRFCRIVDMKEIEENDFNLNISRYIDTLEPEKPIDVQAEL
AKLWDAETARDEAAARMNALLKEMGYVG
>Mature_507_residues
AKLTRTELENHLWKSADILRGSIDSSDYKIYIFGFLFLKRLSDRFEEEAKESIRQGLPENVAYSDPDEHEFFLVERARWS
SIKKLTTGIGDHLNKACAAIEDANPSIEGVLANIDFNSESRLGDAKNREGVLSRLIDHFSRIDLSNASLSEPDMLGRAYE
YLIDKFADDAGKKGGEFYTPHHVVRLIVELLAPKPGMRISDPTCGSGGMLVQVAEHVAKLEGKRLGEALNITLHGQEKNL
GTWAIAKMNLLLHGLRDARIEKGDTIRNPRLLDQDGNLFLYDRVIANPPFSLDSWGAEDVSGDTEKKGHNRFIYGIPPKN
MGDLAFVQHMVATLNTKGVCGVVMPHGVLFRGSGDGRIRESMLKADLFEAIIGLPENLFAGTGIPATVLILNKAKATERK
GRVLFIHGAKEFEERPKKNILGEGNITRIVNAFNAWKDEDRFCRIVDMKEIEENDFNLNISRYIDTLEPEKPIDVQAELA
KLWDAETARDEAAARMNALLKEMGYVG

Specific function: The M And S Subunits Together Form A Methyltransferase (Mtase) That Methylates Two Adenine Residues In Complementary Strands Of A Bipartite DNA Recognition Sequence. In The Presence Of The R Subunit The Complex Can Also Act As An Endonuclease, Binding To

COG id: COG0286

COG function: function code V; Type I restriction-modification system methyltransferase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N(4)/N(6)-methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790808, Length=402, Percent_Identity=25.1243781094527, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022749
- InterPro:   IPR003356
- InterPro:   IPR002052
- InterPro:   IPR002296
- InterPro:   IPR011991 [H]

Pfam domain/function: PF12161 HsdM_N; PF02384 N6_Mtase [H]

EC number: =2.1.1.72 [H]

Molecular weight: Translated: 56747; Mature: 56616

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLTRTELENHLWKSADILRGSIDSSDYKIYIFGFLFLKRLSDRFEEEAKESIRQGLPE
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NVAYSDPDEHEFFLVERARWSSIKKLTTGIGDHLNKACAAIEDANPSIEGVLANIDFNSE
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCC
SRLGDAKNREGVLSRLIDHFSRIDLSNASLSEPDMLGRAYEYLIDKFADDAGKKGGEFYT
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PHHVVRLIVELLAPKPGMRISDPTCGSGGMLVQVAEHVAKLEGKRLGEALNITLHGQEKN
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
LGTWAIAKMNLLLHGLRDARIEKGDTIRNPRLLDQDGNLFLYDRVIANPPFSLDSWGAED
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEEHHHCCCCCCCCCCCCCC
VSGDTEKKGHNRFIYGIPPKNMGDLAFVQHMVATLNTKGVCGVVMPHGVLFRGSGDGRIR
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCHHH
ESMLKADLFEAIIGLPENLFAGTGIPATVLILNKAKATERKGRVLFIHGAKEFEERPKKN
HHHHHHHHHHHHHCCCHHHHCCCCCCEEEEEEECCHHHCCCCCEEEEECCHHHHHCHHHC
ILGEGNITRIVNAFNAWKDEDRFCRIVDMKEIEENDFNLNISRYIDTLEPEKPIDVQAEL
CCCCCCHHHHHHHHHCCCCCCCEEEEECHHHHCCCCCCEEHHHHHHCCCCCCCCCHHHHH
AKLWDAETARDEAAARMNALLKEMGYVG
HHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKLTRTELENHLWKSADILRGSIDSSDYKIYIFGFLFLKRLSDRFEEEAKESIRQGLPE
CCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NVAYSDPDEHEFFLVERARWSSIKKLTTGIGDHLNKACAAIEDANPSIEGVLANIDFNSE
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCC
SRLGDAKNREGVLSRLIDHFSRIDLSNASLSEPDMLGRAYEYLIDKFADDAGKKGGEFYT
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PHHVVRLIVELLAPKPGMRISDPTCGSGGMLVQVAEHVAKLEGKRLGEALNITLHGQEKN
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
LGTWAIAKMNLLLHGLRDARIEKGDTIRNPRLLDQDGNLFLYDRVIANPPFSLDSWGAED
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEEHHHCCCCCCCCCCCCCC
VSGDTEKKGHNRFIYGIPPKNMGDLAFVQHMVATLNTKGVCGVVMPHGVLFRGSGDGRIR
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCHHH
ESMLKADLFEAIIGLPENLFAGTGIPATVLILNKAKATERKGRVLFIHGAKEFEERPKKN
HHHHHHHHHHHHHCCCHHHHCCCCCCEEEEEEECCHHHCCCCCEEEEECCHHHHHCHHHC
ILGEGNITRIVNAFNAWKDEDRFCRIVDMKEIEENDFNLNISRYIDTLEPEKPIDVQAEL
CCCCCCHHHHHHHHHCCCCCCCEEEEECHHHHCCCCCCEEHHHHHHCCCCCCCCCHHHHH
AKLWDAETARDEAAARMNALLKEMGYVG
HHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]