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The map label for this gene is hisB

Identifier: 225853512

GI number: 225853512

Start: 2023494

End: 2024102

Strand: Direct

Name: hisB

Synonym: BMEA_A2143

Alternate gene names: 225853512

Gene position: 2023494-2024102 (Clockwise)

Preceding gene: 225853508

Following gene: 225853513

Centisome position: 95.19

GC content: 59.93

Gene sequence:

>609_bases
ATGACCGCTGAAAGCACCCGCAAGGCCAGCATCGAACGCTCCACCAAGGAAACGAGCATTGCCGTTTCCGTCGATCTGGA
TGGCGTCGGTAAGTTCGACATCACCACCGGCGTCGGCTTTTTCGATCATATGCTGGAACAACTTTCGCGCCATTCACTGA
TCGACATGCGCGTGATGGCCAAGGGCGACCTGCATATCGATGATCACCACACGGTCGAGGATACGGGTATCGCGCTCGGC
CAGGCCGTCGCCAAGGCTCTGGGCGAGCGGCGCGGCATCGTGCGCTATGCCTCGCTCGACCTTGCCATGGACGACACGCT
GACGGGTGCCGCAGTGGACGTATCGGGCCGCGCCTTTCTGGTCTGGAACGTGAATTTCACGACCGCCAAGATCGGCACCT
TCGACACCGAACTGGTGCGCGAATTCTTCCAGGCTTTCGCCATGAATGCTGGCATCACGCTTCATATCAACAATCATTAC
GGCGCCAACAACCACCATATCGCCGAATCGACCTTCAAGGCTGTTGCGCGCGTTCTGCGCGCCGCCCTTGAGACCGATCC
CCGCCAGAAGGACGCGATCCCCTCCACCAAGGGGTCGCTCAAGGGCTAA

Upstream 100 bases:

>100_bases
TTCCTGATTCCGGTTTTCGCCGCATTTATGCTCCGTCAGGTGGTTCCACCAGACTGCAAAATGCTCTAGAACCCCTCCAG
TATTTTCGTGAGGAAAGCCT

Downstream 100 bases:

>100_bases
AGCCTTTCCAGCAAAGCGGGGGGCGTCGGATAATGCGTAAAAACAGAGAAACAGGGCGGGCCCAACGACTCCGTTTCAAC
CGGAAACGTTCCAGACCCGA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MTAESTRKASIERSTKETSIAVSVDLDGVGKFDITTGVGFFDHMLEQLSRHSLIDMRVMAKGDLHIDDHHTVEDTGIALG
QAVAKALGERRGIVRYASLDLAMDDTLTGAAVDVSGRAFLVWNVNFTTAKIGTFDTELVREFFQAFAMNAGITLHINNHY
GANNHHIAESTFKAVARVLRAALETDPRQKDAIPSTKGSLKG

Sequences:

>Translated_202_residues
MTAESTRKASIERSTKETSIAVSVDLDGVGKFDITTGVGFFDHMLEQLSRHSLIDMRVMAKGDLHIDDHHTVEDTGIALG
QAVAKALGERRGIVRYASLDLAMDDTLTGAAVDVSGRAFLVWNVNFTTAKIGTFDTELVREFFQAFAMNAGITLHINNHY
GANNHHIAESTFKAVARVLRAALETDPRQKDAIPSTKGSLKG
>Mature_201_residues
TAESTRKASIERSTKETSIAVSVDLDGVGKFDITTGVGFFDHMLEQLSRHSLIDMRVMAKGDLHIDDHHTVEDTGIALGQ
AVAKALGERRGIVRYASLDLAMDDTLTGAAVDVSGRAFLVWNVNFTTAKIGTFDTELVREFFQAFAMNAGITLHINNHYG
ANNHHIAESTFKAVARVLRAALETDPRQKDAIPSTKGSLKG

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=47.9381443298969, Blast_Score=182, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324776, Length=220, Percent_Identity=38.6363636363636, Blast_Score=152, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_BRUA1 (B2S980)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935906.1
- ProteinModelPortal:   B2S980
- SMR:   B2S980
- GeneID:   6327054
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I19500
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21957; Mature: 21826

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAESTRKASIERSTKETSIAVSVDLDGVGKFDITTGVGFFDHMLEQLSRHSLIDMRVMA
CCCCCHHHHHHHCCCCCCEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEE
KGDLHIDDHHTVEDTGIALGQAVAKALGERRGIVRYASLDLAMDDTLTGAAVDVSGRAFL
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECEEECCCCCCEEEEECCCEEE
VWNVNFTTAKIGTFDTELVREFFQAFAMNAGITLHINNHYGANNHHIAESTFKAVARVLR
EEECCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
AALETDPRQKDAIPSTKGSLKG
HHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAESTRKASIERSTKETSIAVSVDLDGVGKFDITTGVGFFDHMLEQLSRHSLIDMRVMA
CCCCHHHHHHHCCCCCCEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEE
KGDLHIDDHHTVEDTGIALGQAVAKALGERRGIVRYASLDLAMDDTLTGAAVDVSGRAFL
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECEEECCCCCCEEEEECCCEEE
VWNVNFTTAKIGTFDTELVREFFQAFAMNAGITLHINNHYGANNHHIAESTFKAVARVLR
EEECCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
AALETDPRQKDAIPSTKGSLKG
HHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA