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The map label for this gene is guaA [H]

Identifier: 225686194

GI number: 225686194

Start: 341161

End: 342723

Strand: Direct

Name: guaA [H]

Synonym: BMEA_B0360

Alternate gene names: 225686194

Gene position: 341161-342723 (Clockwise)

Preceding gene: 225686193

Following gene: 225686195

Centisome position: 28.78

GC content: 58.54

Gene sequence:

>1563_bases
ATGAGCACCACGGCATATCCTGACACAATCCTTATCATCGACTTTGGCAGCCAGGTCACGCAGCTTATTGCGCGGCGTGT
GCGCGAGGCCAATGTCTATTGCGAAATCGTTCCCTTCCAGTCTGCGGATGAGGCGTTCAAGCGGCTGCAGCCGAAGGGCG
TGATCCTTTCCGGCAGCCCGCATTCAACGACCGATATCGGTTCGCCGCGTGCGCCGCAGGCTATTTTTGATGCGGGTATT
CCGGTTCTCGGCATTTGTTATGGCGAGCAGACCATGTGCGCCCAGCTTGGCGGCAACGTGGAAAGCGGCCATGATCGCGA
GTTCGGCCGTGCTTTTCTCGATGTGCAGGAAGACAGTCCGCTCTTTGCCGGCATATGGGCCAAGGGCACCCGCCATCAGG
TCTGGATGAGCCATGGCGACCGTGTGACCTCGCTGCCGGATGGCTTCACCATCATCGGCACGTCGCCGAATGCGCCCTAC
GCGGTTATTGCGGATGAGAAGCGCAAATATTACGGCGTGCAGTTCCATCCGGAAGTTGTGCACACGCCGGACGGTGCAAA
GCTGTTGCAGAATTTCGTTCATCGCATTGTCGGGGTGAAGCCAGGCTGGACGATGGGGGCCTATCGCGAACAGGCTGTCG
AGGCGATCCGCAAACAGGTCGGCAGCGGCAAGGTTATCTGCGCGCTTTCAGGCGGCGTGGATTCTTCCGTGGCGGCACTT
CTGGCTCATGAAGCTGTCGGCGATCAACTGACATGCATTCTCGTTGATCACGGCCTGATGCGCAAAGACGAAGTGCAACA
GGTCGTGGAAATGTTCCGCGAGCATTACAATCTGCCGCTGATCCTGGTGGATGCTTCCGACCGCTTCATCGGCGCGCTTG
AGGGCGAAAGTGACCCGGAAAAGAAGCGCAAGACCATCGGTCGCCTGTTTATCGAAGTGTTCGAGGAAGAAGCAAGGAAA
CTTGGCGGCGCGGATTTCCTCGTGCAGGGTACGCTTTATCCTGACGTGATCGAAAGTGTTTCCTTTACCGGCGGTCCTTC
GGTCACGATCAAGTCGCACCATAATGTCGGCGGTTTGCCGGAGCGCATGAAGATGCAGCTTGTGGAGCCGCTGCGCGAGC
TTTTCAAGGATGAGGTTCGTCTGCTCGGCAAGGAACTCGGTCTGCCGGACAGCTTCATCGGGCGTCATCCGTTCCCCGGT
CCGGGTCTTGCGATCCGTTGTCCCGGCGGCGTCACGCGCGAGAAACTGGAAATCCTGCGCGAAGCGGACGCAATCTATCT
GGATGAAATCCGCAAGGCTGGCCTCTATGATGCGATCTGGCAGGCTTTCGCGGTTCTGCTTCCGGTGCAGACCGTGGGCG
TGATGGGGGATGGCCGCACTTACGAATTCGTTTGCGCCTTGCGCGCGGTGACTTCGGTGGACGGCATGACGGCGGATTTC
TACCACTACGACATGAATTTCCTCGGCAATGCGGCCACCCGCATCATCAACGAAGTCCGCGGCATCAACCGCGTTGTCTA
TGATGTGACCTCCAAGCCGCCCGGCACGATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
TGTCAGGATAGGCCGATTTTGGCTGCTTCTCCTGTTGAGCAACCCGCAGATAGGTCATATAGGCATTGCATCCCTGCTAG
TTTTTAAATAGACGCTGCAC

Downstream 100 bases:

>100_bases
TCCCGCATCCGGCATCAAAGAGCATTAAAACACCCATAAGCCCGCGTAACTGCGGGCTTTTTCTTGGTATGGGCATCTTC
TCACCATGCAAATGTGCAGG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSTTAYPDTILIIDFGSQVTQLIARRVREANVYCEIVPFQSADEAFKRLQPKGVILSGSPHSTTDIGSPRAPQAIFDAGI
PVLGICYGEQTMCAQLGGNVESGHDREFGRAFLDVQEDSPLFAGIWAKGTRHQVWMSHGDRVTSLPDGFTIIGTSPNAPY
AVIADEKRKYYGVQFHPEVVHTPDGAKLLQNFVHRIVGVKPGWTMGAYREQAVEAIRKQVGSGKVICALSGGVDSSVAAL
LAHEAVGDQLTCILVDHGLMRKDEVQQVVEMFREHYNLPLILVDASDRFIGALEGESDPEKKRKTIGRLFIEVFEEEARK
LGGADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMKMQLVEPLRELFKDEVRLLGKELGLPDSFIGRHPFPG
PGLAIRCPGGVTREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
YHYDMNFLGNAATRIINEVRGINRVVYDVTSKPPGTIEWE

Sequences:

>Translated_520_residues
MSTTAYPDTILIIDFGSQVTQLIARRVREANVYCEIVPFQSADEAFKRLQPKGVILSGSPHSTTDIGSPRAPQAIFDAGI
PVLGICYGEQTMCAQLGGNVESGHDREFGRAFLDVQEDSPLFAGIWAKGTRHQVWMSHGDRVTSLPDGFTIIGTSPNAPY
AVIADEKRKYYGVQFHPEVVHTPDGAKLLQNFVHRIVGVKPGWTMGAYREQAVEAIRKQVGSGKVICALSGGVDSSVAAL
LAHEAVGDQLTCILVDHGLMRKDEVQQVVEMFREHYNLPLILVDASDRFIGALEGESDPEKKRKTIGRLFIEVFEEEARK
LGGADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMKMQLVEPLRELFKDEVRLLGKELGLPDSFIGRHPFPG
PGLAIRCPGGVTREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
YHYDMNFLGNAATRIINEVRGINRVVYDVTSKPPGTIEWE
>Mature_519_residues
STTAYPDTILIIDFGSQVTQLIARRVREANVYCEIVPFQSADEAFKRLQPKGVILSGSPHSTTDIGSPRAPQAIFDAGIP
VLGICYGEQTMCAQLGGNVESGHDREFGRAFLDVQEDSPLFAGIWAKGTRHQVWMSHGDRVTSLPDGFTIIGTSPNAPYA
VIADEKRKYYGVQFHPEVVHTPDGAKLLQNFVHRIVGVKPGWTMGAYREQAVEAIRKQVGSGKVICALSGGVDSSVAALL
AHEAVGDQLTCILVDHGLMRKDEVQQVVEMFREHYNLPLILVDASDRFIGALEGESDPEKKRKTIGRLFIEVFEEEARKL
GGADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMKMQLVEPLRELFKDEVRLLGKELGLPDSFIGRHPFPGP
GLAIRCPGGVTREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADFY
HYDMNFLGNAATRIINEVRGINRVVYDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=553, Percent_Identity=35.0813743218806, Blast_Score=284, Evalue=1e-76,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=54.8571428571429, Blast_Score=597, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI71992710, Length=572, Percent_Identity=36.1888111888112, Blast_Score=275, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI133901714, Length=572, Percent_Identity=36.1888111888112, Blast_Score=275, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI71992717, Length=572, Percent_Identity=36.1888111888112, Blast_Score=275, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6323873, Length=520, Percent_Identity=53.0769230769231, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI281365319, Length=549, Percent_Identity=34.0619307832423, Blast_Score=270, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57170; Mature: 57039

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTAYPDTILIIDFGSQVTQLIARRVREANVYCEIVPFQSADEAFKRLQPKGVILSGSP
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCCCEEEECCC
HSTTDIGSPRAPQAIFDAGIPVLGICYGEQTMCAQLGGNVESGHDREFGRAFLDVQEDSP
CCCCCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCCCHHHHHHHEEECCCCC
LFAGIWAKGTRHQVWMSHGDRVTSLPDGFTIIGTSPNAPYAVIADEKRKYYGVQFHPEVV
EEEEEECCCCCEEEECCCCCEECCCCCCEEEEECCCCCCEEEEECCCCEEECEEECCCEE
HTPDGAKLLQNFVHRIVGVKPGWTMGAYREQAVEAIRKQVGSGKVICALSGGVDSSVAAL
ECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
LAHEAVGDQLTCILVDHGLMRKDEVQQVVEMFREHYNLPLILVDASDRFIGALEGESDPE
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCHH
KKRKTIGRLFIEVFEEEARKLGGADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCCCCEEEEECCCCCCCCH
ERMKMQLVEPLRELFKDEVRLLGKELGLPDSFIGRHPFPGPGLAIRCPGGVTREKLEILR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
EADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
HCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCEEEE
YHYDMNFLGNAATRIINEVRGINRVVYDVTSKPPGTIEWE
EEECHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
STTAYPDTILIIDFGSQVTQLIARRVREANVYCEIVPFQSADEAFKRLQPKGVILSGSP
CCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCCCEEEECCC
HSTTDIGSPRAPQAIFDAGIPVLGICYGEQTMCAQLGGNVESGHDREFGRAFLDVQEDSP
CCCCCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCCCHHHHHHHEEECCCCC
LFAGIWAKGTRHQVWMSHGDRVTSLPDGFTIIGTSPNAPYAVIADEKRKYYGVQFHPEVV
EEEEEECCCCCEEEECCCCCEECCCCCCEEEEECCCCCCEEEEECCCCEEECEEECCCEE
HTPDGAKLLQNFVHRIVGVKPGWTMGAYREQAVEAIRKQVGSGKVICALSGGVDSSVAAL
ECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
LAHEAVGDQLTCILVDHGLMRKDEVQQVVEMFREHYNLPLILVDASDRFIGALEGESDPE
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCHH
KKRKTIGRLFIEVFEEEARKLGGADFLVQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCCCCEEEEECCCCCCCCH
ERMKMQLVEPLRELFKDEVRLLGKELGLPDSFIGRHPFPGPGLAIRCPGGVTREKLEILR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
EADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
HCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCEEEE
YHYDMNFLGNAATRIINEVRGINRVVYDVTSKPPGTIEWE
EEECHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA