Click here to switch to the map view.

The map label for this gene is argH

Identifier: 225853417

GI number: 225853417

Start: 1925993

End: 1927393

Strand: Direct

Name: argH

Synonym: BMEA_A2038

Alternate gene names: 225853417

Gene position: 1925993-1927393 (Clockwise)

Preceding gene: 225853415

Following gene: 225853418

Centisome position: 90.61

GC content: 59.53

Gene sequence:

>1401_bases
ATGAGCGAACAAAAATCAAGCAACCAGATGTGGGGCGGCCGTTTTGCCTCAGGGCCCGATGCGATCATGGAAGAGATCAA
TGCATCAATCGGTTTCGACCGCAAGCTCTATGCGCAGGATATTCAGGGCTCGCTCGCCCATGCAGCCATGCTCGCAAAGA
CGGGCATCATTGCGGCAGAAGACCACAAACAAATTGAAAATGGCTTGAAAACCATCCGCAAGGAAATAGAAGAGGGCAAA
TTCACCTTCTCGCGCAAGCTCGAAGACATTCACATGAACATCGAGGCGCGGCTGGCGGAATTGATCGGCCCTGCCGCCGG
GCGCCTCCACACCGCCCGTTCGCGCAATGACCAGGTGGCCGTCGATTTCCGTCTCTGGGTGAAGCAGGAACTGGAAAAAA
CCGCAGCCGCCCTCAAAAACCTGATCGAAGCGTTTCTGGAGCGCGCGGAAGAACACGCGGCAACAGTCATGCCGGGTTTC
ACCCATCTCCAGACCGCGCAGCCCGTCACCTTCGGCCATCACTGCATGGCCTATGTGGAAATGTTCGGCCGCGATCTTTC
GCGCGTGCGCGACGCCATCGAGCGCATAGACGAATCGCCTTTGGGTGCAGCCGCCCTTGCAGGCACCGGCTTTCCCATCG
ACCGTCACATGACGGCAAAGGCGCTGGGCTTCCGCGAGCCGACCCGCAATTCGCTCGACAGCGTTTCCGACCGCGATTAT
GCGCTGGAATTCCTGTCGCTTGCCGCAATCTGCGCCGGGCATCTTTCGCGCCTTGCCGAAGAGATCGTCATCTGGTCCAC
GCCGCAGTTCAATTTCGTGCGCCTTTCCGACGCCTTCTCCACCGGCTCCTCGATCATGCCGCAGAAGAAGAACCCGGACG
CCGCAGAACTGGTACGCGCCAAGACGGGCCGCATCAATGGTTCGCTGGTCGCACTTCTCACCATCATGAAGGGCCTGCCG
CTCGCCTATTCCAAGGACATGCAGGAAGACAAGGAACAGGTCTTCGACGCTGCCGAAAATCTGGAACTGGCGATTGCCGC
GATGGCTGGAATGGTGCGCGATCTCACCGTCAATGTCGCAGCCATGAAGAAGGCCGCAGGTTCCGGTTATTCCACCGCGA
CCGACCTTGCCGACTGGCTGGTGCGCACACTGGGCCTTCCCTTCCGCGAAGCCCATCACGTAACGGGCCGCGCCGTGGCG
CTTGCCGAAAGCCGCAAGGTCGATCTGGCAAAGCTCTCGCTTGAGGAATTGCAGTCGATCAACCCCGCCATCACAGCAGA
GGTCTTCGGCTATCTGACGGTGGAAAAATCGGTCAAAAGCCGCCAATCCTTCGGCGGCACCGCCCCGCAGGAAGTGCGCC
GCCAGATCCGCTACTGGAAAAAGCGTATTGCCAAGGCCTGA

Upstream 100 bases:

>100_bases
GATTTCGCATTCTGTTCGGATGTCGCCTTTTCGTTGTCTTCTGCCATATCGCGTCACTTCTTTCCAATATTCCGCCAAAT
CGTCTTCGGGGCATATGAGC

Downstream 100 bases:

>100_bases
CAAACGATCAACACCATGCCATGTGGAATCATCCGCCAAGAGATGATTCCACTTTCGGGCAATTTGGGTTAGACCTATCT
CCACAAATCAAATTCCGGGA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSEQKSSNQMWGGRFASGPDAIMEEINASIGFDRKLYAQDIQGSLAHAAMLAKTGIIAAEDHKQIENGLKTIRKEIEEGK
FTFSRKLEDIHMNIEARLAELIGPAAGRLHTARSRNDQVAVDFRLWVKQELEKTAAALKNLIEAFLERAEEHAATVMPGF
THLQTAQPVTFGHHCMAYVEMFGRDLSRVRDAIERIDESPLGAAALAGTGFPIDRHMTAKALGFREPTRNSLDSVSDRDY
ALEFLSLAAICAGHLSRLAEEIVIWSTPQFNFVRLSDAFSTGSSIMPQKKNPDAAELVRAKTGRINGSLVALLTIMKGLP
LAYSKDMQEDKEQVFDAAENLELAIAAMAGMVRDLTVNVAAMKKAAGSGYSTATDLADWLVRTLGLPFREAHHVTGRAVA
LAESRKVDLAKLSLEELQSINPAITAEVFGYLTVEKSVKSRQSFGGTAPQEVRRQIRYWKKRIAKA

Sequences:

>Translated_466_residues
MSEQKSSNQMWGGRFASGPDAIMEEINASIGFDRKLYAQDIQGSLAHAAMLAKTGIIAAEDHKQIENGLKTIRKEIEEGK
FTFSRKLEDIHMNIEARLAELIGPAAGRLHTARSRNDQVAVDFRLWVKQELEKTAAALKNLIEAFLERAEEHAATVMPGF
THLQTAQPVTFGHHCMAYVEMFGRDLSRVRDAIERIDESPLGAAALAGTGFPIDRHMTAKALGFREPTRNSLDSVSDRDY
ALEFLSLAAICAGHLSRLAEEIVIWSTPQFNFVRLSDAFSTGSSIMPQKKNPDAAELVRAKTGRINGSLVALLTIMKGLP
LAYSKDMQEDKEQVFDAAENLELAIAAMAGMVRDLTVNVAAMKKAAGSGYSTATDLADWLVRTLGLPFREAHHVTGRAVA
LAESRKVDLAKLSLEELQSINPAITAEVFGYLTVEKSVKSRQSFGGTAPQEVRRQIRYWKKRIAKA
>Mature_465_residues
SEQKSSNQMWGGRFASGPDAIMEEINASIGFDRKLYAQDIQGSLAHAAMLAKTGIIAAEDHKQIENGLKTIRKEIEEGKF
TFSRKLEDIHMNIEARLAELIGPAAGRLHTARSRNDQVAVDFRLWVKQELEKTAAALKNLIEAFLERAEEHAATVMPGFT
HLQTAQPVTFGHHCMAYVEMFGRDLSRVRDAIERIDESPLGAAALAGTGFPIDRHMTAKALGFREPTRNSLDSVSDRDYA
LEFLSLAAICAGHLSRLAEEIVIWSTPQFNFVRLSDAFSTGSSIMPQKKNPDAAELVRAKTGRINGSLVALLTIMKGLPL
AYSKDMQEDKEQVFDAAENLELAIAAMAGMVRDLTVNVAAMKKAAGSGYSTATDLADWLVRTLGLPFREAHHVTGRAVAL
AESRKVDLAKLSLEELQSINPAITAEVFGYLTVEKSVKSRQSFGGTAPQEVRRQIRYWKKRIAKA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=451, Percent_Identity=43.9024390243902, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI68303542, Length=451, Percent_Identity=43.9024390243902, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=42.1286031042129, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI68303547, Length=451, Percent_Identity=41.6851441241685, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=46.1706783369803, Blast_Score=410, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321806, Length=460, Percent_Identity=42.8260869565217, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI221473854, Length=457, Percent_Identity=38.2932166301969, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI78706858, Length=457, Percent_Identity=38.2932166301969, Blast_Score=343, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_BRUA1 (B2S8N8)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935816.1
- ProteinModelPortal:   B2S8N8
- SMR:   B2S8N8
- GeneID:   6326961
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I18600
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51267; Mature: 51136

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQKSSNQMWGGRFASGPDAIMEEINASIGFDRKLYAQDIQGSLAHAAMLAKTGIIAAE
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEECH
DHKQIENGLKTIRKEIEEGKFTFSRKLEDIHMNIEARLAELIGPAAGRLHTARSRNDQVA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEE
VDFRLWVKQELEKTAAALKNLIEAFLERAEEHAATVMPGFTHLQTAQPVTFGHHCMAYVE
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHH
MFGRDLSRVRDAIERIDESPLGAAALAGTGFPIDRHMTAKALGFREPTRNSLDSVSDRDY
HHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCHHHHCCCCHHH
ALEFLSLAAICAGHLSRLAEEIVIWSTPQFNFVRLSDAFSTGSSIMPQKKNPDAAELVRA
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEECCHHCCCCCCCCCCCCCCHHHHHHH
KTGRINGSLVALLTIMKGLPLAYSKDMQEDKEQVFDAAENLELAIAAMAGMVRDLTVNVA
HCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKKAAGSGYSTATDLADWLVRTLGLPFREAHHVTGRAVALAESRKVDLAKLSLEELQSI
HHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHEEHHHCCCCHHHHHHHHHHHCC
NPAITAEVFGYLTVEKSVKSRQSFGGTAPQEVRRQIRYWKKRIAKA
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEQKSSNQMWGGRFASGPDAIMEEINASIGFDRKLYAQDIQGSLAHAAMLAKTGIIAAE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEECH
DHKQIENGLKTIRKEIEEGKFTFSRKLEDIHMNIEARLAELIGPAAGRLHTARSRNDQVA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEE
VDFRLWVKQELEKTAAALKNLIEAFLERAEEHAATVMPGFTHLQTAQPVTFGHHCMAYVE
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHH
MFGRDLSRVRDAIERIDESPLGAAALAGTGFPIDRHMTAKALGFREPTRNSLDSVSDRDY
HHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCHHHHCCCCHHH
ALEFLSLAAICAGHLSRLAEEIVIWSTPQFNFVRLSDAFSTGSSIMPQKKNPDAAELVRA
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEECCHHCCCCCCCCCCCCCCHHHHHHH
KTGRINGSLVALLTIMKGLPLAYSKDMQEDKEQVFDAAENLELAIAAMAGMVRDLTVNVA
HCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKKAAGSGYSTATDLADWLVRTLGLPFREAHHVTGRAVALAESRKVDLAKLSLEELQSI
HHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHEEHHHCCCCHHHHHHHHHHHCC
NPAITAEVFGYLTVEKSVKSRQSFGGTAPQEVRRQIRYWKKRIAKA
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA