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The map label for this gene is hbdA [H]

Identifier: 225853405

GI number: 225853405

Start: 1916552

End: 1917427

Strand: Reverse

Name: hbdA [H]

Synonym: BMEA_A2026

Alternate gene names: 225853405

Gene position: 1917427-1916552 (Counterclockwise)

Preceding gene: 225853406

Following gene: 225853404

Centisome position: 90.2

GC content: 57.31

Gene sequence:

>876_bases
GTGGCAATCAAGACAGTAGGTATCATCGGCGCTGGCCAGATGGGCAGCGGCATCGCCCATGTATGCGCTCTGGCCGGATA
TAACGTGCTTTTGCATGATGCGGCACCAGACCGGCTGGAAAAGGGGATCGCTACCATCAATGGCAATATGGCGCGGCAGG
TCGCTTCCGGAAAATTGCAGGAAGAACAACGCGCTGACGCGATGAAGCTTATCCGCCCGGCAAACTCCATGCAGGATCTG
GCGGGTGTCGATCTTGCCATCGAGGCGGCGACGGAAGACGAAACCATCAAGCGCAAGATTTTCGCGCAGCTTTGCCCGGT
CCTGAACCCGGAAGCCATTCTGGCAACCAATACGTCATCGATTTCCATTACCCGGCTTGCATCCACGACCGATCGCCCTG
AACGCTTCATCGGCATTCACTTCATGAATCCGGTGCCGGTGATGAAGCTCGTCGAACTGGTGCGCGGCATTGCCACGGAA
GAAGATACGTTCCGCAAGTCCAATGATTTCGTCACCGCTCTCGGCAAAACCGTTACAGTGGCCGAAGACTTCCCGGCTTT
CATCGTCAACCGCATCCTGTTGCCGATGATCAACGAAGCAATCTATACGCTCTATGAAGGCGTGGGCAGCGTGGAAGCGA
TCGATACCGCCATGAAGCTTGGCGCGAACCATCCGATGGGGCCGCTGCAATTGGCCGACTTCATCGGCCTCGATACCTGC
CTTTCCATCATGCAGGTGCTGCATGACGGGCTTGCCGATTCCAAATATCGCCCGTGTCCGCTGCTCGTCAAATATGTCGA
GGCTGGCTGGCTTGGGCGCAAGACGGGCCGCGGCTTTTACGACTATCGCGGCGAACATCCCGTGCCGACGCGATAA

Upstream 100 bases:

>100_bases
AAAACCGTTTCATACTTTTGCTGGAAATGCTCTAGTCGCGAAATTTATACACTACCCGACCCGGTTTCGGGTCGGGCGGG
CGGATGAAGGAGTTAAAACG

Downstream 100 bases:

>100_bases
GGCATTTTCATCGGTGGAAATTCGGGGCTGGTTCAGAGGAACCAGCCCTTTTGTTTTTTCAGGATCTGTGCCGCCCCCAA
TAGGTTGGGTCTGTGGAAAA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MAIKTVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQEEQRADAMKLIRPANSMQDL
AGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSSISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRGIATE
EDTFRKSNDFVTALGKTVTVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLQLADFIGLDTC
LSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR

Sequences:

>Translated_291_residues
MAIKTVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQEEQRADAMKLIRPANSMQDL
AGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSSISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRGIATE
EDTFRKSNDFVTALGKTVTVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLQLADFIGLDTC
LSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR
>Mature_290_residues
AIKTVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQEEQRADAMKLIRPANSMQDLA
GVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSSISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRGIATEE
DTFRKSNDFVTALGKTVTVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLQLADFIGLDTCL
SIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=42.560553633218, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=41.042345276873, Blast_Score=204, Evalue=6e-53,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=31.2056737588652, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI261878539, Length=290, Percent_Identity=32.0689655172414, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI68989263, Length=290, Percent_Identity=32.0689655172414, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI115430219, Length=239, Percent_Identity=28.0334728033473, Blast_Score=78, Evalue=8e-15,
Organism=Escherichia coli, GI1787661, Length=285, Percent_Identity=40.7017543859649, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=31.0861423220974, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788682, Length=266, Percent_Identity=34.9624060150376, Blast_Score=134, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17553560, Length=292, Percent_Identity=43.1506849315069, Blast_Score=218, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=41.522491349481, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=37.7162629757785, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25144276, Length=283, Percent_Identity=33.2155477031802, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17508951, Length=283, Percent_Identity=33.2155477031802, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17508953, Length=283, Percent_Identity=33.2155477031802, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=31.8021201413428, Blast_Score=144, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=29.0780141843972, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=26.4285714285714, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19921000, Length=292, Percent_Identity=34.2465753424658, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24583077, Length=292, Percent_Identity=34.2465753424658, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24583079, Length=292, Percent_Identity=34.2465753424658, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=26.25, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20129993, Length=224, Percent_Identity=25, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31565; Mature: 31434

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKTVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQ
CCEEEEEEEECCCCCCHHHHHHHHHCCCEEEECCCHHHHHHCHHHHCCHHHHHHHHCCHH
EEQRADAMKLIRPANSMQDLAGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSS
HHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCC
ISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRGIATEEDTFRKSNDFVTALGKTVTV
EEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCEEEE
AEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLQLADFIGLDTC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AIKTVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQ
CEEEEEEEECCCCCCHHHHHHHHHCCCEEEECCCHHHHHHCHHHHCCHHHHHHHHCCHH
EEQRADAMKLIRPANSMQDLAGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSS
HHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCC
ISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRGIATEEDTFRKSNDFVTALGKTVTV
EEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCEEEE
AEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLQLADFIGLDTC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LSIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRGEHPVPTR
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]