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The map label for this gene is dhaT [H]

Identifier: 225686504

GI number: 225686504

Start: 697894

End: 699063

Strand: Direct

Name: dhaT [H]

Synonym: BMEA_B0712

Alternate gene names: 225686504

Gene position: 697894-699063 (Clockwise)

Preceding gene: 225686502

Following gene: 225686505

Centisome position: 58.87

GC content: 60.43

Gene sequence:

>1170_bases
ATGACCACATTGACCGCGAAATGGAACTTTCCGACCACTGTGCTTTTCGGGCCGGGGCACATCAAGGAGCTTCCAGCCGT
CCTGAAAGCCGCAGGCATCGAGCACCCGCTTTTCGTCACCGATCCGGGCCTCGCCAAACTGCCTGTGGTCGCCTCGACAT
TGGCCGTTCTGGATGCGGCGGGCGTGCAATATGGCGTGTTTTCCGATGTGAAACCCAATCCGGTCGAGAGCAATCTTCAT
GCCGGCGTAAAGGTTTTCCGGGAAGGCAGGCATGACGGCGTCATCGCCTTTGGCGGCGGTTCCGCGCTCGATCTCGGCAA
GCTCATCGCCTTTCAGGCCGGACAGACCCGGCCCGTCTGGGATTTTGAAGATATCGGCGACTGGTGGACCCGCGCCGACA
GCAACGCCATAGCTCCCGTCATTGCCGTGCCGACCACCGCAGGCACCGGCTCGGAAGTGGGGCGCGCGGGCGTTCTCACC
AATGAATCCACCCACACGAAGAAGGTCATCTTCCACCCCAAAATGCTGCCCGTAACGGTGATCGCCGATCCCGAACTTTC
CACTGGCATGCCGCCCTTCATCACGGCGGGTACGGGCATGGATGCACTGGCGCACTGCCTTGAAGCCTATTGCGCACCGG
GCTTCCATCCCATGGCCGATGGCATTGCCGTGGAGGGCATCCGCCTTGTCTTTGAGAACCTGCCCAAAGCCTATGCCAAT
GGCGGGGATATCGAAGCGCGTGCCAATATGATGGCAGCCGCTGCCATGGGCGCCACGGCCTTCCAGAAGGGCCTCGGTGC
GATCCATTCGCTCTCGCACCCCATCGGCGCGCTCTATGACACACATCACGGCATGACCAATGCCGTCTTCATGCCCTATG
TGCTGCACCACAACCGGGCTGCCATCGAAAAGCGCATTGCCCGGCTGGCCGATTATCTCGGCATCGAAGGCGGGTTCGAC
GGCTTTGCCGATGCGATCATGAAGCTGCGCGCCGAACTTGGCGTGCCGCGCACCCTGCCCGATCTCATCAAGAACCTTCA
GATGGACAATGCCCGCAAGGAGCTGATCGCCGAAATGGCAGTGGCAGATCCCACCGCAGGCGGAAACCCGGTTGAACTTA
CAAAAAACGACGCGCTAAAGTTGCTCAATGCAGCATTGGAAGGTAGATAA

Upstream 100 bases:

>100_bases
CCAACCAGAATTTTTTCAGGAAAAGGCCCGATGAGCGGCCAAAATCCTTCCATCGGCATGAAAAAATCTGACCACTCATC
ATAATTCGGAAGCAATCGAC

Downstream 100 bases:

>100_bases
ATCGCTGGCCAGACGGTAATCAGGTCAGGCGTCGCGCCACCATGGGTGGGGGCGGCGCATGAGGGGGCAGGTTCTTGGGG
AGGAGCCTGCCCCCTTTCAT

Product: 1,3-propanediol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTTLTAKWNFPTTVLFGPGHIKELPAVLKAAGIEHPLFVTDPGLAKLPVVASTLAVLDAAGVQYGVFSDVKPNPVESNLH
AGVKVFREGRHDGVIAFGGGSALDLGKLIAFQAGQTRPVWDFEDIGDWWTRADSNAIAPVIAVPTTAGTGSEVGRAGVLT
NESTHTKKVIFHPKMLPVTVIADPELSTGMPPFITAGTGMDALAHCLEAYCAPGFHPMADGIAVEGIRLVFENLPKAYAN
GGDIEARANMMAAAAMGATAFQKGLGAIHSLSHPIGALYDTHHGMTNAVFMPYVLHHNRAAIEKRIARLADYLGIEGGFD
GFADAIMKLRAELGVPRTLPDLIKNLQMDNARKELIAEMAVADPTAGGNPVELTKNDALKLLNAALEGR

Sequences:

>Translated_389_residues
MTTLTAKWNFPTTVLFGPGHIKELPAVLKAAGIEHPLFVTDPGLAKLPVVASTLAVLDAAGVQYGVFSDVKPNPVESNLH
AGVKVFREGRHDGVIAFGGGSALDLGKLIAFQAGQTRPVWDFEDIGDWWTRADSNAIAPVIAVPTTAGTGSEVGRAGVLT
NESTHTKKVIFHPKMLPVTVIADPELSTGMPPFITAGTGMDALAHCLEAYCAPGFHPMADGIAVEGIRLVFENLPKAYAN
GGDIEARANMMAAAAMGATAFQKGLGAIHSLSHPIGALYDTHHGMTNAVFMPYVLHHNRAAIEKRIARLADYLGIEGGFD
GFADAIMKLRAELGVPRTLPDLIKNLQMDNARKELIAEMAVADPTAGGNPVELTKNDALKLLNAALEGR
>Mature_388_residues
TTLTAKWNFPTTVLFGPGHIKELPAVLKAAGIEHPLFVTDPGLAKLPVVASTLAVLDAAGVQYGVFSDVKPNPVESNLHA
GVKVFREGRHDGVIAFGGGSALDLGKLIAFQAGQTRPVWDFEDIGDWWTRADSNAIAPVIAVPTTAGTGSEVGRAGVLTN
ESTHTKKVIFHPKMLPVTVIADPELSTGMPPFITAGTGMDALAHCLEAYCAPGFHPMADGIAVEGIRLVFENLPKAYANG
GDIEARANMMAAAAMGATAFQKGLGAIHSLSHPIGALYDTHHGMTNAVFMPYVLHHNRAAIEKRIARLADYLGIEGGFDG
FADAIMKLRAELGVPRTLPDLIKNLQMDNARKELIAEMAVADPTAGGNPVELTKNDALKLLNAALEGR

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=310, Percent_Identity=29.3548387096774, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI48994951, Length=388, Percent_Identity=30.4123711340206, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789163, Length=385, Percent_Identity=31.6883116883117, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87082107, Length=337, Percent_Identity=32.3442136498516, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1787493, Length=397, Percent_Identity=29.9748110831234, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789386, Length=347, Percent_Identity=28.2420749279539, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17537053, Length=289, Percent_Identity=27.3356401384083, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321181, Length=391, Percent_Identity=32.4808184143223, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24657991, Length=339, Percent_Identity=27.1386430678466, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 41073; Mature: 40942

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLTAKWNFPTTVLFGPGHIKELPAVLKAAGIEHPLFVTDPGLAKLPVVASTLAVLDAA
CCEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHC
GVQYGVFSDVKPNPVESNLHAGVKVFREGRHDGVIAFGGGSALDLGKLIAFQAGQTRPVW
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCC
DFEDIGDWWTRADSNAIAPVIAVPTTAGTGSEVGRAGVLTNESTHTKKVIFHPKMLPVTV
CHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCEECCCCCCCEEEEECCCCCEEEE
IADPELSTGMPPFITAGTGMDALAHCLEAYCAPGFHPMADGIAVEGIRLVFENLPKAYAN
EECCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
GGDIEARANMMAAAAMGATAFQKGLGAIHSLSHPIGALYDTHHGMTNAVFMPYVLHHNRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHCCHH
AIEKRIARLADYLGIEGGFDGFADAIMKLRAELGVPRTLPDLIKNLQMDNARKELIAEMA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHH
VADPTAGGNPVELTKNDALKLLNAALEGR
HCCCCCCCCCEEECHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTLTAKWNFPTTVLFGPGHIKELPAVLKAAGIEHPLFVTDPGLAKLPVVASTLAVLDAA
CEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHC
GVQYGVFSDVKPNPVESNLHAGVKVFREGRHDGVIAFGGGSALDLGKLIAFQAGQTRPVW
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCC
DFEDIGDWWTRADSNAIAPVIAVPTTAGTGSEVGRAGVLTNESTHTKKVIFHPKMLPVTV
CHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCEECCCCCCCEEEEECCCCCEEEE
IADPELSTGMPPFITAGTGMDALAHCLEAYCAPGFHPMADGIAVEGIRLVFENLPKAYAN
EECCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
GGDIEARANMMAAAAMGATAFQKGLGAIHSLSHPIGALYDTHHGMTNAVFMPYVLHHNRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHCCHH
AIEKRIARLADYLGIEGGFDGFADAIMKLRAELGVPRTLPDLIKNLQMDNARKELIAEMA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHH
VADPTAGGNPVELTKNDALKLLNAALEGR
HCCCCCCCCCEEECHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]