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The map label for this gene is guaB [H]

Identifier: 225686187

GI number: 225686187

Start: 331793

End: 333286

Strand: Direct

Name: guaB [H]

Synonym: BMEA_B0351

Alternate gene names: 225686187

Gene position: 331793-333286 (Clockwise)

Preceding gene: 225686179

Following gene: 225686190

Centisome position: 27.99

GC content: 59.77

Gene sequence:

>1494_bases
ATGGCTAAAATCGTGGAATCGCCCACCGGCGCACTCGCTCTCACATTCGACGATGTGTTGTTGCAGCCGGGCCATTCCGA
AGTGATGCCGGGGCAGGTTGATCTGCGCACCCGTATCGCCAAAGATATCGAACTCAATTTGCCGCTTCTCTCCGCCGCCA
TGGACACGGTGACGGAATCGCGTTTGGCCATAGCCATGGCGCAGGCGGGCGGCATTGGTGTCATCCACCGCAACCTTTCG
CCGGAACGCCAGGCCGAAGAAGTGCGGCAGGTGAAGAAGTTTGAATCCGGCATGGTCGTGAACCCGGTTACTATCGGACC
CGATGCCACGCTGGCCGATGCGCAGGCGCTGATGAAGGCACACGGCATTTCCGGCATTCCGGTGGTGGAAAATGCGACTA
AGGGGCCGGGCCGTCTCGTCGGTATCCTGACCAACCGCGACGTGCGTTTTGCTTCCGATCCCAAGCAGAAAATCTATGAA
CTGATGACCCGTGAAAACCTGATTACGGTTCATGAAAACGTCAATCAGGACGAAGCCAAGCGCCTTCTTCATTCGCATCG
TATCGAAAAACTGCTTGTCGTGGACGATAAGGACCGTTGCGTCGGTCTCGTCACGGTCAAGGATATTGAAAAATCACAGC
TTAACCCGAATGCCGCCAAGGATGCGCAGGGCCGTCTGCGCGCCGCTGCGGCAACCAGCGTTGGCGCGGATGGCTTTGAG
CGCGCCGAACGCCTGATTGATGCCGGTGTCGATCTGCTGGTTGTGGACACGGCGCATGGTCATTCCCAACGTGTTCTCGA
CGCTGTGGCGCGTATCAAGAAAGCCTATCCCAATGTCGCGGTTCTGGCTGGCAATGTGGCAACGACCGCCGGTACGCAGG
CGCTGATCGATGTTGGTGCGGATGCCGTCAAGGTTGGCATCGGACCCGGCTCCATCTGCACCACGCGCATTGTGGCTGGC
GTGGGCGTGCCGCAGCTTTCGGCCATCATGTCGGCTGTTGAAGCCGCGCAGAAGCAGAATATTCCGGTGATTGCCGATGG
CGGCATCAAGTTCTCCGGCGATTTCGCAAAGGCACTTGCCGCAGGCGCGGTTGCGGCCATGGCCGGCTCGCTTCTGGCTG
GCACGGAAGAAAGCCCCGGCGAGGTCTATCTGCATCAGGGCCGTTCCTTCAAGGCTTATCGCGGCATGGGTTCGGTTGGC
GCAATGGCGCGCGGTTCGGCGGATCGTTATTTCCAGGCGGAAGTGCGCGACGAACTGAAACTTGTGCCGGAAGGCATTGA
GGGGCAGGTCGCGTATAAGGGGCCGATCTCGGCGGTCCTGCATCAGCTTGCAGGCGGCTTGCGCGCCTCCATGGGCTATG
TGGGCGCAAAGACGCTGGAAGAATTCCGCGAGAAGGCCACCTTCGTGCGCATTTCCAATGCGGGCCTGCGCGAAAGCCAT
TCGCATGGCGTTGCCATCACCCGTGAAAGCCCGAACTATCCGGGCGGTATGTAA

Upstream 100 bases:

>100_bases
GTTACCAGCCAGTGCCAATTCAACCCAGTAACCCTGAGGCGTCGCTGCTCCCGAACCGTTTTCCGGAGAGGCGGCTTTTC
TTACTTCAAAGGAATTGGCA

Downstream 100 bases:

>100_bases
TACCGTACAACGGTTGAAGACGGACAGGGCGGCCCCAATGGAGCCGCCCTCTTTATTTTTAGAGTGGGATAGCTTTAAGC
CAGGTCAGTATCCCGCTCTA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MAKIVESPTGALALTFDDVLLQPGHSEVMPGQVDLRTRIAKDIELNLPLLSAAMDTVTESRLAIAMAQAGGIGVIHRNLS
PERQAEEVRQVKKFESGMVVNPVTIGPDATLADAQALMKAHGISGIPVVENATKGPGRLVGILTNRDVRFASDPKQKIYE
LMTRENLITVHENVNQDEAKRLLHSHRIEKLLVVDDKDRCVGLVTVKDIEKSQLNPNAAKDAQGRLRAAAATSVGADGFE
RAERLIDAGVDLLVVDTAHGHSQRVLDAVARIKKAYPNVAVLAGNVATTAGTQALIDVGADAVKVGIGPGSICTTRIVAG
VGVPQLSAIMSAVEAAQKQNIPVIADGGIKFSGDFAKALAAGAVAAMAGSLLAGTEESPGEVYLHQGRSFKAYRGMGSVG
AMARGSADRYFQAEVRDELKLVPEGIEGQVAYKGPISAVLHQLAGGLRASMGYVGAKTLEEFREKATFVRISNAGLRESH
SHGVAITRESPNYPGGM

Sequences:

>Translated_497_residues
MAKIVESPTGALALTFDDVLLQPGHSEVMPGQVDLRTRIAKDIELNLPLLSAAMDTVTESRLAIAMAQAGGIGVIHRNLS
PERQAEEVRQVKKFESGMVVNPVTIGPDATLADAQALMKAHGISGIPVVENATKGPGRLVGILTNRDVRFASDPKQKIYE
LMTRENLITVHENVNQDEAKRLLHSHRIEKLLVVDDKDRCVGLVTVKDIEKSQLNPNAAKDAQGRLRAAAATSVGADGFE
RAERLIDAGVDLLVVDTAHGHSQRVLDAVARIKKAYPNVAVLAGNVATTAGTQALIDVGADAVKVGIGPGSICTTRIVAG
VGVPQLSAIMSAVEAAQKQNIPVIADGGIKFSGDFAKALAAGAVAAMAGSLLAGTEESPGEVYLHQGRSFKAYRGMGSVG
AMARGSADRYFQAEVRDELKLVPEGIEGQVAYKGPISAVLHQLAGGLRASMGYVGAKTLEEFREKATFVRISNAGLRESH
SHGVAITRESPNYPGGM
>Mature_496_residues
AKIVESPTGALALTFDDVLLQPGHSEVMPGQVDLRTRIAKDIELNLPLLSAAMDTVTESRLAIAMAQAGGIGVIHRNLSP
ERQAEEVRQVKKFESGMVVNPVTIGPDATLADAQALMKAHGISGIPVVENATKGPGRLVGILTNRDVRFASDPKQKIYEL
MTRENLITVHENVNQDEAKRLLHSHRIEKLLVVDDKDRCVGLVTVKDIEKSQLNPNAAKDAQGRLRAAAATSVGADGFER
AERLIDAGVDLLVVDTAHGHSQRVLDAVARIKKAYPNVAVLAGNVATTAGTQALIDVGADAVKVGIGPGSICTTRIVAGV
GVPQLSAIMSAVEAAQKQNIPVIADGGIKFSGDFAKALAAGAVAAMAGSLLAGTEESPGEVYLHQGRSFKAYRGMGSVGA
MARGSADRYFQAEVRDELKLVPEGIEGQVAYKGPISAVLHQLAGGLRASMGYVGAKTLEEFREKATFVRISNAGLRESHS
HGVAITRESPNYPGGM

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=455, Percent_Identity=41.5384615384615, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI217035146, Length=455, Percent_Identity=41.0989010989011, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI34328930, Length=455, Percent_Identity=41.0989010989011, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI156616279, Length=455, Percent_Identity=41.0989010989011, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI34328928, Length=455, Percent_Identity=41.0989010989011, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI217035152, Length=451, Percent_Identity=41.019955654102, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI217035148, Length=455, Percent_Identity=40.2197802197802, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI217035150, Length=455, Percent_Identity=37.5824175824176, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI50541954, Length=263, Percent_Identity=37.2623574144487, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50541952, Length=263, Percent_Identity=37.2623574144487, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50541948, Length=263, Percent_Identity=37.2623574144487, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50541956, Length=263, Percent_Identity=37.2623574144487, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=36.9918699186992, Blast_Score=163, Evalue=4e-40,
Organism=Escherichia coli, GI1788855, Length=482, Percent_Identity=57.8838174273859, Blast_Score=523, Evalue=1e-149,
Organism=Escherichia coli, GI1786293, Length=259, Percent_Identity=37.4517374517375, Blast_Score=164, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI71994385, Length=474, Percent_Identity=37.1308016877637, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=38.2075471698113, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI17560440, Length=223, Percent_Identity=41.7040358744395, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323585, Length=459, Percent_Identity=38.562091503268, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6323464, Length=460, Percent_Identity=39.1304347826087, Blast_Score=320, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6322012, Length=454, Percent_Identity=37.8854625550661, Blast_Score=320, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=339, Percent_Identity=36.5781710914454, Blast_Score=243, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6319353, Length=114, Percent_Identity=40.3508771929825, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=37.9668049792531, Blast_Score=327, Evalue=9e-90,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=37.9668049792531, Blast_Score=327, Evalue=9e-90,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=38.2352941176471, Blast_Score=296, Evalue=2e-80,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52339; Mature: 52207

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIVESPTGALALTFDDVLLQPGHSEVMPGQVDLRTRIAKDIELNLPLLSAAMDTVTES
CCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
RLAIAMAQAGGIGVIHRNLSPERQAEEVRQVKKFESGMVVNPVTIGPDATLADAQALMKA
HHEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEEECCCCCHHHHHHHHHH
HGISGIPVVENATKGPGRLVGILTNRDVRFASDPKQKIYELMTRENLITVHENVNQDEAK
CCCCCCCCCCCCCCCCCEEEEEEECCCEEECCCHHHHHHHHHHHCCEEEEECCCCHHHHH
RLLHSHRIEKLLVVDDKDRCVGLVTVKDIEKSQLNPNAAKDAQGRLRAAAATSVGADGFE
HHHHHHCCCEEEEECCCCCEEEEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHH
RAERLIDAGVDLLVVDTAHGHSQRVLDAVARIKKAYPNVAVLAGNVATTAGTQALIDVGA
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHCCCCHHHHHCCC
DAVKVGIGPGSICTTRIVAGVGVPQLSAIMSAVEAAQKQNIPVIADGGIKFSGDFAKALA
CEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHH
AGAVAAMAGSLLAGTEESPGEVYLHQGRSFKAYRGMGSVGAMARGSADRYFQAEVRDELK
HHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCHHHCCCCCCEEHHHHHHHHH
LVPEGIEGQVAYKGPISAVLHQLAGGLRASMGYVGAKTLEEFREKATFVRISNAGLRESH
CCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCC
SHGVAITRESPNYPGGM
CCCEEEEECCCCCCCCC
>Mature Secondary Structure 
AKIVESPTGALALTFDDVLLQPGHSEVMPGQVDLRTRIAKDIELNLPLLSAAMDTVTES
CCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
RLAIAMAQAGGIGVIHRNLSPERQAEEVRQVKKFESGMVVNPVTIGPDATLADAQALMKA
HHEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEEECCCCCHHHHHHHHHH
HGISGIPVVENATKGPGRLVGILTNRDVRFASDPKQKIYELMTRENLITVHENVNQDEAK
CCCCCCCCCCCCCCCCCEEEEEEECCCEEECCCHHHHHHHHHHHCCEEEEECCCCHHHHH
RLLHSHRIEKLLVVDDKDRCVGLVTVKDIEKSQLNPNAAKDAQGRLRAAAATSVGADGFE
HHHHHHCCCEEEEECCCCCEEEEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHH
RAERLIDAGVDLLVVDTAHGHSQRVLDAVARIKKAYPNVAVLAGNVATTAGTQALIDVGA
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHCCCCHHHHHCCC
DAVKVGIGPGSICTTRIVAGVGVPQLSAIMSAVEAAQKQNIPVIADGGIKFSGDFAKALA
CEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHH
AGAVAAMAGSLLAGTEESPGEVYLHQGRSFKAYRGMGSVGAMARGSADRYFQAEVRDELK
HHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCHHHCCCCCCEEHHHHHHHHH
LVPEGIEGQVAYKGPISAVLHQLAGGLRASMGYVGAKTLEEFREKATFVRISNAGLRESH
CCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCC
SHGVAITRESPNYPGGM
CCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA