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The map label for this gene is mltB [H]

Identifier: 225853270

GI number: 225853270

Start: 1779024

End: 1779851

Strand: Direct

Name: mltB [H]

Synonym: BMEA_A1877

Alternate gene names: 225853270

Gene position: 1779024-1779851 (Clockwise)

Preceding gene: 225853261

Following gene: 225853275

Centisome position: 83.69

GC content: 59.9

Gene sequence:

>828_bases
ATGGCATTCGTTGCCAAAGGCCGGTCTTGGACGGCAGCAGCAGTTATTGCGGTGGGCATGATGGCAGGTGCGGGCATCGC
CGAGGCAGCACAATGCGGCAACAATGCCGCCGGTTACAATGCCTGGCTTCAGCAGACGATGAAGGAAGCCGCATCGCGAG
GCATTGGCAAGGCAGGCATCAATGCGCTTGCCAACACGAAATATGCGCAGGCCACCATCAATGCCGACCGCAACCAGAAG
AGTTTCAAACTCTCCTTCGAGCAGTTCATGCAGAAGCGCGGGGCAGATACAATCATCAAGCGCGGCCGCGCCATGAAGCA
GCAGAATGCGGCCCTCTTCGCCAATATCGAAAAACGTTATGGCGTACCCGCCGGCCCGCTGATCGCGATCTGGGGTATGG
AAACCGGCTTTGGTTCCTATATGGGCAAGCAGCACACGCTTTCCGCCGTGGCAACGCTTGCCTATGACTGCCGCCGCAGC
GACTATTTCACCGACCAGCTTTACGCCGCCTTGAAGCTCATCGACCGTGAGGATTTGAGCCCAGCCGCCATCGGCGCCAT
GCATGGCGAAATCGGCCAGACCCAGTTCCTGCCCGTCAATGTCCTGAACTATGGTGTAGACGGCGACGGCAGCGGCCATA
TCGACATGGCGCGTTCCAAGGCGGACGCACTCTATTCCACCGCCAACTTCCTCGTCGGCCATGGCTGGCAGCGCGGGGCC
GGCTATCAGCCGGGCGAACCCAATTATGCCGCCATTCAGGGCTGGAATGCCGCACAGGTTTACCAGCGCGCCATCGCCGT
CATGGGCAAGGCCATCGACGGCAAATAA

Upstream 100 bases:

>100_bases
GCTCGGCCGATCACCCCGCCCCGCTGATACGGCATGACATTTGTTGTAAGGGATGGCAAATTCGCGTCGAAGTCGAATCA
AAACTCCAAAGGAGAGACGA

Downstream 100 bases:

>100_bases
TTGCATGAAATACAAGAAAGCCCGGCTTCGGCCGGGCTTTCTTGTACATTCACAATATTTCTATCAAAGTTCAGGGCGTT
TGAAATCACCGGTCTGGTGA

Product: lytic murein transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: 35 kDa soluble lytic transglycosylase; Murein hydrolase B; Slt35 [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MAFVAKGRSWTAAAVIAVGMMAGAGIAEAAQCGNNAAGYNAWLQQTMKEAASRGIGKAGINALANTKYAQATINADRNQK
SFKLSFEQFMQKRGADTIIKRGRAMKQQNAALFANIEKRYGVPAGPLIAIWGMETGFGSYMGKQHTLSAVATLAYDCRRS
DYFTDQLYAALKLIDREDLSPAAIGAMHGEIGQTQFLPVNVLNYGVDGDGSGHIDMARSKADALYSTANFLVGHGWQRGA
GYQPGEPNYAAIQGWNAAQVYQRAIAVMGKAIDGK

Sequences:

>Translated_275_residues
MAFVAKGRSWTAAAVIAVGMMAGAGIAEAAQCGNNAAGYNAWLQQTMKEAASRGIGKAGINALANTKYAQATINADRNQK
SFKLSFEQFMQKRGADTIIKRGRAMKQQNAALFANIEKRYGVPAGPLIAIWGMETGFGSYMGKQHTLSAVATLAYDCRRS
DYFTDQLYAALKLIDREDLSPAAIGAMHGEIGQTQFLPVNVLNYGVDGDGSGHIDMARSKADALYSTANFLVGHGWQRGA
GYQPGEPNYAAIQGWNAAQVYQRAIAVMGKAIDGK
>Mature_274_residues
AFVAKGRSWTAAAVIAVGMMAGAGIAEAAQCGNNAAGYNAWLQQTMKEAASRGIGKAGINALANTKYAQATINADRNQKS
FKLSFEQFMQKRGADTIIKRGRAMKQQNAALFANIEKRYGVPAGPLIAIWGMETGFGSYMGKQHTLSAVATLAYDCRRSD
YFTDQLYAALKLIDREDLSPAAIGAMHGEIGQTQFLPVNVLNYGVDGDGSGHIDMARSKADALYSTANFLVGHGWQRGAG
YQPGEPNYAAIQGWNAAQVYQRAIAVMGKAIDGK

Specific function: Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2951

COG function: function code M; Membrane-bound lytic murein transglycosylase B

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789053, Length=138, Percent_Identity=37.6811594202899, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011757 [H]

Pfam domain/function: NA

EC number: 3.2.1.- [C]

Molecular weight: Translated: 29374; Mature: 29242

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFVAKGRSWTAAAVIAVGMMAGAGIAEAAQCGNNAAGYNAWLQQTMKEAASRGIGKAGI
CCEEECCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
NALANTKYAQATINADRNQKSFKLSFEQFMQKRGADTIIKRGRAMKQQNAALFANIEKRY
HHHHCCCHHEEEECCCCCCHHHEEHHHHHHHHCCHHHHHHHHHHHHHHCCHHEEEHHHHC
GVPAGPLIAIWGMETGFGSYMGKQHTLSAVATLAYDCRRSDYFTDQLYAALKLIDREDLS
CCCCCCEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
PAAIGAMHGEIGQTQFLPVNVLNYGVDGDGSGHIDMARSKADALYSTANFLVGHGWQRGA
HHHHHHHHCCCCCCEEEEEEHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
GYQPGEPNYAAIQGWNAAQVYQRAIAVMGKAIDGK
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AFVAKGRSWTAAAVIAVGMMAGAGIAEAAQCGNNAAGYNAWLQQTMKEAASRGIGKAGI
CEEECCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
NALANTKYAQATINADRNQKSFKLSFEQFMQKRGADTIIKRGRAMKQQNAALFANIEKRY
HHHHCCCHHEEEECCCCCCHHHEEHHHHHHHHCCHHHHHHHHHHHHHHCCHHEEEHHHHC
GVPAGPLIAIWGMETGFGSYMGKQHTLSAVATLAYDCRRSDYFTDQLYAALKLIDREDLS
CCCCCCEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
PAAIGAMHGEIGQTQFLPVNVLNYGVDGDGSGHIDMARSKADALYSTANFLVGHGWQRGA
HHHHHHHHCCCCCCEEEEEEHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
GYQPGEPNYAAIQGWNAAQVYQRAIAVMGKAIDGK
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7476170; 7789526; 9205837; 9278503; 3553176; 9761817; 10570954; 10545329; 10684641 [H]