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The map label for this gene is pyrC [H]

Identifier: 225686386

GI number: 225686386

Start: 565781

End: 567067

Strand: Direct

Name: pyrC [H]

Synonym: BMEA_B0575

Alternate gene names: 225686386

Gene position: 565781-567067 (Clockwise)

Preceding gene: 225686385

Following gene: 225686387

Centisome position: 47.72

GC content: 61.54

Gene sequence:

>1287_bases
ATGAGCGCGATCCTGTTTGAAAACGCCCGGATCGTCGATCCATCACGCGGCCTTGATGAAACCGGCAGCCTTCTGATCGA
AAACGGCAAAATCGTCGCCGCTGGCAGCGAGGCCCGTAATCAGGGCGCGCCGGAAGGTGCTGAAATTGTCGATCTGGATG
GCAAGGCTGTGATGCCGGGTCTCGTGGATTCGCGGGTCTTCATCGGTGAACCGGGGGCTGAACACCGCGAAACAATCGCT
TCGGCAAGCCGGGCGGCTGCGGCAGGCGGCGTCACCTCCATCATCATGATGCCGGACACCGATCCGGTGATCGACGATGT
GGCGCTGGTGGAATTCGTCAAGCGCACAGCGCGCGACACGGCCATCGTCAATGTCCATCCCGCCGCCGCCATCACCAAGG
GCCTGCACGGCGAGGAAATGACCGAATTCGGCCTGCTGCGGGCAGCCGGTGCGGTTGCCTTCACCGAAGGCCGCAATACT
ATCGCCAATACGCAGATCATGCGCCGCGCCCTCACCTATGCGCGCGATTTCAACGCCGTCATCGCCTGCGAAACACGCGA
TCCTTTGCTCGGCGCAAACGGCGTGATGAATGAAGGCCTGTTTGCAAGCTGGCTTGGCCTTTCCGGCACGCCGCGGGAAG
CGGAAGTGATTCCGCTGGAGCGTGATCTGCGTCTTGCGGCCCTCACCCGAAGCCGCTACCACGCCGCGCAGCTTTCCTGC
GCCATGTCGGCGGACGCCATGCGCCGCGCCAAGGATCTGGGCACGAACGTCACGGCGGGCGTGTCGATCAACCATCTGTC
GCTCAACGAGAACGATATCGGCGAGTTCCGCACCTTCTTCCGCCTGTCGCCGCCGCTGCGCGGCGAGGAAGACCGGCTCG
CCATGGTGGAAGCCGTGAAAAACGGCACCATCGACATCGTGGTTTCGGCACATGACCCGCAGGATGTGGATACCAAGCGC
CTGCCCTTTTCAGATGCCGAAGCAGGCGCAATCGGTCTGGAAACGCTGCTCGCGGCGGCACTTCGTCTCTATCATAATGA
CAATATTCCGCTTCTGCGGCTGGTCGAGGTGCTTTCCACGGCGCCAGCAAAAATATTCGGCCTGAATGCCGGTACGCTGA
AACCGGGCGCAAGCGCGGATATCGCCATTGTCGATCTGGAAGAACCATGGGTCGTGCGGGAGGAAGACCTGCATTCGCGC
TCCAAGAATAGCTGCTTTGAAAGTGCGCGGTTCCAGGGGCGCGTGGTTCGCACGATTGTAGCGGGCAAGACCGTTTATTC
GGCTTGA

Upstream 100 bases:

>100_bases
GCGTCATCCAGCAACAGGTGGAAATGGGCGTTGCCGTGCGCATGGCCGTGATGGAGGCTCTGCTCGATCCGCGGCGCAAC
CCAGGCAACGGAGAACCGGC

Downstream 100 bases:

>100_bases
AAAACACCGCATAACCCTGAAAAATCGGACATGGTTTCCGGGTTATGCGCAATCAAAAAACAGAGGGAATTGCAATGGCC
GAACCGGGTTTCTTCAATGC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSAILFENARIVDPSRGLDETGSLLIENGKIVAAGSEARNQGAPEGAEIVDLDGKAVMPGLVDSRVFIGEPGAEHRETIA
SASRAAAAGGVTSIIMMPDTDPVIDDVALVEFVKRTARDTAIVNVHPAAAITKGLHGEEMTEFGLLRAAGAVAFTEGRNT
IANTQIMRRALTYARDFNAVIACETRDPLLGANGVMNEGLFASWLGLSGTPREAEVIPLERDLRLAALTRSRYHAAQLSC
AMSADAMRRAKDLGTNVTAGVSINHLSLNENDIGEFRTFFRLSPPLRGEEDRLAMVEAVKNGTIDIVVSAHDPQDVDTKR
LPFSDAEAGAIGLETLLAAALRLYHNDNIPLLRLVEVLSTAPAKIFGLNAGTLKPGASADIAIVDLEEPWVVREEDLHSR
SKNSCFESARFQGRVVRTIVAGKTVYSA

Sequences:

>Translated_428_residues
MSAILFENARIVDPSRGLDETGSLLIENGKIVAAGSEARNQGAPEGAEIVDLDGKAVMPGLVDSRVFIGEPGAEHRETIA
SASRAAAAGGVTSIIMMPDTDPVIDDVALVEFVKRTARDTAIVNVHPAAAITKGLHGEEMTEFGLLRAAGAVAFTEGRNT
IANTQIMRRALTYARDFNAVIACETRDPLLGANGVMNEGLFASWLGLSGTPREAEVIPLERDLRLAALTRSRYHAAQLSC
AMSADAMRRAKDLGTNVTAGVSINHLSLNENDIGEFRTFFRLSPPLRGEEDRLAMVEAVKNGTIDIVVSAHDPQDVDTKR
LPFSDAEAGAIGLETLLAAALRLYHNDNIPLLRLVEVLSTAPAKIFGLNAGTLKPGASADIAIVDLEEPWVVREEDLHSR
SKNSCFESARFQGRVVRTIVAGKTVYSA
>Mature_427_residues
SAILFENARIVDPSRGLDETGSLLIENGKIVAAGSEARNQGAPEGAEIVDLDGKAVMPGLVDSRVFIGEPGAEHRETIAS
ASRAAAAGGVTSIIMMPDTDPVIDDVALVEFVKRTARDTAIVNVHPAAAITKGLHGEEMTEFGLLRAAGAVAFTEGRNTI
ANTQIMRRALTYARDFNAVIACETRDPLLGANGVMNEGLFASWLGLSGTPREAEVIPLERDLRLAALTRSRYHAAQLSCA
MSADAMRRAKDLGTNVTAGVSINHLSLNENDIGEFRTFFRLSPPLRGEEDRLAMVEAVKNGTIDIVVSAHDPQDVDTKRL
PFSDAEAGAIGLETLLAAALRLYHNDNIPLLRLVEVLSTAPAKIFGLNAGTLKPGASADIAIVDLEEPWVVREEDLHSRS
KNSCFESARFQGRVVRTIVAGKTVYSA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786722, Length=444, Percent_Identity=27.7027027027027, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI87082175, Length=446, Percent_Identity=25.5605381165919, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI86575075, Length=444, Percent_Identity=25.4504504504505, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322218, Length=201, Percent_Identity=25.8706467661692, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24642586, Length=380, Percent_Identity=26.3157894736842, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI18859883, Length=424, Percent_Identity=25.2358490566038, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45715; Mature: 45584

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAILFENARIVDPSRGLDETGSLLIENGKIVAAGSEARNQGAPEGAEIVDLDGKAVMPG
CCCEEECCCEEECCCCCCCCCCCEEEECCEEEEECCHHHCCCCCCCCEEEECCCCEECCC
LVDSRVFIGEPGAEHRETIASASRAAAAGGVTSIIMMPDTDPVIDDVALVEFVKRTARDT
CCCCEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCC
AIVNVHPAAAITKGLHGEEMTEFGLLRAAGAVAFTEGRNTIANTQIMRRALTYARDFNAV
EEEEECCHHHHHCCCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEE
IACETRDPLLGANGVMNEGLFASWLGLSGTPREAEVIPLERDLRLAALTRSRYHAAQLSC
EEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHH
AMSADAMRRAKDLGTNVTAGVSINHLSLNENDIGEFRTFFRLSPPLRGEEDRLAMVEAVK
HHHHHHHHHHHHCCCCEECCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHC
NGTIDIVVSAHDPQDVDTKRLPFSDAEAGAIGLETLLAAALRLYHNDNIPLLRLVEVLST
CCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
APAKIFGLNAGTLKPGASADIAIVDLEEPWVVREEDLHSRSKNSCFESARFQGRVVRTIV
CCCEEEECCCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHCCEEEEEEH
AGKTVYSA
HCCHHCCC
>Mature Secondary Structure 
SAILFENARIVDPSRGLDETGSLLIENGKIVAAGSEARNQGAPEGAEIVDLDGKAVMPG
CCEEECCCEEECCCCCCCCCCCEEEECCEEEEECCHHHCCCCCCCCEEEECCCCEECCC
LVDSRVFIGEPGAEHRETIASASRAAAAGGVTSIIMMPDTDPVIDDVALVEFVKRTARDT
CCCCEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCC
AIVNVHPAAAITKGLHGEEMTEFGLLRAAGAVAFTEGRNTIANTQIMRRALTYARDFNAV
EEEEECCHHHHHCCCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEE
IACETRDPLLGANGVMNEGLFASWLGLSGTPREAEVIPLERDLRLAALTRSRYHAAQLSC
EEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHH
AMSADAMRRAKDLGTNVTAGVSINHLSLNENDIGEFRTFFRLSPPLRGEEDRLAMVEAVK
HHHHHHHHHHHHCCCCEECCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHC
NGTIDIVVSAHDPQDVDTKRLPFSDAEAGAIGLETLLAAALRLYHNDNIPLLRLVEVLST
CCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
APAKIFGLNAGTLKPGASADIAIVDLEEPWVVREEDLHSRSKNSCFESARFQGRVVRTIV
CCCEEEECCCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHCCEEEEEEH
AGKTVYSA
HCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA