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The map label for this gene is trpA [H]

Identifier: 225853535

GI number: 225853535

Start: 2051796

End: 2052635

Strand: Reverse

Name: trpA [H]

Synonym: BMEA_A2168

Alternate gene names: 225853535

Gene position: 2052635-2051796 (Counterclockwise)

Preceding gene: 225853536

Following gene: 225853534

Centisome position: 96.56

GC content: 58.45

Gene sequence:

>840_bases
ATGACTACTCGCATCGACACCAAATTCGCCGAACTGAAGGCCGAGGGCCGTCCGGCGCTCGTTACCTATTTCATGGGCGG
CGATCCCGATCTGGAAACCGCGCTGAAGGTGATGAAAGCCCTGCCGAAAGCCGGCGCTGACGTGATCGAGCTTGGTATGC
CCTTCTCCGACCCGATGGCGGATGGACCCGCCATTCAGGCGGCTGGCCTTCGCGCCCTGAACGCCGGACAGACGCTGGCG
AAGACGCTTTATATGGCAGCAAAATTCCGCAAGGAAGACGATACGACCCCGATCGTCATGATGGGCTATTACAATCTGAT
CTATATCTATGGCGTGGAGCGTTTTCTGACCGATGCCAAGGCATCCGGCGTGGATGGGCTGATCGTTGTCGATCTTCCTT
CCGAAATGGATGCCGAGCTTTGCATTCCGGCAATGAAGGCGGGCATCAATTTCATCCGCCTCACCACGCCGACCACGGAC
GACAAGCGCCTGCCGAAAGTGCTGCATAATTCATCGGGCTTTGTCTATTATGTCTCGATGAACGGCATCACCGGCGCGGC
CATTGCCGATACGGCAAAGGTCGGCGAAGCGGTTCGCCATATCAAGAAAAGCACCGACCTGCCGATCTGTGTCGGTTTCG
GCGTCAAGACGCCGGAACAGGCTGCGGCAATCGCAACCCATGCCGATGGCGTCGTCGTGGGCACGGCCATTGTCAACGCA
ATTGCCGGTGAACTCGATGAAAAGGGCAAGGTGAAGGGTGATCCGGTTGCCGCCGCAACCCGGCTTGTCCACGCTCTTGC
AGAGAGTGTGCGCGCCACACGCCTTGAAGCCGCCCAATAA

Upstream 100 bases:

>100_bases
TTGGGATTATTGATTTTGAACGGCGTGCATGGATGGAAACGGCAATGGCTGGCAAGCCTGTTGCCGATTATCTCGCACGC
ACTTTGCCACGGGGCACGGT

Downstream 100 bases:

>100_bases
ATCGTCCATTTAAGCGGCTGAGAAGTCGTTGCCGAAGAACAAGAAACGGAACCAAACGTCATGAACTGGATCACCAACTA
CGTTCGTCCGAAGATCAATT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTTRIDTKFAELKAEGRPALVTYFMGGDPDLETALKVMKALPKAGADVIELGMPFSDPMADGPAIQAAGLRALNAGQTLA
KTLYMAAKFRKEDDTTPIVMMGYYNLIYIYGVERFLTDAKASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLTTPTTD
DKRLPKVLHNSSGFVYYVSMNGITGAAIADTAKVGEAVRHIKKSTDLPICVGFGVKTPEQAAAIATHADGVVVGTAIVNA
IAGELDEKGKVKGDPVAAATRLVHALAESVRATRLEAAQ

Sequences:

>Translated_279_residues
MTTRIDTKFAELKAEGRPALVTYFMGGDPDLETALKVMKALPKAGADVIELGMPFSDPMADGPAIQAAGLRALNAGQTLA
KTLYMAAKFRKEDDTTPIVMMGYYNLIYIYGVERFLTDAKASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLTTPTTD
DKRLPKVLHNSSGFVYYVSMNGITGAAIADTAKVGEAVRHIKKSTDLPICVGFGVKTPEQAAAIATHADGVVVGTAIVNA
IAGELDEKGKVKGDPVAAATRLVHALAESVRATRLEAAQ
>Mature_278_residues
TTRIDTKFAELKAEGRPALVTYFMGGDPDLETALKVMKALPKAGADVIELGMPFSDPMADGPAIQAAGLRALNAGQTLAK
TLYMAAKFRKEDDTTPIVMMGYYNLIYIYGVERFLTDAKASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLTTPTTDD
KRLPKVLHNSSGFVYYVSMNGITGAAIADTAKVGEAVRHIKKSTDLPICVGFGVKTPEQAAAIATHADGVVVGTAIVNAI
AGELDEKGKVKGDPVAAATRLVHALAESVRATRLEAAQ

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=265, Percent_Identity=35.0943396226415, Blast_Score=154, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6321412, Length=239, Percent_Identity=42.6778242677824, Blast_Score=193, Evalue=3e-50,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 29485; Mature: 29354

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRIDTKFAELKAEGRPALVTYFMGGDPDLETALKVMKALPKAGADVIELGMPFSDPMA
CCCCCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCC
DGPAIQAAGLRALNAGQTLAKTLYMAAKFRKEDDTTPIVMMGYYNLIYIYGVERFLTDAK
CCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECHHHEEHEEHHHHHHHHHH
ASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLTTPTTDDKRLPKVLHNSSGFVYYVSM
CCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEE
NGITGAAIADTAKVGEAVRHIKKSTDLPICVGFGVKTPEQAAAIATHADGVVVGTAIVNA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHCCCCCEEHHHHHHHH
IAGELDEKGKVKGDPVAAATRLVHALAESVRATRLEAAQ
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTRIDTKFAELKAEGRPALVTYFMGGDPDLETALKVMKALPKAGADVIELGMPFSDPMA
CCCCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCC
DGPAIQAAGLRALNAGQTLAKTLYMAAKFRKEDDTTPIVMMGYYNLIYIYGVERFLTDAK
CCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECHHHEEHEEHHHHHHHHHH
ASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLTTPTTDDKRLPKVLHNSSGFVYYVSM
CCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEE
NGITGAAIADTAKVGEAVRHIKKSTDLPICVGFGVKTPEQAAAIATHADGVVVGTAIVNA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHCCCCCEEHHHHHHHH
IAGELDEKGKVKGDPVAAATRLVHALAESVRATRLEAAQ
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA