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The map label for this gene is ccdA [H]

Identifier: 225686370

GI number: 225686370

Start: 547441

End: 548202

Strand: Reverse

Name: ccdA [H]

Synonym: BMEA_B0558

Alternate gene names: 225686370

Gene position: 548202-547441 (Counterclockwise)

Preceding gene: 225686373

Following gene: 225686369

Centisome position: 46.24

GC content: 59.06

Gene sequence:

>762_bases
ATGAAAGAGGTACTGGTGCTTGATATTTCCTATATGACCGCCGCCGGAGCAGGCGCGCTGTCTTTCCTTTCGCCATGCGT
CCTGCCGCTCGTGCCGCCCTATTTGTGCTATATGGCCGGTGTCAGTGTCGAGGATTTTCGTGCCGATGCATCGAAGGCAA
CAGCAAAACCTTCCGCACGCCGTTCGCTGGGTTTCGCCGCGCTTTGCTTCGTCCTGGGCTTTACCACGGTTTTTGTCGCA
CTTGGCGCGGGCGCGTCGTCCATCGGCGCCTTCCTGCGCACCTGGCAGCAGCAGATCGCCATCGTTGCGGGTGTCGTCAT
CATTTTGATGGGGCTCAACTTTCTGGGTTTGCTGAGGCTTTCGTTCCTCTCGCGTGAGGCGCGATTCCAGGCCCGCAATG
CGCCTGCCTCACCGCTTGGTGCCTATATCATGGGGCTTGCCTTTGCTTTCGGTTGGACGCCCTGCATCGGGCCGGTGCTT
GGACCAATCCTGACGCTTGCAGGCGGCAGCAGCACGGTGGGTGAGGGCGCGCTTCTGCTTGCCACCTATTCGCTAGGCCT
TGGCATTCCGTTTCTCATCGCTGCTCTTTTTTCCGGTGCATTCATGCGCTTTCTTTCGCGCTTCCGGGTGCATCTGGGCA
AGGTTGAAAAAGCCATGGGCGTGCTTCTCATCATTGCGGGCGTCGTGTTCCTGACAGGCGGCATGCAATCCTTCTCGTTC
TGGCTGCTTGAAAACTTCCCGGCACTGGGGCGCTTGGGCTAA

Upstream 100 bases:

>100_bases
TGTTCGAACGAGATGCCGCATTGAAAATAGTCACCGTAAGGCTGAAGTTGGTTTATATAACCCTCGCGGTTGGCCCGGGC
CGTAGTAATATTATGAATGG

Downstream 100 bases:

>100_bases
AACTGTGCCAGCAATCCGTAAGTTTCCATATACGCTTTGATGCTATGTGCGTATAAGTCTTCAAAAAATTCGGACAACAC
CATGACTGACCGTACATGCC

Product: cytochrome c biogenesis protein

Products: DsbDoxidized; DsbGreduced [C]

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MKEVLVLDISYMTAAGAGALSFLSPCVLPLVPPYLCYMAGVSVEDFRADASKATAKPSARRSLGFAALCFVLGFTTVFVA
LGAGASSIGAFLRTWQQQIAIVAGVVIILMGLNFLGLLRLSFLSREARFQARNAPASPLGAYIMGLAFAFGWTPCIGPVL
GPILTLAGGSSTVGEGALLLATYSLGLGIPFLIAALFSGAFMRFLSRFRVHLGKVEKAMGVLLIIAGVVFLTGGMQSFSF
WLLENFPALGRLG

Sequences:

>Translated_253_residues
MKEVLVLDISYMTAAGAGALSFLSPCVLPLVPPYLCYMAGVSVEDFRADASKATAKPSARRSLGFAALCFVLGFTTVFVA
LGAGASSIGAFLRTWQQQIAIVAGVVIILMGLNFLGLLRLSFLSREARFQARNAPASPLGAYIMGLAFAFGWTPCIGPVL
GPILTLAGGSSTVGEGALLLATYSLGLGIPFLIAALFSGAFMRFLSRFRVHLGKVEKAMGVLLIIAGVVFLTGGMQSFSF
WLLENFPALGRLG
>Mature_253_residues
MKEVLVLDISYMTAAGAGALSFLSPCVLPLVPPYLCYMAGVSVEDFRADASKATAKPSARRSLGFAALCFVLGFTTVFVA
LGAGASSIGAFLRTWQQQIAIVAGVVIILMGLNFLGLLRLSFLSREARFQARNAPASPLGAYIMGLAFAFGWTPCIGPVL
GPILTLAGGSSTVGEGALLLATYSLGLGIPFLIAALFSGAFMRFLSRFRVHLGKVEKAMGVLLIIAGVVFLTGGMQSFSF
WLLENFPALGRLG

Specific function: Cytochrome c oxidase activity is partially restored by mutations in bdbC or bdbD that are defective in the synthesis of disulfide bond containing proteins. The same mutations abrogate the need for CcdA in sporulation [H]

COG id: COG0785

COG function: function code O; Cytochrome c biogenesis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DsbD family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834 [H]

Pfam domain/function: PF02683 DsbD [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 26541; Mature: 26541

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCCCCC
>Mature Secondary Structure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HHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DsbGoxidized; DsbDreduced/thiol:disulfide reductase [C]

Specific reaction: DsbDreduced/thiol:disulfide reductase + DsbCoxidized = DsbDoxidized + DsbCreduced DsbGoxidized + DsbDreduced/thiol:disulfide reductase = DsbGreduced + DsbDoxidized [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969507; 9068642; 9384377; 10781554; 11844773 [H]