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The map label for this gene is hemE [H]

Identifier: 225853496

GI number: 225853496

Start: 2010733

End: 2011758

Strand: Reverse

Name: hemE [H]

Synonym: BMEA_A2127

Alternate gene names: 225853496

Gene position: 2011758-2010733 (Counterclockwise)

Preceding gene: 225853497

Following gene: 225853495

Centisome position: 94.64

GC content: 55.56

Gene sequence:

>1026_bases
ATGAATCTCAAGGTCTTGAAAGTGATCGACGGGGAAACAGTCTTTCCACCACCCATCTGGATGATGCGGCAGGCTGGGCG
CTATCTTCCCGAATATCGCGAAACACGGAAGAAGGCCGGAAGCTTTCTCGATTTGTGTTATTCGCCCGATCTGGCAGTTG
AAGTGACATTGCAGCCAATCCGCCGTTTCGGTTTTGATGCCGCCATTCTGTTTTCAGATATTCTTGTCGTCCCTCATGCA
CTTGGGCGAGACCTTCGCTTTGAAGAAGGCAAGGGACCATTGATGACGCCTATCGACGCCGATGAAATATTCTGGCTGGA
AACAGAAGGTGTCGCAAAGAGGCTGGAGCCGGTCTATGAGACGGTACGGCTGGTGCGCGAGCAACTCCCCGACGAAACCA
CGCTGCTTGGCTTCTGTGGCGCTCCCTGGACCGTTGCAACCTATATGATAGCCGGTCATGGCACACCCGATCAGGCGCCA
GCCCGTCTTTTCGCCTATCGTTTCCCCGAAGCTTTTGAAAAGCTCCTCAACGATCTCGCCGATGTTTCTGCGGAATATCT
GATCGAACAGCTTGGAGCTGGCGCAGATGCGGTCCAGATTTTCGATTCCTGGTCCGGTGTTCTGGATGAGGATTGCTTTG
AACGGTTCTGTATCCGCCCTGTTGCCCGGATCGTGCAGAAGGTGAGGGCGGTTTACCCGCAGGCCCGGATCATCGGCTTT
CCGAAGGGAGCGGGGATGCTCTATGCCGGGTATCGCGAGAAAACCGGCGTGGATATGCTGGGCCTCGACTGGTCGGTTCC
CCTGTCCTTTGCTGCCCTTCTTCAGGAAGAGGGCGCCGTTCAGGGCAATCTCGATCCCTTGCGCGTGGTTGCTGGCGGAA
ATGCGCTTGATGAAGGTGTTGATGCCATTCTGGAGCGTATGGGGCAGGGGCCGCTTGTCTTCAATCTCGGCCATGGTATT
ACACCGCAGGCGCCAATTGAAAATGTTCAGCGTATGATCGACAGGGTTCGCGGGGGGAAATCATGA

Upstream 100 bases:

>100_bases
AAGAATCAAAAGATTCCTGAATCATCCTTTCTTTATGAGAACCGGAACTGGATAAGTACGGAACCGGCCAACCCAACCAA
CAGCGTGGAATGGACAACCA

Downstream 100 bases:

>100_bases
CAGCAGCAACACCGGACAATAGTGGGCGGGCTGTGCTGATACGCACCGTCGTTTCACTGGTCATCGTGGTGCTCGGCGTC
TGGGCATTGTTTCACGTGAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MNLKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPIRRFGFDAAILFSDILVVPHA
LGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYETVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAP
ARLFAYRFPEAFEKLLNDLADVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGF
PKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGVDAILERMGQGPLVFNLGHGI
TPQAPIENVQRMIDRVRGGKS

Sequences:

>Translated_341_residues
MNLKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPIRRFGFDAAILFSDILVVPHA
LGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYETVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAP
ARLFAYRFPEAFEKLLNDLADVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGF
PKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGVDAILERMGQGPLVFNLGHGI
TPQAPIENVQRMIDRVRGGKS
>Mature_341_residues
MNLKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPIRRFGFDAAILFSDILVVPHA
LGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYETVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAP
ARLFAYRFPEAFEKLLNDLADVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGF
PKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGVDAILERMGQGPLVFNLGHGI
TPQAPIENVQRMIDRVRGGKS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=344, Percent_Identity=37.5, Blast_Score=212, Evalue=4e-55,
Organism=Escherichia coli, GI2367337, Length=345, Percent_Identity=41.1594202898551, Blast_Score=225, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6320252, Length=338, Percent_Identity=36.094674556213, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=37.7906976744186, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=37.7906976744186, Blast_Score=221, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37788; Mature: 37788

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPI
CCEEEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCCCEEEEEHHHH
RRFGFDAAILFSDILVVPHALGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYE
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHH
TVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFAYRFPEAFEKLLNDLA
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHH
DVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGF
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEC
PKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGV
CCCCCEEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHH
DAILERMGQGPLVFNLGHGITPQAPIENVQRMIDRVRGGKS
HHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNLKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPI
CCEEEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCCCEEEEEHHHH
RRFGFDAAILFSDILVVPHALGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYE
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHH
TVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFAYRFPEAFEKLLNDLA
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHH
DVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGF
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEC
PKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGV
CCCCCEEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHH
DAILERMGQGPLVFNLGHGITPQAPIENVQRMIDRVRGGKS
HHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA