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The map label for this gene is folC [H]

Identifier: 225853533

GI number: 225853533

Start: 2049499

End: 2050827

Strand: Reverse

Name: folC [H]

Synonym: BMEA_A2166

Alternate gene names: 225853533

Gene position: 2050827-2049499 (Counterclockwise)

Preceding gene: 225853534

Following gene: 225853519

Centisome position: 96.48

GC content: 59.89

Gene sequence:

>1329_bases
GTGACAGGAAAAGCCGCCGCCGCAATCGAGCGGCTTATGCAGTTGCATCCCAAGGGCTTCGATCTTTCGCTGGACCGCAT
TCGCGGCCTTCTGGAAAAGCTCGGCAATCCGCATCTGAAACTGCCGCCTGTGATCCATATCGCCGGGACCAACGGCAAGG
GATCGGCCACCGCCTTTTGCCGCGCGCTGCTTGAAGCGGGCGGCTTTAATGTTCACGTCCACACTTCGCCGCACCTCGTC
AACTGGCACGAACGCTATCGCCTTGCCGCGCCGGGCGGCGGCAAGCTGGTGGATGACGATGTGCTGGCGCAAGCCGTCGA
GCGCGTCGCTGCCGCCAATGGCGGACAGCACATCACGGTTTTCGAGATATTGACCGCCGTTGCCTTCGTCCTGTTTTCAG
AACATCCCGCCGATGCGGTCATCATGGAAGTCGGCCTTGGCGGGCGTTTCGACGCCACCAATGTCATTCCCGAGCCTGCG
GTCTCGCTCATCATGCCGGTTTCGATCGATCATCAAGCCTATCTCGGCGATACGGCAGAACTGATCGCAGCCGAAAAGGC
GGGCATCATCAAGAAGAACTGCCCGGTGGTCATCGGTTTCCAGCCTTTCGATACGGCGCGCGAAGTGCTCGTCTCGACTG
CCGATCGTCTCGACTGCCCTGTTTCTGTCTATGGTCAGGATTTCCTTGCCTTCGAGGAACATGGCCGCATGGTGTTCCAG
AACGAAGACGGGCTGATCGACCTGCCCTTGCCGCGCCTGCCGGGACGTCACCAGATATCCAACGCCGCCGCGGCAATCGA
AGCGGTGCAGATGGCGGGTTTCAACATTCCCGATAAGGCGGTTGAAAAGGCGCTTATGGTCGTGGACTGGCCGGCGCGTA
TGCAGCGCATGACGCATGGCAAGCTGATTGATCTTGCTCCGCCCGCTTCCGAAATCTGGCTCGATGGCGGCCATAATCCG
GGTGCGGGTGTGGTTATCGCGGAAGCTTTCGGCGACCTTGAAGAACGCAATGCGCGCCCGCTTTTCCTAATTACCGGCAT
GATCAACACGAAAGATCCGGTCGGCTATTTCGAGGCCTTCGCAGGCATGGCCCGCCATGTCTTCACCGTGCCCATTCCTT
CCAGCGATGCCGGAATTGCGAACACTGAACTGGCGCTTTCAGCCGAAAAGGCCGGGCTTTCCGCAGAGCCGGTTCATTCG
GTCGCCAATGCGCTGAAACTTCTGCACGATACCTGGCCCGCCGATGAGGCTCCGCCACGCATTCTGATTGGCGGATCGCT
CTATCTGGCGGGTGAAGTCCTGCGCGATAACGATACGCCCCCCCAATAA

Upstream 100 bases:

>100_bases
CAACGATTGCACGGCTTCTCAAGATCATGACGAAGCAGCCTGCCAACAGCGATGCACCCGCCCCCCAGAAGCCGGATGCT
GACAGCAAGGCAGCCTGATC

Downstream 100 bases:

>100_bases
GCAAAACCCGGCGCAAAGGCCGGGTCAGGCTGCTGACAAACCTCGGGCAGGGTCAAAATGGCCTCAGATTCACGGAACGT
CACAGATTCAAAACATGAAC

Product: folylpolyglutamate synthase FolC

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTGKAAAAIERLMQLHPKGFDLSLDRIRGLLEKLGNPHLKLPPVIHIAGTNGKGSATAFCRALLEAGGFNVHVHTSPHLV
NWHERYRLAAPGGGKLVDDDVLAQAVERVAAANGGQHITVFEILTAVAFVLFSEHPADAVIMEVGLGGRFDATNVIPEPA
VSLIMPVSIDHQAYLGDTAELIAAEKAGIIKKNCPVVIGFQPFDTAREVLVSTADRLDCPVSVYGQDFLAFEEHGRMVFQ
NEDGLIDLPLPRLPGRHQISNAAAAIEAVQMAGFNIPDKAVEKALMVVDWPARMQRMTHGKLIDLAPPASEIWLDGGHNP
GAGVVIAEAFGDLEERNARPLFLITGMINTKDPVGYFEAFAGMARHVFTVPIPSSDAGIANTELALSAEKAGLSAEPVHS
VANALKLLHDTWPADEAPPRILIGGSLYLAGEVLRDNDTPPQ

Sequences:

>Translated_442_residues
MTGKAAAAIERLMQLHPKGFDLSLDRIRGLLEKLGNPHLKLPPVIHIAGTNGKGSATAFCRALLEAGGFNVHVHTSPHLV
NWHERYRLAAPGGGKLVDDDVLAQAVERVAAANGGQHITVFEILTAVAFVLFSEHPADAVIMEVGLGGRFDATNVIPEPA
VSLIMPVSIDHQAYLGDTAELIAAEKAGIIKKNCPVVIGFQPFDTAREVLVSTADRLDCPVSVYGQDFLAFEEHGRMVFQ
NEDGLIDLPLPRLPGRHQISNAAAAIEAVQMAGFNIPDKAVEKALMVVDWPARMQRMTHGKLIDLAPPASEIWLDGGHNP
GAGVVIAEAFGDLEERNARPLFLITGMINTKDPVGYFEAFAGMARHVFTVPIPSSDAGIANTELALSAEKAGLSAEPVHS
VANALKLLHDTWPADEAPPRILIGGSLYLAGEVLRDNDTPPQ
>Mature_441_residues
TGKAAAAIERLMQLHPKGFDLSLDRIRGLLEKLGNPHLKLPPVIHIAGTNGKGSATAFCRALLEAGGFNVHVHTSPHLVN
WHERYRLAAPGGGKLVDDDVLAQAVERVAAANGGQHITVFEILTAVAFVLFSEHPADAVIMEVGLGGRFDATNVIPEPAV
SLIMPVSIDHQAYLGDTAELIAAEKAGIIKKNCPVVIGFQPFDTAREVLVSTADRLDCPVSVYGQDFLAFEEHGRMVFQN
EDGLIDLPLPRLPGRHQISNAAAAIEAVQMAGFNIPDKAVEKALMVVDWPARMQRMTHGKLIDLAPPASEIWLDGGHNPG
AGVVIAEAFGDLEERNARPLFLITGMINTKDPVGYFEAFAGMARHVFTVPIPSSDAGIANTELALSAEKAGLSAEPVHSV
ANALKLLHDTWPADEAPPRILIGGSLYLAGEVLRDNDTPPQ

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=326, Percent_Identity=28.2208588957055, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI66932990, Length=326, Percent_Identity=28.2208588957055, Blast_Score=122, Evalue=7e-28,
Organism=Escherichia coli, GI1788654, Length=374, Percent_Identity=30.4812834224599, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17553150, Length=484, Percent_Identity=25.4132231404959, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17553148, Length=484, Percent_Identity=25.4132231404959, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71984923, Length=484, Percent_Identity=25.4132231404959, Blast_Score=122, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323760, Length=436, Percent_Identity=30.5045871559633, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324815, Length=336, Percent_Identity=25.297619047619, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24641571, Length=179, Percent_Identity=33.5195530726257, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24581568, Length=220, Percent_Identity=27.7272727272727, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 47231; Mature: 47100

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS01012 FOLYLPOLYGLU_SYNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKAAAAIERLMQLHPKGFDLSLDRIRGLLEKLGNPHLKLPPVIHIAGTNGKGSATAFC
CCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCEECCCEEEEECCCCCCHHHHHH
RALLEAGGFNVHVHTSPHLVNWHERYRLAAPGGGKLVDDDVLAQAVERVAAANGGQHITV
HHHHHCCCCEEEEECCCCEECHHHCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEHH
FEILTAVAFVLFSEHPADAVIMEVGLGGRFDATNVIPEPAVSLIMPVSIDHQAYLGDTAE
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHEEEEECCCCHHHCCCHHH
LIAAEKAGIIKKNCPVVIGFQPFDTAREVLVSTADRLDCPVSVYGQDFLAFEEHGRMVFQ
HHHHHHCCCEECCCCEEEEECCCHHHHHHHHHHHHHCCCCEEECCCHHEEEHHCCCEEEE
NEDGLIDLPLPRLPGRHQISNAAAAIEAVQMAGFNIPDKAVEKALMVVDWPARMQRMTHG
CCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCEEEEEECHHHHHHHHCC
KLIDLAPPASEIWLDGGHNPGAGVVIAEAFGDLEERNARPLFLITGMINTKDPVGYFEAF
CEEECCCCHHHEEEECCCCCCCCEEEEHHHCCHHHCCCCEEEEEEECCCCCCCHHHHHHH
AGMARHVFTVPIPSSDAGIANTELALSAEKAGLSAEPVHSVANALKLLHDTWPADEAPPR
HHHHHCEEEEECCCCCCCCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCE
ILIGGSLYLAGEVLRDNDTPPQ
EEECCCEEEEEEEECCCCCCCC
>Mature Secondary Structure 
TGKAAAAIERLMQLHPKGFDLSLDRIRGLLEKLGNPHLKLPPVIHIAGTNGKGSATAFC
CCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCEECCCEEEEECCCCCCHHHHHH
RALLEAGGFNVHVHTSPHLVNWHERYRLAAPGGGKLVDDDVLAQAVERVAAANGGQHITV
HHHHHCCCCEEEEECCCCEECHHHCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEHH
FEILTAVAFVLFSEHPADAVIMEVGLGGRFDATNVIPEPAVSLIMPVSIDHQAYLGDTAE
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHEEEEECCCCHHHCCCHHH
LIAAEKAGIIKKNCPVVIGFQPFDTAREVLVSTADRLDCPVSVYGQDFLAFEEHGRMVFQ
HHHHHHCCCEECCCCEEEEECCCHHHHHHHHHHHHHCCCCEEECCCHHEEEHHCCCEEEE
NEDGLIDLPLPRLPGRHQISNAAAAIEAVQMAGFNIPDKAVEKALMVVDWPARMQRMTHG
CCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCEEEEEECHHHHHHHHCC
KLIDLAPPASEIWLDGGHNPGAGVVIAEAFGDLEERNARPLFLITGMINTKDPVGYFEAF
CEEECCCCHHHEEEECCCCCCCCEEEEHHHCCHHHCCCCEEEEEEECCCCCCCHHHHHHH
AGMARHVFTVPIPSSDAGIANTELALSAEKAGLSAEPVHSVANALKLLHDTWPADEAPPR
HHHHHCEEEEECCCCCCCCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCE
ILIGGSLYLAGEVLRDNDTPPQ
EEECCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]