Click here to switch to the map view.

The map label for this gene is proA [H]

Identifier: 225853285

GI number: 225853285

Start: 1792313

End: 1793596

Strand: Reverse

Name: proA [H]

Synonym: BMEA_A1893

Alternate gene names: 225853285

Gene position: 1793596-1792313 (Counterclockwise)

Preceding gene: 225853286

Following gene: 225853284

Centisome position: 84.38

GC content: 61.21

Gene sequence:

>1284_bases
ATGTTGGTCAAGGCGGATATGACGAAGGATATTGCGCAAGTGATGGCGGAGGTTGGCCGCAAGGCAAAAGCCGCTGCGGC
TCCTCTCTCCATTGCCACGAGCGAGCAGAAGAACAAGGCGCTGAATGCCGCTGCCGATGCAATCCTTGAAGCGCGCGCCG
ATATTCTTGAAGCCAACAGGCTTGATCTGGCCAATGCGGAAAAGAACGGCATGGCCGCTTCCTTCGTGGACCGGCTGACG
CTCAACGAAGCGCGCATTGACGCGATTGCGGAAGGTATCCGCGCCATTGCCACACTGCCCGACCCGGTTGGTGAAGTGAT
TGCCGAATGGGACCGCCCCAACGGCCTGCATATCGAACGTGTGCGCACGCCGCTTGGCGTGATCGGTGTCATCTATGAAA
GCCGCCCCAATGTGACCGCCGATGCCGGCGCGCTGTGCCTCAAGGCGGGCAATGCCGTCATCCTGCGTGGCGGCTCGGAT
TCGGCGCATTCCTCGGCTGCCATTTACAAGGCGCTGGTCAAGGGGCTTGAAGCCGCCAATCTGCCAGCCGATGCAATCCA
GATCGTGCCGGTGACGGACAGGGCTGCCGTTGGTGAAATGCTCAAAGGTCTTGGCGGCGCGATTGATGTCATTGTGCCGC
GCGGCGGCAAAAGCCTCGTTGCCCGCGTGCAATCGGAAGCGCGGGTGCCGGTTTTCGCGCATCTGGAAGGCATCTGCCAT
CTTTATATCGACAAGTCGGCTGATCTGGACATGGCGCGCAGGATTGCGCTCGATGCCAAGATGCGGCGCACCGGCATTTG
CGGGGCTGCGGAAACGCTGCTGGTGGATCGTGCCGTAGCTTCGACGCATCTGGCGCCGATCCTCGGCGATCTGGCTGCCG
GGGGCTGCGAAATTCGCGGCAGCGCGGAGGTGCTGGCGCTCTATCCGGCGGCAAAGCCTGCGACGGAGGAGGACTGGTCA
ACCGAATATCTCGACGCGATCATTTCCGTGGCGCTGGTTGACGGCATTTCGGGTGCGATAGACCATATCAACCGCTATTC
TTCGCATCACACCGAAGCCATCGTGGCCGAGGATGCGCAGACCGTTGCGCGTTTCTTCAACGAGATCGATTCAGCCATTT
TGCTGCACAATGCCTCCACGCAATTTGCCGATGGCGGCGAGTTCGGCATGGGCGCGGAAATCGGCATCGCCACCGGTAAG
ATGCATGCGCGCGGGCCGGTTGGCGTCGAGCAGCTGACCTCGTTCAAATATCGTGTGCGCGGCAGCGGCCAGGTTCGGGG
TTAA

Upstream 100 bases:

>100_bases
CAGTGCCATTCTTGGCTATGATGCCCGCGCGGCGATGATCCATCGCAACGATCTGGTGGTGCGGGCCGCCAGCGATGCGA
AAGCCGCATAGGGGGATAGG

Downstream 100 bases:

>100_bases
TGAAATTCGGCTTCGGGCTTTCTGCGCTCAAGGAACAATATCCCGGCGTTGATGCGCATTATCTGCGTATGCCGCATGTC
GAAAAGGGCATGACGGTGGG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLVKADMTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANRLDLANAEKNGMAASFVDRLT
LNEARIDAIAEGIRAIATLPDPVGEVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSD
SAHSSAAIYKALVKGLEAANLPADAIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICH
LYIDKSADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEVLALYPAAKPATEEDWS
TEYLDAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVARFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGK
MHARGPVGVEQLTSFKYRVRGSGQVRG

Sequences:

>Translated_427_residues
MLVKADMTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANRLDLANAEKNGMAASFVDRLT
LNEARIDAIAEGIRAIATLPDPVGEVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSD
SAHSSAAIYKALVKGLEAANLPADAIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICH
LYIDKSADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEVLALYPAAKPATEEDWS
TEYLDAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVARFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGK
MHARGPVGVEQLTSFKYRVRGSGQVRG
>Mature_427_residues
MLVKADMTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANRLDLANAEKNGMAASFVDRLT
LNEARIDAIAEGIRAIATLPDPVGEVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSD
SAHSSAAIYKALVKGLEAANLPADAIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICH
LYIDKSADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEVLALYPAAKPATEEDWS
TEYLDAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVARFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGK
MHARGPVGVEQLTSFKYRVRGSGQVRG

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=36.8292682926829, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=36.8292682926829, Blast_Score=260, Evalue=2e-69,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=39.6634615384615, Blast_Score=311, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI17569967, Length=418, Percent_Identity=35.4066985645933, Blast_Score=251, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI17569969, Length=418, Percent_Identity=35.4066985645933, Blast_Score=250, Evalue=8e-67,
Organism=Saccharomyces cerevisiae, GI6324899, Length=431, Percent_Identity=35.0348027842227, Blast_Score=262, Evalue=8e-71,
Organism=Drosophila melanogaster, GI21357643, Length=419, Percent_Identity=36.9928400954654, Blast_Score=244, Evalue=7e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44726; Mature: 44726

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVKADMTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANR
CCCCCHHHHHHHHHHHHHCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
LDLANAEKNGMAASFVDRLTLNEARIDAIAEGIRAIATLPDPVGEVIAEWDRPNGLHIER
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEHHH
VRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSAHSSAAIYKALVKGLEAAN
HHCCHHEEEEEEECCCCCCCCCCHHEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
LPADAIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICH
CCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHCCEEE
LYIDKSADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRG
EEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
SAEVLALYPAAKPATEEDWSTEYLDAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQ
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHH
TVARFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVR
HHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCCEEEC
GSGQVRG
CCCCCCC
>Mature Secondary Structure
MLVKADMTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANR
CCCCCHHHHHHHHHHHHHCCHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
LDLANAEKNGMAASFVDRLTLNEARIDAIAEGIRAIATLPDPVGEVIAEWDRPNGLHIER
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEHHH
VRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSAHSSAAIYKALVKGLEAAN
HHCCHHEEEEEEECCCCCCCCCCHHEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
LPADAIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICH
CCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHCCEEE
LYIDKSADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRG
EEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
SAEVLALYPAAKPATEEDWSTEYLDAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQ
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHH
TVARFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVR
HHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCCEEEC
GSGQVRG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA